A carbon fiber composite material chest rib integrated artificial bone and a preparation method thereof

Abstract

The application discloses a kind of carbon fiber composite material chest rib integrated artificial bone and preparation method thereof, belong to the technical field of biomedical prosthesis.The preparation method of chest rib integrated artificial bone is as follows:1) design chest rib integrated artificial bone mould by three-dimensional modeling;2) carbon fiber chest rib integrated artificial bone preform is formed by using mould auxiliary carbon fiber fabric forming;3) baking setting;4) composite matrix carbon.Chest rib integrated artificial bone has porous structure, solves the technical problems such as lack of large hole, low through hole rate and poor tissue growth in carbon-based artificial bone in the prior art, and has sufficient strength, plasticity, X-ray permeability, and the advantages such as elastic modulus close to autologous cortical bone.

Description

Technical Field

[0001] This invention relates to an artificial bone, particularly to a carbon fiber composite integrated chest and rib artificial bone, and also to its preparation method, belonging to the field of biomedical prosthesis technology. Background Technology

[0002] Simultaneous defects of the sternum and ribs in the chest wall are commonly seen after tumor treatment interventions and direct damage from trauma. Clinically, when the diameter of a bony defect in the chest wall is greater than 5 cm, bony reconstruction surgery of the chest wall is required to achieve the following objectives: 1) complete protection of the thoracic cavity and upper abdominal organs; 2) ensuring complete respiratory function; 3) reshaping the shape of the chest wall to maximize the stability and aesthetic effect of the chest wall structure, facilitating the patient's recovery of confidence.

[0003] Current technologies commonly used for rib and chest bone defect replacement include titanium and titanium alloys, nickel-titanium alloys, and stainless steel. However, these materials have poor mechanical properties and compatibility with autologous bone, leading to implant loosening or dislocation. Large implants also cause significant weight gain, potentially affecting respiratory function. Carbon fiber composites, using carbon materials as the matrix and carbon fibers and their fabrics as reinforcement, offer advantages such as light weight, good chemical stability, mechanical properties similar to human bone, good fatigue resistance, and high design flexibility. Their excellent biocompatibility makes them an ideal material for artificial bone. Compared to conventional metal implant materials, carbon fiber composite materials have the following main advantages: 1) Lightweight, with a density 1 / 5 that of stainless steel and 1 / 3 that of titanium alloy; 2) Non-reactive to human tissue, able to withstand subtle changes in the body's acid-base environment without degradation; 3) Facilitates close integration with surrounding bone tissue, promoting bone growth; 4) Elastic modulus between 1 and 40 GPa, very close to the elastic modulus of human bone (1 to 30 GPa), effectively avoiding complications such as bone resorption caused by prosthesis stress shielding; 5) Carbon fiber reinforcement has good toughness, resulting in a certain degree of plasticity in fracture behavior, avoiding the significant risks associated with sudden material fracture. However, to date, carbon fiber composite materials have not been used to construct integrated rib-chest artificial bones. Summary of the Invention

[0004] To address the shortcomings of existing technologies, the first objective of this invention is to provide a carbon fiber composite integrated thoracic and rib artificial bone. This carbon fiber composite integrated thoracic and rib artificial bone has the following characteristics: 1) It has through holes and transverse micropores, which facilitate the delivery of biological media, promote tissue attachment and ingrowth, improve biocompatibility, and solve the problems of insufficient macropores, low porosity, and poor tissue ingrowth in existing carbon-based artificial bones; 2) It has sufficient strength to ensure the stability of the thoracic cavity, protect vital organs and tissues within the chest, and prevent paradoxical breathing; 3) It is implantable, allowing fibrous tissue to adhere to the wall, is stable, not prone to infection, and non-carcinogenic; 4) It is malleable, making it easy to conform to the shape of the thoracic cavity; 5) It is X-ray permeable, allowing radiation to penetrate, facilitating postoperative examination and follow-up; 6) Its elastic modulus is close to that of autologous cortical bone, avoiding restrictive pulmonary ventilation dysfunction.

