Mouse treadmill based on circadian rhythm regulation

Abstract

The present application relates to the mouse treadmill technical field, disclose a kind of mouse treadmill based on circadian rhythm regulation, including running track, lighting mechanism, feeding mechanism and detection mechanism, multiple feeding areas are provided in running track, and the one end of feeding area is divided into exercise area, and driving mechanism is provided in feeding area, driving mechanism includes mounting plate and baffle, mounting plate is slidably installed in feeding area, baffle is installed in the side of mounting plate close to exercise area, for driving mouse in feeding area to exercise area, and mouse is limited in exercise area, mounting plate is used to drive baffle to move, the bottom of exercise area is provided with running assembly, and running assembly is used to drive mouse to move.The present application is used to solve the problem that mouse is taken away from experimental device in prior art to detect physiological index in exercise state, more troublesome, and easy to affect experimental result.

Description

Technical Field

[0001] This invention relates to the field of mouse treadmill technology, and more particularly to a mouse treadmill based on circadian rhythm regulation. Background Technology

[0002] Circadian rhythm refers to the variation of life activities in a cycle of approximately 24 hours. It is also known as daily rhythm. Because natural light can influence the circadian rhythm of life activities, living organisms automatically adjust their circadian rhythm in response to changes in natural light. However, for people who do not receive natural light for extended periods, such as workers in indoor artificial lighting environments, the body cannot automatically adjust its circadian rhythm, leading to circadian rhythm disorders. This can result in decreased appetite, reduced work efficiency, increased accidents, and even various diseases.

[0003] In response to the above situation, existing technologies involve establishing a mouse model of circadian rhythm disorder to disrupt the mouse's circadian rhythm, then treating the mice with a series of treatments and detecting various physiological indicators to achieve the therapeutic effect of the experimental treatments.

[0004] Current experimental devices for mouse circadian rhythm disorder models, such as the rodent circadian rhythm regulation experimental device disclosed in Chinese Patent [Publication No.: CN205623727U], include an experimental box with a metal wire mesh bottom, an environmental simulation component, and a monitoring component.

[0005] When testing physiological indicators of mice under exercise conditions, it is necessary to remove the mice from the experimental device, break them from their original circadian rhythm, and then put them into devices such as treadmills or cages to force them to exercise. This is quite troublesome, and removing the mice from the experimental device can easily affect the experimental results. Summary of the Invention

[0006] In view of this, the purpose of the present invention is to provide a mouse treadmill based on circadian rhythm regulation, which solves the problem that in the prior art, removing mice from the experimental device to detect physiological indicators of their exercise state is cumbersome and can easily affect the experimental results.

[0007] The present invention solves the above-mentioned technical problems through the following technical means:

[0008] A mouse treadmill based on circadian rhythm regulation includes a treadmill, a lighting mechanism, a feeding mechanism, and a detection mechanism. The lighting mechanism provides illumination, the feeding mechanism provides food for the mice, and the detection mechanism detects physiological indicators of the mice. The treadmill has multiple feeding zones, one end of which is divided into an exercise zone. A driving mechanism is provided within the feeding zone, comprising a mounting plate and a partition. The mounting plate is slidably installed within the feeding zone, and the partition is installed on the side of the mounting plate near the exercise zone to drive the mice from the feeding zone into the exercise zone and confine them within the exercise zone. The mounting plate drives the partition to move. A running component is located at the bottom of the exercise zone to move the mice.

[0009] By setting up the above structure, when it is necessary to detect physiological indicators of mouse movement, the mounting plate is moved within the feeding area, the mouse is pushed to the exercise area by the partition, and then the running component, in conjunction with the partition, forces the mouse to move. Compared with existing technologies, it is not necessary to remove the mice from their original experimental environment to a new environment for detecting physiological indicators of movement, ensuring the accuracy of experimental results and effectively reducing the workload of experimental personnel.

[0010] Furthermore, a cover is fixedly connected to the top of the running platform, a locking element is provided on the cover, and a locking assembly is provided on the mounting plate. The locking assembly is used to lock with the locking element to fix the mounting plate on the cover.

[0011] By setting up the above structure, when the mounting plate moves to the corresponding position, the locking assembly and locking element can fix the mounting plate in place, preventing the mounting plate from moving at will.

