Manufacturing process of in-column filter plate

Abstract

The application belongs to the technical field of manufacturing of the filter plate in the chromatographic column, and proposes a manufacturing process of the filter plate in the chromatographic column, which comprises the following steps: S1, raw material processing: a plurality of stainless steel nets are stacked and pressed to form a material plate, and the surface of the material plate is subjected to chemical polishing treatment; S2, circle cutting: the edge of the material plate is cut into a circle to form a circular filter plate by wire cutting; S3, edge pressing: the edge of the circular filter plate is stamped by using a stamping machine tool; S4, edge grinding: the circular filter plate after edge pressing is fixed and ground by an edge grinding device; S5, cleaning: the circular filter plate after edge grinding is soaked in an isopropyl alcohol solution and cleaned by using ultrasonic waves, and after being taken out, the circular filter plate is blown dry by hot air to form a filter plate. Through the above technical scheme, the problem that the existing chromatographic column filter plate can only be installed in the chromatographic column by adding a fluorine ring outside the filter plate, which causes the fluorine ring to produce chromatographic expansion during the purification and separation process, and affects the separation effect is solved.

Description

Technical Field

[0001] This invention relates to the field of manufacturing technology of filter plates for chromatographic columns, and more particularly to a manufacturing process for filter plates for chromatographic columns. Background Technology

[0002] In chromatographic analysis, the chromatographic column is a core component, and its performance directly affects the efficiency and accuracy of chromatographic separation. The internal filter plate (often called a packing bed support rod or sieve plate) is a crucial part of the column, its main functions including supporting the packing material, uniformly distributing the mobile phase, preventing packing leakage, and providing sufficient surface area for fluid flow between the packing materials. Currently, the widely used method for installing internal filter plates is to fix them with PTFE rings. However, these PTFE rings can cause chromatographic spread during purification and separation, affecting the separation effect. Therefore, there is an urgent need to develop an internal filter plate that can be installed inside the column without PTFE rings and can withstand the back pressure from impurities and insoluble substances accumulating on the filter plate. Summary of the Invention

[0003] The main objective of this invention is to provide a manufacturing process for a filter plate inside a chromatographic column, in order to solve the problem that existing chromatographic column filter plates can only be installed inside the chromatographic column by adding a PTFE ring to the outside of the filter plate, which causes chromatographic expansion of the PTFE ring during the purification and separation process, thus affecting the separation effect.

[0004] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows: A process for manufacturing a filter plate for a chromatographic column includes the following steps: S1. Raw material processing: Multiple layers of stainless steel mesh are stacked and pressed to form a material plate, and the surface of the material plate is chemically polished. S2. Cutting the edge of the material plate into a circular filter plate by wire cutting. S3, Edge pressing: The edges of the circular filter plate are pressed using a stamping machine. S4. Edge grinding: The circular filter plate after pressing is fixed and the edge is ground by the edge grinding device; S5. Cleaning: Immerse the round filter plate after edge grinding in isopropanol solution and clean it with ultrasound. After taking it out, blow it dry with hot air to form a filter plate.

[0005] As a further technical solution, the edge grinding device mentioned in step S4 includes: frame; A grinding assembly, which is slidably mounted on the frame; A clamping assembly is disposed on the frame and located on one side of the grinding assembly for clamping the circular filter plate; The limiting wheels, of which there are multiple, are all disposed within the clamping assembly. The central axis of the limiting wheels is arranged in a vertical direction, and the sidewall of the limiting wheels is used to abut against the edge of the circular filter plate.

[0006] As a further technical solution, the clamping assembly includes: Support rods, of which there are multiple support rods arranged in a circle around the perimeter, with the bottom connected to the frame and the top extending upward, and the top sidewall of the support rods is provided with threads; A lower fixing plate is fixedly inserted through the middle of the plurality of support rods; The lower clamping plate is cylindrical and is rotatably mounted on the top of the lower fixed plate; An upper mounting plate is located above the lower fixed plate and is detachably mounted on multiple support rods; The upper clamping plate is cylindrical and is rotatably disposed at the bottom of the upper mounting plate and located above the lower clamping plate; The number of locking nuts corresponds one-to-one with the number of support rods, and they are screwed onto the support rods respectively, for locking the upper mounting plate.