[0005] The second objective of this invention is to provide a method for preparing an integrated rib and chest bone made of carbon fiber composite material. This method is simple, low-cost, and easy to mass-produce.

[0006] To achieve the above-mentioned technical objectives, the present invention provides a method for preparing a carbon fiber composite integrated rib-chest artificial bone, the method comprising the following steps:

[0007] 1) Construct a 3D model of an integrated thoracic and ribcage artificial bone using human CT image data, and design a convex and concave mold based on the 3D model; the convex and concave mold includes a convex mold and a concave mold, and through holes are distributed at the same position in the vertical direction on the surfaces of the convex mold and the concave mold, and the through holes are used to insert rods;

[0008] 2) Carbon fiber bundles or carbon fiber ropes are woven into carbon fiber strips as artificial ribs, and carbon fiber fabric is used as artificial sternum. One end of the carbon fiber strip is embedded in the carbon fiber fabric or the carbon fiber strip passes through the carbon fiber fabric to obtain an integrated carbon fiber rib and chest body. The carbon fiber fabric is formed by superimposing carbon fiber nonwoven fabric and carbon fiber woven fabric, and the surface of the carbon fiber fabric is carbon fiber nonwoven fabric.

[0009] 3) Place the carbon fiber chest and rib integrated blank in the convex and concave molds, insert rods into the through holes on the surfaces of the convex and concave molds, bake and shape it, then remove the rods and convex and concave molds, and insert carbon fiber bundles into the pre-reserved holes of some rods on the surface of the carbon fiber fabric for sewing, to obtain the carbon fiber chest and rib integrated artificial bone prefabricated body.

[0010] 4) The carbon fiber integrated rib and chest artificial bone prefabrication body is processed by chemical vapor deposition and / or impregnation-pyrolysis to generate carbon matrix and / or silicon carbide matrix and / or tantalum carbide matrix, thus obtaining the prefabricated body.

[0011] This invention constructs a sternum using carbon fiber nonwoven fabric and carbon fiber woven fabric through superposition and stitching or needle punching. While carbon fiber nonwoven fabric has low density and high porosity, its mechanical properties are poor. Conversely, carbon fiber woven fabric has high density, low porosity, and good mechanical properties. The sternum constructed by superimposing these two materials not only possesses good mechanical properties but also abundant internal pores. The sternum surface has through-pores, and the carbon fiber nonwoven fabric provides lateral pores for the sternum, facilitating the delivery of biological media, promoting tissue attachment and ingrowth, and improving biocompatibility. This addresses the problems of insufficient macropores, low porosity, and poor tissue ingrowth in existing carbon-based artificial bones, while the carbon fiber woven fabric primarily imparts better mechanical properties to the sternum.

[0012] As a preferred embodiment, the carbon fiber bundle is 1k, 3k, 6k, 12k, 18k, 24k, 36k, 40k or 48k carbon fiber.

[0013] As a preferred embodiment, the carbon fiber rope is formed by spirally twisting multiple strands of carbon fiber in the same direction.

[0014] As a preferred embodiment, the carbon fiber strip is formed by two-dimensional weaving of multiple carbon fiber bundles or ropes. Common two-dimensional weaving techniques include diamond weaving, regular weaving, or Hercules weaving. The mechanical properties of carbon fiber ropes and bundles are significantly improved after weaving, meeting the performance requirements of artificial ribs.

[0015] As a preferred embodiment, the carbon fiber strip has a width of 6–20 mm and a thickness of 1.5–5.5 mm. Its dimensions are primarily modeled after human ribs.

[0016] As a preferred embodiment, the areal density of the carbon fiber nonwoven fabric is 20–100 g / m². 2 Further preferred is 40–80 g / m³ 2 .

