A traditional Chinese medicine composition for treating traumatic chest pain and application thereof

Abstract

The application discloses a traditional Chinese medicine composition for treating traumatic chest and hypochondrium pain and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-10 parts by weight of prepared cyperus rotundus, 1-10 parts by weight of vinegar cortex rhizome, 1-10 parts by weight of angelica, 1-10 parts by weight of red peony root, 1-10 parts by weight of persicae semen, 1-10 parts by weight of fried eclipta, 1-10 parts by weight of fried purple yam, 1-10 parts by weight of fried eupolyphaga, 1-10 parts by weight of rhizoma drynariae, 1-10 parts by weight of luffa, 0.5-10 parts by weight of fried liquorice, 1-10 parts by weight of dried tangerine or orange peel, and the composition meets the compatibility principle of'monarch, minister, assistant and courier', is safe, economical, has no obvious toxic and side effects, has the functions of regulating qi and relieving pain and soothing liver and stopping cough, has remarkable clinical curative effects on traumatic chest and rib injury, rib fracture and chest pain and cough, is suitable for traumatic chest and hypochondrium pain patients, and has a wide clinical application prospect.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating traumatic chest and rib pain and its application. Background Technology

[0002] The ribs are an important barrier protecting the heart, lungs, and other organs and tissues within the chest cavity. Rib fractures, however, can transform the ribs into a dangerous factor threatening these vital organs and tissues. Acute respiratory distress syndrome, massive blood loss, and pulmonary infection are significant factors leading to or exacerbating shock. Rib fractures are a common traumatic orthopedic condition, primarily caused by violent impacts, falls, and other injuries. They have a high incidence rate, mostly presenting as simple rib fractures. Clinical symptoms typically include swelling, pain, tenderness, percussion pain, ecchymosis, and limited mobility at the injured site. In severe cases, they can cause pain and discomfort throughout the chest and rib area or the front and back. The pain can restrict breathing, leading to varying degrees of chest tightness and dyspnea. The treatment principles for rib fractures include pain relief, promoting expectoration, stabilizing the chest wall, restoring chest wall function, and preventing complications. In Traditional Chinese Medicine, this falls under the categories of "fracture" and "chest and rib pain."

[0003] Post-traumatic chest and rib pain refers to pain caused by trauma to the chest and rib area. It manifests as localized pain that worsens with deep breathing and coughing. The chest and rib area is where the liver meridian runs and where the lungs reside; injury to this area inevitably leads to blood stasis in the chest, damaging the lungs. The lungs govern the body's Qi; obstructed Qi flow can cause Qi stagnation and blood stasis. Although the pain may be localized, it is closely related to breathing, thus Qi stagnation is more severe than blood stasis. Treatment must first regulate Qi; when Qi flows smoothly, blood stasis is eliminated; when blood stasis is eliminated, the meridians are unblocked; and when the meridians are unblocked, the pain is relieved. Post-traumatic chest and rib pain is a common condition in orthopedics. Injuries to the chest and rib area from falls result in blood stasis, which congeals with Qi, obstructing the meridians and causing rib pain. It is often caused by single or multiple rib fractures due to chest impact or compression, resulting in severe local swelling and pain. Multiple rib fractures, in particular, are often accompanied by pulmonary contusion and laceration, hemopneumothorax, etc., making the injury complex and the condition variable, easily leading to respiratory or circulatory failure. Most patients with simple rib fractures in clinical practice have no significant displacement of the fracture ends, no serious complications, and no indication for surgery. Poor fracture healing may be due to damage to the arteries and veins supplying the area by the fracture ends, which can then damage surrounding tissues, causing edema, and in severe cases, local gangrene. Pain is the main clinical manifestation of simple rib fractures, which worsens with breathing, coughing, and sneezing, and can induce atelectasis and pneumonia, seriously affecting the patient's quality of life.

[0004] Traditional Chinese medicine believes that rib fractures damage the blood vessels in the chest, causing blood to spill out of the vessels, leading to obstruction of the meridians and stagnation of blood, resulting in pain due to obstruction. If the fracture involves a tendon fracture, the bone loses its supporting function, causing damage to the internal organs, impairing the lungs' ability to purify and cleanse, and obstructing the flow of qi, thus inducing clinical symptoms such as shortness of breath, cough, and chest tightness. Because fractures damage local muscles and tendons, disrupting the flow of qi, blood spills out of the vessels and stagnates in the skin and muscles, causing pain due to obstruction. Whether the obstruction is caused by qi stagnation or blood stasis, the muscles lack blood nourishment, leading to pain. Therefore, treatment must focus on promoting blood circulation and removing blood stasis.

