A traditional Chinese medicine composition for treating low back pain and application thereof

Abstract

The application provides a traditional Chinese medicine composition for treating lumbago and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition for treating lumbago comprises 55-65 parts of prepared rehmannia, 85-95 parts of white atractylodes, 55-65 parts of psoralea, 85-95 parts of eucommia, 25-35 parts of cistanche, 25-35 parts of radix morindae officinalis, 55-65 parts of fennel, 10-20 parts of plantago and 25-35 parts of green salt. The traditional Chinese medicine composition has the effects of strengthening muscles and bones and resisting inflammation and analgesia, can effectively treat lumbago, is not prone to relapse, and has therapeutic effects on different types of lumbago.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a traditional Chinese medicine composition for treating lower back pain, its preparation method, and its application. Background Technology

[0002] Lower back pain, characterized primarily by pain on one or both sides of the lower back and often radiating to the legs, is a common clinical symptom. The causes of lower back pain are multifaceted and complex, with common causes including trauma, overexertion, lumbar spine deformities, and lumbar spine tumors. It can be a symptom of multiple diseases or an independent condition. During treatment, most patients do not experience effective relief from lower back pain. While conservative treatments such as bed rest, lumbar traction, lumbar physical therapy, and medication can provide relief, the recurrence rate for lower back pain with conservative treatment is 90-100%. Therefore, there is a desire for a medication that can effectively treat lower back pain and prevent recurrence. Summary of the Invention

[0003] The purpose of this invention is to provide a medicine that can effectively treat lower back pain and is less likely to recur.

[0004] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0005] This invention provides a traditional Chinese medicine composition for treating lower back pain, comprising the following raw materials in parts by weight: 55-65 parts of Rehmannia glutinosa (processed), 85-95 parts of Atractylodes macrocephala, 55-65 parts of Psoralea corylifolia, 85-95 parts of Eucommia ulmoides, 25-35 parts of Cistanche deserticola, 25-35 parts of Morinda officinalis, 55-65 parts of Foeniculum vulgare, 10-20 parts of Plantago asiatica, and 25-35 parts of rock salt.

[0006] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 57-63 parts of Rehmannia glutinosa, 87-93 parts of Atractylodes macrocephala, 57-63 parts of Psoralea corylifolia, 87-93 parts of Eucommia ulmoides, 27-33 parts of Cistanche deserticola, 27-33 parts of Morinda officinalis, 57-63 parts of Foeniculum vulgare, 12-18 parts of Plantago asiatica, and 27-33 parts of rock salt.

[0007] More preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 59-61 parts of Rehmannia glutinosa, 89-91 parts of Atractylodes macrocephala, 59-61 parts of Psoralea corylifolia, 89-91 parts of Eucommia ulmoides, 29-31 parts of Cistanche deserticola, 29-31 parts of Morinda officinalis, 59-61 parts of Foeniculum vulgare, 14-26 parts of Plantago asiatica, and 29-31 parts of rock salt.

[0008] Most preferably, the traditional Chinese medicine composition consists of the following raw materials in parts by weight: 60 parts Rehmannia glutinosa, 90 parts Atractylodes macrocephala, 60 parts Psoralea corylifolia, 90 parts Eucommia ulmoides, 30 parts Cistanche deserticola, 30 parts Morinda officinalis, 60 parts Foeniculum vulgare, 15 parts Plantago asiatica, and 30 parts rock salt.

[0009] The present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition, wherein each raw material is pulverized to 50-150 mesh and then mixed.

[0010] The present invention also provides the application of the traditional Chinese medicine composition in the preparation of a medicine for treating lower back pain.

[0011] Beneficial effects:

[0012] The traditional Chinese medicine composition for treating lower back pain provided by this invention has a synergistic effect among the raw materials, complementing each other, strengthening muscles and bones, and having good anti-inflammatory and analgesic effects. It can effectively treat lower back pain with a total effective rate of 98%, and is not prone to recurrence. It has good therapeutic effects on different types of lower back pain. Detailed Implementation

[0013] In the following embodiments of the present invention:

[0014] Prepared Rehmannia glutinosa: Originally named Rehmannia glutinosa, also known as Huaiqing Rehmannia glutinosa or Prepared Rehmannia. It is a processed form of Rehmannia glutinosa (Gaetn.) Libosch. ex Fisch. et Mey., belonging to the Scrophulariaceae family and the Rehmannia genus. It has a sweet taste and slightly warm nature, and possesses the effects of nourishing yin and blood, replenishing essence and marrow. It is mainly used to treat symptoms such as liver and kidney yin deficiency, soreness and weakness of the lower back and knees, bone steaming fever, night sweats and seminal emission, internal heat and thirst, blood deficiency and chlorosis, palpitations, irregular menstruation, dizziness and tinnitus, and premature graying of hair.

[0015] Atractylodes macrocephala: Also known as Yu Shu, Dong Bai Shu, and Zhe Shu. It is the rhizome of Atractylodes macrocephala Koidz., a plant in the Asteraceae family. It tastes bitter and sweet, and is warm in nature. It enters the spleen and stomach meridians. It invigorates the spleen and replenishes qi, dries dampness and promotes diuresis. It is mainly used for wind-cold-dampness arthralgia, dead muscle, spasms, jaundice, stopping sweating, clearing heat and promoting digestion.

