一种靶向SARS-CoV-2的siRNA自组装纳米颗粒及其制备方法与应用
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SUN YAT SEN UNIV
- Filing Date
- 2024-06-24
- Publication Date
- 2026-07-17
AI Technical Summary
Existing siRNA drugs are ineffective against SARS-CoV-2 variants due to insufficient delivery methods and stability, easy degradation, and issues with biocompatibility and immunogenicity.
We designed siRNA self-assembling nanoparticles targeting highly conserved regions of SARS-CoV-2. These nanoparticles were then self-assembled in MgSO4 solution using specific RNA motifs to form stable nanoparticles, thereby enhancing the targeting and inhibitory effect on the virus.
The prepared siRNA self-assembled nanoparticles exhibited highly efficient inhibitory effects on multiple mutant strains, strong stability, and could be stored and transported at room temperature, significantly reducing viral replication and outperforming simple mixtures of siRNA.
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