A traditional Chinese medicine composition for treating chronic fatigue syndrome of qi-yin deficiency and application thereof

Abstract

The application discloses a traditional Chinese medicine composition for treating chronic fatigue syndrome of qi-yin deficiency and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: Renshen 5-10g, Shenghuangqi 5-15g, Roushui 3-6g, Danggui 5-10g, Baishao 5-10g, Gegen 5-15g, Jiuhuangjing 5-10g, Xianhecao 5-12g, Maidong 5-10g, Shenglonggu 9-15g, Shengmuli 9-15g, Hehuanhua 5-10g, Chaozuoshiren 10-20g, Fushen 5-10g, Fuling 5-10g, Niuxi 5-10g and Zhigancao 3-6g. The application is strict in compatibility and reasonable in prescription. Through clinical experiment verification, the traditional Chinese medicine composition has remarkable treatment effect on chronic fatigue syndrome, especially on fatigue of qi-yin deficiency, and is worthy of clinical popularization and application.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for treating chronic fatigue syndrome of Qi and Yin deficiency type and its application. Background Technology

[0002] Chronic fatigue syndrome (CFS) is a syndrome characterized by prolonged fatigue, a symptom predominantly associated with the fast-paced, stressful lifestyles of modern society. Its clinical manifestations primarily involve a decline and exhaustion in the functions of the nervous, musculoskeletal, digestive, urinary, and sensory systems. Its defining characteristic is prolonged, extreme lethargy that is not relieved by rest, without any underlying organic lesions detected in examinations. CFS has a high incidence rate, predominantly affecting women, and shows a trend of increasing prevalence, younger age of onset, and higher education levels. It severely impacts normal work, reduces quality of life, and causes incalculable losses to individual health, family well-being, and societal development, becoming a pressing issue in contemporary society. Its pathogenesis is complex, resulting from the combined effects of multiple factors, including genetics, environment, infection, immunity, and neurological dysfunction. Viral infections, such as novel coronavirus, norovirus, and herpesvirus, have become a major contributing factor to CFS in recent years. Chronic fatigue syndrome is characterized by fatigue as the main symptom, accompanied by a variety of physical and neuropsychiatric symptoms such as short-term memory loss or inability to concentrate, physical discomfort after mental work, sleep disorders, and depression, with fatigue and sleep disorders being the main manifestations.

[0003] Even though there is no specific disease name for chronic fatigue syndrome in traditional Chinese medicine, ancient texts contain numerous descriptions of fatigue as a symptom. The *Huangdi Neijing* (Yellow Emperor's Inner Classic) uses dozens of terms related to "fatigue," such as "jie ren yi," "heng jie," "kun bo," "dai lao," "xie lao," "si zhi bu you dong," and "suo wo." The *Jingyue Quanshu* (Complete Works of Jingyue) states, "If one does not know one's limits and insists on forcing oneself, then all reckless actions will lead to injury." The *Huangdi Neijing Suwen* (Plain Questions of the Yellow Emperor's Inner Classic) points out, "Prolonged staring injures the blood, prolonged lying injures the qi, prolonged sitting injures the flesh, prolonged standing injures the bones, and prolonged walking injures the tendons; these are called the five types of fatigue." The *Yijia Siyao* (Four Essentials of Medicine) also states, "Excessive mental activity strains the mind; excessive planning strains the liver; excessive thinking about unexpected events strains the spleen; worrying about matters beforehand strains the lungs; and excessive sexual desire strains the kidneys." Viral infections fall under the category of exogenous pathogenic factors. All six pathogenic factors can lead to dysfunction of the five internal organs. As Wu Cheng of the Qing Dynasty stated in his *Buju Ji*, deficiency and weakness are not solely caused by internal injury; exogenous pathogenic factors are also common. Furthermore, wind is not the primary pathogenic factor among the six exogenous pathogenic factors; all six can cause fatigue. Its etiology is both internal and external, involving multiple organs and systems. The nature of the disease can be deficiency or excess, or a mixture of both. Therefore, its pathogenesis can be summarized as deficiency and weakness of the internal organs, resulting in decreased bodily function and manifesting as fatigue.