[0005] Based on the development of the injury, fractures are divided into three stages: early, middle, and late. In the early stage, generally within two weeks after injury, there is local swelling and pain, and the fracture ends are prone to displacement again. Treatment focuses on promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain. In the middle stage, after two weeks, the swelling has largely subsided, the pain has significantly decreased, the fracture site gradually stabilizes, and new bone begins to grow. However, because the blood stasis has not been completely absorbed, the pain has not completely disappeared, and treatment still focuses on promoting blood circulation, removing blood stasis, and healing the tendons and bones. In the late stage, after seven weeks after injury, the fracture has reached clinical healing, and splints or braces have been removed. However, the bone has not fully healed. At this stage, the focus is on functional exercises to prevent joint stiffness and muscle atrophy. Drug treatment mainly focuses on nourishing qi and blood, tonifying the liver and kidneys, and strengthening tendons and bones. Therefore, the treatment of bone injuries must take into account both promoting blood circulation and removing blood stasis, regulating qi and relieving pain, and balancing yin and yang.

[0006] The principles of Western medicine in treating rib fractures are pain relief and prevention of lung infection. Clinically, pain relief for rib fractures is often achieved through oral or intramuscular injection. For multiple rib fractures requiring continuous and effective analgesia, epidural analgesia, intravenous analgesia, intercostal nerve blocks, and intrapleural analgesia are commonly used. Epidural analgesia offers the advantages of regional nerve blocks, providing the most comprehensive analgesic effect. Furthermore, it allows for patient-controlled analgesia with the aid of devices, reducing the side effects of systemic intravenous analgesia such as drowsiness, cough suppression, and respiratory inhibition. It also avoids the drawbacks of short duration of intercostal nerve block analgesia and unstable effects of intrapleural analgesia, as well as the suppression of diaphragmatic function. Ideal analgesia can effectively improve lung function, reduce pulmonary complications, promote early ambulation, and improve the patient's quality of life.

[0007] Sternocostal fracture belongs to the categories of "fracture" and "hypochondriac pain" in traditional Chinese medicine, with its basic pathogenesis being blood stasis syndrome. Drugs with the effects of regulating qi to relieve pain and activating blood circulation to resolve stasis are used for treatment. In the early stage, patients with simple rib fracture often suffer from disharmony of qi and blood caused by violent trauma, resulting in pain due to obstruction. Moreover, patients reduce respiratory amplitude and spontaneous cough due to pain, which easily leads to complications such as atelectasis and pulmonary infection. The treatment should focus on activating blood circulation, resolving stasis and relieving pain, while protecting lung function. The key to the treatment of rib fracture is to correct the syndrome of qi stagnation and blood stasis. If stasis is not removed, new blood cannot be generated and bones cannot be connected, while new blood can nourish bones and accelerate fracture healing. In addition, the pain in such patients is mostly "pain due to obstruction" caused by blood stasis. Activating blood circulation, resolving stasis and reducing swelling can promote the absorption of accumulated blood and relieve pain. Modern pharmacological studies have confirmed that blood-activating and stasis-resolving drugs can improve microcirculatory blood flow velocity by dilating capillaries, accelerate the clearance of blood clots and metabolites, improve local blood circulation at the fracture end, increase the thickness of local callus, and also accelerate the repair of soft tissue injury and the absorption of edema, so as to achieve the purpose of promoting hemothorax absorption and fracture healing.

[0008] At present, clinical practice is more inclined to use Chinese patent medicines because of their convenience, remarkable curative effect, low economic burden and small side effects. There are mainly two categories of Chinese patent medicines for treating rib fracture in the market: drugs for activating blood and dredging collaterals, and drugs for promoting fracture healing. Generally, for Chinese patent medicines that activate blood and dredge collaterals, Die Da Wan, San Qi Pian, Jie Gu Qi Li Pian, Du Yi Wei Capsules are mostly selected. These medicines have excellent effects of activating blood circulation, resolving stasis and promoting blood absorption, and can also well relieve swelling and pain. In the later period, that is, 2 to 4 weeks after injury, Chinese patent medicines that tonify liver and kidney and promote fracture healing can be substituted. This stage is mainly the healing stage of callus, and Heng Gu Gu Shang Yu He Ji, Teng Huang Jian Gu Pian, Jin Tian Ge Capsules, Jin Gu Lian Capsules, Gu Kang Capsules, Jie Gu Xu Jin Capsules are usually selected. All these medicines can well promote and improve fracture healing. For pain and cough caused by rib fracture, the main treatments are analgesic and sedative drugs, and regulating qi, resolving phlegm and relieving cough. Therefore, it is urgent to give full play to the characteristic advantages of traditional Chinese medicine, explore traditional Chinese medicine therapies for treating chest pain and cough, innovate the research and development of new traditional Chinese medicines, and provide more options for effectively preventing hypostatic pneumonia and delaying disease progression. Summary of the Invention

