Biological medicine low-temperature freeze-drying experimental device

Abstract

The application provides a biological medicine low-temperature freeze-drying experimental device, which comprises a freeze-drying machine body, a freeze-drying bin is arranged in the freeze-drying machine body, a movable freeze-drying frame assembly is arranged in the freeze-drying bin, the freeze-drying frame assembly comprises an outer frame, a movable frame, a tray, a turnover driving device and a displacement driving assembly, the outer frame is driven to rotate by the turnover driving device arranged in the freeze-drying machine body, and the freeze-drying frame assembly is inclined forward or backward and is moved to a reduced-pressure evaporation position or a low-temperature freezing position, respectively; the movable frame is arranged on the inner side of the outer frame, is driven by the displacement driving assembly and slides transversely along the outer frame, the tray is slidably arranged on the inner side of the movable frame, a discharging groove is arranged at the front end of the tray, a heating block is arranged in the discharging groove, a clamping seat is arranged on the heating block, the strip-shaped bone raw material is clamped and fixed by the clamping seat, the freeze-drying frame assembly is inclined backward by the turnover driving device, so that the strip-shaped bone raw material is in a state of hanging downward, the problem of icing and adhesion caused by the contact between the strip-shaped bone raw material and the tray is avoided, and the freeze-drying quality is ensured.

Description

Technical Field

[0001] This invention belongs to the field of collagen matrix processing technology, specifically relating to a biomedical low-temperature freeze-drying experimental device for use in oral collagen matrix materials. Background Technology

[0002] Currently, dental socket filling materials can be broadly categorized into synthetic materials and biomaterials. Synthetic materials are gradually being replaced by biomaterials, which are often made from pig or bovine bone. Biomaterials degrade in the human body almost in sync with tissue repair, and their degradation products do not alter the local environment, thus not affecting periodontal tissue repair or bone regeneration in the extraction socket; in fact, they promote bone regeneration in the extraction socket. Before final packaging, biomaterials undergo freeze-drying to extend their shelf life and maintain their stability.

[0003] Currently, when freeze-drying strips of biological bone material processed through a series of biochemical methods, the strips must be manually and neatly laid out in containers one by one, and then the containers are placed one by one on the freeze-drying rack in the freeze dryer. This process is relatively cumbersome, and the flat placement can easily cause the strips of bone material to bend and deform, thus affecting the quality of subsequent cutting. Because the strips of bone material are in a low-temperature and humid state after the rinsing process, ice can form between adjacent strips, causing them to stick together. Furthermore, the bottom of the strips of bone material is prone to incomplete freeze-drying, which can also cause ice to form between the strips of bone material and the container. Ultimately, it is difficult to separate the strips of bone material after freeze-drying, thus affecting the quality of the dental filling material. Summary of the Invention

[0004] The main objective of this invention is to provide a low-temperature freeze-drying experimental device for biomedicine, which enables strip-shaped bone raw materials to remain straight during freeze-drying, preventing the bone raw materials from freezing and sticking together, thus ensuring product quality.

[0005] The specific technical solution is as follows: A low-temperature freeze-drying experimental apparatus for biomedicine includes a freeze dryer body. The freeze dryer body contains a freeze-drying chamber. An inlet / outlet channel is inclined at the lower front side of the freeze-drying chamber, and a door is provided at the front opening of the inlet / outlet channel. The inner wall of the front of the freeze-drying chamber is inclined, and a sealing plate is protruding on the inner wall of the front of the freeze-drying chamber. A vacuum suction port is provided on the sealing plate and is connected to a vacuum pump via a pipeline. A freeze-drying rack assembly is movably mounted inside the freeze-drying chamber. The freeze-drying rack assembly includes an outer frame, a movable frame, a material tray, and a tilting drive device. The outer frame includes a displacement drive assembly. Symmetrical rotating shafts are located at the upper ends of both sides of the outer frame. These shafts horizontally penetrate both sides of the freeze-drying chamber and are driven to rotate by a tilting drive device located within the freeze dryer body. This causes the freeze-drying rack assembly to tilt forward or backward and move to either the reduced-pressure evaporation position or the low-temperature freezing position, respectively. Several movable frames are arranged sequentially inside the outer frame, and all movable frames are slidably connected to the outer frame. Except for the foremost movable frame, each movable frame is driven by a displacement drive assembly located at the upper end of the outer frame and slides laterally along the outer frame. The material trays are longitudinally slidable inside the movable frame. Each material tray has a handle at the bottom and a feeding groove at the front end. A sealing gasket is located around the feeding groove of each material tray. Several heating blocks are located in the feeding groove, and each heating block has a clamping seat for fixing the strip-shaped bone material. When the freeze-drying rack assembly tilts backward and moves to the low-temperature freezing position, the strip-shaped bone material in each clamping seat hangs down under gravity and is frozen by the freeze dryer's cooling system. Except for the last material tray, each... The material trays all have transverse through holes, so that when the freeze-drying rack assembly tilts forward and moves to the depressurization evaporation position, the displacement drive assembly drives the movable frame and material trays to move forward and fit together. The bottom of the freeze-drying chamber is equipped with a pressure sealing mechanism, which is used to press the material tray at the rear end forward and make the material tray at the front end abut against the sealing plate. At the same time, several material trays are tightly fitted together and connected through through holes, so that the vacuum suction port can depressurize the material trays and the heating block can evaporate the moisture in the material trays.

