A traditional Chinese medicine composition with the function of maintaining healthy blood sugar level and a granular type tea bag

Abstract

The application provides a traditional Chinese medicine formula with the function of maintaining blood sugar health level and a granular type tea bag, and belongs to the technical field of health food. The traditional Chinese medicine formula comprises the following components in mass fraction: 3-7 parts of rhizoma polygonati, 2-6 parts of dioscorea, 2-6 parts of medlar, 1-4 parts of licorice, 1-4 parts of poria cocos, 1-5 parts of dogwood, and 1-5 parts of sargassum fusiforme. The formula can effectively maintain blood sugar balance after being prepared into a granular type tea bag.

Description

Technical Field

[0001] This invention belongs to the field of health food technology, and in particular relates to a traditional Chinese medicine formula that has the function of maintaining healthy blood sugar levels and a granular tea bag. Background Technology

[0002] Abnormal blood sugar levels can pose a threat to health. For sub-healthy individuals with abnormal glucose metabolism, early intervention and timely regulation of blood sugar levels can help prevent more serious consequences.

[0003] my country has a long-standing tradition of "preventing disease before it occurs and preventing its progression once it has occurred." With the development of medicine and diet sharing a common origin, many foods can be used both medicinally and as food to nourish the body and mind, establishing the traditional Chinese medicine concepts of "dual nature of medicine and food" and "medicine and food sharing the same origin." Using medicinal herbs that are both food and medicine to regulate blood sugar levels is characterized by high safety, stable properties, and mild effects. In recent years, with in-depth research, the hypoglycemic effects of these herbs have attracted considerable attention from researchers. The development of functional health foods using these herbs as natural raw materials aligns with the health needs of the times. Against this backdrop, granular tea bags offer advantages such as high safety and a wide range of applicable populations, possessing significant economic and social value.

[0004] Compared to the use of single herbs, traditional Chinese medicine (TCM) prescriptions emphasize holistic treatment, possessing advantages such as hierarchical structure, synergistic effects, and mutual restraint. According to ancient TCM texts, the "Zuogui Yin" prescription recorded in the *Jingyue Quanshu* has a certain effect on regulating blood sugar levels. However, the original prescription contains Rehmannia glutinosa, a non-food and medicinal herb. Improper use could damage the kidneys and other organs, making it unsafe. Further improvements are needed to obtain a safer and more effective prescription. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a traditional Chinese medicine formula with the function of maintaining healthy blood sugar levels and a granular tea bag.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0007] This invention provides a traditional Chinese medicine formula for maintaining healthy blood sugar levels, comprising the following components by mass fraction:

[0008] Polygonatum 3-7 parts, Dioscorea opposita 2-6 parts, Lycium barbarum 2-6 parts, Glycyrrhiza uralensis 1-4 parts, Poria cocos 1-4 parts, Cornus officinalis 1-5 parts, Sargassum fusiforme 1-5 parts.

[0009] Preferably, the component comprises the following mass fractions:

[0010] Polygonatum 4-6 parts, Dioscorea opposita 3-5 parts, Lycium barbarum 3-5 parts, Glycyrrhiza uralensis 1.5-3 parts, Poria cocos 1.5-3 parts, Cornus officinalis 2-4 parts, Sargassum fusiforme 2-4 parts.

[0011] Preferably, the component comprises the following mass fractions:

[0012] 5 parts Polygonatum, 4 parts Dioscorea opposita, 4 parts Lycium barbarum, 2 parts Glycyrrhiza uralensis, 2 parts Poria cocos, 3 parts Cornus officinalis, and 3 parts Sargassum fusiforme.

[0013] This invention provides the application of the aforementioned traditional Chinese medicine formula in the preparation of drugs that maintain healthy blood glucose levels.

[0014] This invention provides granular tea bags containing the aforementioned traditional Chinese medicine formula, and the preparation method of the granular tea bags is as follows:

[0015] (1) Take 3-7 parts of Polygonatum sibiricum, 1-5 parts of Cornus officinalis and 2-6 parts of Lycium barbarum, crush them and mix them with water. After soaking, heat and reflux to extract, filter, precipitate with alcohol, and collect the precipitate to obtain the first extract.

