A traditional Chinese medicine composition for identifying and treating cough-variant asthma and application thereof

Abstract

The application discloses a disease-differentiating and treating cough variant asthma traditional Chinese medicine composition and application, and relates to the field of traditional Chinese medicine, which comprises honey ephedra, cassia twig, dried ginger, baizhi, schisandra chinensis, white peony root, platycodon grandiflorum, radix baiqian, honey mulberry white bark, jujube and honeyed licorice. The composition has the effects of dispersing lung and cold, eliminating phlegm and cough, and astringing lung and relieving asthma, can be used for disease-differentiating and treating cough variant asthma, effectively alleviates the clinical symptoms of cough variant asthma, and achieves outstanding clinical curative effect through clinical verification. The medicine is more in line with the actual scene of clinical use of traditional Chinese medicine preparations.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically, it relates to a traditional Chinese medicine composition for treating cough variant asthma and its application. Background Technology

[0002] Cough variant asthma is a latent form of asthma, characterized by chronic cough as the sole clinical manifestation, but with airway hyperresponsiveness and no obvious wheezing or shortness of breath. Because of the lack of obvious wheezing and shortness of breath, and its resemblance to an irritating cough, it is often misdiagnosed as bronchitis in its early stages. However, its pathophysiological changes are very similar to those of asthma, including persistent airway inflammation and airway hyperresponsiveness. While asthma can be effectively controlled with treatment, it remains incurable, severely impacting patients' physical and mental health and quality of life, and increasing the socioeconomic burden.

[0003] In recent years, epidemiological surveys both domestically and internationally have shown that the prevalence of asthma is increasing year by year. Data shows that in my country, the clinically diagnosed prevalence of asthma among people aged 14 and above is 1.24%, with newly diagnosed asthma accounting for 26%. The prevalence of cough-variant asthma is also increasing annually, possibly due to environmental pollution and increased atypical pathogen infections. Current treatment mainly follows asthma prevention and treatment guidelines, divided into initial treatment and long-term (stepwise) treatment, primarily using controller medications and reliever medications. The advantage of Traditional Chinese Medicine (TCM) treatment lies in its combination of syndrome differentiation and disease-based treatment. However, according to incomplete statistics, the vast majority of cough-variant asthma patients consult respiratory specialists, adopting the above treatment model and widely using traditional Chinese medicine preparations. Only a very small number of patients consult TCM specialists, using a treatment method that combines disease and syndrome differentiation, primarily using decoctions or granules of Chinese medicine. Currently, respiratory physicians generally lack the ability to differentiate syndromes using TCM, making disease-based treatment with traditional Chinese medicine preparations more in line with clinical practice. Therefore, developing traditional Chinese medicine preparations for treating cough-variant asthma that only require disease differentiation is more meaningful. A literature review and review of the National Essential Medicines List revealed that there are currently no specific traditional Chinese medicine (TCM) preparations for treating cough-variant asthma. Most TCM preparations available are designed to relieve cough symptoms and are based on the TCM theory of syndrome differentiation and treatment. These TCM preparations are primarily used by physicians lacking TCM diagnostic skills, leading to inconsistent efficacy in treating cough-variant asthma with existing technology. Although different patients with cough-variant asthma have different TCM syndrome types, and even the same patient may have different syndrome types at different stages of the disease, cough-variant asthma has its own unique pathogenesis and evolutionary patterns. The development and improvement of TCM compositions for cough-variant asthma are ongoing. Therefore, based on clinical practice, we have developed an effective TCM composition formula for treating cough-variant asthma, grounded in TCM disease differentiation theory. Summary of the Invention

[0004] The technical problem to be solved by this invention is to overcome the shortcomings of the prior art and provide a traditional Chinese medicine composition for the treatment of cough variant asthma and its application. To solve the above technical problem, the basic concept of the technical solution adopted by this invention is as follows:

[0005] This invention provides a traditional Chinese medicine composition for treating cough variant asthma, comprising the following parts by weight of traditional Chinese medicine raw materials: 6-9 parts of honey-processed ephedra, 9-12 parts of cinnamon twig, 6-9 parts of dried ginger, 9-12 parts of angelica dahurica, 12-15 parts of schisandra chinensis, 12-15 parts of white peony root, 9-12 parts of platycodon grandiflorus, 9-12 parts of cynanchum paniculatum, 6-9 parts of honey-processed mulberry bark, 12-15 parts of jujube, and 6-9 parts of prepared licorice root.

