一种氘代烯烃的制备方法
By using a trifluorophenylborane catalyst and heavy water to carry out the deuteration reaction at room temperature, the problems of large catalyst consumption and high reaction conditions in the prior art are solved, realizing the preparation of deuterated olefins in a highly efficient and environmentally friendly manner, which is applicable to the deuteration of a variety of olefin compounds.
CN118546048BActive Publication Date: 2026-07-17NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
- Filing Date
- 2024-05-24
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing olefin deuteration methods involve large amounts of expensive catalysts, require high-temperature reaction conditions, and are not easy to scale up, resulting in high costs and complex operations.
Method used
Tris(5-fluorophenylborane) was used as a catalyst, and heavy water was used as the deuterium source to carry out a deuteration reaction with olefins at room temperature. A low catalyst amount and atmospheric pressure were used. The deuterated product was obtained by separation and purification after the reaction.
Benefits of technology
The method enables the preparation of deuterated olefins with high degree of deuteration and high yield. It is simple to operate, environmentally friendly, applicable to a variety of olefin compounds, and has commercial potential.
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Smart Images
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Abstract
本发明公开了一种氘代烯烃的制备方法，以式I所示的烯烃类化合物为原料，常压下，有机溶剂中，在催化剂作用下与氘源试剂发生氘代反应，反应产物经过分离提纯，获得式I所示的烯烃类化合物的α‑氘代产物。本发明采用的三五氟苯基硼烷催化剂商业可得并且用量小，开发的氘代方法具有较好的可操作性和稳定性、催化效率高、反应无需强碱性、底物适用范围广、反应规模易于放大等特点，具有潜在的商业化前景。
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