[0007] As a further technical solution, a plurality of the limiting wheels are arranged around the outside of the lower clamping plate and located between the upper mounting plate and the lower fixing plate; The frame, the upper mounting plate, and the lower fixing plate are all provided with sliding grooves on the same side. The length direction of the sliding grooves is arranged along the radial direction of the lower clamping plate. One of the support rods slides through the three sliding grooves in sequence, and the bottom of the support rod is locked to the frame by a second nut. The bottoms of the other support rods are fixed to the frame. One of the limiting wheels is rotatably sleeved on the support rod located in the sliding groove. The other limiting wheels slide along the radial direction of the lower clamping plate on the lower fixing plate.

[0008] As a further technical solution, the limiting wheel is slidably mounted on the lower fixed plate via an adjustment assembly, the adjustment assembly comprising: The mounting slot is formed on the lower fixing plate; A slider is slidably disposed in the mounting groove along the radial direction of the lower clamping plate, and a limiting wheel is rotatably disposed on the top of the slider via a rotating shaft; An adjusting screw is rotatably disposed within the mounting groove, with one end extending out of the side wall of the mounting groove. A slider is threaded onto the adjusting screw and slides within the mounting groove as the adjusting screw rotates.

[0009] As a further technical solution, the grinding assembly is slidably mounted on the frame via a transmission assembly, the transmission assembly comprising: A wire block, which is slidably mounted on the frame, and a grinding assembly is mounted on the wire block; A lead screw, which is rotatably mounted on the frame, and a lead block is slidably sleeved on the lead screw; A handle is fixedly mounted on one end of the lead screw.

[0010] As a further technical solution, step S4 includes the following steps: S41. Before starting edge grinding, use PE film to stick the front and back of the circular filter plate to prevent the powder generated during edge grinding from falling onto the surface of the circular filter plate and clogging the filter holes of the circular filter plate. S42. According to the radius of the filter plate to be processed, adjust the position of the support rod in the sliding groove to be close to the limit wheel, and lock the bottom of the support rod with the second nut. S43. Loosen the locking nut, remove the upper mounting plate and the upper clamping plate on it, place the circular filter plate on the lower clamping plate, and ensure that the center point of the circular filter plate is aligned with the center point of the lower clamping plate. Then place the upper clamping plate on the circular filter plate and tighten the locking nut. S44. Adjust the position of other limit wheels by adjusting the components so that the side wall of the limit wheel abuts against the side wall of the circular filter plate; S45. Turn the handle to rotate the lead screw, causing the lead block to slide the grinding component on it towards the clamping component until the grinding surface of the grinding component contacts the side of the circular filter plate, and ensure that the contact surface between the grinding surface of the grinding component and the side of the circular filter plate remains vertical. S46. Start the grinding assembly and rotate the lower clamp to perform the edge grinding operation. During the edge grinding operation, ensure that the grinding surface of the grinding assembly is perpendicular to the top surface of the circular filter plate. S47. After the edge grinding is completed, check the edge grinding effect to ensure that there are no obvious gaps or pinholes visible to the naked eye, and that there are no burrs on the edges. Also, measure whether the diameter of the round filter plate after edge grinding is within 0.1mm of the specified production size. S48. Chamfer the intersection of the grinding surface and the filter plate surface; S49. Remove the PE film from both sides of the circular filter plate.

[0011] As a further technical solution, in step S1, the thickness of the pressed material plate is between 4.8-5.2 mm, and the pore size of the filter holes on the material plate is between 2-5 μm.

[0012] As a further technical solution, in step S2, the diameter of the material plate after being cut into a circle is 0.4-0.6 mm larger than the diameter of the filter plate.

[0013] As a further technical solution, in step S3, the thickness of the circular filter plate at the edge 1mm after pressing is between 3.8-4.2mm.

[0014] The beneficial effects of this invention are as follows: This invention produces a filter plate with a certain edge pressing by processing the raw materials, cutting into circles, pressing the edges, grinding the edges, and cleaning the multi-layer stainless steel mesh. The filter plate produced by this process can be directly installed in the chromatographic column through interference fit, avoiding the spread effect that occurs during the purification and separation process when installing the filter plate with a PTFE ring. This ensures the accuracy of the chromatographic separation results and also facilitates installation. Attached Figure Description

[0015] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0016] Figure 1 This is a structural block diagram of the present invention; Figure 2 This is a three-dimensional structural diagram of the edge grinding device of the present invention; Figure 3 for Figure 2 Enlarged structural diagram of part A in the middle; Figure 4 This is a schematic diagram of the front view structure of the edge grinding device of the present invention.

