一种具有超氧化物歧化酶活性的碳点的制备方法
By preparing amino acid and resveratrol-based carbon dots, the problems of low enzyme activity and high biotoxicity of existing nanomaterials have been solved, resulting in a highly active and low-toxic superoxide dismutase mimic that is suitable for the biomedical field.
CN118637602BActive Publication Date: 2026-07-17JILIN UNIV FIRST HOSPITAL
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JILIN UNIV FIRST HOSPITAL
- Filing Date
- 2024-06-03
- Publication Date
- 2026-07-17
Smart Images
Figure CN118637602B_ABST
Abstract
本发明适用于生物医学领域，提供了一种具有超氧化物歧化酶活性的碳点的制备方法，所述方法包括：向氢氧化钠水溶液中加入氨基酸和白藜芦醇，超声溶解后将溶液转移至聚四氟乙烯内衬反应釜中，置于烘箱内加热，一段时间后取出反应釜。待反应釜冷却至室温后，以0.22μm的滤膜过滤产物水溶液并透析得到提纯的碳点溶液，冻干得到碳点固体。本发明以来源广泛、价格低廉、官能团丰富、生物安全性高的氨基酸和能够降低氧化应激水平、对抗活性氧损伤的白藜芦醇为原料，成功制备出具有超氧化物歧化酶活性的碳点。该制备方法简便，对多种氨基酸均适用，具有普适性，在生物医学领域具有良好的应用价值。
Need to check novelty before this filing date? Find Prior Art