[0016] (2) Take 2-6 parts of yam, 1-4 parts of licorice, and 1-4 parts of poria cocos. Stir-fry over low heat for 3-7 minutes, then grind and sieve to obtain coarse powder of the medicinal materials.

[0017] (3) Take 1-5 parts of Sargassum fusiforme, crush it, mix it with water, soak it, extract it with microwave, collect the extract, concentrate it, precipitate it with alcohol, collect the precipitate to obtain the second extract.

[0018] (4) Mix the first extract, crude powder and second extract, and add 0.05 to 0.15 parts of hydroxypropyl methylcellulose aqueous solution with a concentration of 6 to 10%, 1 to 3 parts of lactose and 0.5 to 1.5 parts of mannitol. Mix, granulate and dry to obtain granular tea bags.

[0019] Preferably, in step (1), the mass ratio of the pulverized Chinese medicine to water is 1:8 to 12, and the soaking time is 40 to 80 minutes.

[0020] The reflux extraction temperature is 80-100℃, the reflux extraction is performed 1-5 times, and the reflux extraction time is 60-120 min each time;

[0021] The alcohol precipitation is carried out using 80-100% (v / v) ethanol, and the volume of the ethanol is 3-5 times the volume of the extract.

[0022] The alcohol precipitation temperature is 2-6°C, and the alcohol precipitation time is 20-30 hours.

[0023] The precipitate is collected by centrifugation at a speed of 5000–9000 r / min. After centrifugation, the precipitate is washed with ethanol 1–5 times. The precipitate after washing is the first extract.

[0024] Preferably, the sieve mesh size in step (2) is 40 to 80 mesh.

[0025] Preferably, the mass of the water in step (3) is 8 to 12 times the mass of the Sargassum fusiforme, and the soaking time is 40 to 80 minutes;

[0026] The microwave treatment is performed at 80–120°C, 450–750W, for 8–12 minutes.

[0027] The ethanol concentration during the alcohol precipitation process is 80-100%;

[0028] The concentration is achieved by reducing the pressure and concentrating the volume to 1 / 3 of its original volume.

[0029] Preferably, the ratio of lactose to mannitol in the excipients added in step (4) is 1.5 to 2.5:1.

[0030] Preferably, the granules are packaged using non-woven fabric material.

[0031] Compared with the prior art, the present invention has the following beneficial effects:

[0032] This invention provides a traditional Chinese medicine formula and a granular tea bag for maintaining healthy blood sugar levels. It optimizes the formula "Zuogui Yin" recorded in the *Jingyue Quanshu* by replacing Rehmannia glutinosa with Polygonatum sibiricum, ensuring all ingredients are food-grade and medicinal, resulting in a milder effect. Polygonatum sibiricum nourishes Yin and tonifies the kidneys, replenishing essence and marrow, serving as the principal ingredient. Dioscorea opposita tonifies spleen Yin and strengthens essence, while Cornus officinalis tonifies the liver and kidneys and astringes essence, serving as the assistant ingredients. Lycium barbarum and Poria cocos are added to aid the function of Dioscorea opposita, and Glycyrrhiza uralensis harmonizes the other ingredients. The entire formula nourishes kidney Yin, regulates the liver and spleen, and promotes recovery from various symptoms. Sargassum fusiforme lowers blood pressure and lipids, clears heat and detoxifies, and helps repair pancreatic cells. The above-mentioned medications, used in combination, primarily aim to control blood sugar while secondarily focusing on repair. They replenish qi and strengthen the spleen, nourish yin and tonify the kidneys, significantly and rapidly lowering blood sugar and regulating and maintaining blood sugar balance in diabetic patients. They also improve the body's immune regulation, strengthen the repair and protection of kidney function in the middle and late stages of diabetes, and better prevent and control the occurrence and development of diabetes and its complications. This invention offers significant and lasting efficacy, rapid onset of action, and is safe and reliable, effectively controlling and maintaining blood sugar balance and promoting bodily repair. Detailed Implementation

[0033] This invention provides a traditional Chinese medicine formula for maintaining healthy blood sugar levels, comprising the following components by mass fraction:

[0034] 3-7 parts of Polygonatum, preferably 4-6 parts, and more preferably 5 parts;

[0035] 2 to 6 parts of yam, preferably 3 to 5 parts, and more preferably 4 parts;

[0036] 2 to 6 parts of wolfberry, preferably 3 to 5 parts, and more preferably 4 parts;

[0037] Licorice 1 to 4 parts, preferably 1.5 to 3 parts, more preferably 2 parts;

[0038] Poria cocos 1 to 4 parts, preferably 1.5 to 3 parts, and even more preferably 2 parts;

[0039] 1 to 5 parts of Cornus officinalis, preferably 2 to 4 parts, and more preferably 3 parts;

[0040] The amount of Sargassum fusiforme is 1 to 5 parts, preferably 2 to 4 parts, and even more preferably 3 parts.

