A lactation composition and a method of making the same

Abstract

The application discloses a lactation composition and a preparation method thereof. The lactation composition is an oral preparation prepared from the following raw materials in parts by weight: Houttuynia cordata 10-20 parts, Lonicera japonica 2-7 parts, dried tangerine or orange peel 10-20 parts, Mentha haplocalyx 2-7 parts, Platycodon grandiflorum 10-20 parts, Citrus medica 2-7 parts, Carica papaya 20-40 parts and Lagenaria vulgaris 10-20 parts. The lactation composition is prepared by a specific preparation process, and medicinal and edible Chinese herbal medicines are combined. The lactation composition not only has a remarkable lactation effect, but also has an excellent taste without adding auxiliary materials, improves the compliance of puerpera when using the lactation composition, and has a clinical popularization and application value.

Description

Technical Field

[0001] This invention specifically relates to a lactation-promoting composition and its preparation method. Background Technology

[0002] Postpartum women are prone to qi stagnation and poor blood circulation due to physical weakness, insufficient rest, prolonged sitting or lying down, etc. This can lead to blood stasis, obstruction of the collaterals, and phlegm accumulation in the breast. During lactation, blocked milk ducts and poor milk flow can cause milk stasis in the breast, resulting in symptoms such as poor milk drainage, breast engorgement, and lumps. This affects normal breastfeeding, causing significant physical discomfort and psychological stress for the mother. In severe cases, it can lead to the termination of breastfeeding, impacting the health of both mother and baby.

[0003] Modern medicine offers various treatments for poor milk flow, primarily involving massage directly applied to the breast. This effectively drains accumulated milk, prevents bacterial growth, reduces resistance in the mammary ducts, and alleviates pressure on surrounding blood vessels and lymphatic vessels, thoroughly clearing the milk ducts. This achieves the goals of regulating qi and dispersing stagnation, overcoming the "sucking blockage" phenomenon, and enabling mothers to breastfeed normally. It also facilitates milk flow and relieves symptoms such as breast engorgement and pain. While massage has some effect, vigorous pressure on the breast during the process can cause significant pain, which may persist even after the process is complete. Furthermore, excessive pressure can cause breast damage, congestion, and even subcutaneous bruising. If the patient has benign or malignant tumors, applying pressure to the breast can promote tumor growth and spread. For patients with breast hyperplasia, massaging the breast repeatedly and continuously causes congestion, which may worsen the condition. In some cases of mastitis with engorgement, massaging the breast can cause the inflammation to spread.

[0004] Currently, there are also many traditional Chinese medicine formulas used to promote lactation, such as Tongru Sanjie Decoction, which uses Chinese medicinal herbs as active ingredients to soothe the liver and stomach, promote lactation, and disperse lumps after postpartum women take it. However, due to the many flavors and bitter taste, it is not easily accepted by postpartum women. Summary of the Invention

[0005] To address the above problems, the present invention provides a lactation-promoting composition, which is an oral preparation made from the following raw materials in parts by weight:

[0006] 10-20 parts of houttuynia cordata, 2-7 parts of honeysuckle, 10-20 parts of dried tangerine peel, 2-7 parts of mint, 10-20 parts of platycodon grandiflorus, 2-7 parts of citron, 20-40 parts of papaya, 10-20 parts of loofah sponge, and 3-7 grams of ganoderma lucidum.

[0007] Furthermore, it is an oral preparation made from the following raw materials in parts by weight:

[0008] 15g houttuynia cordata, 5g honeysuckle, 15g dried tangerine peel, 5g mint, 15g platycodon grandiflorus, 5g citron, 30g papaya, 15g loofah sponge, 5g ganoderma lucidum.

[0009] Furthermore, the method for preparing the oral formulation is as follows:

[0010] 1) Take the raw material, soak it in water, extract it, concentrate the extract, and dry it to obtain dried powder A; dry and crush the raw material residue, and sieve it to obtain dried powder B;

[0011] 2) Take the dried powder A and dried powder B from step 1) and mix them evenly to obtain the final product.

[0012] Further, in step 1), the soaking for 30 minutes and the extraction are carried out by decoction extraction, twice, each time for 60 minutes, with the amount of water added each time being 10 times that of the raw material, w / w.

[0013] Further, the concentration in step 1) is vacuum concentration at a temperature of 50°C and a vacuum degree of 0.08 MPa; the concentrate obtained by vacuum concentration is spray dried, with a feed temperature of 50-60°C, an air inlet temperature of 180-190°C, and an air outlet temperature of 95-105°C; the relative density of the concentrate is 1.08-1.10.

[0014] Further, in step 1), the raw material residue is first heated and dried at 120°C for 30 minutes, and then heated and dried at 60°C for 120 minutes; the sieving is done through a 100-mesh sieve.