[0004] Current Western medicine treatments primarily focus on symptomatic support, including immunosuppressive therapy, antidepressants, antivirals, sedatives and hypnotics, and high-dose vitamin supplements. These methods only alleviate some clinical symptoms, and Western medicines often have side effects and are prone to relapse, failing to provide effective improvement. Traditional Chinese medicine (TCM) has unique advantages in treating Qi and Yin deficiency type chronic fatigue syndrome. This invention proposes a TCM composition for treating Qi and Yin deficiency type chronic fatigue syndrome, providing a new strategy for its treatment. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine composition for treating chronic fatigue syndrome of Qi and Yin deficiency type and its application, thereby solving the problems existing in the prior art. The combined use of the herbs in this invention is based on tonifying Qi and nourishing blood, while also calming the mind and soothing the nerves. This formula greatly replenishes vital energy without causing internal heat, raises clear Yang and lowers turbid Yin, strengthens the foundation and nourishes the source. With strict compatibility and rational formulation, it has a significant therapeutic effect on chronic fatigue syndrome, especially fatigue syndrome of Qi and Yin deficiency type, and is worthy of clinical promotion and application.

[0006] To achieve the above objectives, the present invention provides the following solution:

[0007] This invention provides a traditional Chinese medicine composition for treating chronic fatigue syndrome of Qi and Yin deficiency type, comprising the following ingredients: ginseng 5-10g, raw astragalus 5-15g, cinnamon 3-6g, angelica 5-10g, white peony root 5-10g, kudzu root 5-15g, processed polygonatum 5-10g, agrimony 5-12g, ophiopogon 5-10g, raw dragon bone 9-15g, raw oyster shell 9-15g, albizia flower 5-10g, stir-fried jujube seed 10-20g, poria cocos 5-10g, poria cocos 5-10g, achyranthes bidentata 5-10g, and prepared licorice root 3-6g.

[0008] Furthermore, it includes the following ingredients: 6g ginseng, 15g raw astragalus, 3g cinnamon, 10g angelica, 10g white peony root, 12g kudzu root, 10g wine-processed polygonatum, 12g agrimony, 10g ophiopogon, 15g raw dragon bone, 15g raw oyster shell, 10g albizia flower, 20g stir-fried jujube seed, 10g poria cocos, 10g achyranthes bidentata, and 6g prepared licorice root.

[0009] The present invention also provides a traditional Chinese medicine preparation for treating chronic fatigue syndrome of Qi and Yin deficiency type, wherein the effective component of the traditional Chinese medicine preparation is the aforementioned traditional Chinese medicine composition.

[0010] Furthermore, it also includes carriers and excipients that are acceptable in traditional Chinese medicine.

[0011] The present invention also provides the application of the aforementioned traditional Chinese medicine composition or the aforementioned traditional Chinese medicine preparation in the preparation of a drug for treating chronic fatigue syndrome of Qi and Yin deficiency type.

[0012] Furthermore, the dosage form of the drug includes granules.

[0013] Furthermore, the method of administration of the drug includes oral and non-gastrointestinal administration.

[0014] Chronic fatigue syndrome, diagnosed as "xu lao" in Traditional Chinese Medicine (TCM), is believed to have two main causes: congenital and acquired. Those who develop xu lao in childhood often have a predominantly congenital cause, while those who develop it in adulthood often have a predominantly acquired cause. Factors such as congenital weakness, acquired diseases, overwork, and improper diet can lead to deficiencies in the Qi, blood, Yin, and Yang of the internal organs, preventing long-term recovery. Therefore, the pathological changes in "xu lao" of chronic fatigue syndrome are primarily related to the spleen and kidneys, but its pathological changes are also influenced by external environmental factors. The Lingnan region has a subtropical monsoon climate, and its population is predominantly young and middle-aged adults with a fast-paced lifestyle and high levels of stress. The common type of chronic fatigue syndrome in this region is Qi and Yin deficiency. Qi deficiency prevents the proper transformation and nourishment of nutrients, while Yin deficiency leads to insufficient nourishment of the limbs, joints, and sensory organs, resulting in this condition. The TCM formula of this invention (Yu Shen Xiao Pi Granules) is based on the holistic TCM diagnostic approach, regulating the functions of the internal organs to achieve therapeutic goals and effects. Through years of clinical application and experience, it is found that for such patients, emphasis is placed on harmonizing the body, mind, Qi, and blood. With the general principle of invigorating qi and nourishing yin, and strengthening the body's resistance, this formula also calms the mind and soothes the spirit. It greatly replenishes vital energy without causing fire, nourishes yin and dispels pathogens without generating dampness, raises clear yang and lowers turbid yin, strengthens the body's foundation and nourishes the original qi. When vital energy is sufficient, the spirit is at peace and sleep is good, and fatigue is relieved.

