Bifidobacterium longum for improving cAMP / PKA / CREB pathway to repair intestinal nerves and application thereof
By repairing the enteric nervous system with Bifidobacterium bifidum CCFM1390, the problems of abnormal intestinal motility and enteric nerve damage caused by antibiotics were resolved. It significantly increased the number of enteric neurons and glial cells, promoted the secretion of BDNF and the release of excitatory neurotransmitters, improved intestinal inflammation, and restored intestinal function.
CN118813466BActive Publication Date: 2026-06-12JIANGNAN UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JIANGNAN UNIV
- Filing Date
- 2024-07-30
- Publication Date
- 2026-06-12
Smart Images
Figure CN118813466B_ABST
Abstract
The application discloses a bifidobacterium longum for repairing intestinal nerves through a cAMP / PKA / CREB pathway and an application thereof, and belongs to the field of microorganisms. The bifidobacterium longum CCFM1390 provided by the application can significantly increase the number of intestinal nerve glial cells and intestinal neurons, especially can improve cAMP / PKA / CREB, promote the secretion of neurotrophic factors and neurotransmitters, and repair the damaged intestinal nervous system of mice. Meanwhile, the bifidobacterium longum can relieve the inflammatory response of intestinal tissues and repair the intestinal mechanical barrier. Therefore, a more personalized treatment scheme can be adopted for gastrointestinal diseases caused by abnormal intestinal nervous system, and the bifidobacterium longum has considerable application prospect.
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