[0017] Explanation of reference numerals in the attached figures 1. Frame; 2. Grinding assembly; 21. Mounting base; 22. Drive pulley; 23. Driven pulley; 24. Grinding belt; 25. Grinding motor; 3. Clamping assembly; 31. Support rod; 32. Lower fixing plate; 33. Lower clamping plate; 34. Upper mounting plate; 35. Upper clamping plate; 36. Locking nut; 4. Limit wheel; 5. Rotating motor; 6. Slide groove; 7. Second nut; 8. Adjustment assembly; 81. Mounting groove; 82. Slider; 83. Adjusting screw; 9. Transmission assembly; 91. Thread block; 92. Thread screw; 93. Handle; 94. Guide rod; 10. Circular filter plate. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art can make similar extensions without departing from the spirit of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0019] like Figure 1 As shown, this invention proposes a process for manufacturing a filter plate for a chromatographic column, comprising the following steps: S1. Raw material processing: The filter plate inside the chromatographic column is made of 316L stainless steel. Twelve layers of stainless steel mesh are stacked and pressed to form a material plate. The thickness of the material plate is between 4.8-5.2mm, and the pore size of the filter holes on the material plate is between 2-5μm. The surface of the material plate is chemically polished to remove surface impurities, improve surface smoothness, and enhance the corrosion resistance and wear resistance of the filter plate.

[0020] S2. Cutting a circle: The edge of the material plate is cut into a circle using wire cutting to form a circular filter plate 10. The diameter of the material plate after cutting the circle is 0.4-0.6 mm larger than the diameter of the filter plate to be manufactured. Preferably, the diameter of the material plate after cutting the circle is 0.5 mm larger than the diameter of the filter plate to be manufactured. The extra 0.5 mm is the amount required for subsequent edge grinding.

[0021] S3. Edge pressing: The edge of the circular filter plate 10 is pressed using a stamping machine. The thickness of the edge of the circular filter plate 10 after edge pressing is between 3.8-4.2mm at 1mm. The preferred thickness of the edge of the circular filter plate 10 after edge pressing is 4mm. The stamping machine used in this step is existing equipment and will not be described in detail here. S4. Edge grinding: The circular filter plate 10 after pressing is fixed and the edge is ground by the edge grinding device; Among them, such as Figures 2-4 As shown, the edge grinding device in step S4 mainly includes a frame 1, a grinding assembly 2, a clamping assembly 3, and a limiting wheel 4. The grinding assembly 2 includes a mounting base 21, a driving pulley 22, a driven pulley 23, a grinding belt 24, and a grinding motor 25. The mounting base 21 is slidably mounted on the frame 1. The driving pulley 22 and the driven pulley 23 are arranged vertically and are both rotatably mounted on the mounting base 21. The grinding belt 24 is driven and sleeved on the driving pulley 22 and the driven pulley 23. The grinding motor 25 is fixedly mounted on the mounting base 21, and its output shaft is fixedly connected to the rotating shaft of the driving pulley 22. The specific operation process of the grinding assembly 2 is as follows: the grinding motor 25 drives the active pulley 22 to rotate, the active pulley 22 and the driven pulley 23 together drive the grinding belt 24 to rotate, and the length direction of the grinding belt 24 is kept vertical. The side of the grinding belt 24 away from the active pulley 22 and the driven pulley 23 (i.e. the outer side) is the grinding surface. This grinding surface is used to contact the edge of the circular filter plate 10 during the rotation.