[0041] The present invention also provides the application of the aforementioned traditional Chinese medicine formula in the preparation of drugs that maintain healthy blood glucose levels.

[0042] This invention also provides granular tea bags containing a traditional Chinese medicine formula, and the preparation method of the granular tea bags is as follows:

[0043] (1) Take 3-7 parts of Polygonatum sibiricum, 1-5 parts of Cornus officinalis and 2-6 parts of Lycium barbarum, crush them and mix them with water. After soaking, heat and reflux to extract, filter, precipitate with alcohol, and collect the precipitate to obtain the first extract.

[0044] (2) Take 2-6 parts of yam, 1-4 parts of licorice, and 1-4 parts of poria cocos. Stir-fry over low heat for 3-7 minutes, then grind and sieve to obtain coarse powder of the medicinal materials.

[0045] (3) Take 1-5 parts of Sargassum fusiforme, crush it, mix it with water, soak it, extract it with microwave, collect the extract, concentrate it, precipitate it with alcohol, collect the precipitate to obtain the second extract.

[0046] (4) Mix the first extract, crude powder and second extract, and add 0.05 to 0.15 parts of hydroxypropyl methylcellulose aqueous solution with a concentration of 6 to 10%, 1 to 3 parts of lactose and 0.5 to 1.5 parts of mannitol. Mix, granulate and dry to obtain granular tea bags.

[0047] In this invention, 3-7 parts of Polygonatum sibiricum, 1-5 parts of Cornus officinalis and 2-6 parts of Lycium barbarum are pulverized and mixed with water. After soaking, the mixture is heated and refluxed for extraction, filtered, and precipitated with alcohol. The precipitate is collected to obtain the first extract.

[0048] The preferred mass ratio of the pulverized Chinese herbal medicine to water is 1:8-12, more preferably 1:9-11, and even more preferably 1:10; the preferred soaking time is 40-80 min, more preferably 50-70 min, and even more preferably 60 min; the preferred temperature for the reflux extraction is 80-100℃, more preferably 85-95℃, and even more preferably 90℃; the preferred number of reflux extractions is 1-5 times, more preferably 2-4 times, and even more preferably 3 times; the preferred time for each extraction is 60-120 min, more preferably 70-100 min, and even more preferably 90 min; the alcohol precipitation is performed using 80-100% (v / v) ethanol, with the ethanol concentration more preferably 85-120%. The ethanol content is 95%, more preferably 90%; the volume of the ethanol is preferably 3 to 5 times the volume of the extract, more preferably 3.5 to 4.5 times, and even more preferably 4 times; the temperature of the alcohol precipitation is 2 to 6°C, more preferably 3 to 5°C, and even more preferably 4°C; the alcohol precipitation time is preferably 20 to 30 hours, more preferably 22 to 28 hours, and even more preferably 24 hours; the precipitate is preferably collected by centrifugation; the centrifugation speed is preferably 5000 to 9000 r / min, more preferably 6000 to 8000 r / min, and even more preferably 7000 r / min; after centrifugation, the precipitate is washed with ethanol, preferably 1 to 5 times, more preferably 2 to 4 times, and even more preferably 3 times.

[0049] In this invention, 2-6 parts of yam, 1-4 parts of licorice, and 1-4 parts of poria cocos are stir-fried over low heat for 3-7 minutes, then pulverized and sieved to obtain coarse powder of the medicinal materials. The stir-frying time is preferably 3-7 minutes, more preferably 4-6 minutes, and even more preferably 5 minutes; the sieve mesh size is preferably 40-80 mesh, more preferably 50-70 mesh, and even more preferably 60 mesh.

[0050] In this invention, 1 to 5 parts of Sargassum fusiforme are crushed, mixed with water and soaked, extracted by microwave, the extract is collected, concentrated and precipitated with alcohol, and the precipitate is collected to obtain the second extract.