[0006] Furthermore, both the outer frame and the movable frame have an inverted U-shaped structure. The inner walls on both sides of the outer frame are symmetrically provided with slide rails, which are arranged along the front and rear ends of the outer frame. The outer walls on both sides of the movable frame are slidably connected to the slide rails by sliders, realizing the lateral sliding connection between the movable frame and the outer frame. The inner walls on both sides of the movable frame and the outer walls on both sides of the material tray are provided with longitudinally cooperating guide rail assemblies, so that the material tray and the movable frame are longitudinally slidably connected. The top of the material tray is magnetically attracted and fixed to the inner wall of the top of the movable frame by magnets.

[0007] Furthermore, the top of the outer frame is provided with an equipment compartment, and the bottom of the equipment compartment is provided with an opening. The displacement drive assembly is installed inside the equipment compartment. The displacement drive assembly includes a servo motor, a worm gear, a worm wheel, a transmission rod, a lead screw, and a flexible shaft seat. The servo motor is located on the top of the outer frame, and its output end extends longitudinally into the equipment compartment and connects to the worm gear. One side of the worm gear meshes with the worm wheel, which is mounted on the transmission rod. The transmission rod is horizontally rotatable in the equipment compartment via a rotating seat, and both ends of the transmission rod are provided with active bevel gears. The number of lead screws is several groups, and the pitch and lead of each group of lead screws are different. Each group of lead screws consists of two screws distributed on the left and right sides of the equipment compartment. Each lead screw has two ends rotatably mounted on elastic bearings, allowing the lead screw to move laterally between the two elastic bearings under external force. Adjacent lead screws are connected by a transmission wheel and a transmission belt. The lead screw closest to the transmission rod has a driven bevel gear that meshes with the driving bevel gear. The driven bevel gear is located on the side of the driving bevel gear closest to the sealing plate, so that the servo motor drives each lead screw to rotate through the transmission rod. Each lead screw is threaded with a threaded seat. The lower end of the threaded seat on the same set of lead screws passes through the movable opening and is fixedly connected to the top of the same movable frame, so that the displacement drive assembly drives each movable frame to move a different distance, and makes the material trays fit together or separate.

[0008] Furthermore, the top of the freeze-drying chamber is inclined and has a accommodating compartment for housing the servo motor. When the freeze-drying rack assembly tilts backward and moves to the low-temperature freezing position, the servo motor moves into the accommodating compartment under the drive of the outer frame. The top of the outer frame is attached to the bottom of the freeze-drying chamber to achieve a seal for the accommodating compartment.

[0009] Furthermore, each of the elastic bearings includes a bearing housing, a bushing, and a spring. The bearing housing has a receiving groove for accommodating the bushing, and the spring is disposed in the receiving groove. The spring supports the bushing outward. One end of the bushing is closed, and the other end of the bushing is sleeved on one end of the lead screw.