[0015] The herbal composition of this invention uses ginseng, astragalus, and cinnamon as the principal ingredients. Ginseng greatly replenishes vital energy and nourishes the deficiencies of the five internal organs. Raw astragalus "can replenish qi, raise qi, and consolidate the exterior." It can both replenish the qi of the lungs and spleen and also play a role in raising clear yang and consolidating the exterior. When used together with ginseng, it enhances the effect of replenishing qi and nourishing vital energy. The addition of cinnamon is intended to utilize its warming and blood-circulating properties, which can guide other herbs into the blood and also warm the kidneys and assist yang. As stated in *Ancient and Modern Famous Physicians' Prescriptions*: "Ginseng and astragalus cannot achieve their effects independently without cinnamon as a guide; the three herbs combined work together to invigorate qi, warm yang, and unblock blood vessels." The addition of wine-processed polygonatum nourishes the yin qi of the lungs, spleen, and kidneys. The *Huangdi Neijing* states: "At the age of forty, a person's yin qi is halved," hence polygonatum is specifically used to nourish yin qi. Its wine-processing nature is mild and does not harm the spleen and stomach. As mentioned earlier, ginseng, astragalus, and cinnamon warm and nourish yang qi. Wine-processed polygonatum, combined with ophiopogon japonicus, nourishes yin qi, replenishes qi, and generates fluids, thus achieving a dual tonification of yin and yang qi, complementing each other and also counteracting the dryness of ginseng, astragalus, and cinnamon. Ophiopogon japonicus, combined with ginseng, further enhances its blood-activating properties. Agrimonia pilosa, also known as the "decompression herb," ​​strengthens the body and replenishes deficiencies. The main ingredient in the "Three Immortals Decoction," a formula created by the famous physician Gan Zuwang for strengthening the body and replenishing deficiencies, is a key ingredient. Angelica sinensis is combined with white peony root... Nourishing and invigorating blood also has the effect of nourishing yin blood, combining movement and stillness. Poria cocos calms the mind and soothes the nerves, while Poria cocos strengthens the spleen and eliminates dampness. Furthermore, ginseng combined with Poria cocos replenishes the original qi of the lower jiao and clears the fire in the kidneys, nourishing yin and dispelling evil without generating dampness. Albizia julibrissin flower relieves depression and calms the mind, while stir-fried jujube seed nourishes blood and calms the mind, working together to nourish the mind and soothe the nerves, resulting in good sleep, sufficient vital energy, and the elimination of fatigue. Raw dragon bone and raw oyster shell can store yang qi and protect the original qi. Combined with astragalus, they strengthen the exterior, preventing excessive dissipation and protecting the ying and wei qi, ensuring that "when the righteous qi is stored internally, evil cannot invade." Prepared licorice not only assists ginseng and astragalus in replenishing qi, tonifying the spleen and harmonizing the middle jiao, but also harmonizes the effects of the other herbs. Kudzu root acts as an adjuvant, raising clear yang and also has the effect of generating fluids and moistening dryness, thus nourishing yin. Achyranthes bidentata guides fire downwards. When combined with kudzu root, it can raise clear yang and lower turbid qi. When combined with cinnamon, it enhances the warming yang, invigorating blood, and unblocking the meridians.

[0016] The present invention discloses the following technical effects:

[0017] This invention combines various herbs with the overall principle of tonifying Qi and nourishing Yin, strengthening the body's resistance and consolidating its foundation, while also calming the mind and soothing the nerves. This formula greatly replenishes vital energy without generating heat, nourishes Yin and dispels pathogens without producing dampness, raises clear Yang and lowers turbid Yin, consolidating the foundation and nourishing the source. It effectively targets the pathogenesis of chronic fatigue syndrome of Qi and Yin deficiency type, with strict compatibility and a rational formulation. Clinical trials have verified that the herbal composition provided by this invention can alleviate symptoms such as fatigue, drowsiness, and dizziness in patients with chronic fatigue syndrome, especially those experiencing fatigue after viral infection, and has the effects of tonifying Qi and raising Yang, and strengthening the body's exterior. A three-month follow-up study revealed significant long-term effects, making it worthy of clinical promotion and application. Detailed Implementation

[0018] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0019] It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the invention. Furthermore, with respect to numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any stated value or intermediate value within a stated range, as well as each smaller range between any other stated value or intermediate value within said range, is also included in this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0020] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein may be used in the implementation or testing of this invention. All references to this specification are incorporated by way of citation to disclose and describe methods and / or materials associated with those references. In the event of any conflict with any incorporated reference, the content of this specification shall prevail.