[0022] The grinding assembly 2 is slidably mounted on the frame 1 via a transmission assembly 9, which includes a wire block 91, a lead screw 92, and a handle 93. Two guide rods 94 are arranged laterally on the frame 1. The wire block 91 is slidably fitted onto the two guide rods 94. The bottom of the mounting base 21 is fixedly mounted on the wire block 91. The lead screw 92 is rotatably mounted on the frame 1 and located between the two guide rods 94. The wire block 91, fitted onto the lead screw 92, slides along the lead screw 92 as the lead screw 92 rotates. The handle 93 is fixedly mounted on one end of the lead screw 92. By rotating the handle 93, the lead screw 92 can be rotated, thereby causing the wire block 91 to slide along the lead screw 92, and the mounting base 21 on the wire block 91 to slide. This allows the entire grinding assembly 2 to slide on the frame 1, facilitating the adjustment of the distance between the grinding belt 24 and the clamping assembly 3, ensuring that the grinding surface of the grinding belt 24 always contacts the edge of the circular filter plates 10 of different sizes, thus enhancing its practicality.

[0023] The clamping assembly 3 is mounted on the frame 1 and located on one side of the grinding assembly 2. It is used to clamp the circular filter plate 10. The clamping assembly 3 includes a support rod 31, a lower fixing plate 32, a lower clamping plate 33, an upper mounting plate 34, an upper clamping plate 35, and a locking nut 36. There are multiple support rods 31, three in this embodiment. The three support rods 31 are evenly arranged around the outside of the lower clamping plate 33. The bottom of the support rod 31 is connected to the frame 1, and the top extends upward. The top sidewall of the support rod 31 is provided with threads. The lower fixing plate 32 passes through the middle of the multiple support rods 31 and is fixed to the support rods 31 in the axial direction. That is, the positional relationship between the lower fixing plate 32 and the support rod 31 in the longitudinal direction is fixed, but the connection relationship in the transverse direction is not limited. Plate 33 is rotatably mounted on top of lower fixed plate 32 by rotating motor 5. Rotating motor 5 is fixed on frame 1. Lower clamping plate 33 is cylindrical, and its diameter is always smaller than the diameter of circular filter plate 10. Upper mounting plate 34 is located above lower fixed plate 32 and is detachably mounted on multiple support rods 31. Upper clamping plate 35 is rotatably mounted at the bottom of upper mounting plate 34 and directly above lower clamping plate 33. Upper clamping plate 35 is cylindrical, and its diameter is always smaller than the diameter of circular filter plate 10. The central axes of upper clamping plate 35 and lower clamping plate 33 are collinear. The number of locking nuts 36 corresponds one-to-one with the support rods 31 and are screwed onto the support rods 31 for locking the upper mounting plate 34. In this embodiment, during the clamping operation, first loosen the locking nut 36, remove the upper mounting plate 34 and the upper clamping plate 35 on it, place the circular filter plate 10 on the lower clamping plate 33, ensuring that the center point of the circular filter plate 10 is aligned with the center point of the lower clamping plate 33, then place the upper clamping plate 35 on the circular filter plate 10 and tighten the locking nut 36, thus completing the clamping and fixing of the circular filter plate 10 by the upper clamping plate 35 and the lower clamping plate 33; the upper clamping plate 35 and the lower clamping plate 33 are respectively rotatably set on the upper mounting plate 34 and the lower fixing plate 32, so that the upper clamping plate 35 and the lower clamping plate 33 drive the circular filter plate 10 to rotate during the edge grinding operation, thereby making the rotating circular filter plate 10 cooperate with the grinding belt 24, so that the side of the circular filter plate 10 contacts the grinding belt 24 under its rotation, realizing the grinding of the entire curved surface of the circular filter plate 10.

[0024] In this embodiment, a sliding groove 6 is provided on the same side of the frame 1, the upper mounting plate 34, and the lower fixing plate 32. The length direction of the sliding groove 6 is arranged radially along the lower clamping plate 33. One of the support rods 31 slides radially through the three sliding grooves 6 along the lower clamping plate 33. The diameter of the part of the support rod 31 located in the sliding groove 6 of the lower fixing plate 32 is smaller than the diameter of the part of the support rod 31 located below the lower fixing plate 32. That is, the diameter of the part of the support rod 31 located below the lower fixing plate 32 is larger than the width of the sliding groove 6 of the lower fixing plate 32. Thus, the support rod 31 can slide along the sliding groove of the lower fixing plate 32. Based on the sliding along the length direction, the portion of the support rod 31 located below the lower fixed plate 32 acts as a limit for the lower fixed plate 32, ensuring that the horizontal position of the lower fixed plate 32 remains unchanged. The bottom of the support rod 31 is locked onto the frame 1 by the second nut 7. The diameter of the portion of the support rod 31 located above the slide groove 6 of the frame 1 is larger than the width of the slide groove 6, so that the second nut 7 and the portion of the support rod 31 located above the slide groove 6 of the frame 1 cooperate to clamp on both sides of the slide groove 6 of the frame 1, locking the adjusted support rod 31; the bottoms of the other support rods 31 are fixedly mounted on the frame 1.

