A traditional Chinese medicine health-care patch with antipyretic effect and a preparation method thereof

Abstract

This invention discloses a traditional Chinese medicine health care patch with antipyretic effect and its preparation method. The traditional Chinese medicine health care patch includes an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment includes the following raw materials in parts by weight: honeysuckle 60-80 parts, forsythia 35-55 parts, scutellaria baicalensis 30-50 parts, isatis root 60-80 parts, light bamboo leaf 15-35 parts, peppermint 35-55 parts, indigo leaf 55-75 parts, chrysanthemum 35-55 parts, borneol 10-20 parts, sandalwood 10-20 parts, laurocapram 10-20 parts, yellow rice wine 10-20 parts, aged vinegar 10-20 parts, lubricant 15-25 parts, and honey 480-520 parts. This invention utilizes a combination of ten traditional Chinese medicines—honeysuckle, forsythia, scutellaria, isatis root, light bamboo leaf, mint, indigo leaf, chrysanthemum, borneol, and sandalwood—to synergistically exert an antipyretic effect.

Description

Technical Field

[0001] This invention belongs to the field of medical and health care products technology, specifically relating to a traditional Chinese medicine health care patch with antipyretic effect and its preparation method. Background Technology

[0002] Fever due to external pathogens is the most common illness in childhood, ranking first among pediatric diseases. It is mainly caused by external pathogenic factors such as heat and dampness, and is clinically treated with antipyretics, sedatives, and antibiotics. While these are fast-acting, they have certain side effects, and parents are concerned about the long-term effects of medication on their children. Traditional Chinese medicine believes that children are in a state of immature Yin and Yang, with weaker internal organs, making them susceptible to external pathogens. This leads to a high incidence of illness and rapid disease progression. Furthermore, the bitter taste of traditional Chinese medicine decoctions often makes it difficult for children to take medication, resulting in poor compliance.

[0003] Acupoint application is a traditional Chinese medicine external treatment method for treating fever in children. It involves mixing pulverized or ground Chinese medicinal herbs into a paste using various liquid media, and then applying it to specific functional acupoints on the skin, such as Shenque (CV8) and Dazhui (GV14). The active ingredients of the medicine penetrate the skin, stimulating the meridians and producing a response that strengthens the body's resistance and eliminates pathogenic factors. This method is convenient, effective, and safe, and is widely used in pediatrics. The Shenque acupoint, located at the navel, is considered the root of the five internal organs and six bowels, and the origin of the six qi, capable of treating various diseases. The Dazhui acupoint is the meeting point of the three Yang meridians of the hand and foot and the Governing Vessel; historical records state that "draining Dazhui reduces fever." Using these two acupoints together can achieve the effects of clearing heat and purging fire, relieving exterior cold, and dispelling pathogenic factors. Summary of the Invention

[0004] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a traditional Chinese medicine health care patch with antipyretic effect and its preparation method.

[0005] The objective of this invention is achieved through the following technical solution:

[0006] In a first aspect, the present invention provides a traditional Chinese medicine ointment comprising the following raw materials in parts by weight: 60-80 parts honeysuckle, 35-55 parts forsythia, 30-50 parts scutellaria, 60-80 parts isatis root, 15-35 parts light bamboo leaf, 35-55 parts peppermint, 55-75 parts indigo leaf, 35-55 parts chrysanthemum, 10-20 parts borneol, 10-20 parts sandalwood, 10-20 parts laurocapram, 10-20 parts rice wine, 10-20 parts aged vinegar, 15-25 parts lubricant, and 480-520 parts honey.

[0007] Preferably, the honey is in the form of 495-505 parts by weight.

[0008] Preferably, the herbal ointment comprises the following ingredients in parts by weight: 70 parts honeysuckle, 45 parts forsythia, 40 parts scutellaria, 70 parts isatis root, 25 parts light bamboo leaf, 45 parts peppermint, 65 parts indigo leaf, 45 parts chrysanthemum, 15 parts borneol, 15 parts sandalwood, 15 parts laurocapram, 15 parts rice wine, 15 parts aged vinegar, 20 parts lubricant, and 500 parts honey.