[0051] The water is preferably 8 to 12 times the mass of Sargassum fusiforme, more preferably 9 to 11 times, and even more preferably 10 times; the soaking time is preferably 40 to 80 minutes, more preferably 50 to 70 minutes, and even more preferably 60 minutes; the microwave treatment temperature is preferably 80 to 120°C, more preferably 90 to 110°C, and even more preferably 100°C; the treatment power is preferably 450 to 750W, more preferably 500 to 700W, and even more preferably 600W; the treatment time is preferably 8 to 12 minutes, more preferably 9 to 11 minutes, and even more preferably 10 minutes; the concentration is preferably reduced pressure to 1 / 3 of the original volume; the ethanol concentration during alcohol precipitation is preferably 80 to 100%, more preferably 85 to 95%, and even more preferably 90%; the alcohol precipitation temperature is 2 to 6°C, more preferably 3 to 5°C, and even more preferably 4°C; the alcohol precipitation time is preferably 20 to 30 hours, more preferably 22 to 28 hours, and even more preferably 24 hours.

[0052] In this invention, the first extract, crude powder, and second extract are mixed, and preferably 0.05-0.15 parts of an aqueous solution of hydroxymethyl cellulose are added, more preferably 0.07-0.12 parts, and even more preferably 0.10 parts; the concentration of hydroxymethyl cellulose is preferably 6-10%, more preferably 7-9%, and even more preferably 8%, serving as a binder to facilitate granulation; the amount of lactose added is preferably 1-3 parts, more preferably 1.5-2.5 parts, and even more preferably 2 parts; the amount of mannitol added is preferably 0.5-1.5 parts, more preferably 0.7-1.2 parts, and even more preferably 1.0 part; preferably, a swing granulator is used for granulation through a screen, and the drying method is preferably to place the wet granules in a hot air drying oven for drying, the drying temperature is preferably 40-80°C, more preferably 50-70°C, and even more preferably 60°C, until the moisture content of the granules is 1-3%, more preferably 1.5-2.5%, and even more preferably 2%, then removed and cooled to obtain the final product. The ratio of lactose to mannitol is preferably 1.5 to 2.5:1, more preferably 1.7 to 2.3:1, and even more preferably 2:1.

[0053] In this invention, non-woven fabric material is preferably used to package the granules.

[0054] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0055] Example 1

[0056] (1) Take 60g of Polygonatum sibiricum, 10g of Cornus officinalis and 60g of Lycium barbarum, crush them and mix them with 8 times the mass of water. After soaking for 60min, heat to 90℃ and reflux for extraction. Extract 4 times, 90min each time. Filter out the residue and collect the extract. Then precipitate with 3 times the volume of 80% (v / v) ethanol at 4℃ for 24h. Collect the precipitate to obtain the first extract.

[0057] (2) Take 20g of yam, 40g of licorice and 10g of poria, stir-fry over low heat for 5 minutes, then pulverize and pass through an 80-mesh sieve to obtain coarse powder of medicinal materials.

[0058] (3) Take 30g of Sargassum fusiforme, crush it and mix it with 10 times the weight of water, soak it for 60min, extract it with microwave assisted extraction at 100℃ and 600W for 10min, collect the extract, concentrate it to 1 / 3 of the original volume, and then precipitate it with 3 times the volume of 80% (v / v) ethanol at 4℃ for 24h, collect the precipitate to obtain the second extract.

[0059] (4) Mix the first extract, crude powder and second extract, and add 1.5g of 6% hydroxypropyl methylcellulose aqueous solution, 30g of lactose and 15g of mannitol. After mixing, granulate through a sieve, and then put the wet granules into a hot air drying oven to dry. The drying temperature is preferably 60℃. Dry until the moisture content of the granules is 2%. Take them out, let them cool, divide them into 10 portions, and pack them into bags to obtain 10 portions of granular tea bags.

[0060] Example 2

[0061] (1) Take 70g of Polygonatum sibiricum, 30g of Cornus officinalis and 60g of Lycium barbarum, crush them and mix them with 12 times the volume of water. After soaking for 40 minutes, heat to 100℃ and reflux to extract. Extract 3 times, 120 minutes each time. Collect the extract and then precipitate it with 5 times the volume of 90% (v / v) ethanol at 4℃ for 20 hours. Collect the precipitate to obtain the first extract.