[0006] Furthermore, the herbal ingredients include the following parts by weight: 9 parts honey-processed ephedra, 12 parts cinnamon twig, 9 parts dried ginger, 12 parts angelica dahurica, 15 parts schisandra chinensis, 15 parts white peony root, 12 parts platycodon grandiflorus, 12 parts cynanchum paniculatum, 9 parts honey-processed mulberry bark, 15 parts jujube, and 9 parts prepared licorice root.

[0007] Another aspect of the present invention provides a drug for treating cough variant asthma, comprising the above-mentioned traditional Chinese medicine composition.

[0008] Furthermore, the drug also includes pharmaceutically acceptable excipients.

[0009] Furthermore, the excipients include excipients.

[0010] Furthermore, the excipient is honey.

[0011] Furthermore, the dosage form of the drug is a decoction, tablet, pill, granule, or capsule.

[0012] While there is no specific disease called "cough-variant asthma" in ancient Chinese medical texts, based on its etiology, pathogenesis, and symptoms, it can be categorized under "cough," "asthma," and "wheezing." The term "cough" first appeared in the *Huangdi Neijing* (Yellow Emperor's Inner Classic), such as in the *Suwen* (Plain Questions) chapter "Xuanming Wuqi" which states, "Diseases caused by the five qi...cause cough in the lungs," indicating that the location of cough is in the lungs. The *Suwen* chapter "Cough Theory" states, "The skin and hair are first affected by pathogenic qi, which then follows its pathway," and "All five viscera and six bowels can cause cough, not just the lungs," indicating that cough is not only caused by pathogenic qi invading the lungs, but also by dysfunction of other organs. It wasn't until the *Jingyue Quanshu* (Complete Works of Jingyue) chapter "Cough" that a more concise and comprehensive approach was taken, dividing cough into two main categories: exogenous and endogenous, which aligns with clinical practice. Ancient physicians discussed the treatment of cough extensively. The *Jingyue Quanshu* chapter "Cough" proposed the treatment principle of "pungent and warm" dispersing methods for exogenous cough and "sweet and neutral" nourishing yin methods for endogenous cough. The *Medical Orthodox Transmission* emphasizes that treating coughs requires prioritizing the regulation of Qi, stating, "To treat a cough, one should first address phlegm. Addressing phlegm must primarily focus on regulating Qi." The *Medical Laws* outlines contraindications for cough treatment, stating, "When pathogenic factors are strong and coughs are frequent, astringent and purgative drugs should never be used. Only when the cough has been prolonged and its intensity has weakened can astringent drugs be applied." In short, coughs, whether caused by external pathogenic factors or internal ones, are all due to the lungs' failure to disperse and descend Qi, resulting in the upward reversal of lung Qi.

[0013] Through in-depth study of traditional Chinese medicine classics and literature review, summarizing the views of physicians from the Han Dynasty to the present, and combining long-term clinical practice, the inventor innovated while inheriting tradition. He believes that the main location of cough variant asthma is the lungs, and the pathogenesis is the same as that of ordinary cough, which is the invasion of pathogenic factors into the lungs and the upward reversal of lung qi. However, it is different from ordinary cough, as it is a combination of exogenous cough and endogenous cough. In the early stage of the disease, the pathogenic factors of wind and cold are the main pathogenic factors. Due to the failure or mistreatment of traditional Chinese medicine, the pathogenic factors in the lungs have not been expelled, and there is a state of cold transformation and phlegm and lung qi damage. Therefore, there is a persistent cough, intermittent cough, and it is characterized by being induced or aggravated by exercise, cold air, climate change or upper respiratory tract infection, and the cough is more obvious at night or in the early morning.

