A formula for treating acute gastrointestinal injury / gastrointestinal dysfunction in sepsis, its preparation method, and its application.

By preparing the Shenlian Tiaozhong formula, which combines ginseng, coptis, and other Chinese herbal medicines, the treatment challenges of acute gastrointestinal injury and dysfunction in sepsis have been solved. Significant relief of inflammation and improvement of intestinal permeability have been achieved, providing a new TCM treatment option for sepsis.

CN118697846BActive Publication Date: 2026-07-17THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
Filing Date
2024-06-12
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively treat acute gastrointestinal injury and gastrointestinal dysfunction caused by sepsis, leading to worsening of the patient's condition and multiple organ dysfunction. Traditional Chinese medicine lacks effective treatment methods.

Method used

The formula "Shenlian Tiaozhong" is composed of Chinese herbal medicines such as ginseng, coptis, scutellaria, white peony root, immature bitter orange, dried ginger, bupleurum, licorice, and jujube. It is prepared by ethanol extraction and water decoction. It works together to clear heat and dry dampness, purge fire and detoxify, invigorate qi and nourish blood, and benefit the lungs and strengthen the spleen.

Benefits of technology

It significantly alleviates the inflammatory response caused by sepsis, improves intestinal permeability, provides an effective treatment for acute gastrointestinal injury/gastrointestinal dysfunction in sepsis, and improves patient prognosis and quality of life.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention provides a traditional Chinese medicine formula for treating acute gastrointestinal injury / dysentery in sepsis, its preparation method, and its application, belonging to the field of traditional Chinese medicine technology. The formula comprises the following ingredients in parts by weight: 20-30 parts ginseng, 9-15 parts coptis chinensis, 6-12 parts scutellaria baicalensis, 9-15 parts white peony root, 6-9 parts immature bitter orange, 6-9 parts dried ginger, 3-6 parts bupleurum chinense, 6-9 parts licorice root, and 4-8 parts jujube. This invention uses ginseng and coptis chinensis as the principal herbs, scutellaria baicalensis, white peony root, and immature bitter orange as the assistant herbs, dried ginger and bupleurum chinense as adjuvant herbs, and licorice root and jujube as guiding herbs. Together, they clear heat and dry dampness, purge fire and detoxify, invigorate qi and nourish blood, benefit the lungs, strengthen the spleen, and nourish the stomach. This formula can effectively alleviate gastrointestinal dysfunction and inflammatory reactions caused by sepsis and improve intestinal permeability.
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