[0009] Preferably, the herbal ointment comprises the following ingredients in parts by weight: 65 parts honeysuckle, 50 parts forsythia, 35 parts scutellaria, 75 parts isatis root, 20 parts light bamboo leaf, 50 parts peppermint, 60 parts indigo leaf, 50 parts chrysanthemum, 10 parts borneol, 20 parts sandalwood, 10 parts laurocapram, 20 parts rice wine, 10 parts aged vinegar, 20 parts lubricant, and 505 parts honey.

[0010] Preferably, the herbal ointment comprises the following ingredients in parts by weight: 75 parts honeysuckle, 40 parts forsythia, 45 parts scutellaria, 65 parts isatis root, 30 parts light bamboo leaf, 40 parts peppermint, 70 parts indigo leaf, 40 parts chrysanthemum, 20 parts borneol, 10 parts sandalwood, 20 parts laurocapram, 10 parts rice wine, 20 parts aged vinegar, 20 parts lubricant, and 495 parts honey.

[0011] Preferably, the lubricant is sesame oil.

[0012] Secondly, the present invention provides an application of traditional Chinese medicine ointment in the preparation of traditional Chinese medicine health care patches.

[0013] Thirdly, the present invention provides a traditional Chinese medicine health care patch with antipyretic effect, comprising an applicator containing medical pressure-sensitive adhesive and the aforementioned traditional Chinese medicine ointment.

[0014] Fourthly, the present invention provides a method for preparing the aforementioned traditional Chinese medicine health patch with antipyretic effect, comprising the following steps:

[0015] A1. Refining honey: Heat the honey to a boil, then keep it at a gentle boil to remove foam and floating wax. Then refine it for a certain period of time. Remove the refined honey from the pot and let it cool.

[0016] A2. Grinding: Mix the weighed honeysuckle, forsythia, scutellaria, isatis root, light bamboo leaves, mint, indigo leaves, chrysanthemum, borneol, and sandalwood, then grind and sieve.

[0017] A3. Mixing and forming: While mixing the powdered and sieved medicine from step A2, add laurocapram, aged vinegar and rice wine, then add refined honey and continue mixing to obtain the medicine mixture.

[0018] A4. Shaping: After the drug mixture is cooled, it is made into strips of uniform thickness, then lubricant is added and it is cut and pressed into cake-shaped Chinese medicine paste.

[0019] A5. Assembly and Packaging: Assemble and package the cake-shaped herbal ointment with the applicator containing medical pressure-sensitive adhesive.

[0020] Preferably, in step A1, the refining process is carried out for a certain period of time until the material is sticky when rubbed between the fingers, but no long white threads appear when the two fingers are separated, and the relative density is 1.38 to 1.42.

[0021] Preferably, in step A2, the sieving is done through a 100-mesh sieve.

[0022] Preferably, in step A3, the weight of the herbal ointment for the symptoms is 1.5 to 2.5 g per piece.

[0023] This invention utilizes the principle of monarch, minister, assistant, and guide in drug formulation to leverage the synergistic effects of each drug and improve therapeutic efficacy.

[0024] Honeysuckle, forsythia, and isatis root are all excellent medicines for clearing heat and detoxifying. Honeysuckle is sweet and cold in nature, clearing heat and detoxifying, and reducing swelling and boils. Forsythia is bitter and cold, clearing heat and detoxifying, and reducing swelling and nodules. Isatis root clears heat and detoxifies, cools the blood and soothes the throat. These three herbs work together as the principal herbs to exert the effect of clearing heat and detoxifying.

[0025] Scutellaria baicalensis is bitter and cold, clearing heat and drying dampness; Isatis tinctoria clears heat and detoxifies, cools the blood and eliminates spots; Chrysanthemum disperses heat in the liver meridian and clears heat and detoxifies. These three herbs also have the effect of clearing heat, which can enhance the effect of the principal herb in clearing heat and detoxifying, and are therefore the assistant herbs.

[0026] Lophatherum gracile is sweet, bland, and cold in nature. It clears heat from the heart and relieves heat from the small intestine. It has the effect of clearing heat and relieving irritability. Mentha haplocalyx has a fragrant and dispersing aroma. It can not only disperse the heat of the liver meridian to relieve the exterior, but also disperse the stagnant qi in the stomach to harmonize the stomach. These two herbs, as adjuvant herbs, can assist the principal and assistant herbs in clearing the heat of the heart and lungs in the upper burner, allowing the medicine to be guided to the whole body.