[0009] The main objective of this invention is to provide a traditional Chinese medicine composition for treating traumatic chest and rib pain caused by chest and rib injuries and rib fractures. It consists of 14 medicinal materials, including prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, Prunus persica, Prunus armeniaca, stir-fried Tribulus terrestris, prepared Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared Commiphora myrrha, Luffa cylindrica, prepared Glycyrrhiza uralensis, and Citrus reticulata. It has the effects of regulating qi and relieving pain, soothing the liver and relieving cough, and is mainly used to treat chest and rib injuries, rib fractures, and chest pain with cough. The proportions of each herbal ingredient in this herbal composition by weight are as follows: 1-10 parts by weight of processed Cyperus rotundus, 1-10 parts by weight of vinegar-processed Corydalis yanhusuo, 1-10 parts by weight of Angelica sinensis, 1-10 parts by weight of Paeonia lactiflora, 1-10 parts by weight of Prunus persica, 1-10 parts by weight of Prunus armeniaca, 1-10 parts by weight of stir-fried Tribulus terrestris, 1-10 parts by weight of processed Aster tataricus, 1-10 parts by weight of stir-fried Eupolyphaga sinensis, 1-10 parts by weight of Dipsacus asper, 1-10 parts by weight of processed Commiphora myrrha, 1-10 parts by weight of Luffa cylindrica, 0.5-10 parts by weight of processed Glycyrrhiza uralensis, and 1-10 parts by weight of Citrus reticulata peel.

[0010] Preferably, the proportions of each herbal ingredient in the herbal composition by weight are as follows: 2 parts by weight of processed Cyperus rotundus, 1.5 parts by weight of vinegar-processed Corydalis yanhusuo, 2 parts by weight of Angelica sinensis, 2 parts by weight of Paeonia lactiflora, 2 parts by weight of Prunus persica, 2 parts by weight of Prunus armeniaca, 2 parts by weight of stir-fried Tribulus terrestris, 2 parts by weight of processed Aster tataricus, 1.5 parts by weight of stir-fried Eupolyphaga sinensis, 2 parts by weight of Dipsacus asper, 1.5 parts by weight of processed Commiphora myrrha, 2 parts by weight of Luffa cylindrica, 0.5 parts by weight of processed Glycyrrhiza uralensis, and 1 part by weight of Citrus reticulata peel.

[0011] Preferably, the proportions of each Chinese herbal raw material in the herbal composition by weight are as follows: 10 parts by weight of processed Cyperus rotundus, 10 parts by weight of vinegar-processed Corydalis yanhusuo, 10 parts by weight of Angelica sinensis, 10 parts by weight of Paeonia lactiflora, 10 parts by weight of simmered peach kernel, 10 parts by weight of simmered bitter apricot kernel, 10 parts by weight of stir-fried Tribulus terrestris, 10 parts by weight of honey-processed Aster tataricus, 6 parts by weight of stir-fried Eupolyphaga sinensis, 10 parts by weight of Dipsacus asper, 6 parts by weight of processed Myrrh, 10 parts by weight of Luffa cylindrica, 3 parts by weight of honey-processed Glycyrrhiza uralensis, and 6 parts by weight of Citrus reticulata peel.

[0012] The traditional Chinese medicine composition for treating traumatic chest and rib pain described in this invention is developed based on the clinical experience formula Chest Pain Relief Compound by Dr. Ye Jinghua, a renowned traditional Chinese medicine doctor in Shanghai. It consists of 14 medicinal herbs, including prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, Prunus persica, Prunus armeniaca, stir-fried Tribulus terrestris, prepared Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared Commiphora myrrha, Luffa cylindrica, prepared Glycyrrhiza uralensis, and Citrus reticulata. The principal, assistant, and adjuvant relationships of this traditional Chinese medicine composition are as follows: Principal herbs: prepared Cyperus rotundus and vinegar-processed Corydalis yanhusuo; Assistant herbs: Angelica sinensis and Prunus persica. The formula consists of: apricot kernel, roasted aster, red peony root, and stir-fried ground beetle; adjuvant herbs: loofah sponge, tangerine peel, teasel root, stir-fried tribulus terrestris, and prepared myrrh; and guiding herb: roasted licorice root. The main ingredients are prepared cyperus rhizome and vinegar-processed corydalis rhizome, which soothe the liver, regulate qi, and relieve pain. Angelica sinensis, peach kernel, apricot kernel, roasted aster, red peony root, and stir-fried ground beetle invigorate blood and remove blood stasis, serving as assistant herbs to help relieve chest and rib pain caused by qi stagnation and blood stasis. Loofah sponge, tangerine peel, teasel root, stir-fried tribulus terrestris, and prepared myrrh regulate qi and unblock the meridians. Roasted licorice root harmonizes the effects of the other herbs. This traditional Chinese medicine composition excels at regulating qi, relieving pain, soothing the liver, and stopping coughs. It has been used clinically for over 30 years and has shown significant clinical efficacy in treating chest and rib injuries, rib fractures, and chest pain with cough.

