一种猪瘟病毒E2-IL28B融合蛋白及其作为抗原在制备猪瘟亚单位疫苗中的应用
The E2-IL28B fusion protein prepared by CHO-S cells was mixed with ISA 201 VG adjuvant to prepare a classical swine fever subunit vaccine. This solved the safety risks of CSF attenuated vaccines and the problem of insufficient immunization efficacy of E2 subunit vaccines, and achieved a stronger immune response and antibody production.
CN118530369BActive Publication Date: 2026-07-17LANZHOU VETERINARY RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES(LANZHOU BRANCH CENTER OF CHINA ANIMAL HEALTH & EPIDEMIOLOGY CENTER)
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- LANZHOU VETERINARY RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES(LANZHOU BRANCH CENTER OF CHINA ANIMAL HEALTH & EPIDEMIOLOGY CENTER)
- Filing Date
- 2024-01-19
- Publication Date
- 2026-07-17
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Abstract
本发明公开了一种猪瘟病毒E2‑IL28B融合蛋白及其作为抗原在制备猪瘟亚单位疫苗中的应用。猪瘟病毒E2‑IL28B融合蛋白的核苷酸序列如SEQ ID NO.1所示。本发明将E2蛋白与免疫增强剂IL‑28B蛋白融合，利用哺乳动物CHO‑S细胞表达E2‑IL28B融合蛋白，免疫小鼠后发现，E2‑IL28B融合蛋白的体液免疫和细胞免疫效果均优于E2蛋白，表明E2‑IL28B融合蛋白更适合作为CSF亚单位疫苗的有效抗原。本发明将为CSF新型疫苗的研发提供技术支撑。
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