[0062] (2) Take 60g of yam, 30g of licorice and 40g of poria, stir-fry over low heat for 3 minutes, then grind into coarse powder through a 60-mesh sieve.

[0063] (3) Take 20g of Sargassum fusiforme, crush it and mix it with 12 times the mass of water, soak it for 40min, extract it with microwave assisted extraction at 110℃ and 600W for 12min, collect the extract, concentrate it to 1 / 3 of the original volume, and then precipitate it with 4 times the volume of 80% (v / v) ethanol at 3℃ for 24h, collect the precipitate to obtain the second extract.

[0064] (4) Mix the first extract, crude powder and second extract, and add 0.5g of 10% hydroxypropyl methylcellulose aqueous solution, 20g of lactose and 10g of mannitol. After mixing, granulate through a sieve, and then put the wet granules into a hot air drying oven to dry. The drying temperature is preferably 40℃. Dry until the moisture content of the granules is 1%. Take them out, let them cool, divide them into 10 portions, and pack them into bags to obtain 10 portions of granular tea bags.

[0065] Example 3

[0066] (1) Take 40g of Polygonatum sibiricum, 50g of Cornus officinalis and 30g of Lycium barbarum, crush them and mix them with 12 times the volume of water. After soaking for 80 minutes, heat to 80℃ and reflux for extraction. Extract 5 times, 60 minutes each time. Collect the extract and then precipitate it with 5 times the volume of 80% (v / v) ethanol at 2℃ for 30 hours. Collect the precipitate to obtain the first extract.

[0067] (2) Take 30g of yam, 30g of licorice and 20g of poria, stir-fry over low heat for 7 minutes, then grind through a 60-mesh sieve to obtain coarse powder of medicinal materials.

[0068] (3) Take 50g of Sargassum fusiforme, crush it and mix it with 12 times the mass of water, soak it for 80min, extract it with microwave assisted extraction at 120℃ and 450W for 8min, collect the extract, concentrate it to 1 / 3 of the original volume, and then precipitate it with 3 times the volume of 80% (v / v) ethanol at 4℃ for 28h, collect the precipitate to obtain the second extract.

[0069] (4) Mix the first extract, crude powder and second extract, and add 0.5g of 10% hydroxypropyl methylcellulose aqueous solution, 10g of lactose and 10g of mannitol. After mixing, granulate through a sieve, and then put the wet granules into a hot air drying oven to dry. The drying temperature is preferably 50℃. Dry until the moisture content of the granules is 3%. Take them out, let them cool, divide them into 10 portions, and bag them to obtain 10 portions of granular tea bags.

[0070] Comparative Example 1 (Zuogui Yin)

[0071] Take 9g of Rehmannia glutinosa, 6g of Dioscorea opposita, 6g of Lycium barbarum, 3g of Glycyrrhiza uralensis (processed), 4.5g of Poria cocos, and 3g of Cornus officinalis. Decoction is prepared by a pharmacy to obtain 250ml of medicinal liquid.

[0072] Comparative Example 2

[0073] (1) Take 90g of Polygonatum sibiricum, 10g of Cornus officinalis and 60g of Lycium barbarum, crush them and mix them with 8 times the volume of water. After soaking for 60 minutes, heat to 90℃ and reflux to extract. Extract 4 times, 90 minutes each time. Filter out the residue and collect the extract. Then precipitate with 3 times the volume of 80% (v / v) ethanol at 4℃ for 24 hours. Collect the precipitate to obtain the extract.

[0074] (2) Take 20g of yam, 40g of licorice and 10g of poria, stir-fry over low heat for 5 minutes, then pulverize and pass through an 80-mesh sieve to obtain coarse powder of medicinal materials.

[0075] (3) Mix the extract and coarse powder, and add 1.5g of 6% hydroxypropyl methylcellulose aqueous solution, 30g of lactose and 15g of mannitol. After mixing, granulate through a sieve, and then put the wet granules into a hot air drying oven to dry. The drying temperature is preferably 60℃. Dry until the moisture content of the granules is 2%. Take them out, let them cool, divide them into 10 portions, and pack them into bags to obtain 10 portions of granular tea bags.