[0025] There are multiple limiting wheels 4, three in this embodiment. The central axis of the limiting wheels 4 is set vertically. The multiple limiting wheels 4 are arranged around the outside of the lower clamping plate 33 and are located between the upper mounting plate 34 and the lower fixing plate 32. The sidewall of the limiting wheel 4 is used to abut against the edge of the circular filter plate 10. One of the limiting wheels 4 is rotatably sleeved on the support rod 31 located in the slide groove 6, and the other limiting wheels 4 are slidably arranged on the lower fixing plate 32 along the radial direction of the lower clamping plate 33. In use, the position of the limiting wheel 4 near the slide groove 6 is first determined according to the radius of the filter plate to be processed, so that the minimum distance from the sidewall of the limiting wheel 4 to the center of the lower clamping plate 33 is the radius of the filter plate. The position of the limiting wheel 4 is adjusted by sliding the support rod 31 in the slide groove 6. After the adjustment is completed, the second nut 7 at the bottom of the support rod 31 is locked to realize the adjustment and locking of the position of the limiting wheel 4, which is beneficial for the production of filter plates of different specifications. After the position of the limiting wheel 4 is adjusted, in order to ensure processing accuracy, the positions of the limiting wheel 4 and the support rod 31 are locked and no longer changed. Then, the filter plates of this specification are batch ground. When it is necessary to change the specification of the filter plate to be processed, the positions of the limiting wheel 4 and the support rod 31 are adjusted again.

[0026] The other two limiting wheels 4 are slidably mounted on the lower fixed plate 32 via the adjusting assembly 8. The adjusting assembly 8 includes a mounting groove 81, a slider 82, and an adjusting screw 83. The mounting groove 81 is formed on the lower fixed plate 32. The slider 82 is slidably mounted in the mounting groove 81 along the radial direction of the lower clamping plate 33. The limiting wheels 4 are rotatably mounted on the top of the slider 82 via a rotating shaft. When the upper clamping plate 35 and the lower clamping plate 33 drive the circular filter plate 10 to rotate, the limiting wheels 4 can rotate synchronously with the circular filter plate 10, thereby reducing the friction between the limiting wheels 4 and the circular filter plate 10. The adjusting screw 83 is rotatably mounted in the mounting groove 81, with one end extending out of the side wall of the mounting groove 81. The slider 82 is threaded onto the adjusting screw 83 and slides in the mounting groove 81 as the adjusting screw 83 rotates. The specific operation process of adjusting component 8 is as follows: Place the circular filter plate 10 onto the lower clamping plate 33 and clamp it with the upper clamping plate 35. Ensure that the side wall of the limiting wheel 4 near the slide groove 6 abuts against the side wall of the circular filter plate 10. Then, rotate the two adjusting screws 83 respectively. The adjusting screws 83 drive the slider 82 to slide towards the circular filter plate 10 within the mounting groove 81, thereby driving the limiting wheel 4 on the slider 82 to slide towards the circular filter plate 10 until the side walls of both limiting wheels 4 abut against the side walls of the circular filter plate 10, at which point the adjustment is complete. This is beneficial for limiting the circular filter plate 10 during the edge grinding process, ensuring the uniformity of the edge grinding. Since the diameter difference between the circular filter plate 10 after edge grinding and the circular filter plate 10 before edge grinding is very small, at most about 0.1mm, the slight decrease in diameter of the circular filter plate 10 during the edge grinding process will not affect the limiting effect of the limiting wheel 4.