[0017] As a preferred embodiment, the areal density of the carbon fiber woven fabric is 100–400 g / m². 2 Further preferred values ​​are 120–360 g / m³. 2 The woven fabrics include plain weave, twill weave, or satin weave.

[0018] The areal density of the carbon fiber nonwoven fabric and carbon fiber woven fabric involved in this invention mainly affects their mechanical properties and porosity. Therefore, it is necessary to strictly control the areal density of the carbon fiber nonwoven fabric and carbon fiber woven fabric.

[0019] As a preferred embodiment, the carbon fiber nonwoven fabric and carbon fiber woven fabric in the carbon fiber fabric are stacked in the following manner: one layer of carbon fiber nonwoven fabric and one layer of carbon fiber woven fabric are stacked as a unit layer, and multiple unit layers are stacked to achieve a total thickness of 8-20 mm. The contact between the unit layers is either same-side contact or opposite-side contact, with the carbon fiber nonwoven fabric in the surface unit layer placed on the outer side. Because the carbon fibers in the carbon fiber nonwoven fabric are irregularly arranged and have a low volume content, its porosity is high, and its contact surface with biological tissue is large, which can promote tissue regeneration and help accelerate the recovery of function at the repair site.

[0020] As a preferred embodiment, the surface of the carbon fiber rib integrated preform is uniformly distributed with small holes, which are arranged in a matrix or quincunx pattern, with a hole spacing of 5–20 mm. The hole diameter Φ = 2.5–4.5 mm is found on the carbon fiber fabric portion of the carbon fiber rib integrated preform, while the hole diameter Φ = 1.5–2.5 mm is found on the carbon fiber strip portion.

[0021] As a preferred embodiment, the baking and shaping conditions are: baking at 150–300°C for 1–4 hours.

[0022] As a preferred embodiment, the conditions for generating the carbon matrix by chemical vapor deposition are as follows: using a gaseous carbon source, deposition is carried out at a temperature of 850–1250 °C for 30–120 h.

[0023] As a preferred embodiment, the conditions for impregnation-pyrolysis to generate the carbon matrix are as follows: using resin (phenolic resin, furan resin, furfuryl ketone resin, etc.) or asphalt as the carbon source, and forming the carbon matrix through impregnation, curing, and pyrolysis; the impregnation pressure is 2.0–6.0 MPa, and the impregnation time is 5–15 h; the curing temperature is 180–250 °C, and the curing time is 10–50 h; the pyrolysis temperature of the resin is 900–1050 °C, the pyrolysis pressure is atmospheric pressure, and the pyrolysis time is 5–20 h; the pyrolysis temperature of the asphalt is 750–850 °C, the pyrolysis pressure is 50–200 MPa, and the pyrolysis time is 5–20 h.

[0024] As a preferred embodiment, the conditions for generating the silicon carbide matrix by chemical vapor deposition are as follows: using chlorosilane as the silicon carbide source, and depositing at a temperature of 1000–1400°C for 40–100 hours.

[0025] As a preferred embodiment, the conditions for generating the silicon carbide matrix by impregnation-pyrolysis are as follows: using organopolysilane as the silicon carbide source, the silicon carbide matrix is ​​formed through impregnation, curing, pyrolysis, and ceramization; the impregnation pressure is 2.0–6.0 MPa, and the impregnation time is 5–15 h; the curing temperature is 180–250 °C, and the curing time is 10–50 h; the pyrolysis temperature is 800–1200 °C, and the pyrolysis time is 5–20 h; the ceramization temperature is 1250–1650 °C, and the ceramization time is 2–10 h.

[0026] As a preferred embodiment, the conditions for chemical vapor deposition to generate the tantalum carbide substrate are as follows: using tantalum halide as the tantalum source, employing a gaseous carbon source, and depositing at a temperature of 1200–2000°C for 40–100 hours. Examples of tantalum halide include tantalum pentachloride and tantalum pentafluoride. An example of a gaseous carbon source is natural gas.