[0076] Comparative Example 3

[0077] (1) Take 10g of Cornus officinalis and 60g of Lycium barbarum, crush them and mix them with 8 times the volume of water. After soaking for 60 minutes, heat to 90℃ and reflux to extract. Extract 4 times, 90 minutes each time. Filter out the residue and collect the extract. Then precipitate with 3 times the volume of 80% (v / v) ethanol at 4℃ for 24 hours. Collect the precipitate to obtain the first extract.

[0078] (2) Take 20g of yam, 40g of licorice and 10g of poria, stir-fry over low heat for 5 minutes, then pulverize and pass through an 80-mesh sieve to obtain coarse powder of medicinal materials.

[0079] (3) Take 90g of Sargassum fusiforme, crush it and mix it with 10 times the mass of water, soak it for 60min, extract it with microwave assisted extraction at 100℃ and 600W for 10min, collect the extract, concentrate it to 1 / 3 of the original volume, and then precipitate it with 3 times the volume of 80% (v / v) ethanol at 4℃ for 24h, collect the precipitate to obtain the second extract.

[0080] (4) Mix the first extract, crude powder and second extract, and add 1.5g of 6% hydroxypropyl methylcellulose aqueous solution, 30g of lactose and 15g of mannitol. After mixing, granulate through a sieve, and then put the wet granules into a hot air drying oven to dry. The drying temperature is preferably 50℃. Dry until the moisture content of the granules is 3%. Take them out, let them cool, divide them into 10 portions, and pack them into bags to obtain 10 portions of granular tea bags.

[0081] Pharmacodynamic studies:

[0082] 1. Experimental Materials

[0083] 1.1 Animals

[0084] Seventy BKS-DB clean-grade mice with genotype mut / mut, weighing 20±2g, and ten BKS clean-grade mice with genotype wt / wt served as a blank control group. All mice were obtained from the laboratory of Ningxia Medical University.

[0085] 1.2 Test Samples and Reagents

[0086] Examples 1-3, Comparative Examples 1-3, Model Group, and Blank Group of the present invention.

[0087] 2. Experimental grouping and administration method

[0088] One portion of the granular tea bags prepared in Examples 1-3 and Comparative Examples 2-3 was brewed to prepare 250 mL of medicinal solution. 0.87 mL of each of the medicinal solutions from Examples 1-3 and Comparative Examples 1-3 was taken and concentrated to 0.2 mL. Mice were randomly divided into a model group, Example 1-3, and Comparative Examples 1-3 groups based on their fasting blood glucose levels. The mice in the corresponding groups were administered the drug once daily in the morning. The model group and the control group were given 0.2 mL of water. During the experiment, rats in all groups had free access to food and water.

[0089] 3 Experimental Methods

[0090] Blood glucose levels in mice were measured on the first day, 70th day, and 90th day after gavage administration. Tail blood was collected on the 90th day after gavage administration to measure liver glycogen levels in mice. The experimental results are shown in Table 1-2.

[0091] 3.1 Experimental Results

[0092] Table 1. Effects of the pharmaceutical composition of the present invention on liver glycogen in transgenic mice (n=10, ...). )

[0093] Blank group 33.32±10.75 Model group 11.44±3.62 Example 1 28.53±4.62 Example 2 25.67±6.46 Example 3 26.03±8.12 Comparative Example 1 24.06±7.28 Comparative Example 2 20.22±9.23 Comparative Example 3 19.01±8.76

[0094] Table 2. Effects of the pharmaceutical composition of the present invention on blood glucose in transgenic mice (n=10, )

[0095]

[0096] Tables 1 and 2 show the experimental results: The blood glucose levels of wild-type mice remained relatively stable over 12 weeks, while the blood glucose levels of mut / mut transgenic mice gradually increased, reaching their highest level on day 70. Furthermore, the blood glucose levels of the model group mice were significantly higher than the control group on days 70 and 90 after gavage, exhibiting typical hyperglycemic symptoms. The blood glucose levels in the embodiments of this invention were significantly lower than those in the model group, roughly equivalent to the reduction in Comparative Example 1. However, compared to Comparative Examples 2 and 3, replacing Rehmannia glutinosa with Polygonatum sibiricum or Sargassum fusiforme resulted in better efficacy. This indicates that the combined use of Sargassum fusiforme and Polygonatum sibiricum produced a better therapeutic effect, yielding unexpected technical results. The efficacy of this invention is similar to, or even better than, Comparative Example 1. Moreover, Sargassum fusiforme and Polygonatum sibiricum are both medicinal and edible herbs, making them safer and less irritating to the human body than Rehmannia glutinosa in Comparative Example 1.