[0013] The present invention also provides the use of the traditional Chinese medicine composition for treating traumatic chest and rib pain in the preparation of a medicament for treating traumatic chest and rib pain.

[0014] Preferably, the active ingredients of the traditional Chinese medicine composition are extracted and then mixed to prepare a pharmaceutically acceptable drug preparation.

[0015] More preferably, the pharmaceutical preparation comprises an extract of the above-mentioned traditional Chinese medicine composition and a pharmaceutically acceptable drug carrier or excipient, and the dosage form includes decoction, granules, pills or capsules.

[0016] Preferably, the pharmaceutical preparation is a decoction, and the preparation method includes: taking prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, Prunus persica, Prunus armeniaca, stir-fried Tribulus terrestris, processed Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared Commiphora myrrha, Luffa cylindrica, processed Glycyrrhiza uralensis, and Citrus reticulata according to the raw materials and weight ratio of the traditional Chinese medicine composition, cleaning and coarsely crushing them to obtain coarse particles of raw materials; adding water three times the weight of the raw materials and soaking for 60 minutes, then boiling over high heat, then simmering over low heat for 30 minutes to obtain concentrated liquid; then adding an equal amount of water for a second decoction, and mixing the two concentrated liquids to obtain the decoction.

[0017] Preferably, the pharmaceutical preparation is in the form of granules, and the preparation method includes: taking prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, roasted peach kernel, roasted bitter almond, stir-fried Tribulus terrestris, honey-processed Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared Myrrh, Luffa cylindrica, honey-processed Glycyrrhiza uralensis, and Citrus reticulata peel according to the raw materials and weight ratio of the traditional Chinese medicine composition, cleaning and coarsely crushing them to obtain coarse granules of raw materials; soaking them in 6-10 times the weight of the raw materials in water, decocting them 2-3 times, each time for 1.5-2 hours, combining the decoctions, concentrating them into a clear extract with a relative density of 1.14-1.15, spray drying them at 135-165℃, sieving them, adding an appropriate amount of excipients, mixing them evenly, making them into granules, and drying them to obtain granules.

[0018] Preferably, the pharmaceutical preparation is a pill, and the preparation method includes: taking prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, roasted peach kernel, roasted bitter almond, stir-fried Tribulus terrestris, honey-processed Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared myrrh, Luffa cylindrica, honey-processed Glycyrrhiza uralensis, and Citrus reticulata peel according to the raw materials and weight ratio of the traditional Chinese medicine composition, cleaning and coarsely crushing them to obtain coarse particles of raw materials; soaking them in 6-10 times the weight of the raw materials in water, decocting them 2-3 times, each time for 1.5-2 hours, combining the decoctions, concentrating them into a clear paste with a relative density of 1.14-1.15, spray drying them at 135-165℃, sieving them, adding an appropriate amount of excipients, mixing them evenly, making them into granules, drying them, and then making them into water-honey pills to obtain the pill.

[0019] Preferably, the pharmaceutical preparation is a capsule, and the preparation method includes: taking prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, roasted peach kernel, roasted bitter almond, stir-fried Tribulus terrestris, honey-processed Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared myrrh, Luffa cylindrica, honey-processed licorice, and Citrus reticulata peel according to the raw materials and weight ratio of the traditional Chinese medicine composition, cleaning and coarsely crushing them to obtain coarse particles of raw materials; adding 6-10 times the weight of water of the raw materials for soaking, decocting 2-3 times, each time for 1.5-2 hours, combining the decoctions, concentrating to a clear extract with a relative density of 1.14-1.15, spray drying at 135-165℃, sieving, adding an appropriate amount of excipients, mixing well, making granules, drying, and capsule filling to obtain the capsule.