[0027] As a preferred embodiment, the conditions for generating the tantalum carbide matrix by impregnation-pyrolysis are as follows: using an organic tantalum salt (such as tantalum ethoxide) as the carbon tantalum source, tantalum carbide is formed through impregnation, curing, pyrolysis, and ceramization; the impregnation pressure is 2.0–6.0 MPa, and the impregnation time is 5–15 h; the curing temperature is 180–250 °C, and the curing time is 10–50 h; the pyrolysis temperature is 900–1200 °C, and the pyrolysis time is 5–20 h; the ceramization temperature is 1300–1800 °C, and the ceramization time is 2–10 h.

[0028] In the carbon fiber composite rib-chest integrated artificial bone of the present invention, the carbon matrix, silicon carbide matrix and tantalum carbide matrix can coexist in one, two or three ways. For example, when it is necessary to form a composite matrix of carbon and silicon carbide or tantalum carbide, the silicon carbide or tantalum carbide matrix can be formed first and then the carbon matrix can be formed, or the carbon matrix can be formed first and then the silicon carbide or tantalum carbide matrix can be formed.

[0029] The carbon fiber integrated rib and chest artificial bone preform of the present invention is produced by chemical vapor deposition and / or impregnation-pyrolysis to generate carbon matrix and / or silicon carbide matrix and / or tantalum carbide matrix, and then subjected to conventional machining, including cutting edges, grinding surfaces, etc.

[0030] The carbon fiber composite integrated chest and rib artificial bone of the present invention can be further deposited with PyC coating, tantalum-doped DLC coating, or tantalum carbide coating on its surface as needed.

[0031] The present invention also provides a carbon fiber composite integrated rib and chest bone, which is obtained by the aforementioned preparation method.

[0032] The carbon fiber composite sternal rib integrated bone of the present invention comprises two parts: a rigid sternum and several flexible ribs (up to 10), both parts having through holes on their surfaces.

[0033] The sternum has a thickness of 8–20 mm and a width of 20–60 mm. Its surface features through-holes and is composed of multiple stacked unit layers. Each unit layer consists of stacked A (formed from carbon fiber nonwoven fabric) and B (formed from carbon fiber woven fabric), such as AB…ABCAB…BA or AB…ABCBA…BA. Layer B has a carbon fiber volume content of 60–75%, a matrix volume content of 15–20%, a porosity of 5–25%, and a thickness of 0.5–2 mm. Layer A has a carbon fiber volume content of 20–30%, a matrix volume content of 20–30%, a porosity of 40–60%, and a thickness of 1–5 mm. Layer C consists of carbon fiber strips embedded in the sternum. The layers are sutured together using carbon fiber through-holes. Its mechanical properties include a tensile strength of over 90 MPa, a tensile modulus of 10–20 GPa, and a flexural strength of 90–150 MPa. The sternum has through-holes and numerous transversely connected pores, facilitating the delivery of biological media, promoting tissue adhesion and ingrowth, and improving biocompatibility.

[0034] The ribs are 1.5–5.5 mm thick and 6–20 mm wide. Their mechanical properties include an axial tensile strength of over 120 MPa, a tensile modulus of 3–10 GPa, and a flexural strength of 40–80 MPa. The ribs contain numerous through-holes, with pores of 50–300 μm in diameter accounting for 30–50% of the total volume, which is beneficial for bone growth and the formation of bony connections with the autologous bone.

[0035] The function of the through holes (diameter Φ2.5~4.5mm in the sternal portion, diameter Φ1.5~2.5mm in the rib portion, and spacing 5~20mm between holes) is to facilitate hard tissue connection fixation and soft tissue fixation. Hard tissue connection fixation is for connection with autologous bone during clinical surgery, while soft tissue fixation is to facilitate the penetration and growth of chest wall tissue, ultimately achieving biological fixation.