[0027] Borneol is pungent, bitter, and slightly cold, and enters the heart and lung meridians. It has the effects of clearing heat and relieving pain, dispersing nodules and opening the orifices. Sandalwood is pungent and warm in nature, and enters the spleen, stomach, and liver meridians. It has the effects of warming the middle and dispersing cold, promoting qi and relieving pain. The combined effect of these two drugs is to harmonize the properties of other drugs and, as guiding drugs, direct them to the affected area.

[0028] In summary, this formula primarily focuses on clearing heat and detoxifying, supplemented by clearing heat from the upper burner (heart and lungs), and harmonizing qi and blood, allowing the medicine to directly reach the affected area. This formula has a good therapeutic effect on fever caused by wind-heat colds.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] This invention utilizes a combination of ten traditional Chinese medicines—honeysuckle, forsythia, scutellaria, isatis root, light bamboo leaf, mint, indigo leaf, chrysanthemum, borneol, and sandalwood—to synergistically exert an antipyretic effect. Detailed Implementation

[0031] The present invention will now be described in detail with reference to specific embodiments. These embodiments will help those skilled in the art to further understand the present invention, but do not limit the invention in any way. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention. These all fall within the scope of protection of the present invention.

[0032] The terms "preferred," "more preferably," and "more suitable" used in this invention refer to embodiments of the invention that provide certain beneficial effects under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the description of one or more preferred embodiments does not imply that other embodiments are unavailable, nor is it intended to exclude other embodiments from the scope of this invention.

[0033] It should be understood that, except in any operational instance or otherwise indicated, all figures representing the amounts of ingredients used, for example, in the specification and claims, should be understood to be modified in all cases by the term "about". Therefore, unless otherwise stated, the numerical parameters set forth in the following specification and appended claims are approximations varying with the desired performance to be obtained according to the invention. It is not at all an attempt to limit the application of the doctrine of equivalents to the scope of the claims; each numerical parameter should be interpreted at least according to the number of significant figures reported and by applying ordinary rounding techniques.

[0034] Although the numerical ranges and parameters illustrating the broad scope of the invention are approximate, the values ​​listed in the specific examples are reported as precisely as possible. However, any numerical value inherently contains some error that is necessarily caused by the standard deviation found in their respective test measurements.

[0035] In the following examples, all raw materials used are commercially available.

[0036] Example 1

[0037] This embodiment provides a fever-reducing and health-preserving patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment includes the raw materials and their weight proportions shown in Table 1 below.

[0038] The preparation method of the fever-reducing health patch includes the following steps:

[0039] A1. Honey Refining: Place the purified honey in a honey refining jar and heat it to a gentle boil (approximately 116-118°C). Maintain a gentle boil and remove any foam and floating wax. Pour the mixture into a larger pot and refine until it becomes sticky when rubbed between your fingers, but no long white threads appear when you separate your fingers. Immediately remove it from the pot and transfer it to a special honey storage container to cool.

[0040] A2. Grinding: Mix the following ten Chinese medicinal herbs: honeysuckle, forsythia, scutellaria, isatis root, light bamboo leaves, mint, indigo leaves, chrysanthemum, borneol, and sandalwood. Grind the herbs using a Chinese medicine grinder and pass them through a 100-mesh sieve.

[0041] A3. Mixing and Forming: Place the raw material powder obtained in step A2 into a mixer in the appropriate amount, and spray in laurocapram, rice wine, and aged vinegar while mixing. Mix for 30 minutes. Remove and place in a trough mixer, add the appropriate amount of refined honey obtained in step A1, and mix for 15 minutes to obtain the drug mixture.

[0042] A4. Shaping: Cool the drug mixture obtained in step A3, add it to the feeding hopper of the strip making machine to make strips of uniform thickness, use sesame oil as a lubricant, cut with a knife, and press with a mold to make round cake-shaped plasters of 1.8-2.0g / piece.

[0043] A5. Assembly and Packaging: Assemble the disc-shaped plaster obtained in A4 with the applicator containing medical pressure-sensitive adhesive, and then package it to obtain the final product.

[0044] Example 2

[0045] This embodiment provides a fever-reducing and health-preserving patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment includes the raw materials and their weight proportions shown in Table 1 below.