[0016] Psoralea corylifolia: also known as Hu Jiu Zi, Po Gu Zhi, Hei Gu Zi, Hu Gu Zi. It is the fruit of the legume Psoralea corylifolia L. It has a pungent and bitter taste, and is warm in nature. It enters the kidney and spleen meridians. It tonifies the kidney and strengthens yang, regulates qi and relieves asthma, warms the spleen and stops diarrhea.

[0017] Eucommia ulmoides: Also known as Sixian, Sizhong, Chesipi, and Silianpi. It is the bark of the Eucommia ulmoides Oliv. plant, belonging to the Eucommiaceae family. It has a sweet taste and warm properties. It enters the liver and kidney meridians. It tonifies the liver and kidneys, strengthens tendons and bones, and calms the fetus.

[0018] Cistanche deserticola: also known as Huanrong, Dayun, Cunyun, and Jinsun. It is the fleshy stem with scaly leaves of the plants *Cistanche cedarticola* YCMa or *Cistanche tubulosa* (Schrenk) Wight, belonging to the Orobanchaceae family. It has a sweet and salty taste and is warm in nature. It enters the kidney and large intestine meridians. It tonifies kidney yang, nourishes essence and blood, and moistens the intestines to relieve constipation.

[0019] Morinda officinalis (also known as Bajitian, Jitian, and Tu'erchang) is the root of the plant Morinda officinalis How, belonging to the Rubiaceae family. It has a pungent and sweet taste, and is slightly warm in nature. It enters the liver and kidney meridians. It tonifies kidney yang, strengthens tendons and bones, and dispels wind and dampness.

[0020] Fennel seeds: also known as anise seeds, wild fennel, or fennel. It is the mature fruit of *Foeniculum vulgare* Mill., a plant in the Apiaceae family. It has a pungent taste and warm properties. It enters the liver, kidney, spleen, and stomach meridians. It dispels cold, relieves pain, regulates qi, and harmonizes the stomach.

[0021] Plantain seed: Plantain seed is a traditional Chinese medicine. It is the dried, mature seed of Plantago asiatica L. or Plantago depressa Willd., belonging to the Plantaginaceae family. It is sweet in taste and cold in nature. It enters the kidney and bladder meridians. It promotes urination, clears heat, improves eyesight, and eliminates phlegm. It is mainly used for urinary retention, pain relief, promoting urination, and eliminating dampness and numbness.

[0022] Qingyan (also known as Rongyan): It is sweet, salty, and cold in nature. It enters the kidney meridian. It benefits the water element, calms blood heat, and strengthens bones and teeth.

[0023] Lower back pain involves the five internal organs: liver, spleen, and kidney. The liver governs the tendons, the kidney governs the bones, and the spleen governs the muscles. Lower back pain is mostly in the bones, but it often affects the tendons and muscles as well. In this formula, Atractylodes macrocephala and Eucommia ulmoides are the main herbs, which nourish yin and moisten dryness, strengthen tendons and bones, and unblock the qi of the lower back and navel, while also having a tonifying effect. Rehmannia glutinosa, Psoralea corylifolia, and Foeniculum vulgare are the assistant herbs, which warm the kidneys and assist yang, making the kidney-tonifying effect even better. Cistanche deserticola, Morinda officinalis, Plantago asiatica, and rock salt are the adjuvant herbs, which dispel wind and dampness, enhance the warming and yang-tonifying effect of the kidneys, and moisten dryness appropriately, guiding the other herbs into the kidney meridian to moisten dryness and subdue dryness.

[0024] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0025] Example 1

[0026] A traditional Chinese medicine composition for treating lower back pain, comprising the following raw materials in parts by weight: 57 parts Rehmannia glutinosa, 87 parts Atractylodes macrocephala, 57 parts Psoralea corylifolia, 87 parts Eucommia ulmoides, 27 parts Cistanche deserticola, 27 parts Morinda officinalis, 57 parts Foeniculum vulgare, 12 parts Plantago asiatica, and 27 parts rock salt.

[0027] After pulverizing the above-mentioned raw materials to 100 mesh, they are mixed to obtain the traditional Chinese medicine composition for treating lower back pain.

[0028] Example 2

[0029] A traditional Chinese medicine composition for treating lower back pain is composed of the following raw materials in parts by weight: 63 parts Rehmannia glutinosa, 93 parts Atractylodes macrocephala, 63 parts Psoralea corylifolia, 93 parts Eucommia ulmoides, 33 parts Cistanche deserticola, 33 parts Morinda officinalis, 63 parts Foeniculum vulgare, 18 parts Plantago asiatica, and 33 parts rock salt. The preparation method is the same as in Example 1.