[0012] Furthermore, the partition is provided with multiple stimulators on the side near the exercise area. The stimulators are used to stimulate the mouse to run towards the exercise area. The partition is slidably mounted on the mounting plate. A transmission assembly is provided between the mounting plate and the partition. When the partition moves towards the mounting plate and comes into contact with the transmission assembly, the transmission assembly can drive the locking assembly to disengage from the locking member. A first elastic member is provided between the mounting plate and the end wall of the running platform. The first elastic member is used to give the mounting plate a tendency to move away from the exercise area.

[0013] By setting up the above structure, the stimulator can stimulate the mouse, preventing it from remaining stationary at the partition. If the mouse still remains at the partition under the stimulation of the stimulator, it indicates that the mouse is in a state of exhaustion. The running component will then push the partition to move through the mouse. The partition will disengage the locking component from the locking member through the transmission component. The first elastic member will move the mounting plate away from the movement area, allowing the stimulator to stop stimulating the mouse and enabling the mouse to leave the movement area, thus protecting the mouse.

[0014] Furthermore, a third sliding rod is fixedly installed on the side of the partition plate near the mounting plate. A third through hole is provided on the mounting plate, and the third sliding rod passes through the third through hole. A third spring is provided between the partition plate and the mounting plate, and the third spring is sleeved on the third sliding rod.

[0015] By setting the above structure, a sliding connection between the partition and the mounting plate is achieved. Furthermore, by setting a third spring, after the locking component is disengaged from the locking member, the third spring is a compression spring, which gives the partition a tendency to move away from the mounting plate, thus preventing the partition from moving arbitrarily.

[0016] Furthermore, a conductive ring is provided on the third slide rod, and a conductive seat is provided at one end of the third through hole. When the conductive ring contacts the conductive seat, the stimulation element starts to work.

[0017] By setting up the above structure, the stimulation device can be automatically turned on and off. As the mouse squeezes the partition and moves toward the mounting plate, the conductive ring gradually moves closer to the conductive seat. When the conductive ring contacts the conductive seat, the stimulation device starts to work, stimulating the mouse and forcing it to move.

[0018] Furthermore, a first sliding rod is provided at the top of the feeding area, the mounting plate is slidably mounted on the first sliding rod, a first sliding groove is provided on the cover, the top of the mounting plate is slidably disposed in the first sliding groove, and the top of the mounting plate protrudes out of the cover, and the locking member is fixedly connected to the end wall of the first sliding groove near the movement area.

[0019] By setting up the above structure, the mounting plate can be slidably installed in the feeding area.

[0020] Furthermore, the locking assembly includes a locking block, a second sliding groove is provided on the mounting plate, the locking block is slidably disposed in the second sliding groove, a second sliding rod is fixedly installed on the top of the locking block, a second through hole is provided on the top of the second sliding groove, the second sliding rod passes through the second through hole, a locking groove is provided on the locking member, and when the locking block is engaged in the locking groove, the mounting plate is locked on the cover.

[0021] By setting the above structure, when the lock block slides down into the lock groove, the locking assembly and the locking element can be locked together. When the lock block slides up and disengages from the lock groove, the locking assembly and the locking element can be disengaged. The structure is simple and easy to adjust.

[0022] Furthermore, the transmission assembly includes a transmission rod, and a first mounting groove is provided on the mounting plate. The transmission rod is rotatably mounted in the first mounting groove by a torsion spring. The first mounting groove is connected to a second sliding groove. The transmission rod includes an abutting end and a driving end. An extension is fixedly connected to the side of the locking block away from the movement area. The driving end abuts against the bottom of the extension. The driving end is located between the partition and the mounting plate.

[0023] By setting the above structure, when the partition plate abuts against the drive end, it drives the transmission rod to rotate. The drive end of the transmission rod pushes the extension of the lock block to force the lock block to move upward, thereby realizing the disengagement of the locking assembly from the locking member without manual operation.

[0024] Furthermore, the running assembly includes a running belt and a drive motor. A second mounting groove is provided at the bottom of the exercise area. Drive shafts are rotatably mounted at both ends of the second mounting groove. The running belt is tensioned between the two drive shafts. The drive motor is connected to the drive shafts in a transmission manner.