[0036] The present invention utilizes human CT image data to construct a 3D model of an integrated thoracic and ribcage artificial bone, and employs a method for designing convex and concave molds based on this 3D model—a conventional approach in existing technology. The convex and concave molds are typically made of steel or carbon materials.

[0037] Compared with existing technologies, the beneficial technical effects of the present invention are as follows:

[0038] The carbon fiber composite rib-chest integrated artificial bone provided by this invention has the following significant advantages compared with existing metal artificial bones: 1) It has through holes and transverse micropores, which facilitates the delivery of biological media, promotes tissue attachment and ingrowth, improves biocompatibility, and solves the problems of insufficient macropores, low porosity, and poor tissue ingrowth in existing carbon-based artificial bones; 2) It has sufficient strength to ensure the stability of the thoracic cage, protect important organs and tissues in the chest, and prevent paradoxical breathing; 3) It is implantable, allowing fibrous tissue to adhere to the wall, is stable, not prone to infection, and non-carcinogenic; 4) It is malleable, making it easy to conform to the shape of the thoracic cage; 5) It is X-ray permeable, allowing radiation to penetrate, which facilitates postoperative examination and follow-up; 6) Its elastic modulus is close to that of autologous cortical bone, avoiding restrictive pulmonary ventilation dysfunction.

[0039] The method for preparing the carbon fiber composite integrated chest and rib artificial bone provided by this invention is simple, low-cost, and easy to mass-produce. Attached Figure Description

[0040] Figure 1 This is a schematic diagram of the convex and concave mold structure.

[0041] Figure 2 It is a carbon fiber composite integrated ribcage containing 8 ribs.

[0042] Figure 3 It is a carbon fiber composite integrated ribcage containing 6 ribs. Detailed Implementation

[0043] The following specific embodiments are intended to further illustrate the content of the present invention, rather than to limit the scope of protection of the claims of the present invention.

[0044] Example 1

[0045] 1) A 3D model of the integrated chest and rib implant was constructed using human CT image data. A convex and concave mold for one sternum and eight ribs was designed based on the 3D model, using 45# steel as the mold material. Alignment holes were provided in the workpiece area of ​​the mold. The holes in the sternum portion had a diameter of Φ4.0mm and were arranged in a matrix. The holes in the rib portion had a diameter of Φ2.0mm and were arranged linearly with a hole spacing of 10mm.

[0046] 2) Preparation of the integrated rib and chest preform: 24k carbon fiber bundles are woven into continuous strip-shaped carbon fiber fabric to serve as the rib portion. Multiple layers of carbon fiber fabric are riveted to the surface of the four carbon fiber strip-shaped structures in the middle to form the sternum portion, thus forming the integrated rib and chest carbon fiber preform. The carbon fiber fabric includes components with an areal density of 40 g / m². 2 Carbon fiber nonwoven fabric and 200g / m 2The carbon fiber plain weave fabric was then used. The integrated carbon fiber preform for the sternal rib was placed in a mold, and a ceramic rod was inserted into the alignment hole on the surface of the mold to form a pre-drilled hole. The preform was then baked at 180°C for 3 hours to set the shape. After the baking and setting were completed, the ceramic rod and the convex and concave molds were removed. A 24k carbon fiber bundle was inserted and sutured into the large hole on the surface of the sternum (leaving one of the two adjacent pre-drilled holes for tissue adhesion) to obtain the integrated carbon fiber artificial bone preform for the sternal rib.