[0021] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be readily apparent to those skilled in the art. This specification and embodiments are merely exemplary.

[0022] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0023] Unless otherwise specified, the experimental methods used in the following examples are conventional methods, performed according to the techniques or conditions described in the literature in this field or according to the product instructions. Unless otherwise specified, the materials and reagents used in the following examples are commercially available.

[0024] Example 1

[0025] A traditional Chinese medicine granule for treating chronic fatigue syndrome of Qi and Yin deficiency type, comprising the following components by weight:

[0026] Ginseng 6g, raw astragalus 15g, cinnamon 3g, angelica 10g, white peony root 10g, kudzu root 12g, wine-processed polygonatum 10g, agrimony 12g, ophiopogon 10g, raw dragon bone 15g, raw oyster shell 15g, albizia flower 10g, stir-fried jujube seed 20g, poria cocos 10g, poria cocos 10g, achyranthes bidentata 10g, and prepared licorice root 6g.

[0027] Preparation method: The traditional Chinese medicine granules are prepared using existing conventional granule preparation methods, as shown below:

[0028] Mix the above-mentioned medicinal materials, add water and decoct. The amount of water used each time is 8 times the weight of the medicinal materials. Decoction is carried out twice, 1 hour each time. The two decoctions are combined and concentrated under reduced pressure to obtain concentrated liquid.

[0029] Add anhydrous ethanol to the concentrate until the ethanol content is 60 vol%, let stand, filter to obtain filtrate, remove the ethanol from the filtrate, and concentrate under reduced pressure to obtain a thick paste.

[0030] The thick paste and dextrin (excipient) are mixed evenly at a mass ratio of 10:1, dried, and granulated to obtain the Chinese medicine granules for treating chronic fatigue syndrome of qi and yin deficiency type.

[0031] The above-mentioned Chinese herbal granules were packaged in 10g bags and named Yu Shen Xiao Pi Granules.

[0032] Example 2

[0033] A traditional Chinese medicine granule for treating chronic fatigue syndrome of Qi and Yin deficiency type, comprising the following components by weight:

[0034] Ginseng 5g, raw astragalus 5g, cinnamon 3g, angelica 5g, white peony root 5g, kudzu root 5g, wine-processed polygonatum 5g, agrimony 5g, ophiopogon japonicus 5g, raw dragon bone 9g, raw oyster shell 9g, albizia flower 5g, stir-fried jujube seed 10g, poria cocos 5g, poria cocos 5g, achyranthes bidentata 5g, and prepared licorice root 3g.

[0035] The preparation method is the same as in Example 1.

[0036] Example 3

[0037] A traditional Chinese medicine granule for treating chronic fatigue syndrome of Qi and Yin deficiency type, comprising the following components by weight:

[0038] Ginseng 10g, raw astragalus 15g, cinnamon 6g, angelica 10g, white peony root 10g, kudzu root 15g, wine-processed polygonatum 10g, agrimony 12g, ophiopogon 10g, raw dragon bone 15g, raw oyster shell 15g, albizia flower 10g, stir-fried jujube seed 20g, poria cocos 10g, poria cocos 10g, achyranthes bidentata 10g, and prepared licorice root 6g.

[0039] The preparation method is the same as in Example 1.

[0040] Comparative Example 1

[0041] A traditional Chinese medicine granule for treating chronic fatigue syndrome of Qi and Yin deficiency type, comprising the following components by weight:

[0042] Ginseng 6g, raw astragalus 15g, white peony root 3g, angelica 10g, cinnamon 10g, kudzu root 12g, wine-processed polygonatum 10g, agrimony 12g, ophiopogon 10g, raw dragon bone 15g, raw oyster shell 15g, albizia flower 10g, stir-fried jujube seed 20g, poria cocos 10g, poria cocos 10g, achyranthes bidentata 10g, prepared licorice root 6g.

[0043] The preparation method is the same as in Example 1.

[0044] Comparative Example 2

[0045] A traditional Chinese medicine granule for treating chronic fatigue syndrome of Qi and Yin deficiency type, comprising the following components by weight:

[0046] Ginseng 6g, raw astragalus 15g, cinnamon 3g, angelica 10g, white peony root 10g, kudzu root 12g, wine-processed polygonatum 10g, agrimony 12g, ophiopogon 10g, alisma 15g, peach kernel 15g, safflower 15g, salvia miltiorrhiza 15g, poria cocos 10g, achyranthes bidentata 10g, prepared licorice root 6g.