[0027] Specifically, step S4 includes the following steps: S41. Before starting edge grinding, use PE film to stick the front and back of the circular filter plate 10 to prevent the powder generated during edge grinding from falling onto the surface of the circular filter plate 10 and clogging the filter holes of the circular filter plate 10. S42. According to the radius of the filter plate to be processed, the support rod 31 in the sliding groove 6 is adjusted to the position of the limiting wheel 4 close to the sliding groove 6, and the bottom of the support rod 31 is locked by the second nut 7 to realize the adjustment and locking of the position of the limiting wheel 4. S43. Loosen the locking nut 36, take out the upper mounting plate 34 and the upper clamping plate 35 on it, place the circular filter plate 10 on the lower clamping plate 33, ensure that the center point of the circular filter plate 10 is aligned with the center point of the lower clamping plate 33, then place the upper clamping plate 35 on the circular filter plate 10 and tighten the locking nut 36. S44. Adjust the position of the other limiting wheels 4 by adjusting the adjusting component 8 so that the side wall of the limiting wheel 4 abuts against the side wall of the circular filter plate 10. S45. Rotate handle 93 to drive lead screw 92 to rotate, causing lead block 91 to drive grinding component 2 on it to slide towards clamping component 3 until the grinding surface of grinding component 2 contacts the side of circular filter plate 10, and ensure that the contact surface between the grinding surface of grinding component 2 and the side of circular filter plate 10 remains vertical. S46. Start the grinding motor 25. The grinding motor 25 drives the grinding belt 24 to rotate. The speed of the grinding motor 25 is maintained at 80-120 rpm. At the same time, turn on the rotating motor 5. The rotating motor 5 drives the lower clamping plate 33 and the upper clamping plate 35, as well as the circular filter plate 10 between the lower clamping plate 33 and the upper clamping plate 35, to rotate for edge grinding. The speed of the rotating motor 5 is maintained at 10-15 rpm. During the edge grinding operation, ensure that the grinding surface of the grinding component 2 is perpendicular to the top surface of the circular filter plate 10. S47. After the edge grinding is completed, check the edge grinding effect to ensure that there are no obvious gaps or pinholes visible to the naked eye, and that there are no burrs on the edges. Also, measure whether the diameter of the round filter plate 10 after edge grinding is within 0.1mm of the specified manufacturing size. S48. Chamfer the intersection of the grinding surface and the filter plate surface; S49. Remove the PE film from both sides of the circular filter plate 10.

[0028] S5. Cleaning: Immerse the round filter plate 10 after edge grinding in isopropanol solution and clean it with ultrasonic waves. After taking it out, blow it dry with hot air to complete the filter plate manufacturing process.

[0029] The above description is merely a preferred embodiment of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

Claims

1. A process for manufacturing a filter plate for a chromatographic column, characterized in that, Includes the following steps: S1. Raw material processing: Multiple layers of stainless steel mesh are stacked and pressed to form a material plate, and the surface of the material plate is chemically polished. S2. Cutting the edge of the material plate into a circular filter plate by wire cutting. S3, Edge pressing: The edges of the circular filter plate are pressed using a stamping machine. S4. Edge grinding: The circular filter plate after pressing is fixed and the edge is ground by the edge grinding device; The aforementioned edge grinding device includes: frame; A grinding assembly, which is slidably mounted on the frame; A clamping assembly is disposed on the frame and located on one side of the grinding assembly for clamping the circular filter plate; The limiting wheels, which are multiple in number, are all disposed within the clamping assembly. The central axis of each limiting wheel is arranged in a vertical direction, and the sidewall of each limiting wheel is used to abut against the edge of the circular filter plate. The clamping assembly includes: Support rods, of which there are multiple support rods arranged in a circle around the perimeter, with the bottom connected to the frame and the top extending upward, and the top sidewall of the support rods is provided with threads; A lower fixing plate is disposed in the middle of the plurality of support rods and is fixed to the support rods in the axial direction; The lower clamping plate is cylindrical and is rotatably mounted on the top of the lower fixed plate; An upper mounting plate is located above the lower fixed plate and is detachably mounted on multiple support rods; The upper clamping plate is cylindrical and is rotatably disposed at the bottom of the upper mounting plate and located above the lower clamping plate; Locking nuts, the number of which corresponds one-to-one with the support rods, and each of which is screwed onto the support rod, are used to lock the upper mounting plate above it; The plurality of limiting wheels are arranged around the outside of the lower clamping plate and are located between the upper mounting plate and the lower fixing plate; The frame, the upper mounting plate, and the lower fixing plate are all provided with sliding grooves on the same side. The length direction of the sliding grooves is arranged along the radial direction of the lower clamping plate. One of the support rods slides through the three sliding grooves, and the bottom of the support rod is locked to the frame by a second nut. The bottoms of the other support rods are fixed to the frame. One of the limiting wheels is rotatably sleeved on the support rod located in the sliding groove. The other limiting wheels slide along the radial direction of the lower clamping plate on the lower fixing plate. S5. Cleaning: Immerse the round filter plate after edge grinding in isopropanol solution and clean it with ultrasound. After taking it out, blow it dry with hot air to form a filter plate.