[0047] 3) The carbon fiber breast rib integrated preform is first processed using an impregnation-pyrolysis process to generate matrix carbon: The carbon fiber preform undergoes a matrix composite process including furan resin impregnation, curing, and pyrolysis. The impregnation pressure is 3.0 MPa, the impregnation time is 10 h; the curing temperature is 180℃, the curing time is 20 h; the pyrolysis temperature is 1000℃, and the time is 10 h; then it is placed in a vacuum furnace at 1300℃, and a mixture of tantalum pentachloride, propylene, and argon gas (flow ratio of 2:3:10) is introduced. After pyrolysis, the chemical vapor phase permeates into the carbon fiber preform. After 50 hours, a carbon fiber reinforced carbon and tantalum carbide composite preform is prepared.

[0048] 4) Finally, the surface of the above blank is processed to obtain carbon fiber integrated chest and rib artificial bone.

[0049] Structure and performance of the fabricated integrated chest lock component:

[0050] The sternum is 13mm thick and 30mm wide. It consists of a perforated multi-layered periodic structure, ABABCBA. Layer B (formed by carbon fiber plain weave fabric) has a carbon fiber volume content of 73%, a matrix volume content of 15%, a porosity of 12%, and a thickness of 1mm. Layer A (formed by carbon fiber nonwoven fabric) has a carbon fiber volume content of 24%, a matrix volume content of 22%, a porosity of 54%, and a thickness of 2mm. Layer C is a fiber braided strip. The layers are sewn together through perforations by carbon fiber bundles. The tensile strength is 96MPa, the tensile modulus is 12GPa, and the flexural strength is 110MPa.

[0051] The ribs are 4mm thick and 10mm wide, with mechanical properties including an axial tensile strength of 138MPa, a tensile modulus of 5GPa, and a bending strength of 65MPa.

[0052] The sternal portion has a hole diameter of Φ4.0mm, the rib portion has a hole diameter of Φ2.0mm, and the hole spacing is 10mm.

[0053] Example 2

[0054] 1) A 3D model of the integrated chest and rib implant was constructed using human CT image data. A convex and concave mold for one sternum and six ribs was designed based on the 3D model. The mold was made of carbon material. Alignment holes were provided in the workpiece area of ​​the mold. The holes in the sternum portion had a diameter of Φ3.5mm and were arranged in a matrix. The holes in the rib portion had a diameter of Φ1.8mm and were arranged linearly with a hole spacing of 15mm.

[0055] 2) Preparation of the integrated rib and chest preform: Three bundles of 6k carbon fibers are twisted into ropes and then woven into continuous carbon fiber strips to form the rib portion. Multiple layers of carbon fiber fabric are riveted to one end of the six-carbon fiber strip structure to form the sternum portion, thus forming the integrated rib and chest carbon fiber preform. The carbon fiber fabric includes components with an areal density of 50 g / m². 2 Carbon fiber nonwoven fabric and 200g / m 2 The carbon fiber plain weave fabric was then used. The integrated carbon fiber preform for the sternal rib was then placed into a mold, and a ceramic rod was inserted into the alignment hole on the surface of the mold to form a pre-drilled hole. The preform was then baked at 200°C for 2 hours to set the shape. After the baking and setting were completed, the ceramic rod and the convex and concave molds were removed. A large hole on the surface of the sternum (one of the two adjacent pre-drilled holes was left for tissue adhesion) was sutured with an 18k carbon fiber bundle to obtain the carbon fiber integrated artificial bone preform for the sternal rib.

[0056] 3) The carbon fiber breast rib integrated preform is placed in a vacuum furnace. First, methane and nitrogen are introduced at 1150℃, with a carbon source gas to dilution gas flow ratio of 2:3, and deposition is carried out for 60 hours. Then, at 1200℃, a mixture of tantalum pentachloride, propylene, and argon (flow ratio of 2:3:10) is introduced. After pyrolysis, the chemical vapor phase permeates into the carbon fiber preform. After 10 hours, a carbon fiber reinforced tantalum carbide composite preform is prepared.

[0057] 4) Finally, the surface of the above blank is processed to obtain carbon fiber integrated chest and rib artificial bone.