[0015] The present invention also provides the use of the aforementioned composition in the preparation of pharmaceuticals or food products having a galactagogue effect.

[0016] Furthermore, the food in question is a health food.

[0017] In this lactation-promoting composition, loofah sponge has the effects of clearing the meridians, detoxifying, reducing swelling, promoting lactation, and invigorating blood circulation, and is the principal ingredient. Buddha's hand citron soothes the liver, strengthens the spleen, regulates qi, and resolves phlegm; peppermint soothes the liver, strengthens the spleen, regulates qi, and clears the orifices; papaya strengthens the spleen and promotes digestion. According to *Modern Practical Chinese Medicine*, "the juice of unripe fruit treats indigestion, is a nutritional supplement, and is also a lactation-promoting agent," thus promoting milk secretion. The three combined achieve the effects of soothing the liver, regulating qi, clearing the meridians, and promoting lactation, and are therefore the assistant ingredients. Houttuynia cordata clears heat, detoxifies, relieves pain, reduces swelling, strengthens the stomach, and aids digestion; honeysuckle clears heat, detoxifies, and disperses wind-heat; Ganoderma lucidum invigorates qi and calms the mind. The three combined clear heat, detoxify, and clear the meridians to prevent mastitis caused by prolonged stagnation of milk secretion, and are therefore the adjuvant ingredients. Tangerine peel regulates qi, strengthens the spleen, harmonizes the middle jiao, dries dampness, and resolves phlegm; Platycodon grandiflorus promotes lung function and invigorates qi. The two combined regulate qi and assist the other ingredients in ascending and promoting lactation, and are therefore the guiding ingredients. When used together, these herbs can soothe the liver, regulate qi, and promote blood circulation, thus achieving the effect of promoting lactation.

[0018] Experiments have shown that the lactation-promoting composition of the present invention, through a specific preparation process, combines medicinal and edible herbs, which not only have a significant lactation-promoting effect, but also achieve an excellent taste without the addition of excipients, thereby improving the compliance of postpartum women and having clinical application value.

[0019] Obviously, based on the above description of the present invention, and according to common technical knowledge and conventional methods in the field, various other modifications, substitutions or alterations can be made without departing from the basic technical concept of the present invention.

[0020] The following detailed embodiments further illustrate the above-described content of the present invention. However, this should not be construed as limiting the scope of the present invention to the following examples. All technologies implemented based on the above-described content of the present invention fall within the scope of the present invention. Detailed Implementation

[0021] Example 1: Preparation of the lactation-promoting composition of the present invention

[0022] Formula: 15g houttuynia cordata, 5g honeysuckle, 15g dried tangerine peel, 5g mint, 15g platycodon grandiflorus, 5g citron, 30g papaya, 15g loofah sponge, 5g ganoderma lucidum.

[0023] Preparation method:

[0024] 1) Weigh the above raw materials according to the ratio, and perform water extraction at a material-to-liquid ratio of 1:10 (w / w). The raw materials are soaked for 30 minutes and extracted for 60 minutes. After extraction twice, filter to obtain the extract.

[0025] 2) The extract is concentrated under reduced pressure (temperature 50℃, vacuum degree 0.08Mpa) to a density of 1.08-1.10 (60℃) to obtain a concentrated solution.

[0026] 3) The concentrate is spray-dried, with the feed temperature controlled at 50-60℃, the liquid density at 1.08-1.10 (60℃), the air inlet temperature at 180-190℃, and the air outlet temperature at 95-105℃ to obtain dried powder for later use.

[0027] 4) Place the raw material residue in an oven and heat it at 120℃ for 30 minutes, then heat it at 60℃ for 120 minutes. Crush the dried raw material residue and sieve it to 100 mesh for later use.

[0028] 5) After mixing all the dried materials thoroughly, package them into individual portions to obtain the finished product.

[0029] Example 2: Preparation of the lactation-promoting composition of the present invention

[0030] Formula: 10g houttuynia cordata, 2g honeysuckle, 2g mint, 10g platycodon grandiflorus, 2g citron, 20g papaya, 10g loofah sponge, 3g ganoderma lucidum.

[0031] Preparation method: Same as in Example 1.

[0032] Example 3: Preparation of the lactation-promoting composition of the present invention

[0033] Ingredients: 20g houttuynia cordata, 7g honeysuckle, 7g mint, 20g platycodon grandiflorus, 7g citron, 40g papaya, 20g loofah sponge, 7g ganoderma lucidum.

[0034] Preparation method: Same as in Example 1.

[0035] The following experimental examples illustrate the beneficial effects of the present invention.

[0036] Experimental Example 1: Taste Study of the Composition of the Invention

[0037] 1. Experimental materials

[0038] Sample 1:

[0039] Formula: 15g houttuynia cordata, 5g honeysuckle, 15g dried tangerine peel, 5g mint, 15g platycodon grandiflorus, 5g citron, 30g papaya, 15g loofah sponge, 5g ganoderma lucidum.