[0047] The preparation method is the same as in Example 1.

[0048] Example of effect

[0049] 1. Effect Verification

[0050] 1.1 Experimental Methods

[0051] This invention is based on the 1994 diagnostic criteria of the Centers for Disease Control and Prevention (CDC): Patients have clinically assessed, unexplained, persistent or recurrent chronic fatigue symptoms that are new or have a clear onset (e.g., not lifelong), are not the result of sustained exertion, are not adequately relieved by rest, and have led to a significant decline in work, education, social or personal activity levels compared to the past; and four or more of the following symptoms are present simultaneously and have been present or recurrent for three months or longer: (1) post-exertional discomfort (a general feeling of discomfort or unease, a nonspecific feeling, often a precursor to sensory or other illnesses) lasting more than 24 hours; (2) sleep that does not relieve fatigue; (3) severe short-term memory or attention deficit; (4) a new type, pattern or severity of headache; (5) muscle pain; and (6) polyarticular pain without joint swelling or redness.

[0052] A total of 324 patients meeting the criteria for "Qi and Yin deficiency type fatigue syndrome" were selected. They were randomly divided into three groups: Example 1 group, Comparative Example 1 group, and Comparative Example 2 group. Example 1 group was treated with the herbal granules of Example 1, Comparative Example 1 group was treated with the herbal granules of Comparative Example 1, and Comparative Example 2 group was treated with the herbal granules of Comparative Example 2. Dosage: One packet twice daily after meals, for a course of 4 weeks.

[0053] 1.2 Observation Indicators

[0054] Fatigue symptom and sign score, Fatigue Severity Scale (FSS), Qi deficiency syndrome score, and TCM meridian detection.

[0055] 1.3 Efficacy Evaluation Criteria

[0056] According to the TCM syndrome and symptom efficacy evaluation criteria: the efficacy is determined by the overall TCM syndrome score and the individual symptom scores, with reference to the "Guiding Principles for Clinical Research of New Chinese Medicines".

[0057] ① Cured: The clinical symptoms and signs in traditional Chinese medicine have disappeared or basically disappeared, n≥95%;

[0058] ②Significant effect: Significant improvement in TCM clinical symptoms and signs, 70% ≤ n < 95%;

[0059] ③ Effective: Clinical symptoms and signs in Traditional Chinese Medicine improved, with 30% ≤ n < 70%;

[0060] ④ Ineffective: No significant improvement in TCM clinical symptoms and signs, or even worsening, n < 30%.

[0061] 1.4 Overall Efficacy Assessment Criteria

[0062] Significant efficacy = (Number of cured cases in this group + Number of cases with significant improvement in this group) / Total number of cases in this group × 100%.

[0063] Effective rate = (Number of cured cases in this group + Number of cases with significant improvement in this group + Number of effective cases in this group) / Total number of cases in this group × 100%.

[0064] Total efficiency = apparent efficiency + efficiency.

[0065] The experimental results are shown in Table 1:

[0066] Table 1. Therapeutic effects of each group

[0067] Example 1 Group 11 75 22 79.63 20.37 Comparative Example 1 5 64 39 63.89 36.11 Comparative Example 2 0 59 49 54.63 45.37

[0068] The experimental results above show that the total effective rate of Example 1 group reached over 79%, and the ineffective rate was less than 21%, while the total effective rates of Comparative Examples 1-2 were all below 64%, showing a significant difference from Example 1 group. Therefore, the traditional Chinese medicine composition provided by this invention can treat chronic fatigue syndrome of Qi and Yin deficiency type and has a significant therapeutic effect.

[0069] 1.5 Long-term effect survey

[0070] A three-month follow-up study was conducted on 86 patients in the Example 1 group. Of these, 56 patients showed no significant relapse, 26 patients experienced mild relapse, and 4 patients experienced severe relapse. This indicates that the traditional Chinese medicine composition provided by this invention for treating chronic fatigue syndrome of Qi and Yin deficiency type has significant long-term effects and is worthy of clinical promotion and application.

