一种多相一体化制备三叶青提取物的方法及其在口腔护理组合物中的应用

By employing a multiphase integrated extraction process and low-temperature centrifugation technology, steroidal, polysaccharide, and flavonoid components in *Trifolium repens* are efficiently extracted and preserved. This addresses the shortcomings of existing technologies in the application of *Trifolium repens* extract in oral care products, achieving highly effective hemostatic and coagulation effects as well as prevention and treatment of various oral diseases.

CN118512523BActive Publication Date: 2026-07-17NICE ZHEJIANG TECH CO LTD +1

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NICE ZHEJIANG TECH CO LTD
Filing Date
2024-05-13
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

There is a lack of effective development of using Tripterygium wilfordii extract alone in oral care products in the existing technology, and existing methods are difficult to efficiently extract and maintain the activity of multiple active ingredients of Tripterygium wilfordii.

Method used

A multiphase integrated extraction process was adopted, using dichloromethane, water and petroleum ether as three-phase extraction solvents. Combined with the addition of acetonitrile and low-temperature centrifugation technology, steroidal, polysaccharide and flavonoid components in Trifolium repens were separated to ensure efficient extraction and preservation of activity.

Benefits of technology

It achieves efficient extraction of Trifoliate Oral Extract, maintains the high activity of various components, and has excellent hemostatic and coagulation effects when added to oral care compositions. It can quickly eliminate gum bleeding, swelling and other phenomena, and effectively prevent and treat a variety of oral diseases.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明涉及植物提取技术领域,公开了一种多相一体化制备三叶青提取物的方法及其在口腔护理组合物中的应用。该方法包括:1)将三叶青和乙腈添加至三相萃取液中振摇;2)搅拌,超声震荡萃取;3)静置,离心,过滤;4)滤液静置,低温离心,分层;取上层,浓缩,干燥,得甾体类;取中间层,浓缩,加乙醇醇沉,离心,取沉淀物,冷冻干燥,得多糖;将下层浓缩,干燥,得黄酮类。本发明的多相一体化制备三叶青提取物的方法,工艺简单,可一次性提取多种三叶青有效成分,不仅提取效率 / 提取率高,且可确保有效成分维持高活性;将本发明的三叶青提取物添加至口腔护理组合物中可迅速消除牙龈出血、肿胀等现象。
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