[0046] The preparation method of the antipyretic health patch is the same as that in Example 1.

[0047] Example 3

[0048] This embodiment provides a fever-reducing and health-preserving patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment includes the raw materials and their weight proportions shown in Table 1 below.

[0049] The preparation method of the antipyretic health patch is the same as that in Example 1.

[0050] Table 1

[0051] honeysuckle 70 65 75 Forsythia 45 50 40 Scutellaria baicalensis 40 35 45 Isatis root 70 75 65 Lophatherum gracile 25 20 30 Mint 45 50 40 Daqingye 65 60 70 chrysanthemum 45 50 40 Borneol 15 10 20 sandalwood 15 20 10 Lauryl azelastone 15 10 20 Shaoxing wine 15 20 10 Aged vinegar 15 10 20 sesame oil 20 20 20 Honey 500 505 495

[0052] Comparative Example 1

[0053] This comparative example provides a fever-reducing health care patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment comprises the raw materials and weight proportions shown in Table 2 below. Compared with Example 1, the only difference is that no light bamboo leaves are added in this comparative example.

[0054] The preparation method of the antipyretic health patch is the same as that in Example 1.

[0055] Comparative Example 2

[0056] This comparative example provides a fever-reducing health care patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment comprises the raw materials and weight proportions shown in Table 2 below. Compared with Example 1, the only difference is that Daqingye (Isatis tinctoria leaf) is not added in this comparative example.

[0057] The preparation method of the antipyretic health patch is the same as that in Example 1.

[0058] Comparative Example 3

[0059] This comparative example provides a fever-reducing health care patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment comprises the raw materials and weight proportions shown in Table 2 below. Compared with Example 1, the only difference is that chrysanthemum is not added in this comparative example.

[0060] The preparation method of the antipyretic health patch is the same as that in Example 1.

[0061] Comparative Example 4

[0062] This comparative example provides a fever-reducing health care patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment comprises the raw materials and weight proportions shown in Table 2 below. Compared with Example 1, the only difference is that sandalwood is not added in this comparative example.

[0063] The preparation method of the antipyretic health patch is the same as that in Example 1.

[0064] Comparative Example 5

[0065] This comparative example provides a fever-reducing health care patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment comprises the raw materials and weight parts shown in Table 2 below. Compared with Example 2, the only difference is that 50 parts of honeysuckle and 65 parts of forsythia are added to this comparative example.

[0066] The preparation method of the antipyretic health patch is the same as that in Example 1.

[0067] Comparative Example 6

[0068] This comparative example provides a fever-reducing health care patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment comprises the raw materials and weight parts shown in Table 2 below. Compared with Example 2, the only difference is that 40 parts of light bamboo leaves and 40 parts of Daqing leaves are added to this comparative example.

[0069] The preparation method of the antipyretic health patch is the same as that in Example 1.

[0070] Comparative Example 7

[0071] This comparative example provides a fever-reducing health care patch for acupoints such as Shenque (CV8) and Dazhui (GV14), comprising an applicator containing medical pressure-sensitive adhesive and a traditional Chinese medicine ointment. The traditional Chinese medicine ointment comprises the raw materials and weight proportions shown in Table 2 below. Compared with Example 2, the only difference is that in this comparative example, perilla leaves are used instead of indigo leaves.

[0072] The preparation method of the antipyretic health patch is the same as that in Example 1.

[0073] Table 2

[0074]

[0075]

[0076] Efficacy verification test

[0077] Experimental Example 1:

[0078] (1) Experimental materials: Chinese herbal health care patches prepared in Examples 1-3 and Comparative Examples 1-7 and commercially available Chinese herbal antipyretic patches for children.

[0079] (2) Experimental animals: More than 130 SPF-grade healthy SD rats, weighing between 130 and 170g, all of which were male.