[0020] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0021] Based on previous experience and following the principles of TCM syndrome differentiation and treatment, this invention provides a Chinese herbal composition for treating traumatic chest and rib pain. It conforms to the principle of "principal, assistant, adjuvant, and guide" in drug formulation, demonstrating proper compatibility. Clinical application shows that this herbal composition retains the efficacy of the drugs, is safe, economical, and has no obvious toxic side effects. It has the functions of regulating qi and relieving pain, soothing the liver and stopping cough, and has significant clinical efficacy for chest and rib injuries, rib fractures, and chest pain with cough. It is suitable for patients with traumatic chest and rib pain and has broad clinical application prospects. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the described embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0023] The following examples present a traditional Chinese medicine composition for treating traumatic chest and rib pain. It is developed based on the clinical experience formula Chest Pain Relief Compound by Dr. Ye Jinghua, a renowned traditional Chinese medicine doctor in Shanghai. It consists of 14 medicinal materials, including prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, Prunus persica, Prunus armeniaca, stir-fried Tribulus terrestris, prepared Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared Commiphora myrrha, Luffa cylindrica, prepared Glycyrrhiza uralensis, and Citrus reticulata. It is effective in regulating qi and relieving pain, soothing the liver and relieving cough. It has significant clinical efficacy for chest and rib injuries, rib fractures, and chest pain with cough. The proportions of the raw materials in this traditional Chinese medicine composition by weight are as follows: 1-10 parts by weight of processed Cyperus rotundus, 1-10 parts by weight of vinegar-processed Corydalis yanhusuo, 1-10 parts by weight of Angelica sinensis, 1-10 parts by weight of Paeonia lactiflora, 1-10 parts by weight of Prunus persica, 1-10 parts by weight of Prunus armeniaca, 1-10 parts by weight of stir-fried Tribulus terrestris, 1-10 parts by weight of processed Aster tataricus, 1-10 parts by weight of stir-fried Eupolyphaga sinensis, 1-10 parts by weight of Dipsacus asper, 1-10 parts by weight of processed Commiphora myrrha, 1-10 parts by weight of Luffa cylindrica, 0.5-10 parts by weight of processed Glycyrrhiza uralensis, and 1-10 parts by weight of Citrus reticulata peel. This traditional Chinese medicine composition can be used to prepare a drug for treating traumatic chest and rib pain. The dosage form includes decoction, granules, pills, or capsules. There are no particular limitations on the preparation method; those skilled in the art can prepare it using conventional methods.

[0024] In some embodiments, the proportions of each Chinese herbal raw material in the composition by weight are as follows: 2 parts by weight of processed Cyperus rotundus, 1.5 parts by weight of vinegar-processed Corydalis yanhusuo, 2 parts by weight of Angelica sinensis, 2 parts by weight of Paeonia lactiflora, 2 parts by weight of Prunus persica, 2 parts by weight of Prunus armeniaca, 2 parts by weight of stir-fried Tribulus terrestris, 2 parts by weight of processed Aster tataricus, 1.5 parts by weight of stir-fried Eupolyphaga sinensis, 2 parts by weight of Dipsacus asper, 1.5 parts by weight of processed Commiphora myrrha, 2 parts by weight of Luffa cylindrica, 0.5 parts by weight of processed Glycyrrhiza uralensis, and 1 part by weight of Citrus reticulata peel, which are then prepared into granules.

[0025] In some embodiments, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 parts of processed Cyperus rotundus, 10 parts of vinegar-processed Corydalis yanhusuo, 10 parts of Angelica sinensis, 10 parts of Paeonia lactiflora, 10 parts of roasted peach kernel, 10 parts of roasted bitter apricot kernel, 10 parts of stir-fried Tribulus terrestris, 10 parts of honey-processed Aster tataricus, 6 parts of stir-fried Eupolyphaga sinensis, 10 parts of Dipsacus asper, 6 parts of processed Myrrh, 10 parts of Luffa cylindrica, 3 parts of honey-processed Glycyrrhiza uralensis, and 6 parts of Citrus reticulata peel, and is prepared into a decoction.

[0026] This study investigated the effects of treating 35 patients with rib fractures with Chest Pain Relief Decoction at the Trauma Emergency Center of Shanghai Seventh People's Hospital (affiliated with Shanghai University of Traditional Chinese Medicine) from 2019 to 2022. Chest Pain Relief Decoction contains the following herbal composition, prepared from the following raw materials in parts by weight: 10 parts of prepared Cyperus rotundus, 10 parts of vinegar-processed Corydalis yanhusuo, 10 parts of Angelica sinensis, 10 parts of Paeonia lactiflora, 10 parts of roasted peach kernel, 10 parts of roasted bitter almond, 10 parts of stir-fried Tribulus terrestris, 10 parts of honey-processed Aster tataricus, 6 parts of stir-fried Eupolyphaga sinensis, 10 parts of Dipsacus asper, 6 parts of prepared Myrrh, 10 parts of Luffa cylindrica, 3 parts of honey-processed Glycyrrhiza uralensis, and 6 parts of Citrus reticulata peel. One course of treatment consisted of 7 doses, decocted in water and taken twice daily in divided doses.

[0027] The efficacy evaluation criteria are as follows:

[0028] Cured: The pain disappeared after taking 7 doses, and no further treatment was required;

[0029] Significant effect: After taking 7 doses consecutively, the pain was significantly relieved; after taking another 7 doses, the pain disappeared.

[0030] Effective: Pain was relieved after taking 7 doses, but local pain persisted after taking another 7 doses;

[0031] Ineffective: No significant changes after taking the medication.

[0032] Clinical observation results showed that 15 cases were cured, 20 cases showed significant improvement, and the total effective rate was 100%.