[0040] Preparation process: Weigh a total of 110g of all the above-mentioned raw materials and extract them with water at a material-to-liquid ratio of 1:10 (w / w). Soak the raw materials for 30min and extract for 60min. After extraction twice, filter the extract. Concentrate the extract under reduced pressure (temperature 60℃, vacuum degree 0.08Mpa) to a density of 1.08-1.10 (60℃). Spray dry the extract into powder (feed temperature 50-60℃, liquid density 1.08-1.10 (60℃), air inlet temperature 185-195℃, air outlet temperature 95-105℃).

[0041] Sample 2:

[0042] Take all the ingredients according to the formula of Sample 1, crush them directly, pass them through a 100-mesh sieve, and mix all the powdered ingredients to obtain Sample 2.

[0043] Sample 3:

[0044] Preparation process:

[0045] 1) According to the formula of Sample 1, houttuynia cordata, honeysuckle, dried tangerine peel, mint, platycodon grandiflorus, citron, papaya, loofah, and ganoderma lucidum were subjected to water extraction with a material-to-liquid ratio of 1:10 (w / w) based on the extract content. The raw materials were soaked for 30 minutes and extracted for 60 minutes. After extraction twice, the mixture was filtered, and the extract content reached 14.5%.

[0046] 2) The extract is concentrated under reduced pressure (temperature 50℃, vacuum degree 0.08Mpa) to a density of 1.08-1.10 (60℃), which is conducive to drying into powder.

[0047] 3) The concentrate is spray-dried, with the feed temperature controlled at 50-60℃, the liquid density at 1.08-1.10 (60℃), the air inlet temperature at 180-190℃, and the air outlet temperature at 95-105℃ to obtain dried powder for later use.

[0048] 4) Place the raw material residue in an oven and heat it at 120℃ for 30 minutes, then heat it at 60℃ for 120 minutes. Crush the dried raw material residue and sieve it to 100 mesh for later use. The raw material residue obtained under these conditions has low moisture content and a suitable sensory taste.

[0049] 5) After mixing all the dried materials evenly, package them into portions to obtain the finished product.

[0050] 2. Sensory evaluation of oral preparations

[0051] Ten participants were tested (five from traditional Chinese medicine and five from food science, all of whom were trained and qualified according to GB / T 16291.1). A double-blind method was used, and the participants directly consumed equal amounts (2g) of samples 1-3. The taste was scored according to the standards in Table 1, and the results are shown in Table 2.

[0052] Table 1. Taste Rating Criteria (out of 10)

[0053]

[0054]

[0055] Table 2 Sensory evaluation results

[0056]

[0057] The results above show that sensory evaluation of samples prepared using the three processes significantly affects the taste of oral compound preparations. Prescription ingredients, without separate processing or innovative techniques, are directly extracted or pulverized for consumption, resulting in a less palatable taste that is not conducive to the long-term effects of traditional Chinese medicine, thus greatly diminishing the efficacy of the oral compound preparation. In contrast, the process of first extracting and drying, then mixing with the processed residue, yields an oral preparation for promoting lactation with good sensory qualities, making it more acceptable to consumers. Its superior taste allows for long-term use and promotes efficacy.

[0058] Experimental Example 2: Study on the Influence of Process Parameters on Taste

[0059] 1. Experimental materials

[0060] Sample 1:

[0061] Formula: 15g houttuynia cordata, 5g honeysuckle, 15g dried tangerine peel, 5g mint, 15g platycodon grandiflorus, 5g citron, 30g papaya, 15g loofah sponge, 5g ganoderma lucidum.

[0062] Preparation process:

[0063] 1. According to the formula of Sample 1, houttuynia cordata, honeysuckle, dried tangerine peel, mint, platycodon grandiflorus, citron, papaya, loofah, and ganoderma lucidum were subjected to water extraction with a material-to-liquid ratio of 1:10 (w / w), using the extract content as the indicator. The raw materials were soaked for 30 minutes and extracted for 60 minutes. After extraction twice, the mixture was filtered, and the extract content reached 14.5%.

[0064] 2. The extract is concentrated under reduced pressure (temperature 50℃, vacuum degree 0.08Mpa) to a density of 1.08-1.10 (60℃), which facilitates drying into powder.

[0065] 3. The concentrate is spray-dried, with the feed temperature controlled at 50-60℃, the liquid density at 1.08-1.10 (60℃), the air inlet temperature at 180-190℃, and the air outlet temperature at 95-105℃, to obtain dried powder for later use.