[0010] Furthermore, the bottom of the freeze-drying chamber is provided with a drive chamber for accommodating the pressure sealing mechanism. The pressure sealing mechanism includes a drive cylinder, a tilting arm, and a pressure plate. The tilting arm is L-shaped and bent. The middle part of the tilting arm is hinged to the upper end of the drive chamber through a hinge shaft. The lower end of the tilting arm is hinged to the piston rod of the drive cylinder. The drive cylinder is hinged in the drive chamber through a hinge seat. The other end of the tilting arm is located at the bottom of the freeze-drying chamber, and the pressure plate is provided on the other end of the tilting arm. This allows the drive cylinder to drive the tilting arm to rotate counterclockwise and press the material tray in the freeze-drying rack assembly forward through the pressure plate, so that the material trays are tightly fitted together by the sealing gasket, thereby sealing the material discharge trough.

[0011] Furthermore, the clamping seat includes two symmetrically arranged clamping plates. The front and rear ends of the two clamping plates are both outwardly expanded. The middle part of the two clamping plates is closely arranged to clamp and fix the top end of the strip bone material. Several through holes are opened laterally in the middle part of the clamping plates.

[0012] Furthermore, the inclination direction of the feed channel is the same as the inclination direction of the tray located at the reduced pressure evaporation position, and the height dimension of the feed channel is greater than the sum of the thicknesses of several trays.

[0013] The beneficial effects of this invention are reflected in: (1) Compared with the traditional flat placement structure, the freeze-drying rack assembly of the present invention uses a longitudinally arranged material tray with a clamping seat to clamp and fix the strip bone raw material. Then, the freeze-drying rack assembly is tilted backward by a flipping drive device, so that the strip bone raw material can be in a hanging and suspended state, effectively avoiding the problem of freezing and sticking due to full contact with the material tray, and allowing the bone raw material to be fully frozen, thereby ensuring the freeze-drying quality.

[0014] (2) In this invention, the displacement drive component drives the movable frame to move, so that the material tray group can shrink or expand. When performing depressurization evaporation, the drive cylinder drives the flipping arm to flip, so that the pressure plate presses the material tray. The material tray and the screw move towards the front end, so that the material tray presses against the sealing plate and the material trays fit tightly together, ensuring the sealing of the discharge trough and meeting the vacuum suction requirements for the sealing between the material trays. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the structure of the present invention.

[0016] Figure 2 This is a schematic diagram of the freeze-drying rack assembly in the present invention when it is located in the low-temperature freezing position.

[0017] Figure 3 This is a schematic diagram of the freeze-drying rack assembly in the present invention when it is located in the reduced pressure evaporation position.

[0018] Figure 4 This is a schematic diagram of the structure of the freeze-drying rack assembly during loading and unloading in this invention. Figure 5 This is a side sectional view of the freeze-drying rack assembly in this invention.

[0019] Figure 6 This is a front view of the freeze-drying rack assembly in this invention.

[0020] Figure 7 This is a schematic diagram of the displacement driving component in this invention.

[0021] Figure 8This is a schematic diagram of the structure of the elastic bearing in this invention.

[0022] Figure 9 This is a schematic diagram of the clamping seat in this invention.

[0023] Explanation of reference numerals in the attached drawings: 1. Freeze dryer body; 2. Freeze drying chamber; 21. Inlet / outlet channel; 22. Door; 23. Sealing plate; 24. Vacuum suction port; 25. Containing chamber; 26. Drive chamber; 27. Vacuum pump. Freeze-drying rack assembly 3, outer frame 31, rotating shaft 311, slide rail 312, equipment compartment 313, movable opening 314, movable frame 32, material tray 33, material discharge trough 331, sealing gasket 332, heating block 333, clamping seat 334, clamping plate 335, through hole 3351, through hole 336, guide rail assembly 337, handle 338; Displacement drive assembly 4, servo motor 41, worm gear 42, worm wheel 43, transmission rod 44, lead screw 45, transmission wheel 451, transmission belt 452, elastic bearing 46, bearing housing 461, bushing 462, spring 463, driving bevel gear 47, driven bevel gear 48, threaded seat 49; The pressure sealing mechanism 5, the drive cylinder 51, the tilting arm 52, and the pressure plate 53 are included. Detailed Implementation

[0024] To make the technical solution of this invention clearer and more explicit, the invention will be further described below with reference to the accompanying drawings. Any solution derived by equivalent substitution and conventional reasoning of the technical features of this invention falls within the protection scope of this invention. The fixed connections and fixed installations mentioned in this invention are all common connection methods in the mechanical field, including welding, bolt and nut connections, and screw connections.