[0058] Structure and performance of the fabricated integrated chest lock component:

[0059] The sternum is 17mm thick and 36mm wide. It consists of a perforated multi-layered periodic structure, ABABBACBA. Layer B (formed by carbon fiber woven fabric) has a carbon fiber volume content of 62%, a matrix volume content of 18%, a porosity of 20%, and a thickness of 2.5mm. Layer A (formed by carbon fiber nonwoven fabric) has a carbon fiber volume content of 24%, a matrix volume content of 22%, a porosity of 54%, and a thickness of 1mm. The layers are sewn together by carbon fiber through-holes. The tensile strength is 109MPa, the tensile modulus is 18GPa, and the flexural strength is 123MPa.

[0060] The ribs are 3mm thick and 12mm wide, with mechanical properties including an axial tensile strength of 148MPa, a tensile modulus of 7GPa, and a bending strength of 63MPa.

[0061] The sternal portion has a hole diameter of Φ3.5mm, the rib portion has a hole diameter of Φ1.8mm, and the hole spacing is 15mm.

[0062] Comparative Example 1

[0063] Except for the sternal layer cycle being set to ABBBCBA, everything else was the same as in Example 2. The tensile strength of the sternum was 168 MPa, the tensile modulus was 23 GPa, and the flexural strength was 50 MPa. Compared to Example 2, the tensile properties in the parallel direction were improved, but its planar flexural properties deteriorated. Additionally, the internal porosity was approximately 10%, which is low and unfavorable for the transport of biological media and tissue attachment and ingrowth.

Claims

1. A method for preparing an integrated artificial bone for the chest and ribs made of carbon fiber composite material, characterized in that: Includes the following steps: 1) Construct a 3D model of an integrated thoracic and ribcage artificial bone using human CT image data, and design a convex and concave mold based on the 3D model; the convex and concave mold includes a convex mold and a concave mold, and through holes are distributed at the same position in the vertical direction on the surfaces of the convex mold and the concave mold, and the through holes are used to insert rods; 2) Carbon fiber bundles or carbon fiber ropes are woven into carbon fiber strips to serve as the artificial rib portion, and carbon fiber fabric is used as the artificial sternum portion; one end of the carbon fiber strip is embedded in the carbon fiber fabric or the carbon fiber strip passes through the carbon fiber fabric to obtain an integrated carbon fiber sternum and rib blank; The carbon fiber fabric is formed by superimposing carbon fiber nonwoven fabric and carbon fiber woven fabric, and the surface of the carbon fiber fabric is carbon fiber nonwoven fabric. 3) Place the carbon fiber chest and rib integrated blank in the convex and concave molds, insert rods into the through holes on the surfaces of the convex and concave molds, bake and shape it, then remove the rods and convex and concave molds, and insert carbon fiber bundles into the pre-reserved holes of some rods on the surface of the carbon fiber fabric for sewing, to obtain the carbon fiber chest and rib integrated artificial bone prefabricated body. 4) The carbon fiber integrated rib and chest artificial bone prefabrication body is processed by chemical vapor deposition and / or impregnation-pyrolysis to generate carbon matrix and / or silicon carbide matrix and / or tantalum carbide matrix, thus obtaining the prefabricated body.

2. The method for preparing a carbon fiber composite integrated rib-chest artificial bone according to claim 1, characterized in that: The carbon fiber bundles are 1k, 3k, 6k, 12k, 18k, 24k, 36k, 40k or 48k carbon fibers; The carbon fiber rope is formed by twisting multiple strands of carbon fiber in the same direction in a spiral. The carbon fiber strip is formed by two-dimensional weaving of multiple carbon fiber bundles or carbon fiber ropes.

3. A method for preparing a carbon fiber composite integrated rib-chest artificial bone according to claim 1 or 2, characterized in that: The carbon fiber strip has a width of 6~20mm and a thickness of 1.5~5.5mm.