[0014] Traditional Chinese medicine (TCM) considers the lungs to be the "Minister of the Body," governing qi, regulating the hundred vessels, controlling the flow of qi and blood, regulating water metabolism, and controlling respiration. Combining the etiology, pathogenesis, and symptom characteristics of cough-variant asthma, the inventor pioneered a treatment principle based on restoring the physiological functions of the lungs according to TCM: 1. Identifying the disease and treating accordingly is fundamental; 2. Restoring the physiological functions of the lungs (in TCM) is essential; 3. Warming and transforming cold phlegm and astringing lung qi are key; 4. Using a combination of dispersing and astringing, combining ascending and descending, and warming while clearing are methods; 5. Strengthening the earth element to generate metal is the finishing touch. Based on the principle of "prescribing medicine according to the method," and adhering to the theory of "principal, assistant, adjuvant, and guide," we fully utilize the advantages of TCM's "multiple effects from one medicine" and "synergistic effects," using the classic formulas Xiao Qinglong Tang and Xie Bai San as base formulas. Through more than eight years of clinical practice and continuous exploration and optimization, we have formed the TCM composition scheme of this invention.

[0015] The self-developed traditional Chinese medicine formula of this invention consists of: honey-processed ephedra, cinnamon twig, dried ginger, angelica dahurica, schisandra chinensis, white peony root, platycodon grandiflorus, cynanchum paniculatum, honey-processed mulberry bark, jujube, and prepared licorice root.

[0016] In this invention's formula, honey-processed ephedra and cinnamon twig serve as the principal herbs, working together to disperse latent cold in the lungs and warm and transform phlegm-dampness. Ephedra disperses lung qi and relieves cough and asthma, while cinnamon twig transforms qi and promotes water metabolism to facilitate the transformation of phlegm-dampness in the lungs. Dried ginger is pungent, sweet, and very hot, effectively warming the lungs and transforming phlegm; angelica dahurica can promote lung qi, raise clear qi in the yangming channel, and clear blocked orifices, serving as the assistant herbs. However, given the long course of the disease and the damage to lung qi, using only pungent and warm dispersing herbs might further deplete lung qi. Therefore, schisandra is added to astringe the lungs and stop coughing, and white peony root nourishes the blood. These two herbs, combined with the pungent and dispersing herbs, enhance the cough-relieving and asthma-relieving effects while mitigating the excessive pungent, warm, and drying properties. Platycodon grandiflorus is bitter, pungent, and neutral in nature, effectively opening and dispersing lung qi; Cynanchum paniculatum is pungent, sweet, and neutral in nature, effectively descending qi and resolving phlegm. The combined ascending and descending effects of these two herbs restore the descending and dispersing functions of lung qi and also stop coughing and resolve phlegm. Honey-processed mulberry bark is sweet, cold, and descending in nature, specifically entering the lung meridian to clear lung heat. This formula, used in conjunction with warm and pungent herbs, provides both warmth and clarity. The lungs are a delicate organ, intolerant of both heat and cold; this formula prevents the excessive use of warming herbs while clearing and purifying lung qi, restoring its descending function. These five herbs serve as adjuvants. Jujube, sweet and warm, tonifies the middle jiao and benefits qi; prepared licorice root, sweet and neutral, strengthens the spleen and benefits qi. Together, these two herbs tonify the spleen qi, promoting the generation of lung qi. Jujube also nourishes blood, assisting white peony in nourishing blood and regulating the body. Prepared licorice root and platycodon root also benefit the throat and relieve cough. Prepared licorice root further harmonizes the other herbs, serving as adjuvants and guiding herbs. The combination of these herbs fully utilizes the advantages of traditional Chinese medicine, such as "treatment based on evidence," "medication based on principles," "multiple effects from one herb," ​​and "synergistic enhancement," completely covering the fundamental causes, key mechanisms, and characteristics of cough-variant asthma. It plays a therapeutic and preventative role by addressing cough and other symptoms by "eliminating if present and preventing if absent."

[0017] By adopting the above technical solution, the present invention has the following beneficial effects compared with the prior art.

[0018] The traditional Chinese medicine composition provided by this invention has the effects of dispelling cold and dampness in the lungs, resolving phlegm and relieving cough, and astringing the lungs and relieving asthma. It can be used to treat cough-variant asthma and effectively alleviate the clinical symptoms of cough-variant asthma. This medicine is based on the theory of disease differentiation and treatment, and can be used based on disease identification, achieving outstanding clinical efficacy. It is more in line with the actual clinical use of traditional Chinese medicine preparations.