[0025] In the description of this invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0026] like Figure 1-9As shown, this embodiment provides a low-temperature freeze-drying experimental device for biomedicine, including a freeze dryer body 1, a freeze-drying chamber 2 inside the freeze dryer body 1, an inlet / outlet channel 21 inclined at the lower front end of the freeze-drying chamber 2, and a door 22 at the front opening of the inlet / outlet channel 21. The inner wall of the front end of the freeze-drying chamber 2 is inclined, and a sealing plate 23 is protruding on the inner wall of the front end of the freeze-drying chamber 2. The sealing plate 23 is provided with a vacuum suction port 24, which is connected to a vacuum pump 27 through a pipeline. The freeze-drying rack assembly 3 is movably installed inside the freeze-drying chamber 2. The freeze-drying rack assembly 3 includes an outer frame 31, a movable frame 32, a tray 33, a tilting drive device, and a displacement drive assembly 4. The upper ends of both sides of the outer frame 31 are symmetrically provided with rotating shafts 311, which are located near the sealing plate 23. The rotating shafts 311 horizontally pass through both sides of the freeze-drying chamber 2 and are driven to rotate by the tilting drive device installed in the freeze dryer body 1. The tilting drive device is a drive motor (not shown in the figure) installed in the freeze dryer body 1, which causes the freeze-drying rack assembly 3 to tilt forward or backward and move to the reduced pressure evaporation position or the low temperature freezing position, respectively.

[0027] Three movable frames 32 are arranged sequentially on the inner side of the outer frame 31, and all movable frames 32 are slidably connected to the outer frame 31. Except for the frontmost movable frame 32, each movable frame 32 is driven by a displacement drive component 4 set on the upper end of the outer frame 31 and slides laterally along the outer frame 31. The material trays 33 are longitudinally slidably arranged on the inner side of the movable frames 32. Each material tray 33 has a handle 338 at the bottom and a feeding groove 331 at the front end of each material tray 33. Each material tray 33 has a sealing gasket 332 on the outside of the feeding groove 331. Several heating blocks 333 are provided in the feeding groove 331. Each heating block 333 is provided with a clamping seat 334 for fixing the strip bone raw material. When the freeze-drying rack assembly 3 tilts backward and moves to the low-temperature freezing position, the strip bone raw material is flexible after the previous process, so the strip bone raw material in each clamping seat 334 hangs down and is suspended in the air under the action of gravity, and is frozen by the freeze dryer cooling system. Except for the last tray 33, each tray 33 has a transverse through-hole 336 in its feeding slot 331. When the freeze-drying rack assembly 3 tilts forward and moves to the depressurization evaporation position, the displacement drive assembly 4 drives the movable frame 32 and the trays 33 to move forward and fit together. The bottom of the freeze-drying chamber 2 is provided with a pressure sealing mechanism 5, which is used to press the tray 33 at the last end forward and make the tray 33 at the front end abut against the sealing plate 23. At the same time, the three trays 33 are tightly fitted together and connected through the through-hole 336, so that the vacuum suction port 24 can depressurize the contents of the trays 33 and the heating block 333 can evaporate the moisture in the trays 33.

[0028] Both the outer frame 31 and the movable frame 32 have an inverted U-shaped structure. The inner walls on both sides of the outer frame 31 are symmetrically provided with slide rails 312. The slide rails 312 are arranged along the front and rear ends of the outer frame 31. The outer walls on both sides of the movable frame 32 are slidably connected to the slide rails 312 through sliders, so as to realize the lateral sliding connection between the movable frame 32 and the outer frame 31. The inner walls on both sides of the movable frame 32 and the outer walls on both sides of the material tray 33 are provided with mutually cooperating guide rail assemblies 337 in the longitudinal direction, so that the material tray 33 and the movable frame 32 are slidably connected in the longitudinal direction. The top of the material tray 33 is magnetically attracted and fixed to the top inner wall of the movable frame 32 by a magnet (not shown in the figure). The thickness of the material tray 33 is greater than the thickness of the movable frame 32, so that the material trays 33 can fit together to seal.