2. The manufacturing process of the filter plate inside the chromatographic column as described in claim 1, characterized in that, The limiting wheel is slidably mounted on the lower fixed plate via an adjusting assembly, the adjusting assembly comprising: The mounting slot is formed on the lower fixing plate; A slider is slidably disposed in the mounting groove along the radial direction of the lower clamping plate, and a limiting wheel is rotatably disposed on the top of the slider via a rotating shaft; An adjusting screw is rotatably disposed within the mounting groove, with one end extending out of the side wall of the mounting groove. A slider is threaded onto the adjusting screw and slides within the mounting groove as the adjusting screw rotates.

3. The manufacturing process of the filter plate inside the chromatographic column as described in claim 2, characterized in that, The grinding assembly is slidably mounted on the frame via a transmission assembly, the transmission assembly comprising: A wire block, which is slidably mounted on the frame, and a grinding assembly is mounted on the wire block; A lead screw, which is rotatably mounted on the frame, and a lead block is slidably sleeved on the lead screw; A handle is fixedly mounted on one end of the lead screw.

4. The manufacturing process of the filter plate inside the chromatographic column as described in claim 3, characterized in that, Step S4 includes the following steps: S41. Before starting edge grinding, use PE film to stick the front and back of the circular filter plate to prevent the powder generated during edge grinding from falling onto the surface of the circular filter plate and clogging the filter holes of the circular filter plate. S42. According to the radius of the filter plate to be processed, adjust the position of the support rod in the sliding groove to be close to the limit wheel, and lock the bottom of the support rod with the second nut. S43. Loosen the locking nut, remove the upper mounting plate and the upper clamping plate on it, place the circular filter plate on the lower clamping plate, and ensure that the center point of the circular filter plate is aligned with the center point of the lower clamping plate. Then place the upper clamping plate on the circular filter plate and tighten the locking nut. S44. Adjust the position of other limit wheels by adjusting the components so that the side wall of the limit wheel abuts against the side wall of the circular filter plate; S45. Turn the handle to rotate the lead screw, causing the lead block to slide the grinding component on it towards the clamping component until the grinding surface of the grinding component contacts the side of the circular filter plate, and ensure that the contact surface between the grinding surface of the grinding component and the side of the circular filter plate remains vertical. S46. Start the grinding assembly and rotate the lower clamp to perform the edge grinding operation. During the edge grinding operation, ensure that the grinding surface of the grinding assembly is perpendicular to the top surface of the circular filter plate. S47. After the edge grinding is completed, check the edge grinding effect to ensure that there are no obvious gaps or pinholes visible to the naked eye, and that there are no burrs on the edges. Also, measure whether the diameter of the round filter plate after edge grinding is within 0.1mm of the specified production size. S48. Chamfer the intersection of the grinding surface and the filter plate surface; S49. Remove the PE film from both sides of the circular filter plate.

5. The manufacturing process of the filter plate inside the chromatographic column as described in claim 1, characterized in that, In step S1, the thickness of the pressed material plate is between 4.8-5.2 mm, and the pore size of the filter holes on the material plate is between 2-5 μm.

6. The manufacturing process of the filter plate inside the chromatographic column as described in claim 1, characterized in that, In step S2, the diameter of the material plate after being cut into a circle is 0.4-0.6 mm larger than the diameter of the filter plate.

7. The manufacturing process of the filter plate inside the chromatographic column as described in claim 1, characterized in that, In step S3, the thickness of the circular filter plate at the edge 1mm after pressing is between 3.8-4.2mm.

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