Magnetic force controlled disintegration and release drug-loaded capsule and process thereof

Abstract

The application discloses a kind of magnetic force control decomposition release drug-loaded capsules and its process, belong to medical drug technical field, including for drug and magnetic force bead are filled and are filled with injection molding integrated molding drug treatment capsule and for magnetic force attraction causes capsule disintegration magnetic force bead, the device patient can be by the way of taking capsule to take it, after taking is completed, capsule is moved to the required treatment position, the magnetic force of the shell wall in the capsule taken is attracted by personnel in the way of applying magnetic force outside, and if a plurality of magnetic force beads are attracted in different directions, a plurality of magnetic force beads will move in different directions, so that the capsule shell is broken, and then the capsule disintegrates, the drug in the capsule can be released after disintegration, to provide accurate treatment for patients, a plurality of magnetic force beads can be subsequently discharged outside with stool, and this treatment method greatly improves the treatment effect and accuracy, and makes significant progress for the rehabilitation of patients.

Description

Technical Field

[0001] This invention relates to the field of medical pharmaceutical technology, and in particular to a magnetically controlled decomposition and release drug-loaded capsule and its manufacturing process. Background Technology

[0002] Capsules are a common oral medication carrier, typically made of rigid or flexible materials and filled with drug powder or other substances. Their basic information is described below:

[0003] Appearance: Capsules are typically round or oval, with a diameter between 3 and 10 mm and a length between 5 and 25 mm. They can be made of plastic, rubber, animal-based materials (such as gelatin), or plant-based materials.

[0004] Contents: The drug powder contained in the capsule can be in a solid or dissolved state, such as tablets or suspensions. The particle size of the drug contents is generally between 1 micrometer and 10 micrometers to ensure rapid dispersion and release of the drug.

[0005] Manufacturing process: Capsules can be prepared by extrusion, compression, or injection molding. Among these methods, capsules produced by injection molding have higher quality and stability.

[0006] Currently, in clinical treatment using capsules, some medications fail to disintegrate at the intended treatment site after ingestion, hindering precise treatment. For example, in patients with gastrointestinal bleeding, such as those undergoing small intestinal bleeding requiring enteroscopy, while lesions can be visually detected, the procedure requires general anesthesia and is relatively complex. Existing capsules cannot accurately reach the bleeding site after ingestion, failing to achieve precise local drug release for hemostasis. Similarly, for local drug treatment of diseases like ulcerative colitis and the release of intestinal flora, current technologies cannot deliver medication precisely. Therefore, those skilled in the art have developed a magnetically controlled drug-loaded capsule and its manufacturing process, enabling more precise drug release within the digestive tract for targeted treatment, thereby simplifying treatment methods and procedures. Summary of the Invention

[0007] This invention provides a magnetically controlled decomposition and release drug-loaded capsule and its process to solve the aforementioned technical problems.

[0008] The present invention adopts the following technical solution: it includes an integrally molded drug therapeutic capsule for containing drugs and magnetic beads, and magnetic beads for magnetic attraction to cause the capsule shell to disintegrate. The magnetic beads are provided in a plurality of them. The capsule includes an upper shell and a lower shell. The lower shell has a drug storage chamber in the middle and can hold the required therapeutic drugs. The upper shell is fitted onto the outer surface of the upper end of the lower shell and sealed by pressing. The thickness of the capsule shell is thicker than that of a traditional capsule shell. The plurality of magnetic beads are arranged in the lower shell wall of the capsule. The arrangement of the plurality of magnetic beads in the lower shell wall of the capsule can be distributed in various forms.

[0009] Patients can take the medication via capsule. After taking the capsule, a metal detector monitors its movement in real time. Once the capsule reaches the desired treatment location, a person applies magnetic force from both the front and back of the capsule to attract magnetic beads inside the capsule shell. When attracted by forces in different directions, the magnetic beads move in different directions, causing the capsule shell to disintegrate. After disintegration, the medication inside the capsule is released, providing accurate treatment to the patient. The magnetic beads are subsequently excreted with feces. This treatment method greatly improves the effectiveness and accuracy of treatment, making significant progress in the patient's recovery.

[0010] Furthermore, the capsule and the several magnetic beads inside its wall are integrally molded by injection molding.

[0011] Furthermore, the size of several of the magnetic beads is 1-2 mm.

[0012] Furthermore, the capsule shell is made of enteric coating materials such as cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, polyvinyl acetate phthalate, or plant-based capsules.