[0029] The outer frame 31 has an equipment compartment 313 at its top. The bottom of the equipment compartment 313 has two openings 314 on each side. A displacement drive assembly 4 is installed inside the equipment compartment 313. The displacement drive assembly 4 includes a servo motor 41, a worm gear 42, a worm wheel 43, a transmission rod 44, a lead screw 45, and an elastic bearing 46. The servo motor 41 is located at the top of the outer frame 31, and its output end extends longitudinally into the equipment compartment 313 and connects to the worm gear 42. The worm gear 42 is rotatably mounted in the equipment compartment 313. One side of the worm gear 42 meshes with the worm wheel 43, which is mounted on the transmission rod 44. The transmission rod 44 is horizontally rotatably mounted in the equipment compartment 313 via a rotating seat. Both ends of the transmission rod 44 are equipped with active bevel gears 47. There are two sets of lead screws 45, each with a different pitch and lead. Two lead screws 45 are distributed at the left and right ends of the equipment compartment 313. Each lead screw 45 is rotatably mounted on an elastic bearing 46 at both ends, allowing the lead screw 45 to move laterally between the two elastic bearings 46 under the action of external force. Adjacent lead screws 45 are connected by a transmission wheel 451 and a transmission belt 452. The lead screw 45 closest to the transmission rod 44 is provided with a driven bevel gear 48 that meshes with the active bevel gear 47, so that the servo motor 41 drives each lead screw 45 to rotate through the transmission rod. Each lead screw 45 is threaded with a threaded seat 49 corresponding to its thread direction. The lower end of the threaded seat 49 on the same set of lead screws 45 passes through the movable opening 314 and is fixedly connected to the top of the same movable frame 32, so that the displacement drive assembly 4 drives each movable frame 32 to move a different distance, and causes the material trays 33 to fit together or separate.

[0030] In this embodiment, the driven bevel gear 48 is located on the side of the driving bevel gear 47 near the sealing plate 23. When the pressing and sealing mechanism 5 pushes the material tray 33 forward, the material tray 33, the movable frame 32, and the lead screw 45 move forward. The driven bevel gear 48 can move forward and separate from the driving bevel gear 47. After the pressing and sealing mechanism 5 is reset, the lead screw 45 can be reset under the action of the elastic shaft seat 46, and the driven bevel gear 48 can re-mesh with the driving bevel gear 47, so that the transmission operation can be performed again.

[0031] In this embodiment, to prevent the servo motor 41 from being damaged by low temperature inside the freeze-drying chamber 2, the top of the freeze-drying chamber 2 is inclined and has a receiving chamber 25 for accommodating the servo motor 41. When the freeze-drying rack assembly 3 tilts backward and moves to the low-temperature freezing position, the servo motor 41 moves into the receiving chamber 25 under the drive of the outer frame 31. At this time, the top of the outer frame 31 is attached to the bottom of the freeze-drying chamber 2 to seal the receiving chamber 25. The top of the outer frame 31 is also provided with a sealing gasket to improve the sealing performance, thereby reducing the impact of the low temperature inside the freeze-drying chamber 2 on the motor equipment.

[0032] In this embodiment, each elastic bearing 46 includes a bearing housing 461, a bushing 462, and a spring 463. The bearing housing 461 has a receiving groove for accommodating the bushing 462, and the spring 463 is disposed in the receiving groove, supporting the bushing 462 outward. One end of the bushing 462 is closed, and the other end of the bushing 462 is sleeved on one end of the lead screw 45 through a bearing. The outer wall of the bushing 462 and the opening of the receiving groove are limited by a limiting structure. The lead screw 45 between the two elastic bearings 46 has a telescoping variable through the elastic structure, so that it can move back and forth with the movable frame 32 under the action of external force.

[0033] In this embodiment, the clamping base 334 includes two symmetrically arranged clamping plates 335. The clamping plates 335 are made of metal and have a certain degree of elasticity. The front and rear ends of the two clamping plates 335 are both outwardly expanded. The middle part of the two clamping plates 335 is closely arranged to clamp and fix the top end of the strip bone material. Several through holes 3351 are opened laterally in the middle part of the clamping plate 335. By adding the through hole 3351 structure, the contact area between the clamping plate 335 and the bone material is reduced, so as to avoid the problem of freezing and adhesion.