[0033] Example 1

[0034] Take 10g of prepared Cyperus rotundus, 10g of vinegar-processed Corydalis yanhusuo, 10g of Angelica sinensis, 10g of Paeonia lactiflora, 10g of Prunus persica, 10g of Prunus armeniaca, 10g of stir-fried Tribulus terrestris, 10g of processed Aster tataricus, 6g of stir-fried Eupolyphaga sinensis, 10g of Dipsacus asper, 6g of prepared Commiphora myrrha, 10g of Luffa cylindrica, 3g of processed Glycyrrhiza uralensis, and 6g of Citrus reticulata. Soak these ingredients in three times their weight of water for 60 minutes. Then bring the mixture to a boil over high heat, followed by simmering over low heat for 30 minutes to obtain a concentrated liquid. Add an equal amount of water and boil the mixture a second time to obtain another concentrated liquid. Combine the two concentrated liquids to obtain the decoction.

[0035] Example 2

[0036] Take 5 kg of prepared Cyperus rotundus, 3.75 kg of vinegar-processed Corydalis yanhusuo, 5 kg of Angelica sinensis, 5 kg of Paeonia lactiflora, 5 kg of roasted peach kernel, 5 kg of roasted bitter apricot kernel, 5 kg of stir-fried Tribulus terrestris, 5 kg of honey-processed Aster tataricus, 3.75 kg of stir-fried Eupolyphaga sinensis, 5 kg of Dipsacus asper, 3.75 kg of prepared Myrrh, 5 kg of Luffa cylindrica, 1.25 kg of honey-processed Glycyrrhiza uralensis, and 2.5 kg of Citrus reticulata peel. Soak these ingredients in 6-10 times their weight of water, decoct 2-3 times, each time for 1.5-2 hours, combine the decoctions, concentrate to a clear extract with a relative density of 1.14-1.15, spray dry at 135-165℃, sieve, add an appropriate amount of excipients, mix well, granulate, dry, and further prepare into granules.

[0037] Example 3

[0038] Take 5 kg of prepared Cyperus rotundus, 3.75 kg of vinegar-processed Corydalis yanhusuo, 5 kg of Angelica sinensis, 5 kg of Paeonia lactiflora, 5 kg of roasted peach kernel, 5 kg of roasted bitter apricot kernel, 5 kg of stir-fried Tribulus terrestris, 5 kg of honey-processed Aster tataricus, 3.75 kg of stir-fried Eupolyphaga sinensis, 5 kg of Dipsacus asper, 3.75 kg of prepared Myrrh, 5 kg of Luffa cylindrica, 1.25 kg of honey-processed Glycyrrhiza uralensis, and 2.5 kg of Citrus reticulata peel. Soak these ingredients in 6-10 times their weight of water, decoct 2-3 times, each time for 1.5-2 hours, combine the decoctions, concentrate to a clear paste with a relative density of 1.14-1.15, spray dry at 135-165℃, sieve, add an appropriate amount of excipients, mix well, granulate, dry, and further make into water-honey pills, which are the pills.

[0039] Example 4

[0040] Take 5 kg of prepared Cyperus rotundus, 3.75 kg of vinegar-processed Corydalis yanhusuo, 5 kg of Angelica sinensis, 5 kg of Paeonia lactiflora, 5 kg of roasted peach kernel, 5 kg of roasted bitter apricot kernel, 5 kg of stir-fried Tribulus terrestris, 5 kg of honey-processed Aster tataricus, 3.75 kg of stir-fried Eupolyphaga sinensis, 5 kg of Dipsacus asper, 3.75 kg of prepared Myrrh, 5 kg of Luffa cylindrica, 1.25 kg of honey-processed Glycyrrhiza uralensis, and 2.5 kg of Citrus reticulata peel. Soak these ingredients in 6-10 times their weight of water, decoct 2-3 times, each time for 1.5-2 hours, combine the decoctions, concentrate to a clear extract with a relative density of 1.14-1.15, spray dry at 135-165℃, sieve, add an appropriate amount of excipients, mix well, granulate, dry, and encapsulate to obtain capsules.

[0041] The invention will be further illustrated below with reference to typical cases, but these typical cases are by no means intended to limit the invention in any way.

[0042] Example of efficacy 1

[0043] Mr. Gu, male, Shanghai Seventh People's Hospital, hospital number 600***

[0044] The patient was riding an electric scooter when it collided with a van, impacting the left side of the chest. He experienced significant pain and difficulty breathing, and was brought to our emergency department. Chest CT scan: 1. Multiple rib fractures on the left side; please confirm with 3D rib reconstruction. 2. Left lung contusion, with thickening of the left posterior pleura. 3. Right paratracheal diverticulum. CT scan report: The head CT scan showed no obvious traumatic lesions in the brain; follow-up is recommended. General radiography report: 1. Right calcaneal fracture; please correlate with clinical findings. 2. No obvious fracture signs in the right ankle joint; please correlate with clinical findings and repeat examination if necessary to rule out occult injury. 3. Lumbar spondylosis; slight wedge-shaped deformation of the T12-L2 vertebral bodies; please correlate with clinical findings. Considering the occult and delayed nature of the injury, the patient was admitted to the emergency department with a preliminary diagnosis of "rib fractures" for further treatment.

