A 5α-reductase inhibitor alcohol-containing emulsion and its preparation method and application

By developing a mellow emulsion, the existing 5α-reducing enzyme inhibitors scalp external preparations have poor stability, poor emulsification effect, and limited pharmaceutical absorption of drug transparent skin, and achieve more efficient and safer therapeutic effects.

CN118831050BActive Publication Date: 2025-01-28AURORA CUTIS MEDICAL TECHNOLOGY (SHANGHAI) CO LTD
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Patent Information

Application Number
CN202411281626.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-09-12
Publication Date
2025-01-28
Estimated Expiration
2044-09-12

AI Technical Summary

Technical Problem

The existing 5α-reductase inhibitor topical preparations for scalp have problems such as poor stability, poor emulsification effect, limited transdermal absorption of drugs and greasy feeling, making it difficult to meet the needs of efficient and safe treatment.

Method used

The development of a alcohol-containing emulsion, through reasonable formulation of 5α-reducing enzyme inhibitors, alcohol, oil phase, emulsifiers, diluents, and infiltration agents to form a stable emulsion system, which improves the dermatological absorption and medicinal compliance of the drug.

Benefits of technology

Achieve the stability of the lotion and the improvement of the permeable absorption effect, reduce the amount of drugs exposed throughout the body, and improve the safety of treatment and the compliance of the patient's medication.

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Abstract

The invention discloses an alcoholic emulsion of a 5α-reductase inhibitor, which comprises a 5α-reductase inhibitor, an alcohol, an oil phase, an emulsifier, a diluent and a penetration enhancer. The alcoholic emulsion of the invention not only retains the refreshing skin feel of the alcoholic preparation, but also solves the technical problem that ethanol destroys the stability of the emulsion, has excellent stability and transdermal performance, is suitable for use on the scalp, and is used for the treatment of androgenic alopecia.
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Citation Information

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