[0080] (3) Experimental Methods: Three hours before modeling on the day of the experiment, the body temperature of the rats was measured once every hour, and the average of the three measurements was taken as the basal body temperature. If the body temperature was >38℃ or the difference between two consecutive body temperatures was greater than 0.5℃, the animal was eliminated. Ten SPF-grade healthy SD rats were randomly selected according to their body weight as the normal group and injected subcutaneously with 0.9% sodium chloride injection (10mL / kg). The remaining SD rats were injected subcutaneously with 20% yeast suspension at the standard dose of 10mL / kg on their backs to establish a fever model. The body temperature was measured 5 hours after modeling. Rats whose body temperature increased by more than 0.8℃ from the basal body temperature were considered successful model animals. The successfully modeled rats were randomly divided into 12 groups: model group, positive control group, and 10 traditional Chinese medicine health care patch treatment groups, with 10 rats in each group. The rats were treated by hair removal. 8% sodium sulfide was applied to the abdomen and back of the rats, with a hair removal area of ​​3cm×3cm. After 1 minute, the skin was washed with distilled water and the rats were fed normally for 24 hours. The model group received no drug treatment, the positive control group (commercially available pediatric Chinese herbal antipyretic patches cut into 2cm×2cm pieces, one for the abdomen and one for the back), and the Chinese herbal health care patch treatment group (Chinese herbal health care patches prepared in Examples 1-3 and Comparative Examples 1-7, one for the abdomen and one for the back).

[0081] (4) Observation indicators: The rectal temperature of rats was measured at regular intervals as a direct evaluation indicator. The rats were fasted for 6 hours before the experiment but allowed to drink water. Before measuring the rectal temperature, the rats were allowed to empty their feces. Before each temperature measurement, the probe of the electronic thermometer was coated with Vaseline and inserted into the rat's rectum 3 cm (it can be fixed at 3 cm with rubber or tape to ensure that the insertion depth is consistent each time). The body temperature value was recorded after the reading stabilized.

[0082] (5) Experimental results:

[0083] The body temperature values ​​of rats at different stages were statistically analyzed, and the results are shown in Table 3.

[0084] Table 3. Effects of Traditional Chinese Medicine Health Patches on Antipyretic Effects in Rats n=10)

[0085]

[0086]

[0087] Note: Compared with the model group, **P<0.01, *P<0.05

[0088] As shown in Table 3, there was no statistically significant difference in basal body temperature among the rat groups compared to the model group (P>0.05). At 4h and 8h after administration, compared to the model group, the herbal health patch treatment groups prepared in Examples 1-3 significantly reduced rat body temperature (P<0.01), and the results of the herbal health patch treatment groups prepared in Examples 1-3 were all superior to the positive control group, indicating better antipyretic effects. However, compared to the model group, there were no statistically significant differences in the herbal health patch treatment groups prepared in Comparative Examples 1-7 (P>0.05). Furthermore, compared to the herbal health patch treatment groups prepared in Comparative Examples 1-4, the herbal health patch treatment group prepared in Example 1 showed a significantly lower rat body temperature, demonstrating that the specific addition of Lophatherum gracile, Isatis indigotica, Chrysanthemum morifolium, and Sandalwood enhances the antipyretic effect of this invention. Furthermore, compared with the traditional Chinese medicine health care patch treatment groups prepared in Comparative Examples 5-7, the rats in the treatment group prepared in Example 2 had significantly lower body temperatures. This indicates that by adjusting the content of honeysuckle and forsythia, and the content of bamboo leaf and indigo leaf, and by replacing perilla leaf with indigo leaf, the present invention can improve the antipyretic effect.

[0089] Experimental Example 2:

[0090] (1) Test drug: the antipyretic health care patch prepared in Example 1.

[0091] (2) Subjects: Children aged 1-12 years with fever due to exogenous pathogens. Symptoms: Fever. May be accompanied by nasal congestion, runny nose, sneezing, cough, headache, etc., red tongue with thin yellow coating, floating and rapid pulse or floating purple finger veins.

[0092] (3) Experimental Methods: Sixty-two eligible subjects were randomly divided into two groups of 31 each. There were no statistically significant differences between the two groups in terms of gender, age, and duration of illness. All patients had body temperatures between 37.5℃ and 39.5℃ and a duration of illness of less than 3 days. The control group received routine symptomatic treatment, including oral ibuprofen suspension or other antipyretics depending on the condition. The treatment group received the traditional Chinese medicine health care patch prepared in Example 1 of this invention in addition to the treatment provided to the control group. The patch was applied to the disinfected Shenque (CV8) and Dazhui (GV14) acupoints, one patch per acupoint, 2-3 times daily, for 6-8 hours each time. Keeping the patient warm was important, and the patch should be properly secured after application to prevent slippage.