[0045] The diagnosis according to Traditional Chinese Medicine is: injury and pain, qi stagnation and blood stasis syndrome.

[0046] The Western medical diagnosis was: 1. Four or more rib fractures without a first rib fracture; 2. Pulmonary contusion; 3. Right calcaneal fracture.

[0047] The patient's tongue was dark with a thin white coating, and his pulse was wiry. Given the dark tongue, thin white coating, and wiry pulse, the diagnosis was qi stagnation and blood stasis leading to a rib fracture. Due to post-traumatic stress, the patient was given the herbal decoction of this invention orally, twice daily, 200mL each time for 7 days. The patient's condition stabilized and improved, and he was discharged from the hospital.

[0048] During outpatient follow-up, the patient continued to receive the herbal decoction of this invention, twice daily, 200mL each time, for 21 days to consolidate the treatment.

[0049] Example of efficacy 2

[0050] Mr. Gu, male, Shanghai Seventh People's Hospital, hospital number 596***

[0051] The patient accidentally fell into an uncovered manhole on the street at 2 PM, with his right ribs impacting the edge of the manhole. He experienced significant pain but no chest tightness, shortness of breath, abdominal pain or distension, nausea, vomiting, or loss of consciousness. He was transported to our hospital by ambulance at 3 PM. A chest CT scan revealed: 1. Fractures of the 5th-10th ribs on the right side, a small amount of pneumothorax on the right side, and possible minor contusions to both lower lobes; 2. Scattered fibrotic lesions in both lungs, and bilateral pleural thickening; 3. Calcification of the aortic wall. An upper abdominal CT scan showed punctate free gas around the liver, possibly indicating gastrointestinal perforation. Further clinical examination and follow-up are recommended. Multiple low-density lesions were found in the liver; contrast enhancement may be necessary. Gallbladder wall calcification is possible. Multiple low-density lesions were found in the right kidney. Osteophytes were also present in the lumbar and thoracic vertebrae. After consultation with the thoracic surgery department, conservative treatment with a chest brace was initially recommended, followed by a 3D CT scan to determine the need for surgery. For further diagnosis and treatment, the patient is being admitted to the Emergency Trauma Center with a diagnosis of "rib fractures."

[0052] The Western medical diagnosis was 1. Four or more rib fractures without a first rib fracture; 2. Pulmonary contusion; 3. Traumatic pneumothorax. The Traditional Chinese Medicine diagnosis was rib fracture and qi stagnation and blood stasis syndrome.

[0053] The patient's tongue was dark with a thin white coating, and his pulse was wiry. Therefore, the diagnosis was qi stagnation and blood stasis leading to a rib fracture. Due to post-traumatic stress, the patient was given the herbal decoction of this invention orally, twice daily, 200mL each time for 7 days. The patient reported that the tenderness in the right chest had lessened, and the breathing and coughing had also lessened. There was no nausea or vomiting, the appetite was fair, bowel movements were normal, and sleep was generally good. The patient's condition stabilized and improved, and he was discharged from the hospital.

[0054] During outpatient follow-up, patients continued to take the herbal decoction of this invention orally twice a day, 200mL each time for 21 days to consolidate the treatment.

[0055] In summary, this invention, based on previous experience and following the principles of traditional Chinese medicine (TCM) syndrome differentiation and treatment, yields a TCM composition for treating traumatic chest and rib pain. It conforms to the principle of "principal, assistant, adjuvant, and guide" in TCM formulation, demonstrating appropriate compatibility. This composition effectively regulates Qi, relieves pain, soothes the liver, and stops coughing. It exhibits significant clinical efficacy for chest and rib injuries, rib fractures, and chest pain with cough, making it suitable for patients with traumatic chest and rib pain. Furthermore, the drug has few side effects, high safety, and is conveniently administered orally, possessing significant industrial application value.

[0056] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A traditional Chinese medicine composition for treating traumatic chest and rib pain, characterized in that, The proportions of each Chinese herbal raw material in the herbal composition by weight are as follows: 2 parts of processed Cyperus rotundus, 1.5 parts of vinegar-processed Corydalis yanhusuo, 2 parts of Angelica sinensis, 2 parts of Paeonia lactiflora, 2 parts of peach kernel, 2 parts of apricot kernel, 2 parts of stir-fried Tribulus terrestris, 2 parts of processed Aster tataricus, 1.5 parts of stir-fried Eupolyphaga sinensis, 2 parts of Dipsacus asper, 1.5 parts of processed Myrrh, 2 parts of Luffa cylindrica, 0.5 parts of processed Glycyrrhiza uralensis, and 1 part of Citrus reticulata peel.