[0066] 4. Place the raw material residue in an oven and heat it at 120℃ for 30 minutes, then heat it at 60℃ for 120 minutes. Crush the dried raw material residue and sieve it to 100 mesh for later use. The raw material residue obtained under these conditions has low moisture content and a suitable sensory taste.

[0067] 5. After mixing all the dried materials thoroughly, package them into portions to obtain the finished product.

[0068] Sample 2:

[0069] Take all the raw materials according to the formula of Sample 1, and change step 2 to concentration under normal pressure according to the preparation process of Sample 1. Control the density of the concentrate at 1.08-1.10, and keep other operations unchanged to obtain Sample 2.

[0070] Sample 3:

[0071] Take all the raw materials according to the formula of Sample 1, and change step 3 according to the preparation process of Sample 1: control the feed temperature to room temperature of 25℃, the air inlet temperature to 190-200℃, and the air outlet temperature to 95-105℃, while keeping other operations unchanged, and thus obtain Sample 3.

[0072] Sample 4:

[0073] Take all the raw materials according to the formula of Sample 1, and change step 3 according to the preparation process of Sample 1: control the feed temperature to 60-80℃, the air inlet temperature to 150-160℃, and the air outlet temperature to 60-80℃, while keeping other operations unchanged, and thus obtain Sample 4.

[0074] Sample 5:

[0075] Take all the ingredients according to the formula of Sample 1, and follow the preparation process of Sample 1, except for step 4, while keeping other operations unchanged, to obtain Sample 5.

[0076] Sample 6:

[0077] Take all the raw materials according to the formula of Sample 1, and change step 4 according to the preparation process of Sample 1: directly heat and dry at 105-120℃ for 120 minutes, crush the dried raw material residue, and sieve it to 100 mesh for later use. Other operations remain unchanged, thus obtaining Sample 6.

[0078] 2. Process observation under different process parameters and sensory evaluation of oral formulations

[0079] Ten participants were tested (five majoring in Traditional Chinese Medicine and five majoring in Food Science, all of whom were trained and qualified according to GB / T 16291.1). A double-blind method was used, and the subjects directly consumed equal amounts (2g) of samples 1 to 6. The taste was scored according to the standards in Table 1, and the results are shown in Table 3.

[0080] Table 2. Results of process observation and sensory evaluation under different process parameters.

[0081]

[0082] By altering process parameters in steps such as extract concentration, spray drying, and raw material residue powdering, and observing and recording the changes in each step, and conducting sensory evaluations on the obtained samples, it was found that the taste of oral compound preparations is significantly affected by the preparation process parameters, which also affect the yield of the preparation. Sensory evaluation influences consumer acceptance of the final product, while the powder yield relates to the economic costs of the production process. The Detong milk powder obtained through the formulation and preparation method of this invention is not only low in cost but also has a good taste, meeting the needs of postpartum women for long-term use throughout the entire breastfeeding period, and has clinical application value.

Claims

1. A lactation-promoting composition, characterized in that: It is an oral preparation made from the following raw materials in parts by weight: 10-20 parts of houttuynia cordata, 2-7 parts of honeysuckle, 10-20 parts of dried tangerine peel, 2-7 parts of mint, 10-20 parts of platycodon grandiflorus, 2-7 parts of citron, 20-40 parts of papaya, 10-20 parts of loofah sponge, and 3-7 parts of ganoderma lucidum. The method for preparing the oral formulation is as follows: 1) Take the raw material, soak it in water, extract it, concentrate the extract, and dry it to obtain dried powder A; dry and crush the raw material residue, and sieve it to obtain dried powder B; 2) Take the dried powder A and dried powder B from step 1) and mix them evenly to obtain the final product; The concentration is performed under reduced pressure at a temperature of 50°C and a vacuum of 0.08 MPa. The concentrate obtained from the reduced pressure concentration is then spray-dried at a feed temperature of 50-60°C, an inlet air temperature of 180-190°C, and an outlet air temperature of 95-105°C. The relative density of the concentrate is 1.08-1.

10. The raw material residue is first heated and dried at 120°C for 30 minutes, and then heated and dried at 60°C for 120 minutes; the sieving is done through a 100-mesh sieve.

2. The lactation-promoting composition according to claim 1, characterized in that: It is an oral preparation made from the following raw materials in parts by weight: 15g houttuynia cordata, 5g honeysuckle, 15g dried tangerine peel, 5g mint, 15g platycodon grandiflorus, 5g citron, 30g papaya, 15g loofah sponge, 5g ganoderma lucidum.

3. The lactation-promoting composition according to claim 1, characterized in that: Step 1) The soaking time is 30 minutes, and the extraction is a decoction extraction, repeated twice, each time for 60 minutes. The amount of water added each time is 10 times that of the raw material, w / w.

4. Use of the composition according to any one of claims 1 to 3 in the preparation of a pharmaceutical product having a galactagogue effect.

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