[0093] (4) Observation indicators: changes in body temperature at different time points and antipyretic effect.

[0094] (5) Efficacy criteria: Formulated with reference to the "Standards for Diagnosis and Efficacy of Diseases and Syndromes in Traditional Chinese Medicine" and the "Clinical Diagnosis and Treatment Guidelines for Pediatric Respiratory Diseases". Significant effect: Body temperature returns to normal and does not rise again. Effective: Body temperature significantly decreases and symptoms improve. Ineffective: Failure to meet the above criteria.

[0095] Overall effectiveness rate = (Number of cases with significant effects + Number of cases with effective results) / Total number of cases × 100%

[0096] (6) Experimental results:

[0097] Before treatment, patients in the treatment group and the control group were compared. There were no significant differences between the two groups in terms of age, disease duration, severity of illness, and symptoms of abdominal distension and pain. The results of the treatment group and the control group after treatment are shown in Tables 1 and 2.

[0098] Table 1. Temperature changes in the two groups of children at different time points.

[0099] Treatment group (n=31) 38.61±0.57 37.38±0.35 37.03±0.28 Control group (n=31) 38.45±0.56 37.75±0.48 37.50±0.47 p-value ＞0.05 ＜0.01 ＜0.001

[0100] Table 2 Comparison of antipyretic effects between the two groups of children after 3 days of treatment (cases)

[0101]

[0102] As shown in Tables 1 and 2, compared with the control group, the traditional Chinese medicine health patch prepared in this invention (treatment group) has a more significant therapeutic effect on pediatric exogenous fever, with a total effective rate as high as 96.8%. The drug of this invention has a rapid onset of action and rapid fever reduction; the body temperature of the treatment group was significantly lower than that of the control group after 12 hours and 24 hours of treatment (P < 0.01), and the body temperature of the treatment group was close to normal after 24 hours. After 3 days of treatment, the body temperature of the children treated with the drug of this invention basically returned to normal and did not recur, and no serious adverse events were found in the experiment.

[0103] Typical case:

[0104] Case 1: Li, male, 4 years old. Two days prior to consultation, the child caught a cold and developed symptoms such as fever, sore throat, nasal congestion, runny nose, and loss of appetite. His temperature was 37.7℃. His parents administered antipyretics, which reduced the fever but then relapsed. The antipyretic health patch prepared in Example 1 was applied to the sterilized Shenque (CV8) and Dazhui (GV14) acupoints, one patch per acupoint, twice daily. After one day of use, his temperature returned to normal, other symptoms significantly improved, and his appetite increased. After five days of use, he was cured.

[0105] Case 2: Mr. Zhou, male, 1 year old. The child developed a fever one day prior, with a temperature of 38.5℃. He had restless sleep, occasional crying, coughing, sneezing, and rattling sounds in his throat. His tongue was red with a thick, yellowish coating, and his pulse was thready and rapid. The antipyretic health patch prepared in Example 1 was applied to the sterilized Shenque (CV8) and Dazhui (GV14) acupoints, one patch per acupoint, twice daily. After two days of use, his temperature returned to normal without recurrence, his spirits improved, he slept soundly at night, and only occasional coughing occurred. He was cured after six days of use.

[0106] Case 3: Ms. Yang, female, 2 years old, presented with a 2-day history of fever due to an external pathogenic factor, constipation, scanty and dark yellow urine, flushed face, dry lips, runny nose with thick discharge, and swollen and red throat. She had previously taken acetaminophen and chlorpheniramine maleate granules and children's cold medicine, but experienced recurring high fevers (above 38.5℃) a few hours after each dose. She also had poor sleep, and other symptoms did not improve. The antipyretic health patch prepared in Example 1 was applied to the sterilized Shenque (CV8) and Dazhui (GV14) acupoints, one patch per acupoint, twice daily. After 3 days of use, her body temperature returned to normal without recurrence, the swollen and red throat disappeared, her urine turned white, and her nasal discharge decreased. She was cured after 7 days of use.