[0071] 2. Typical Cases

[0072] Case 1: Mr. Xu, male, presented with chronic fatigue for 4 months after being diagnosed with Qi and Yin deficiency in December 2022. He frequently experienced diarrhea, 6-7 times per day, and stomach pain and diarrhea after consuming cold foods. He was also prone to abdominal distension, belching, aversion to cold and wind, urinary incontinence and hesitancy, and had fair sleep but poor appetite. After taking the Yu Shen Xiao Pi Granules of this invention for 4 weeks, his energy improved, fatigue lessened, appetite improved, and bowel movements became 1-2 times per day.

[0073] Case 2: Ms. Meng, suffering from Qi and Yin deficiency, experienced heaviness and fatigue for 3 months, weakness in her limbs, significant memory decline, increased melasma, scanty menstruation, and light, easily awakened sleep with frequent dreams. After taking the Yu Shen Xiao Pi Granules of this invention for 4 weeks, her fatigue significantly improved, she slept soundly, her complexion became rosy, and there was no recurrence.

[0074] Case 3: Ms. Lan, a patient with Qi and Yin deficiency, experienced significant fatigue and weakness that had persisted for two months without improvement. She experienced shortness of breath upon exertion, occasional chest tightness, decreased interest, difficulty falling asleep, poor appetite, and a weight loss of 4 catties. After taking the Yu Shen Xiao Pi Granules of this invention for two weeks, her fatigue significantly improved, she fell asleep quickly, experienced no chest tightness or sweating, felt energetic, and the fatigue did not recur.

[0075] Case 4: Mr. Zheng, male, 26 years old, had experienced fatigue and weakness for 2 years, accompanied by lower back pain for 1 year. For the past two years, he had experienced fatigue, weakness, shortness of breath, occasional palpitations, a feeling of blockage in his throat, and occasional lower back and leg weakness due to work pressure. Treatment with both traditional Chinese and Western medicine over the past two years had little effect. After taking the Yu Shen Xiao Pi Granules of this invention for 4 weeks, his fatigue significantly improved, his lower back pain disappeared, he felt stronger in his legs, the feeling of blockage in his throat largely disappeared, he experienced no chest tightness or sweating, he felt energetic, gained weight, and the fatigue did not recur.

[0076] In summary, the traditional Chinese medicine composition provided by this invention can relieve symptoms such as fatigue, drowsiness, and dizziness in patients with chronic fatigue syndrome, and has the effects of tonifying qi and raising yang, and strengthening qi and consolidating the exterior. Clinical trials have verified that this medicine is effective in treating fatigue syndrome. After a 3-month follow-up survey, the long-term effect is quite significant, and it is worthy of clinical promotion and application.

[0077] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A traditional Chinese medicine composition for treating chronic fatigue syndrome of Qi and Yin deficiency type, characterized in that, It is composed of the following ingredients: ginseng 5-10g, raw astragalus 5-15g, cinnamon 3-6g, angelica 5-10g, white peony root 5-10g, kudzu root 5-15g, wine-processed polygonatum 5-10g, agrimony 5-12g, ophiopogon japonicus 5-10g, raw dragon bone 9-15g, raw oyster shell 9-15g, albizia flower 5-10g, stir-fried jujube seed 10-20g, poria cocos 5-10g, poria cocos 5-10g, achyranthes bidentata 5-10g, and prepared licorice root 3-6g.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, It is composed of the following ingredients: ginseng 6g, raw astragalus 15g, cinnamon 3g, angelica 10g, white peony root 10g, kudzu root 12g, wine-processed polygonatum 10g, agrimony 12g, ophiopogon 10g, raw dragon bone 15g, raw oyster shell 15g, albizia flower 10g, stir-fried jujube seed 20g, poria cocos 10g, poria cocos 10g, achyranthes bidentata 10g, and prepared licorice root 6g.

3. A traditional Chinese medicine preparation for treating chronic fatigue syndrome of Qi and Yin deficiency type, characterized in that, The effective component of the traditional Chinese medicine preparation is the traditional Chinese medicine composition as described in claim 1 or 2.

4. The traditional Chinese medicine preparation for treating chronic fatigue syndrome of Qi and Yin deficiency type according to claim 3, characterized in that, It also includes carriers and excipients that are acceptable in traditional Chinese medicine.

5. The use of the traditional Chinese medicine composition according to any one of claims 1-2 or the traditional Chinese medicine preparation according to any one of claims 3-4 in the preparation of a medicament for treating chronic fatigue syndrome of Qi and Yin deficiency type.

6. The application according to claim 5, characterized in that, The drug is in granule form.