[0013] A magnetically controlled decomposition and release drug-loaded capsule and its process, comprising the following steps:

[0014] S1: After the capsule is formed in one piece, the therapeutic drug is located inside the capsule, while several magnetic beads are located in the lower shell wall of the capsule. After the patient takes the capsule, the position of the capsule can be detected by X-ray and metal detector under normal conditions. In the absence of X-ray detection, such as in the wild, earthquake or war, the position of the capsule can be detected by metal detector.

[0015] S2: After the patient takes the capsule and it moves to the desired treatment position, a person applies magnetic force from both the front and back sides of the capsule to attract the magnetic beads inside the capsule shell. When several magnetic beads are attracted by forces in different directions, they will move in different directions, causing the capsule shell to disintegrate and rupture. After disintegration, the medicine inside the capsule is released, and finally, several magnetic beads can be excreted with feces.

[0016] The above-described at least one technical solution adopted in the embodiments of the present invention can achieve the following beneficial effects:

[0017] This device is administered by the patient via capsule. After ingestion, a metal detector continuously monitors the capsule's movement. Once the capsule reaches the desired treatment location, a person applies magnetic force from both the front and back of the capsule to attract magnetic beads inside the capsule shell. When attracted by forces in different directions, the magnetic beads move in those directions, causing the capsule shell to rupture and disintegrate. The medication inside is then released precisely to the desired treatment site, achieving accurate local drug delivery and providing precise treatment. The magnetic beads are subsequently excreted with feces. This treatment method significantly improves the effectiveness and accuracy of treatment, making a significant advancement in patient recovery while simplifying the treatment process. Attached Figure Description

[0018] The accompanying drawings, which are included to provide a further understanding of the invention and form part of this invention, illustrate exemplary embodiments of the invention and are used to explain the invention, but do not constitute an undue limitation of the invention. In the drawings:

[0019] Figure 1 This is a schematic diagram of the capsule being cut open and disassembled according to the present invention;

[0020] Figure 2 This is a three-dimensional structural diagram of the present invention;

[0021] Figure 3 This is a schematic diagram of the storage state of the magnetic beads inside the capsule wall in this invention.

[0022] Figure Labels

[0023] Capsule 1, upper shell 11, lower shell 12, card slot 121, magnetic bead 2. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below in conjunction with specific embodiments and corresponding drawings. Obviously, the described embodiments are only a part of the embodiments of this invention, and not all of them. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0025] The technical solutions provided by the various embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0026] This invention provides a magnetically controlled decomposition and release drug-loaded capsule and its process, comprising an injection-molded one-piece drug therapeutic capsule 1 for containing drugs and magnetic beads 2, and magnetic beads 2 for magnetic attraction causing the capsule 1 shell to disintegrate. The magnetic beads 2 are provided in plurality. The capsule 1 includes an upper shell 11 and a lower shell 12. The lower shell 12 has a drug storage chamber in its central part, which can hold the desired therapeutic drug. The upper shell 11 is fitted onto the outer surface of the upper end of the lower shell 12 and sealed by pressing. The thickness of the capsule 1 shell is greater than that of a conventional capsule 1 shell. The plurality of magnetic beads 2 are arranged within the wall of the lower shell 12 in the capsule 1, and the arrangement of the plurality of magnetic beads 2 within the wall of the lower shell 12 in the capsule 1 can have various forms.

[0027] This device is administered by the patient via capsule 1. After administration, a metal detector continuously monitors the capsule's position. Once the capsule reaches the desired treatment location, a person applies magnetic force from both the front and back of the capsule to attract several magnetic beads 2 within the capsule's shell. These beads, attracted by forces in different directions, move in opposite directions, causing the capsule shell to rupture and disintegrate. The medication inside the capsule is then released and precisely reaches the desired treatment site, achieving accurate local drug delivery. The magnetic beads are subsequently excreted with feces, providing precise treatment for the patient. This treatment method significantly improves the effectiveness and accuracy of the treatment, making a substantial advancement in patient recovery while simplifying the treatment process.

[0028] This device moves the desired capsule to the desired location, causing it to disintegrate and achieve a therapeutic effect. It is more convenient, more efficient, lower in cost, easier to use, and has no side effects or adverse reactions.

[0029] After a patient takes the required treatment capsule, the magnetic beads can be located using X-rays or a metal detector to locate their corresponding positions on the body surface, thus enabling accurate treatment through different detection methods.

[0030] This device's drug-loaded capsules can precisely reach the desired treatment site, achieving accurate local drug release. For digestive tract diseases (such as bleeding, ulcerative colitis, etc.), it can achieve better treatment results. The treatment method greatly improves the treatment effect and accuracy, making significant progress for patient recovery.