[0034] The bottom of the freeze-drying chamber 2 is provided with a drive chamber 26 for accommodating the pressure sealing mechanism 5. The pressure sealing mechanism 5 includes a drive cylinder 51, a tilting arm 52, and a pressure plate 53. The tilting arm 52 is L-shaped and bent. The middle part of the tilting arm 52 is hinged to the upper end of the drive chamber 26 through a hinge shaft. The lower end of the tilting arm 52 is hinged to the piston rod of the drive cylinder 51. The drive cylinder 51 is hinged in the drive chamber 26 through a hinge seat. The other end of the tilting arm 52 is located at the bottom of the freeze-drying chamber 2, and the pressure plate 53 is provided on the other end of the tilting arm 52. This causes the drive cylinder 51 to drive the tilting arm 52 to rotate counterclockwise along the hinge shaft and press the material tray 33 in the freeze-drying rack assembly 3 forward through the pressure plate 53. This causes the material trays 33 to fit tightly together through the sealing gasket 332, thereby sealing the discharge trough 331. The pressure inside the material tray 33 can then be reduced through the vacuum suction port 24. In this embodiment, the drive cylinder 51 should be a low-temperature resistant cylinder, and heat insulation material can be installed in the drive chamber 26 to reduce the impact of low temperature on the drive cylinder 51.

[0035] In this embodiment, the inclination direction of the inlet and outlet channel 21 is the same as the inclination direction of the material tray 33 located at the pressure reduction and evaporation position, and the height dimension of the inlet and outlet channel 21 is greater than the sum of the thicknesses of the three material trays 33. After the bone raw material has undergone pressure reduction and evaporation drying treatment to remove moisture, the material tray 33 can be pulled out by the handle 338, thereby performing loading and unloading processing on the material tray 33.

[0036] The working principle of the freeze dryer of this invention is as follows: When feeding strip-shaped bone raw materials, the material tray 33 is pulled down by the handle 338, and the strip-shaped bone raw materials are directly fixed one by one on the clamping seat 334, so that the two clamping plates 335 clamp and fix the upper end of the strip-shaped bone raw materials. After feeding is completed, the material tray 33 is pushed upward into the movable frame 32 to reset. The material tray 33 is fixed by magnetic attraction. Then the door 22 is closed and the equipment is started to perform freeze drying. The servo motor 41 drives the lead screw 45 to rotate through the transmission rod. The lead screw 45 with different pitches and leads drives the movable frame 32 to move different distances, so that the material trays 33 at different positions can move backward and maintain a distance from each other. Then the flipping drive device drives the freeze drying rack assembly 3 to flip backward. At this time, the strip-shaped bone raw materials on the material tray 33 are all in a hanging and suspended state under the action of gravity. Then the cooling system of the freeze dryer rapidly freezes the bone raw materials to a low temperature, making them frozen.

[0037] After freezing, the flipping drive device drives the freeze-drying rack assembly 3 to flip forward. Then, the servo motor 41 drives the lead screw 45 to rotate, causing the movable frame 32 and the trays 33 to move forward and fit together. Then, the drive cylinder 51 drives the flipping arm 52 to rotate counterclockwise along the hinge axis and presses the last tray 33 in the freeze-drying rack assembly 3 forward through the pressure plate 53. The trays 33 press forward, causing the front trays 33 to press against the sealing plate 23. At the same time, the trays 33 are tightly fitted together and sealed by the sealing gasket 332. Finally, the vacuum suction port 24 depressurizes the discharge trough 331, so that each tray 33 is depressurized, thereby reducing the pressure in the system and causing the frozen water to change directly from a frozen state to a gaseous state. After depressurization, the water is heated by the heating block 333, changing the water from a solid state to a gaseous state, thereby evaporating the water. The water is then extracted from the bone material by the vacuum pump 27, keeping the bone material in a low-temperature and dry state. After freeze-drying is complete, the tilting arm 52 is reset, and at the same time, the material tray 33 and the lead screw 45 are reset under the elastic action of the elastic bearing 46. Finally, the box door 22 is opened, and the material tray 33 is pulled down to unload the freeze-dried strip bone raw material.