[0025] Furthermore, the end wall of the running platform has a through groove corresponding to the exercise area, and the feeding mechanism includes a sealing plate and a box connected to the sealing plate. The sealing plate is slidably engaged in the through groove, and the box is located in the exercise area.

[0026] By setting up the above structure, mice can be placed into or removed from the running platform through the through slot, and by setting the box at one end of the exercise area, the mice can be further induced to move away from the partition.

[0027] The beneficial effects of this invention are:

[0028] 1. By setting up a herding mechanism, when it is necessary to detect physiological indicators of mouse movement, the mounting plate is moved within the feeding area. A partition pushes the mouse to the exercise area, and the running component, in conjunction with the partition, forces the mouse to move. Compared to existing technologies, this eliminates the need to remove mice from their original experimental environment to a new one for physiological indicator detection, ensuring the accuracy of experimental results and effectively reducing the workload of experimental personnel.

[0029] 2. By setting locking components and locking parts, when the mounting plate moves to the corresponding position, the locking parts and locking parts can fix the mounting plate in place, preventing the mounting plate from moving at will.

[0030] 3. By setting up a stimulating element and a transmission assembly, the stimulating element can stimulate the mouse, preventing it from remaining stationary at the partition. If the mouse still remains stationary at the partition under the stimulation of the stimulating element, it indicates that the mouse is in a state of exhaustion. The running assembly will then push the partition to move through the mouse. The partition, through the transmission assembly, will disengage the locking assembly from the locking member. The first elastic member will move the mounting plate away from the movement area, allowing the stimulating element to stop stimulating the mouse and enabling the mouse to leave the movement area, thus protecting the mouse.

[0031] 4. By setting a conductive ring and a conductive seat, as the mouse squeezes the partition and moves toward the mounting plate, the conductive ring gradually moves closer to the conductive seat. When the conductive ring contacts the conductive seat, the stimulator starts to work, stimulating the mouse and forcing it to move. This allows the stimulator to be automatically turned on and off. Attached Figure Description

[0032] Figure 1 This is a schematic diagram of the structure of a mouse treadmill based on circadian rhythm regulation according to the present invention;

[0033] Figure 2 This is a schematic diagram of the internal structure of a mouse treadmill based on circadian rhythm regulation according to the present invention;

[0034] Figure 3 This is a schematic cross-sectional view of a mouse treadmill based on circadian rhythm regulation according to the present invention.

[0035] Figure 4 This is a schematic diagram of the structure of a mouse running platform driven away mechanism based on circadian rhythm regulation according to the present invention;

[0036] Figure 5 This is a schematic diagram of the locking structure between the locking block and the cover in a mouse treadmill based on circadian rhythm regulation according to the present invention;

[0037] Figure 6 yes Figure 4 A schematic diagram of the split structure;

[0038] in,

[0039] 1. Running platform; 11. Feeding area; 111. Exercise area; 112. First slide bar; 113. Slide rail; 12. First elastic element; 13. Second mounting groove; 131. Drive shaft; 132. Support plate; 14. Receiving cavity; 141. Groove opening; 15. Through groove;

[0040] 2. Mounting plate; 21. Third through hole; 211. Conductive seat; 22. Slider; 23. Second slide groove; 231. Second through hole; 24. First mounting groove; 241. Hinge post; 242. Limiting rod;

[0041] 3. Partition; 31. Stimulating element; 32. Third slide bar; 321. Conductive ring; 33. Third spring;

[0042] 4. Cover; 41. Locking element; 411. Locking groove; 412. Inclined surface; 42. First sliding groove;

[0043] 5. Locking block; 51. Second slide rod; 511. Second spring; 52. Adjusting block; 53. Extension piece;

[0044] 6. Transmission rod; 61. Abutment end; 62. Drive end;

[0045] 7. Running belt;