[0019] The specific embodiments of the present invention will be described in further detail below. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments will be clearly and completely described below. The following embodiments are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0021] Example 1

[0022] (1) According to the proportions shown in Example 1 in Table 1, mix and decoct the various Chinese herbal raw materials. Use a clay pot as a container, add an appropriate amount of water, and decoct twice, each time for 25 minutes. Mix the resulting Chinese herbal decoctions together. The weight ratio of the Chinese herbal mixture to water is 1:1, both times. (1:1-1.5 can achieve the same effect. The ratio of the Chinese herbal mixture to water has no effect on the efficacy, but the minimum amount of water is required to ensure that the Chinese herbal mixture can always boil during the 25-minute decoction process. The amount of water can be slightly more, but not less. It is necessary to take all the decoctions as required. For patients who also have other diseases that are not suitable for drinking too much water at one time, choose a 1:1 ratio if possible.)

[0023] (2) Divide all the Chinese herbal decoctions obtained in (1) into two equal portions and take them warm half an hour before breakfast and dinner. Example 1 is more suitable for patients with milder symptoms and shorter disease course.

[0024] Example 2

[0025] Similar to Example 1, the difference lies in the formulation of each Chinese herbal medicine ingredient, as shown in Example 2 in Table 1. Example 2 is more suitable for patients with more severe conditions and longer disease courses.

[0026] Example 3

[0027] Similar to Example 1, the difference lies in the formulation of each Chinese herbal medicine ingredient as shown in Example 3 in Table 1. Example 3 is more suitable for patients with more severe conditions and longer disease courses.

[0028] Table 1. Ingredient Combinations for Each Example

[0029] Principal drug (2) Honey Ephedra 6 8 9 cinnamon twig 9 10 12 Ministerial Medicine (2) Dried ginger 6 8 9 Angelica dahurica 9 10 12 Adjuvant medicine (5) Schisandra chinensis 12 13 15 White peony root 12 13 15 Platycodon grandiflorus 9 10 12 Bai Qian 9 10 12 Honey Mulberry Bark 6 8 9 Adjuvant herbs (2) jujube 12 13 15 Prepared licorice 6 8 9

[0030] The clinical effects of Examples 1-3 are not significantly different, and all can exert the following effects: clearing the lungs and dispelling cold, resolving phlegm and relieving cough, and astringing the lungs and relieving asthma.

[0031] Effect verification

[0032] This invention was developed starting in 2016, with annual clinical trials. Adhering to the principle of identifying and solving problems, it fully leverages the "one drug, multiple effects" and "reduced toxicity, increased efficacy" properties. While ensuring the formula's rationale and efficacy, it minimizes the number of medicinal ingredients. Incorporating new clinical experience and discoveries, the version has been continuously optimized, undergoing three iterations by 2020 to form the traditional Chinese medicine composition version of this invention. These three generations of versions have gradually reduced the number of medicinal ingredients, replacing toxic drugs without diminishing the efficacy against cough-variant asthma. Clinical observation data are as follows.

[0033] 1. First generation version

[0034] 1.1 By weight, the traditional Chinese medicine composition includes the following components: 6 parts honey-processed ephedra, 9 parts cinnamon twig, 6 parts dried ginger, 3 parts asarum, 12 parts schisandra, 12 parts white peony root, 9 parts prepared pinellia, 6 parts platycodon, 6 parts apricot kernel, 6 parts lycium bark, 6 parts honey-processed mulberry bark, and 6 parts prepared licorice root.

[0035] 1.2 Statistical Period

[0036] January 2016 - December 2017

[0037] 1.3 Statistical objects (hereinafter the same):

[0038] The patients who visited the Department of Traditional Chinese Medicine at the Seventh Medical Center of the PLA General Hospital during the aforementioned period, whose diagnoses included cough variant asthma, and who used this traditional Chinese medicine regimen.

[0039] 1.4 Criteria and methods for evaluating efficacy (hereinafter the same):

[0040] 1.4.1 The TCM symptom scoring was based on the TCM symptom scale scoring system outlined in the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines (Trial Implementation)". Cough, sputum production, itchy throat, and chest tightness were categorized into four levels: none, mild, moderate, and severe, scored as 0, 2, 4, and 6 points respectively. The total score was the cumulative score of each symptom; a higher score indicated more severe symptoms. The degree of decrease in the symptom score was calculated as (pre-treatment score - post-treatment score) / pre-treatment score × 100%.