[0038] The above description is merely a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A low-temperature freeze-drying experimental apparatus for biomedicine, comprising a freeze dryer body (1), wherein the freeze dryer body (1) is provided with a freeze-drying chamber (2), characterized in that, The freeze-drying chamber (2) has an inclined inlet / outlet channel (21) at the lower front end, and a door (22) is provided at the opening of the inlet / outlet channel (21). The inner wall of the front end of the freeze-drying chamber (2) is inclined, and a sealing plate (23) is raised on the inner wall of the front end of the freeze-drying chamber (2). A vacuum suction port (24) is provided on the sealing plate (23), and the vacuum suction port (24) is connected to a vacuum pump (27) through a pipeline. The freeze-drying chamber (2) has a freeze-drying rack assembly (3) that is movable inside. The freeze-drying rack assembly (3) includes an outer frame (31), a movable frame (32), a tray (33), a tilting drive device, and a displacement drive assembly (4). Rotating shafts (311) are symmetrically provided on the upper ends of both sides of the outer frame (31). The rotating shaft (311) horizontally passes through both sides of the freeze-drying chamber (2) and is driven to rotate by a flipping drive device set in the freeze dryer body (1), causing the freeze-drying rack assembly (3) to tilt forward or backward and move to the reduced pressure evaporation position or the low temperature freezing position respectively; a number of movable frames (32) are arranged sequentially on the inner side of the outer frame (31), and the movable frames (32) are all slidably connected to the outer frame (31). Except for the frontmost movable frame (32), each movable frame (32) is driven by a displacement drive assembly (4) set on the upper end of the outer frame (31) and slides laterally along the outer frame (31). The material tray (33) is slidably arranged on the inner side of the movable frame (32). 3) Each tray (33) has a handle (338) at the bottom and a feeding groove (331) at the front end. Each tray (33) has a sealing gasket (332) on the outside of the feeding groove (331). The feeding groove (331) has several heating blocks (333). Each heating block (333) has a clamping seat (334) for fixing the strip bone material. When the freeze-drying rack assembly (3) tilts backward and moves to the low-temperature freezing position, the strip bone material in each clamping seat (334) hangs down under the action of gravity and is frozen by the freeze dryer cooling system. Except for the last tray (33), the feeding groove (331) of each tray (33) is horizontal. When the freeze-drying rack assembly (3) tilts forward and moves to the depressurization evaporation position, the displacement drive assembly (4) drives the movable frame (32) and the tray (33) to move forward and fit together. The freeze-drying chamber (2) is provided with a pressure sealing mechanism (5) at the bottom. The pressure sealing mechanism (5) is used to press the tray (33) at the last end forward and make the tray (33) at the front end abut against the sealing plate (23). At the same time, several trays (33) are closely fitted together and connected through the through hole (336) to realize the vacuum suction pipe (24) to depressurize the tray (33) and evaporate the water in the tray (33) through the heating block (333).

2. The biomedical low-temperature freeze-drying experimental apparatus as described in claim 1, characterized in that, Both the outer frame (31) and the movable frame (32) are inverted U-shaped structures. Slide rails (312) are symmetrically arranged on the inner walls of both sides of the outer frame (31). The slide rails (312) are arranged along the front and rear ends of the outer frame (31). The outer walls of both sides of the movable frame (32) are slidably connected to the slide rails (312) through sliders, so as to realize the lateral sliding connection between the movable frame (32) and the outer frame (31). The inner walls of both sides of the movable frame (32) and the outer walls of both sides of the tray (33) are longitudinally provided with mutually cooperating guide rail assemblies (337), so that the tray (33) and the movable frame (32) are longitudinally slidably connected. The top of the tray (33) is magnetically attracted and fixed to the inner wall of the top of the movable frame (32) through a magnet.