[0046] 8. Sealing plate; 81. Box body. Detailed Implementation

[0047] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0048] like Figures 1-6 As shown, this invention discloses a mouse treadmill based on circadian rhythm regulation, comprising a treadmill 1, a lighting mechanism, a feeding mechanism, and a detection mechanism. The treadmill 1 contains multiple feeding zones 11; in this embodiment, seven feeding zones 11 are provided to form a sufficient control group and enrich the experimental content. One end of each feeding zone 11 is divided into an exercise zone 111. A driving mechanism is provided within the feeding zone 11, comprising a mounting plate 2 and a partition 3. The mounting plate 2 is slidably installed within the feeding zone 11, and the partition 3 is installed on the side of the mounting plate 2 near the exercise zone 111, used to drive mice from the feeding zone 11 into the exercise zone 111 and confine the mice within the exercise zone 111. The mounting plate 2 drives the partition 3 to move. A running component is provided at the bottom of the exercise zone 111, used to move the mice. When it is necessary to detect physiological indicators of mouse movement, the mounting plate 2 is controlled to move within the feeding zone 11, the partition 3 pushes the mice into the exercise zone 111, and the running component, in conjunction with the partition 3, forces the mice to move. Compared to existing technologies, this method eliminates the need to move mice from their original experimental environment to a new one to measure their physiological indicators of movement, ensuring the accuracy of experimental results and effectively reducing the workload of experimental personnel.

[0049] In this embodiment, a cover 4 is fixedly connected to the top of the running platform 1 by fixing bolts. A locking element 41 is provided on the cover 4, and a locking assembly is provided on the mounting plate 2. The locking assembly is used to lock with the locking element 41 to fix the mounting plate 2 to the cover 4. When the mounting plate 2 moves to the corresponding position, the cooperation between the locking assembly and the locking element 41 can fix the mounting plate 2, preventing it from moving arbitrarily. In some other embodiments, the cover plate may be omitted, and the locking element 41 can be directly placed on the running platform 1. The cover plate is mainly used to block the exercise area 111, preventing the mouse from escaping from the top of the exercise area 111 when forced to exercise.

[0050] In this embodiment, a plurality of stimulating elements 31 are provided on the side of the partition 3 near the exercise area 111. The stimulating elements 31 are used to stimulate the mouse to run towards the exercise area 111. In this embodiment, the stimulating elements 31 are preferably electrical stimulation pads. In other embodiments, spikes, swing rods, or other structures can also be used, as long as they can stimulate the mouse. The partition 3 is slidably mounted on the mounting plate 2. A transmission assembly is provided between the mounting plate 2 and the partition 3. When the partition 3 moves towards the mounting plate 2 and comes into contact with the transmission assembly, the transmission assembly can drive the locking assembly to disengage from the locking member 41. A first elastic member 12 is provided between the mounting plate 2 and the end wall of the running platform 1. The first elastic member 12 is used to give the mounting plate 2 a tendency to move away from the exercise area 111. Stimulator 31 can stimulate the mouse to prevent it from staying still at partition 3. If the mouse still stops at partition 3 under the stimulation of stimulator 31, it means that the mouse is exhausted. The running component will push partition 3 to move through the mouse. Partition 3 will disengage the locking component from locking member 41 through the transmission component. The first elastic member 12 will move the mounting plate 2 away from the movement area 111, so that stimulator 31 will stop stimulating the mouse and the mouse can leave the movement area 111, thus protecting the mouse.

[0051] In this embodiment, two third sliding rods 32 are integrally formed on the side of the partition 3 near the mounting plate 2. Two third through holes 21 are provided on the mounting plate 2, and the third sliding rods 32 pass through the corresponding third through holes 21, achieving a sliding connection between the partition 3 and the mounting plate 2. A third spring 33 is provided between the partition 3 and the mounting plate 2, and the third spring 33 is sleeved on the third sliding rods 32. The third spring 33 is a compression spring. By providing the third spring 33, after the locking assembly disengages from the locking member 41, the third spring 33, being a compression spring, gives the partition 3 a tendency to move away from the mounting plate 2, preventing the partition 3 from moving arbitrarily.

[0052] In this embodiment, a conductive ring 321 is provided on the third slide bar 32, and a conductive seat 211 is provided at one end of the third through hole 21. When the conductive ring 321 contacts the conductive seat 211, the stimulator 31 starts to work. As the mouse squeezes the partition 3 and moves towards the mounting plate 2, the conductive ring 321 gradually moves closer to the conductive seat 211. When the conductive ring 321 contacts the conductive seat 211, the stimulator 31 starts to work, stimulating the mouse and forcing it to move. This allows the stimulator 31 to automatically open and close. It should be noted that the conductive ring 321 is located in the middle of the third slide bar 32 to avoid stimulating the mouse immediately upon touching the partition 3.

