含取代噁二唑的苯氧基苯甲酰胺类衍生物、制备方法及其应用
By synthesizing phenoxybenzamide derivatives containing substituted oxadiazole structures, the resistance problem of SDHIs fungicides has been solved, achieving a highly efficient and broad-spectrum antibacterial effect against plant pathogens, making it suitable for agricultural fungicides.
CN118546106BActive Publication Date: 2026-07-17NINGXIA UNIVERSITY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NINGXIA UNIVERSITY
- Filing Date
- 2024-05-15
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing SDHI-type fungicides have led to resistance in plant pathogenic fungi due to long-term use, necessitating the development of new, highly effective fungicides to control plant diseases.
Method used
By combining substituted oxadiazoles with diphenyl ether structures via amide bonds, phenoxybenzamide derivatives containing substituted oxadiazole structures are synthesized and applied to agricultural fungicides.
Benefits of technology
These compounds exhibit broad-spectrum antibacterial activity, particularly against Sclerotinia sclerotiorum var. sclerotiorum and Bacillus rotundus of apples. They are novel in structure, simple to synthesize, and are characterized by high efficiency, safety, economy, and environmental friendliness.
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Figure CN118546106B_ABST
Abstract
本发明涉及药物化学技术领域，公开了一种含取代噁二唑的苯氧基苯甲酰胺类衍生物、制备方法及其应用。这种含取代噁二唑的苯氧基苯甲酰胺类衍生物的结构通式(I)如下：其中，R1为甲基、苯环、4‑氯苯基、4‑硝基苯基、2,4‑二氯苯基；R2为氢、甲基、氟、氯、甲氧基、三氟甲基或其多取代组合。本发明通过酰胺键将苯氧基苯甲酸结构与取代噁二唑相结合，合成了一系列新型含取代噁二唑苯氧基苯甲酰胺类衍生物，该类化合物具有良好的抑菌活性。本发明为开发以含取代噁二唑苯氧基苯甲酰胺类衍生物新型杀菌剂提供了基础。
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