[0031] Preferably, the capsule 1 and the plurality of magnetic beads 2 inside its wall are integrally formed by injection molding;

[0032] Patients can directly take capsule 1. During the injection molding process of capsule 1, simply place the magnetic bead 2 into the corresponding mold and ensure that it is located inside the shell of capsule 1 after molding, so that it can be used directly after injection molding.

[0033] Preferably, the magnetic beads 2 are 1-2 mm in size, and the shell of the capsule 1 is made of enteric coating materials such as cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, polyvinyl acetate phthalate, or plant-based capsules.

[0034] Enteric-coated capsules are a drug delivery system that controls the release time of drugs. They are commonly used in oral formulations and allow drugs to be gradually dissolved in the intestines and released into the bloodstream, thereby improving efficacy and reducing side effects.

[0035] Plant-based capsules are biodegradable alternatives made from natural plant fibers and are widely used in oral formulations. Compared to traditional hard or soft capsules, plant-based capsules have the following advantages:

[0036] 1. Good biodegradability; plant capsules can be broken down into water and carbon dioxide in the body, with minimal impact on the environment.

[0037] 2. High safety: Since the main component of plant capsules is natural plant fiber, they have no toxic effects on the human body.

[0038] 3. Good taste; the plant-based capsules have a softer texture, making them more comfortable to swallow;

[0039] 4. Aesthetically pleasing appearance: Plant-based capsules offer a variety of colors and patterns, allowing for greater personalization. Therefore, both enteric-coated and plant-based capsules can improve the stability and bioavailability of oral medications, enhancing the patient's treatment experience.

[0040] A magnetically controlled decomposition and release drug-loaded capsule and its process, comprising the following steps:

[0041] S1: After capsule 1 is injection molded in one piece, the therapeutic drug is located inside capsule 1, while several magnetic beads 2 are located inside the lower shell 12 of capsule 1. After the patient takes capsule 1, the position of the capsule after taking it can be detected by X-ray and metal detector under normal conditions. Under conditions where X-ray detection is not available, such as in the wild, earthquake or war, the position of the capsule after taking it can be detected by metal detector.

[0042] S2: After the patient takes the capsule and it moves to the desired treatment position, a person applies magnetic force from both the front and back sides of the capsule to attract several magnetic beads 2 inside the capsule shell. When the magnetic beads 2 are attracted by forces in different directions, they will move and collide in different directions, causing the capsule shell to disintegrate and break. After disintegration, the medicine inside the capsule is released, and finally the magnetic beads 2 can be excreted with feces.

[0043] The above description is merely an embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principle of the present invention should be included within the scope of the claims of the present invention.

Claims

1. A magnetically controlled decomposition and release drug-loaded capsule, characterized in that, The capsule includes an injection-molded one-piece drug therapy capsule (1) for containing drugs and magnetic beads (2) and magnetic beads (2) for magnetic attraction to cause the capsule (1) shell to disintegrate. The magnetic beads (2) are provided in a plurality of them. The capsule (1) includes an upper shell (11) and a lower shell (12). The lower shell (12) has a drug storage chamber in the middle and holds the drugs required for treatment. The upper shell (11) is fitted onto the outer surface of the upper end of the lower shell (12) and sealed by pressing. The plurality of magnetic beads (2) are arranged inside the lower shell (12) wall in the capsule (1). The magnetic beads (2) are 1-2 mm in size. The method of using the drug-loaded capsule includes the following steps: S1: After the capsule (1) is injection molded in one piece, the therapeutic drug is located inside the capsule (1), and several magnetic beads (2) are located inside the lower shell (12) wall of the capsule (1). After the patient takes the capsule (1), the position of the capsule after taking it is detected by X-ray and metal detector. S2: After the patient takes the capsule, and after the capsule moves to the required treatment position, the personnel use magnetic force to attract several magnetic beads (2) inside the shell wall of the capsule (1) taken by the patient from the outside. When the several magnetic beads (2) are attracted by forces in different directions, the several magnetic beads (2) will move in different directions, which will cause the shell of the capsule (1) to disintegrate and break. After disintegration, the drug inside the capsule (1) is released, and finally the several magnetic beads (2) are excreted with feces.

2. The magnetically controlled decomposition and release drug-loaded capsule according to claim 1, characterized in that, The capsule (1) and several magnetic beads (2) inside its wall are integrally molded by injection molding.

3. The magnetically controlled decomposition and release drug-loaded capsule according to claim 1, characterized in that, The capsule (1) has an enteric-coated shell.

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