[0053] In this embodiment, a first slide bar 112 is provided on the top of the feeding area 11, and the mounting plate 2 is slidably mounted on the first slide bar 112, so that the mounting plate 2 can be slidably mounted in the feeding area 11. In this embodiment, a slide rail 113 is provided on the side wall of the feeding area 11, and a corresponding slider 22 is provided on the mounting plate 2 so that the mounting plate 2 can slide stably and smoothly. A first elastic element 12 is sleeved on the first slide bar 112. The first elastic element 12 is a compression spring. When the locking assembly is disengaged from the locking member 41, the first elastic element 12 can move the mounting plate 2 away from the movement area 111. A first sliding groove 42 is provided on the cover 4. The top of the mounting plate 2 is slidably disposed in the first sliding groove 42, and the top of the mounting plate 2 protrudes outside the cover 4. The locking member 41 is fixedly connected to the end wall of the first sliding groove 42 near the movement area 111.

[0054] In this embodiment, the locking assembly includes a locking block 5. A second sliding groove 23 is provided on the mounting plate 2. The locking block 5 slides vertically within the second sliding groove 23. Two second sliding rods 51 are integrally formed on the top of the locking block 5. Two second through holes 231 are provided on the top of the second sliding groove 23. The second sliding rods 51 pass through the corresponding second through holes 231. A locking groove 411 is provided on the locking member 41. When the locking block 5 is engaged in the locking groove 411, it locks the mounting plate 2 onto the cover 4. It should be noted that an inclined surface 412 is provided at the end of the locking member 41 away from the movement area 111. The inclined surface 412 guides the locking block 5 moving towards the locking member 41, allowing the locking block 5 to smoothly enter the locking groove 411. When the locking block 5 slides down into the locking groove 411, the locking assembly and the locking member 41 are locked together. When the locking block 5 slides up and disengages from the locking groove 411, the locking assembly and the locking member 41 are disengaged. The structure is simple and easy to adjust. In this embodiment, an adjusting block 52 is provided at the top of the second slide rod 51. The adjusting block 52 is used to manually adjust the position of the locking block 5. A second spring 511 is sleeved on the second slide rod 51. The second spring 511 is a compression spring. One end of the second spring 511 is connected to the locking block 5, and the other end is connected to the top of the second slide groove 23. The second spring 511 is used to stably lock the locking block 5 in the locking groove 411.

[0055] In this embodiment, the transmission assembly includes two transmission rods 6. A first mounting groove 24 is provided on both sides of the mounting plate 2. A hinge post 241 is provided within the first mounting groove 24. Both transmission rods 6 are rotatably mounted on the hinge post 241 via torsion springs. It should be noted that a limit rod 242 is provided on the lower side of the transmission rod 6 within the first mounting groove 24. The limit rod 242 is located above the hinge post 241 and is used to limit the maximum tilt angle of the transmission rod 6. The first mounting groove 24 communicates with the second sliding groove 23. The transmission rod 6 includes an abutment end 61 and a drive end 62. An extension 53 is integrally formed on the side of the locking block 5 away from the movement area 111. The drive end 62 abuts against the bottom of the extension 53. The abutment end 61 is located between the partition plate 3 and the mounting plate 2. When the partition 3 abuts against the contact end 61, it drives the transmission rod 6 to rotate. The driving end 62 of the transmission rod 6 pushes the extension 53 of the locking block 5, forcing the locking block 5 to move upward, thereby disengaging the locking assembly from the locking member 41 without manual operation. In some other embodiments, linkage can also be achieved by setting a connecting rod or other mechanism.

[0056] In this embodiment, the running assembly includes a running belt 7 and a drive motor. A second mounting groove 13 is provided at the bottom of the exercise area 111. Drive shafts 131 are rotatably mounted at both ends of the second mounting groove 13. The running belt 7 is tensioned between the two drive shafts 131. The drive motor is connected to the drive shafts 131. It should be noted that the drive motor is a conventional drive mechanism and is therefore not shown in the accompanying drawings. In this embodiment, a support plate 132 is provided within the second mounting groove 13. The support plate 132 is located within the running belt 7 and is used to improve the support force of the running belt 7.