[0107] This invention has many specific applications, and the above description is only a preferred embodiment. It should be noted that the above embodiments are for illustrative purposes only and are not intended to limit the scope of protection of this invention. For those skilled in the art, several improvements can be made without departing from the principle of this invention, and these improvements should also be considered within the scope of protection of this invention.

Claims

1. A traditional Chinese medicine ointment with antipyretic effect, characterized in that, It is composed of the following ingredients in parts by weight: honeysuckle 60-80 parts, forsythia 35-55 parts, scutellaria baicalensis 30-50 parts, isatis root 60-80 parts, lophatherum gracile 15-35 parts, mint 35-55 parts, indigo leaf 55-75 parts, chrysanthemum 35-55 parts, borneol 10-20 parts, sandalwood 10-20 parts, lauryl diazoline 10-20 parts, rice wine 10-20 parts, aged vinegar 10-20 parts, lubricant 15-25 parts, and honey 480-520 parts.

2. The herbal ointment according to claim 1, characterized in that, The honey is in parts by weight of 495-505.

3. The herbal ointment according to claim 1, characterized in that, It is composed of the following ingredients in parts by weight: honeysuckle 70 parts, forsythia 45 parts, scutellaria baicalensis 40 parts, isatis root 70 parts, lophatherum gracile 25 parts, mint 45 parts, indigo leaf 65 parts, chrysanthemum 45 parts, borneol 15 parts, sandalwood 15 parts, lauryl diazoline 15 parts, rice wine 15 parts, aged vinegar 15 parts, lubricant 20 parts, and honey 500 parts.

4. The herbal ointment according to claim 1, characterized in that, It is composed of the following ingredients in parts by weight: honeysuckle 65 parts, forsythia 50 parts, scutellaria baicalensis 35 parts, isatis root 75 parts, lophatherum gracile 20 parts, mint 50 parts, indigo leaf 60 parts, chrysanthemum 50 parts, borneol 10 parts, sandalwood 20 parts, lauryl diazoline 10 parts, rice wine 20 parts, aged vinegar 10 parts, lubricant 20 parts, and honey 505 parts.

5. The herbal ointment according to claim 1, characterized in that, It is composed of the following ingredients in parts by weight: honeysuckle 75 parts, forsythia 40 parts, scutellaria 45 parts, isatis root 65 parts, light bamboo leaf 30 parts, mint 40 parts, indigo leaf 70 parts, chrysanthemum 40 parts, borneol 20 parts, sandalwood 10 parts, lauryl azedarach 20 parts, rice wine 10 parts, aged vinegar 20 parts, lubricant 20 parts, and honey 495 parts.

6. The traditional Chinese medicine ointment according to any one of claims 1-5, characterized in that, The lubricant is sesame oil.

7. The use of a traditional Chinese medicine ointment according to any one of claims 1-5 in the preparation of an antipyretic traditional Chinese medicine patch.

8. A traditional Chinese medicine patch with antipyretic effect, characterized in that, It is made from an applicator containing medical pressure-sensitive adhesive and the traditional Chinese medicine ointment as described in any one of claims 1-5.

9. A method for preparing a traditional Chinese medicine patch with antipyretic effect according to claim 7, characterized in that, Includes the following steps: A1. Refining honey: Heat the honey to a boil, then keep it at a gentle boil to remove foam and floating wax. Then refine the honey and let it cool. A2. Grinding: Mix the weighed honeysuckle, forsythia, scutellaria, isatis root, light bamboo leaves, mint, indigo leaves, chrysanthemum, borneol, and sandalwood, then grind and sieve. A3. Mixing and forming: While mixing the powdered and sieved medicine from step A2, add laurocapram, aged vinegar and rice wine, then add refined honey and continue mixing to obtain the medicine mixture. A4. Shaping: After the drug mixture is cooled, it is made into strips of uniform thickness, then lubricant is added and it is cut and pressed into cake-shaped Chinese medicine paste. A5. Assembly and Packaging: Assemble and package the cake-shaped herbal ointment with the applicator containing medical pressure-sensitive adhesive.

10. The method for preparing the traditional Chinese medicine patch with antipyretic effect according to claim 9, characterized in that, In step A2, the sieving is done through a 100-mesh sieve; In step A3, the weight of the cake-shaped traditional Chinese medicine paste is 1.5 to 2.5 g / piece.

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