3. The biomedical low-temperature freeze-drying experimental apparatus as described in claim 2, characterized in that, The top of the outer frame (31) is provided with an equipment compartment (313), and the bottom of the equipment compartment (313) is provided with an access port (314). The displacement drive assembly (4) is installed inside the equipment compartment (313). The displacement drive assembly (4) includes a servo motor (41), a worm gear (42), a worm wheel (43), a transmission rod (44), a lead screw (45), and an elastic bearing (46). The servo motor (41) is located on the top of the outer frame (31), and the output end of the servo motor (41) extends longitudinally into the top of the outer frame (31). A worm gear (42) is connected in the equipment compartment (313). One side of the worm gear (42) is meshed with the worm wheel (43). The worm wheel (43) is mounted on the transmission rod (44). The transmission rod (44) is horizontally mounted in the equipment compartment (313) via a rotating seat. Both ends of the transmission rod (44) are provided with active bevel gears (47). There are several sets of lead screws (45), and the pitch and lead of each set of lead screws (45) are different. There are two lead screws (45) in each set and they are distributed in the equipment compartment. At both ends of the bin (313), each lead screw (45) is rotatably mounted on an elastic bearing (46), so that the lead screw (45) can move laterally between the two elastic bearings (46) under the action of external force; adjacent lead screws (45) are connected by a transmission wheel (451) and a transmission belt (452), wherein the lead screw (45) near the transmission rod (44) is provided with a driven bevel gear (48) that meshes with the driving bevel gear (47), and the driven bevel gear (48) is located at the driving bevel gear. The wheel (47) is close to the side of the sealing plate (23), so that the servo motor (41) drives each lead screw (45) to rotate through the transmission rod. Each lead screw (45) is threaded with a thread seat (49). The lower end of the thread seat (49) on the same set of lead screws (45) passes through the movable opening (314) and is fixedly connected to the top of the same movable frame (32), so that the displacement drive component (4) drives each movable frame (32) to move a different distance, and makes the material trays (33) fit together or separate.

4. The biomedical low-temperature freeze-drying experimental apparatus as described in claim 3, characterized in that, The freeze-drying chamber (2) is tilted at the top and has a accommodating chamber (25) for accommodating the servo motor (41). When the freeze-drying rack assembly (3) tilts backward and moves to the low-temperature freezing position, the servo motor (41) moves into the accommodating chamber (25) under the drive of the outer frame (31), and the top of the outer frame (31) is attached to the bottom of the freeze-drying chamber (2) to seal the accommodating chamber (25).

5. The biomedical low-temperature freeze-drying experimental apparatus as described in claim 3, characterized in that, Each of the elastic bearings (46) includes a bearing housing (461), a bushing (462), and a spring (463). The bearing housing (461) has a receiving groove for accommodating the bushing (462), and the spring (463) is disposed in the receiving groove. The spring (463) supports the bushing (462) outward. One end of the bushing (462) is closed, and the other end of the bushing (462) is sleeved on one end of the lead screw (45).

6. The biomedical low-temperature freeze-drying experimental apparatus as described in claim 1, characterized in that, The freeze-drying chamber (2) has a drive chamber (26) at the bottom for accommodating the pressure sealing mechanism (5). The pressure sealing mechanism (5) includes a drive cylinder (51), a flipping arm (52), and a pressure plate (53). The flipping arm (52) is bent in an L-shape. The middle part of the flipping arm (52) is hinged to the upper end of the drive chamber (26) through a hinge shaft. The lower end of the flipping arm (52) is hinged to the piston rod of the drive cylinder (51). The drive cylinder (51) is hinged in the drive chamber (26) through a hinge seat. The other end of the flipping arm (52) is located at the bottom of the freeze-drying chamber (2), and the pressure plate (53) is provided on the other end of the flipping arm (52). This allows the drive cylinder (51) to drive the flipping arm (52) to rotate counterclockwise and press the tray (33) in the freeze-drying rack assembly (3) forward through the pressure plate (53).

7. The biomedical low-temperature freeze-drying experimental apparatus as described in claim 1, characterized in that, The clamping seat (334) includes two symmetrically arranged clamping plates (335). The front and rear ends of the two clamping plates (335) are both outwardly expanded. The middle part of the two clamping plates (335) is closely arranged to clamp and fix the top of the strip bone material. The middle part of the clamping plate (335) has several through holes (3351) in the transverse direction.

8. The biomedical low-temperature freeze-drying experimental apparatus as described in claim 1, characterized in that, The inclination direction of the feed channel (21) is the same as the inclination direction of the tray (33) located at the pressure evaporation position, and the height dimension of the feed channel (21) is greater than the sum of the thicknesses of several trays (33).

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