2. A traditional Chinese medicine composition for treating traumatic chest and rib pain, characterized in that, The proportions of each Chinese herbal raw material in the herbal composition by weight are as follows: 10 parts by weight of processed Cyperus rotundus, 10 parts by weight of vinegar-processed Corydalis yanhusuo, 10 parts by weight of Angelica sinensis, 10 parts by weight of Paeonia lactiflora, 10 parts by weight of simmered peach kernel, 10 parts by weight of simmered bitter apricot kernel, 10 parts by weight of stir-fried Tribulus terrestris, 10 parts by weight of honey-processed Aster tataricus, 6 parts by weight of stir-fried Eupolyphaga sinensis, 10 parts by weight of Dipsacus asper, 6 parts by weight of processed Myrrh, 10 parts by weight of Luffa cylindrica, 3 parts by weight of honey-processed Glycyrrhiza uralensis, and 6 parts by weight of Citrus reticulata peel.

3. The use of the traditional Chinese medicine composition according to claim 1 or 2 in the preparation of a medicament for treating traumatic chest and rib pain.

4. The application according to claim 3, characterized in that, The active ingredients of the traditional Chinese medicine composition are extracted and then mixed to prepare a pharmaceutically acceptable drug preparation.

5. The application according to claim 4, characterized in that, The pharmaceutical preparation is made from an extract of the traditional Chinese medicine composition and a pharmaceutically acceptable drug carrier or excipient, and the dosage form includes decoction, granules, pills or capsules.

6. The application according to claim 5, characterized in that, The pharmaceutical preparation is a decoction, and the preparation method includes: taking prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, Prunus persica, Prunus armeniaca, stir-fried Tribulus terrestris, processed Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared Commiphora myrrha, Luffa cylindrica, processed Glycyrrhiza uralensis, and Citrus reticulata according to the raw materials and weight ratio of the Chinese herbal composition, cleaning and selecting them, and coarsely crushing them to obtain coarse particles of raw materials; adding water three times the weight of the raw materials and soaking for 60 minutes, then boiling over high heat, and then simmering over low heat for 30 minutes to obtain concentrated medicinal liquid; then adding an equal amount of water for a second decoction, and mixing the two concentrated medicinal liquids to obtain the decoction.

7. The application according to claim 5, characterized in that, The pharmaceutical preparation is a granule, and the preparation method includes: taking prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, Prunus persica, Prunus armeniaca, stir-fried Tribulus terrestris, processed Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared Commiphora myrrha, Luffa cylindrica, processed Glycyrrhiza uralensis, and Citrus reticulata according to the raw materials and weight ratio of the traditional Chinese medicine composition, cleaning and coarsely crushing them to obtain coarse granules of raw materials; soaking them in 6-10 times the weight of the raw materials in water, decocting them 2-3 times, each time for 1.5-2 hours, combining the decoctions, concentrating them into a clear extract with a relative density of 1.14-1.15, spray drying them at 135-165℃, sieving them, adding an appropriate amount of excipients, mixing them evenly, making them into granules, and drying them to obtain the granule.

8. The application according to claim 5, characterized in that, The pharmaceutical preparation is a pill, and the preparation method includes: taking prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, Prunus persica, Prunus armeniaca, stir-fried Tribulus terrestris, processed Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared Commiphora myrrha, Luffa cylindrica, processed Glycyrrhiza uralensis, and Citrus reticulata according to the raw materials and weight ratio of the Chinese herbal composition, cleaning and coarsely crushing them to obtain coarse particles of raw materials; soaking them in 6-10 times the weight of the raw materials in water, decocting them 2-3 times, each time for 1.5-2 hours, combining the decoctions, concentrating them into a clear paste with a relative density of 1.14-1.15, spray drying them at 135-165℃, sieving them, adding an appropriate amount of excipients, mixing them evenly, making them into granules, drying them, and then making them into water-honey pills to obtain the pill.

9. The application according to claim 5, characterized in that, The pharmaceutical preparation is a capsule, and the preparation method includes: taking prepared Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Angelica sinensis, Paeonia lactiflora, Prunus persica, Prunus armeniaca, stir-fried Tribulus terrestris, processed Aster tataricus, stir-fried Eupolyphaga sinensis, Dipsacus asper, prepared Commiphora myrrha, Luffa cylindrica, processed Glycyrrhiza uralensis, and Citrus reticulata according to the raw materials and weight ratio of the traditional Chinese medicine composition, cleaning and coarsely crushing them to obtain coarse particles of raw materials; soaking them in 6-10 times the weight of the raw materials in water, decocting them 2-3 times, each time for 1.5-2 hours, combining the decoctions, concentrating them into a clear extract with a relative density of 1.14-1.15, spray drying them at 135-165℃, sieving them, adding an appropriate amount of excipients, mixing them evenly, making them into granules, drying them, and filling them into capsules to obtain the capsule preparation.