[0030] Example 3

[0031] A traditional Chinese medicine composition for treating lower back pain is composed of the following raw materials in parts by weight: 60 parts Rehmannia glutinosa, 90 parts Atractylodes macrocephala, 60 parts Psoralea corylifolia, 90 parts Eucommia ulmoides, 30 parts Cistanche deserticola, 30 parts Morinda officinalis, 60 parts Foeniculum vulgare, 15 parts Plantago asiatica, and 30 parts rock salt. The preparation method is the same as in Example 1.

[0032] Experiment Example 1: Animal Experiment

[0033] Fifty healthy male mice, weighing 18–22 g, were randomly divided into 5 groups of 10 mice each: a blank control group (0.1 ml / 10 g, administered by gavage with distilled water), a positive control group (nimesulide dispersible tablets (National Drug Approval Number: H20000121, produced by Hainan Kangzhi Pharmaceutical Co., Ltd., hereinafter the same), 20 mg / kg, administered by gavage), and high, medium, and low dose groups of the composition (the traditional Chinese medicine composition prepared in Example 3, with dosages of 3.6 g / kg, 1.8 g / kg, and 0.9 g / kg, respectively, administered by gavage with warm water). Administration: The mice were administered once daily for 3 days. One hour and 50 minutes after the last administration (mice were fasted for 12 hours before the experiment), 0.2 mL of 0.8% acetic acid saline solution was injected intraperitoneally per mouse. The number of writhing movements (writhing response: abdominal concavity, trunk and hind leg extension, hip elevation, and lateral body twisting) was observed within 20 minutes, and the differences between the groups were compared.

[0034] Drug-induced writhing inhibition rate (%) = (Number of writhing movements in the control group - Number of writhing movements in the drug-treated group) / Number of writhing movements in the control group × 100%

[0035] Table 1. Effects of the traditional Chinese medicine composition in Example 3 on acetic acid-induced writhing response in mice.

[0036] Model comparison 10 55±7 Positive control 10 <![CDATA[25±4 ** ]]> 54.5％ High-dose group 10 <![CDATA[21±8 ** ]]> 61.8％ medium dose group 10 <![CDATA[24±2 ** ]]> 56.4％ low-dose group 10 <![CDATA[27±6 ** ]]> 50.9％

[0037] (Compared with the model control group) * P<0.05, ** P<0.01)

[0038] As can be seen from the above, the traditional Chinese medicine composition of the present invention can significantly reduce the number of writhing responses induced by glacial acetic acid in mice, and has good anti-inflammatory, analgesic, and arthritis-treating effects, providing a pharmacological basis for its clinical application.

[0039] Experiment Example 2: Square Disassembly Experiment

[0040] Seventy healthy male mice, weighing 18–22 g, were randomly divided into seven groups of ten mice each: a blank control group (0.1 ml / 10 g, distilled water by gavage), a positive control group (nimesulide dispersible tablets 20 mg / kg, by gavage), a combination group (the traditional Chinese medicine combination prepared in Example 3, 1.8 g / kg, by gavage), a principal drug group (Atractylodes macrocephala and Eucommia ulmoides), an assistant drug group (Rehmannia glutinosa, Psoralea corylifolia, and Foeniculum vulgare), an adjuvant drug group (Cistanche deserticola and Morinda officinalis), and a guiding drug group (Plantago asiatica and rock salt). All drugs in each group were mixed and pulverized to 100 mesh. The dosage for each group was 1.8 g / kg, administered by gavage. Other procedures were the same as in Experiment 1.

[0041] Table 2. Effects of different formulations on acetic acid-induced writhing response in mice.

[0042]

[0043]

[0044] As shown in the table above, even after breaking down the formula, the combined drug group still exhibits the best therapeutic effect. This demonstrates that the active pharmaceutical ingredients in the drug composition of this application have a synergistic effect and complement each other.

[0045] As can be seen from the above experimental examples, the traditional Chinese medicine composition for treating lower back pain provided by the present invention can effectively treat lower back pain, and it has a therapeutic effect on lower back pain caused by different reasons and is not prone to recurrence.

[0046] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for treating lower back pain, characterized in that, It is composed of the following raw materials in parts by weight: 59-61 parts of Rehmannia glutinosa, 89-91 parts of Atractylodes macrocephala, 59-61 parts of Psoralea corylifolia, 89-91 parts of Eucommia ulmoides, 29-31 parts of Cistanche deserticola, 29-31 parts of Morinda officinalis, 59-61 parts of Foeniculum vulgare, 14-26 parts of Plantago asiatica, and 29-31 parts of rock salt.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition consists of the following raw materials in parts by weight: 60 parts Rehmannia glutinosa, 90 parts Atractylodes macrocephala, 60 parts Psoralea corylifolia, 90 parts Eucommia ulmoides, 30 parts Cistanche deserticola, 30 parts Morinda officinalis, 60 parts Foeniculum vulgare, 15 parts Plantago asiatica, and 30 parts rock salt.

3. A method for preparing a traditional Chinese medicine composition for treating low back pain as described in claim 1 or 2, characterized in that, Crush each raw material into powder to 50-150 mesh and mix them together.

4. The use of a traditional Chinese medicine composition for treating low back pain as described in claim 1 or 2, or a traditional Chinese medicine composition prepared by the preparation method described in claim 3, in the preparation of a medicament for treating low back pain.

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