4. The method for preparing a carbon fiber composite integrated rib-chest artificial bone according to claim 1, characterized in that: The areal density of the carbon fiber nonwoven fabric is 20~100 g / m². 2 ; The areal density of the carbon fiber woven fabric is 100~400 g / m². 2 .

5. A method for preparing a carbon fiber composite integrated rib-chest artificial bone according to claim 1 or 4, characterized in that: The carbon fiber nonwoven fabric and carbon fiber woven fabric in the carbon fiber fabric are stacked in the following manner: one layer of carbon fiber nonwoven fabric and one layer of carbon fiber woven fabric are stacked as a unit layer, and multiple unit layers are stacked to a total thickness of 8~20mm, and the contact between the unit layers is either same-side contact or opposite-side contact, and the carbon fiber nonwoven fabric in the surface unit layer is set on the outside.

6. The method for preparing a carbon fiber composite integrated rib-chest artificial bone according to claim 1, characterized in that: The surface of the carbon fiber breast and rib integrated blank is uniformly distributed with small holes, which are arranged in a matrix or quincunx pattern, with a hole spacing of 5~20mm.

7. The method for preparing a carbon fiber composite integrated rib-chest artificial bone according to claim 1, characterized in that: The baking and shaping conditions are: baking at 150~300℃ for 1~4 hours.

8. The method for preparing a carbon fiber composite integrated rib-chest artificial bone according to claim 1, characterized in that: The conditions for generating the carbon matrix by the chemical vapor deposition method are as follows: using a gaseous carbon source, deposition is carried out at a temperature of 850–1250 °C for 30–120 h. The conditions for generating the carbon matrix using the impregnation-pyrolysis method are as follows: using resin or asphalt as the carbon source, the carbon matrix is ​​formed through impregnation, curing, and pyrolysis; the impregnation pressure is 2.0–6.0 MPa, and the impregnation time is 5–15 h; the curing temperature is 180–250 °C, and the curing time is 10–50 h; the pyrolysis temperature of the resin is 900–1050 °C, the pyrolysis pressure is atmospheric pressure, and the pyrolysis time is 5–20 h; the pyrolysis temperature of the asphalt is 750–850 °C, the pyrolysis pressure is 50–200 MPa, and the pyrolysis time is 5–20 h. The conditions for generating silicon carbide matrix by chemical vapor deposition are as follows: using chlorosilane as silicon carbide source, deposition is carried out at a temperature of 1000-1400℃ for 40-100 hours. The conditions for generating the silicon carbide matrix by the impregnation-pyrolysis method are as follows: using organopolysilane as the silicon carbide source, the silicon carbide matrix is ​​formed through impregnation, curing, pyrolysis, and ceramization; the impregnation pressure is 2.0–6.0 MPa, and the impregnation time is 5–15 h; the curing temperature is 180–250 °C, and the curing time is 10–50 h; the pyrolysis temperature is 800–1200 °C, and the pyrolysis time is 5–20 h; the ceramization temperature is 1250–1650 °C, and the ceramization time is 2–10 h. The conditions for generating tantalum carbide matrix by chemical vapor deposition are as follows: using tantalum halide as tantalum source, employing gaseous carbon source, and depositing at a temperature of 1200–2000℃ for 40–100 h. The conditions for generating tantalum carbide matrix by the impregnation-pyrolysis method are as follows: using organic tantalum salt as the carbon tantalum source, tantalum carbide is formed through impregnation, curing, pyrolysis and ceramization; the impregnation pressure is 2.0-6.0 MPa, the impregnation time is 5-15 h; the curing temperature is 180-250℃, the curing time is 10-50 h; the pyrolysis temperature is 900-1200℃, the pyrolysis time is 5-20 h; and the ceramization temperature is 1300-1800℃, the ceramization time is 2-10 h.

9. A carbon fiber composite integrated rib-chest artificial bone, characterized in that: It is obtained by the preparation method described in any one of claims 1 to 8.

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