一种通过静电纺丝制备防粘连膜的方法
By dissolving chitosan and a toughening agent in a dilute acid solution and then using electrospinning technology to prepare a porous anti-adhesion membrane, the problems of poor toughness and solvent residue in existing technologies have been solved, and the biocompatibility and mechanical properties have been improved, meeting the anti-adhesion requirements for clinical applications.
CN118814361BActive Publication Date: 2026-07-17DONGHUA UNIV +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- DONGHUA UNIV
- Filing Date
- 2023-04-18
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing anti-adhesion films prepared by electrospinning have problems such as poor toughness and solvent residue, and are difficult to meet the requirements of biocompatibility and mechanical properties in clinical applications.
Method used
Chitosan and toughening agents are dissolved in a dilute acid solution and a porous fiber membrane is formed by electrospinning. A low-toxicity and volatile solvent system is selected, and residual solvent is removed by vacuum drying. The mechanical properties are adjusted by controlling the spinning parameters.
Benefits of technology
The prepared anti-adhesion membrane has good biocompatibility, mechanical strength and porosity, and can effectively inhibit tissue adhesion, meeting the needs of clinical applications.
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Figure CN118814361B_ABST
Abstract
本发明公开了一种通过静电纺丝制备防粘连膜的方法，属于生物医用材料技术领域。该方法为将壳聚糖和增韧剂溶解于稀酸溶液体系中形成稳定的透明溶液，然后通过静电纺丝技术形成纤维膜。本发明选择低毒易挥发的溶剂体系，纺丝膜中残余的溶剂可以通过简易的干燥方式祛除。纤维膜中的纤维成型稳定，纤维直径控制在30～4000nm之间。
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