[0097] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A composition having the function of maintaining healthy blood glucose levels, characterized in that, It is made from the following components in parts by mass: Polygonatum 3-7 parts, Dioscorea opposita 2-6 parts, Lycium barbarum 2-6 parts, Glycyrrhiza uralensis 1-4 parts, Poria cocos 1-4 parts, Cornus officinalis 1-5 parts, Sargassum fusiforme 1-5 parts.

2. The composition according to claim 1, characterized in that, It is made from the following components in parts by mass: Polygonatum 4-6 parts, Dioscorea opposita 3-5 parts, Lycium barbarum 3-5 parts, Glycyrrhiza uralensis 1.5-3 parts, Poria cocos 1.5-3 parts, Cornus officinalis 2-4 parts, Sargassum fusiforme 2-4 parts.

3. The composition according to claim 2, characterized in that, It is made from the following components in parts by mass: 5 parts Polygonatum, 4 parts Dioscorea opposita, 4 parts Lycium barbarum, 2 parts Glycyrrhiza uralensis, 2 parts Poria cocos, 3 parts Cornus officinalis, and 3 parts Sargassum fusiforme.

4. Use of the composition according to any one of claims 1 to 3 in the preparation of a medicament for the prevention of diabetes.

5. A granular tea bag comprising the composition of claim 1, characterized in that, The preparation method of the granular tea bags is as follows: (1) Take 3-7 parts of Polygonatum sibiricum, 1-5 parts of Cornus officinalis and 2-6 parts of Lycium barbarum, crush them and mix them with water. After soaking, heat and reflux to extract, filter, precipitate with alcohol, and collect the precipitate to obtain the first extract. (2) Take 2-6 parts of yam, 1-4 parts of licorice, and 1-4 parts of poria cocos. Stir-fry over low heat for 3-7 minutes, then crush and sieve to obtain coarse powder of the medicinal materials. (3) Take 1-5 parts of Sargassum fusiforme, crush it, mix it with water, soak it, extract it with microwave, collect the extract, concentrate it, precipitate it with alcohol, collect the precipitate to obtain the second extract. (4) Mix the first extract, crude powder and second extract, and add 0.05~0.15 parts of hydroxypropyl methylcellulose aqueous solution with a concentration of 6~10%, 1~3 parts of lactose and 0.5~1.5 parts of mannitol. Mix, granulate and dry to obtain granular tea bags.

6. The granular tea bag as described in claim 5, characterized in that, In step (1), the mass ratio of the pulverized Chinese medicine to water is 1:8~12, and the soaking time is 40~80 min; The reflux extraction temperature is 80~100℃, the reflux extraction is performed 1~5 times, and the reflux extraction time is 60~120min each time; The alcohol precipitation is carried out using 80-100% (v / v) ethanol, and the volume of the ethanol is 3-5 times the volume of the extract. The alcohol precipitation temperature is 2~6℃, and the alcohol precipitation time is 20~30h; The sediment was collected by centrifugation. The centrifugation speed is 5000~9000 r / min. After centrifugation, the precipitate is washed with ethanol 1~5 times. The precipitate after washing is the first extract.

7. The granular tea bag as described in claim 5, characterized in that, In step (2), the sieve mesh size is 40~80 mesh.

8. The granular tea bag as described in claim 5, characterized in that, The water used in step (3) should be 8 to 12 times the mass of the seaweed, and the soaking time should be 40 to 80 minutes. The microwave treatment is performed at 80~120℃, 450~750W, for 8~12 minutes. The ethanol concentration during the alcohol precipitation process is 80-100%; The concentration is achieved by reducing the pressure and concentrating the volume to 1 / 3 of its original volume.

9. The granular tea bag as described in claim 5, characterized in that, In step (4), the mass ratio of lactose to mannitol is 1.5~2.5:

1.

10. The granular tea bag as described in claim 5, characterized in that, The granules are packaged using non-woven fabric.

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