[0057] In this embodiment, a receiving cavity 14 is provided at one end of the bottom of the running platform 1, and a number of slots 141 are provided on the ground at the end of the feeding area 11 away from the exercise area 111. The slots 141 are connected to the receiving cavity 14, and the mouse's excrement can enter the receiving cavity 14 through the slots 141 to keep the feeding area 11 clean.

[0058] In this embodiment, the lighting mechanism is used to provide light for the mice in the breeding area 11. The lighting mechanism can be a solar light simulator that is already fully disclosed in the prior art, which provides simulated sunlight for the mice in the breeding area 11, and forces the mice to disrupt their diurnal rhythm by adjusting the irradiation strategy.

[0059] The feeding mechanism is used to provide food for mice. A slot 15 is provided on the end wall of the running platform 1 corresponding to the exercise area 111, allowing mice to be placed into or removed from the running platform 1. The feeding mechanism includes a sealing plate 8 and a box 81 connected to the sealing plate 8. The sealing plate 8 is slidably engaged within the slot 15, and the box 81 is located within the exercise area 111. The sealing plate 8 is removed from the slot 15, food and water are filled into the box 81, and then the box 81 is inserted into the slot 15 to complete the feeding. Furthermore, by positioning the box 81 at one end of the exercise area 111, the mouse can be further induced to move away from the partition 3.

[0060] The testing facility is used to detect various physiological indicators of mice. In this embodiment, the testing facility uses wearable devices (such as electrocardiogram monitoring patches, body temperature monitoring patches, etc.) combined with wireless telemetry technology.

[0061] The working principle of this invention is as follows:

[0062] When it is necessary to detect physiological indicators in mice during exercise:

[0063] First, move the mounting plate 2 toward the movement area 111. The mounting plate 2 moves the partition 3, and the partition 3 pushes the mouse into the movement area 111 until the locking block 5 on the mounting plate 2 is locked into the locking groove 411 of the locking member 41.

[0064] Subsequently, the drive motor is controlled to work. The drive motor, through the cooperation of the running belt 7 and the partition 3, forces the mouse to run in the exercise area 111. Then, the physiological indicators of the mouse in the exercise state can be detected by the detection mechanism.

[0065] During the movement of the mouse within the locomotor zone 111:

[0066] When the mouse stops running on the belt 7, the belt 7 moves the mouse toward the stimulator 31. When the mouse comes into contact with the stimulator 31, the mouse squeezes the partition 3 and moves toward the mounting plate 2. The conductive ring 321 gradually moves closer to the conductive seat 211. When the conductive ring 321 contacts the conductive seat 211, the stimulator 31 starts to work, stimulating the mouse and forcing it to move. After the mouse runs away from the partition 3, the third spring 33 causes the partition 3 to automatically reset, and the stimulator 31 stops working.

[0067] If the mouse remains stationary at the partition 3 under the stimulation of the stimulus 31, it indicates that the mouse is in a state of exhaustion. The running belt 7 will push the partition 3 to move through the mouse. When the partition 3 comes into contact with the abutment end 61, it will drive the transmission rod 6 to rotate. The drive end 62 of the transmission rod 6 will push the extension 53 of the locking block 5 to force the locking block 5 to move upward, so that the locking block 5 is disengaged from the locking member 41. The first elastic member 12 will move the mounting plate 2 away from the movement area 111, so that the stimulus 31 will stop stimulating the mouse, and the mouse can leave the movement area 111, thus protecting the mouse.

[0068] The above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the present invention, and all such modifications and substitutions should be covered within the scope of the claims of the present invention. Technical aspects, shapes, and structures not described in detail in this invention are all well-known technologies.