[0041] 1.4.2 The efficacy evaluation criteria were based on the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines (Trial Implementation)". ① Clinically cured: Clinical symptoms and signs disappeared or basically disappeared, and the syndrome score decreased by ≥95%; ② Significantly effective: Clinical symptoms and signs improved significantly, and the syndrome score decreased by ≥70% and <95%; ③ Effective: Clinical symptoms and signs improved, and the syndrome score decreased by ≥30% and <70%; ④ Ineffective: Clinical symptoms and signs did not improve significantly, or even worsened, and the syndrome score decreased by <30%.

[0042] 1.5. Usage Instructions (hereinafter the same)

[0043] Prepare the traditional Chinese medicine decoction according to the method required in Example 1, and administer it to the patient. One course of treatment lasts for 2 weeks.

[0044] 1.6. Precautions (the same applies below)

[0045] (1) This medicine is contraindicated for patients who are allergic to any of the ingredients in the oral Chinese medicine formula of this invention.

[0046] (2) During the use of this plan, avoid using other traditional Chinese medicine preparations, decoctions or granules at the same time. If you take other Western medicines at the same time, you need to take them at least 1 hour apart.

[0047] (3) Note that the present invention should be taken half an hour before meals.

[0048] 1.7. Statistical Analysis of Clinical Outcome Data

[0049] The treatment outcomes for cough variant asthma are shown in Table 2:

[0050] Table 2

[0051] 97 69 18 5 5 94.85% 0 0

[0052] Note: The results above show that the first-generation formula of this invention achieves a very satisfactory efficacy rate in treating cough-variant asthma based on disease differentiation, verifying the feasibility and effectiveness of using modified classical formulas to treat cough-variant asthma based on disease differentiation, while adhering to the evolutionary laws of etiology and pathogenesis. By strictly adhering to the evolutionary laws of etiology and pathogenesis, rationally modifying the formula, and fully leveraging its "multiple effects of one medicine," the first-generation formula with modified classical formulas was optimized, resulting in a new version, and even a new generation of "disease-differentiated classical formulas." Based on this, the first-generation formula was further optimized to form the second-generation version.

[0053] 2. Second generation version

[0054] 2.1 By weight, the traditional Chinese medicine composition comprises the following components: 6 parts honey-processed ephedra, 9 parts cinnamon twig, 6 parts dried ginger, 3 parts asarum, 12 parts schisandra, 12 parts white peony root, 9 parts prepared pinellia, 6 parts honey-processed mulberry bark, and 6 parts prepared licorice root.

[0055] 2.2 Statistical Period

[0056] January 2018 - December 2019

[0057] 2.3 Statistical subjects (same as above):

[0058] The patients who visited the Department of Traditional Chinese Medicine at the Seventh Medical Center of the PLA General Hospital during the aforementioned period, whose diagnoses included cough variant asthma, and who used this traditional Chinese medicine regimen.

[0059] 2.4 Criteria and methods for evaluating efficacy (same as above):

[0060] 2.5. Usage method (same as above)

[0061] 2.6. Precautions (same as above)

[0062] 2.7. Statistical Analysis of Clinical Outcome Data

[0063] The treatment outcomes for cough variant asthma are shown in Table 3:

[0064] Table 3

[0065] 102 73 17 7 5 95.10% 0 0

[0066] Note: After rational modification of the first-generation Chinese medicine composition, its efficacy in treating cough-variant asthma was comparable to, and slightly improved from, that of the first-generation version, indicating that the optimization of the second-generation version was very successful. Asarum is a key herb for warming the lungs and resolving phlegm, but it is slightly toxic. Modern pharmacology shows that the volatile oil of Asarum has an initial excitatory and then inhibitory effect on the central nervous system; improper use may lead to respiratory paralysis. It also has a direct inhibitory effect on the myocardium, and improper use may cause arrhythmia. Pinellia is a key herb for warming and resolving cold phlegm, but it is toxic; improper use can cause severe laryngeal edema, leading to respiratory distress or even suffocation. Furthermore, it has a damaging effect on animal genetic material, and long-term use may also cause abnormal liver function and hematuria. Although no adverse reactions occurred during the use of the first and second generations, "reducing toxicity and increasing efficacy" is also a principle adhered to in this invention while ensuring efficacy. Based on literature review and clinical practice, Asarum and Pinellia were removed, and Angelica dahurica, Platycodon grandiflorus, Cynanchum paniculatum, and Ziziphus jujuba were added. Angelica dahurica and Asarum are both pungent and warm exterior-releasing herbs. Although they are not particularly effective at warming the lungs and resolving phlegm, they excel at raising the clear Qi of the Yangming channel and clearing the nasal passages, thus helping the principal herb to better promote the dispersing and descending of lung Qi. Cynanchum paniculatum and Pinellia ternata are both warming herbs for resolving cold phlegm. Although their effects are not as strong as Pinellia ternata, when combined with Platycodon grandiflorus, the combination of one ascending and the other descending, working synergistically, is more conducive to the dispersing and descending of lung Qi. Strengthening the spleen to generate lung Qi is achieved by invigorating the spleen and replenishing lung Qi. Cough variant asthma is a state where pathogenic Qi in the lungs has not been expelled, and the transformation of cold phlegm and damage to lung Qi coexist. Replenishing lung Qi remains important. Although the formula already contains Schisandra chinensis and Paeonia lactiflora to astringe lung Qi and nourish blood, the addition of Ziziphus jujuba and Glycyrrhiza uralensis strengthens the spleen Qi, exerting the effect of strengthening the spleen to generate lung Qi. Ziziphus jujuba also nourishes blood, assisting Paeonia lactiflora in nourishing blood and nourishing blood. After optimization, the new formula, based on the classic formula, better utilizes the combined effects of dispersing and astringing, ascending and descending, and warming while clearing to restore the physiological function of the lungs, achieving outstanding therapeutic effects in treating cough variant asthma.

[0067] 3. Third generation version

[0068] 3.1 The third-generation version is the combination ratio in Example 1.

[0069] 3.2 Statistical Period

[0070] January 2020 - May 2024

[0071] 3.3 Statistical Objects:

[0072] The patients who visited the Department of Traditional Chinese Medicine at the Seventh Medical Center of the PLA General Hospital during the aforementioned period, whose diagnoses included cough variant asthma, and who used this traditional Chinese medicine regimen.

[0073] 3.4 Efficacy assessment criteria and methods (same as above):

[0074] 3.5. Usage method (same as above)

[0075] 3.6. Precautions (same as above)

[0076] 3.7. Statistical Analysis of Clinical Outcome Data

[0077] The treatment outcomes for cough variant asthma are shown in Table 4:

[0078] Table 4

[0079] 173 120 33 13 7 95.95% 0 0

[0080] Note: After eight years of continuous practice and optimization, the third-generation Chinese medicine composition (i.e., the composition of this invention) is superior to the classic prescriptions, forming a new prescription meaning and becoming a brand-new Chinese medicine composition scheme. More importantly, it is based on the theory of disease differentiation and treatment in traditional Chinese medicine, which is more in line with the actual clinical treatment of cough variant asthma, and its clinical effect has reached a satisfactory level.

[0081] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-described technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating cough-variant asthma, characterized in that, It is composed of the following Chinese medicinal materials in parts by weight: 6-9 parts honey-processed ephedra, 9-12 parts cinnamon twig, 6-9 parts dried ginger, 9-12 parts angelica dahurica, 12-15 parts schisandra chinensis, 12-15 parts white peony root, 9-12 parts platycodon grandiflorus, 9-12 parts cynanchum paniculatum, 6-9 parts honey-processed mulberry bark, 12-15 parts jujube, and 6-9 parts prepared licorice root.

2. The traditional Chinese medicine composition for treating cough variant asthma according to claim 1, characterized in that, It is composed of the following Chinese medicinal materials in the indicated weight proportions: 9 parts honey-processed ephedra, 12 parts cinnamon twig, 9 parts dried ginger, 12 parts angelica dahurica, 15 parts schisandra chinensis, 15 parts white peony root, 12 parts platycodon grandiflorus, 12 parts cynanchum paniculatum, 9 parts honey-processed mulberry bark, 15 parts jujube, and 9 parts prepared licorice root.

3. A drug for treating cough-variant asthma based on disease differentiation, characterized in that, Includes the traditional Chinese medicine composition as described in claim 1 or 2.

4. The drug according to claim 3, characterized in that, The drug also includes pharmaceutically acceptable excipients.

5. The drug according to claim 4, characterized in that, The excipients include excipients.

6. The drug according to claim 5, characterized in that, The excipient is honey.

7. The drug according to claim 6, characterized in that, The dosage form of the drug is decoction, tablets, pills, granules, or capsules.