Claims

1. A mouse treadmill based on circadian rhythm regulation, comprising a treadmill (1), a lighting mechanism, a feeding mechanism, and a detection mechanism, wherein the lighting mechanism provides illumination, the feeding mechanism provides food to the mice, and the detection mechanism detects physiological indicators of the mice, characterized in that, The running platform (1) is provided with multiple feeding areas (11). One end of the feeding area (11) is divided into a movement area (111). The feeding area (11) is provided with a driving mechanism. The driving mechanism includes a mounting plate (2) and a partition (3). The mounting plate (2) is slidably installed in the feeding area (11). The partition (3) is installed on the side of the mounting plate (2) near the movement area (111) to drive the mice in the feeding area (11) into the movement area (111) and confine the mice in the movement area (111). The mounting plate (2) is used to drive the partition (3) to move. The bottom of the movement area (111) is provided with a running component. The running component is used to drive the mice to move. The top of the running platform (1) is fixedly connected to a cover (4), and a locking element (41) is provided on the cover (4). A locking assembly is provided on the mounting plate (2), and the locking assembly is used to lock with the locking element (41) to fix the mounting plate (2) on the cover (4). The partition (3) is provided with a plurality of stimulators (31) on the side near the exercise area (111). The stimulators (31) are used to stimulate the mouse to run towards the exercise area (111). The partition (3) is slidably mounted on the mounting plate (2). A transmission assembly is provided between the mounting plate (2) and the partition (3). When the partition (3) moves towards the mounting plate (2) and comes into contact with the transmission assembly, it can drive the locking assembly to move through the transmission assembly, so that the locking assembly disengages from the locking member (41). A first elastic member (12) is provided between the mounting plate (2) and the end wall of the running platform (1). The first elastic member (12) is used to make the mounting plate (2) have a tendency to move away from the exercise area (111). The locking assembly includes a locking block (5), a second sliding groove (23) is provided on the mounting plate (2), the locking block (5) is slidably disposed in the second sliding groove (23), a second sliding rod (51) is fixedly installed on the top of the locking block (5), a second through hole (231) is provided on the top of the second sliding groove (23), the second sliding rod (51) passes through the second through hole (231), a locking groove (411) is provided on the locking member (41), and when the locking block (5) is engaged in the locking groove (411), the mounting plate (2) is locked on the cover (4); The transmission assembly includes a transmission rod (6), and a first mounting groove (24) is provided on the mounting plate (2). The transmission rod (6) is rotatably mounted in the first mounting groove (24) by a torsion spring. The first mounting groove (24) is connected to the second sliding groove (23). The transmission rod (6) includes an abutting end (61) and a driving end (62). An extension (53) is fixedly connected to the side of the locking block (5) away from the moving area (111). The driving end (62) abuts against the bottom of the extension (53). The abutting end (61) is located between the partition plate (3) and the mounting plate (2).

2. The mouse treadmill based on circadian rhythm regulation according to claim 1, characterized in that, A third slide rod (32) is fixedly installed on the side of the partition (3) near the mounting plate (2). A third through hole (21) is provided on the mounting plate (2). The third slide rod (32) passes through the third through hole (21). A third spring (33) is provided between the partition (3) and the mounting plate (2). The third spring (33) is sleeved on the third slide rod (32).

3. The mouse treadmill based on circadian rhythm regulation according to claim 2, characterized in that, A conductive ring (321) is provided on the third slide rod (32), and a conductive seat (211) is provided at one end of the third through hole (21). When the conductive ring (321) contacts the conductive seat (211), the stimulation element (31) starts to work.

4. The mouse treadmill based on circadian rhythm regulation according to claim 1, characterized in that, The top of the feeding area (11) is provided with a first sliding rod (112), the mounting plate (2) is slidably mounted on the first sliding rod (112), the cover (4) is provided with a first sliding groove (42), the top of the mounting plate (2) is slidably disposed in the first sliding groove (42), and the top of the mounting plate (2) protrudes out of the cover (4), and the locking member (41) is fixedly connected to the end wall of the first sliding groove (42) near the end of the movement area (111).

5. The mouse treadmill based on circadian rhythm regulation according to claim 1, characterized in that, The running assembly includes a running belt (7) and a drive motor. A second mounting groove (13) is provided at the bottom of the exercise area (111). Drive shafts (131) are rotatably mounted at both ends of the second mounting groove (13). The running belt (7) is tensioned between the two drive shafts (131). The drive motor is connected to the drive shafts (131) in a transmission connection.

6. The mouse treadmill based on circadian rhythm regulation according to claim 1, characterized in that, The end wall of the running platform (1) is provided with a through groove corresponding to the exercise area (111). The feeding mechanism includes a sealing plate (8) and a box (81) connected to the sealing plate (8). The sealing plate (8) is slidably locked in the through groove, and the box (81) is located in the exercise area (111).

Images