A nicotine liquid for an aerosol device and a method of making the same

Abstract

The application relates to the field of nicotine, and specifically discloses a nicotine liquid for an aerosol device, which comprises the following components in mass fractions: nicotine 2-4 parts; magnolia flower extract 8-10 parts; 1,3-propanediol 40-50 parts; and additives 1-3 parts. The nicotine is pretreated in the following manner: S1, preparation of coral powder: natural coral is crushed and soaked in a sodium hydroxide solution, ultrasonic cleaning, and drying to obtain the coral powder; S2, preparation of modified coral powder: the coral powder and an ethanol solution are mixed, and polyethylene glycol is added, drying, grinding, and sieving to obtain the modified coral powder; and S3, pretreatment of the nicotine: the modified coral powder is dissolved in water, and the nicotine is added and uniformly stirred, and after freeze-drying, the pretreated nicotine is obtained. The application has the effects of improving the persistence of nicotine release, reducing the stimulation of aerosol to the skin, reducing the particle size of generated aerosol, improving the atomization effect, and weakening the particle feeling.

Description

Technical Field

[0001] This application relates to the field of nicotine, and more specifically, to a nicotine liquid for an aerosol device and a method for preparing the same. Background Technology

[0002] E-cigarettes are electronic products that mimic traditional cigarettes, possessing the same appearance, smoke, taste, and feel. They are products that use atomization to turn nicotine and other substances into vapor for users to inhale. For many smokers, as the harms of traditional tobacco have become increasingly clear, e-cigarettes, with their health benefits, safety, and convenience, have gradually become a substitute for traditional cigarettes because they do not contain harmful substances such as tar and carbon monoxide, and yet offer a similar taste and feel.

[0003] Currently, nicotine liquid is typically contained in an aerosol device, which atomizes the liquid to create an aerosol. However, the rapid release of nicotine results in a poor user experience. Therefore, there is still room for improvement. Summary of the Invention

[0004] To improve the persistence of nicotine release, provide a better user experience, reduce skin irritation from aerosols to minimize allergic reactions, and reduce the particle size of the generated aerosols for better atomization and reduced particle sensation, this application provides a nicotine liquid for aerosol devices and a method for preparing the same.

[0005] In a first aspect, this application provides a nicotine liquid for an aerosol device, employing the following technical solution: A nicotine liquid for an aerosol device comprises the following components in parts by weight: Nicotine 2-4 parts; Magnolia flower extract 8-10 parts; 40-50 parts of 1,3-propanediol; 1-3 parts of additives; The nicotine is pre-treated as follows: S1. Preparation of coral powder: Natural coral is crushed and added to sodium hydroxide solution, soaked and ultrasonically cleaned, taken out and dried to obtain coral powder. S2. Preparation of modified coral powder: After ball milling the coral powder, it is added to an ethanol solution and mixed into a suspension. Then, polyethylene glycol is added, mixed evenly, dried, taken out, ground, and sieved to obtain modified coral powder. S3. Pre-treatment of nicotine: Dissolve modified coral powder in water, then add nicotine, stir evenly, and finally freeze-dry to obtain pre-treated nicotine.

[0006] By employing the above technical solution, due to the rough and porous surface of coral powder and its numerous layered and cage-like structures, nicotine is easily adsorbed within these structures, making it less likely for nicotine to be released. This improves the duration of nicotine release, providing a better experience and potentially reducing nicotine cravings. Furthermore, the porosity of coral powder prevents nicotine from easily filling the internal pores. When the nicotine concentration decreases, the adsorbed nicotine is released, further enhancing the duration of nicotine release. Since coral powder has a large specific surface area, it is prone to agglomeration when added to nicotine liquids. Therefore, grafting polyethylene glycol onto the surface of the coral powder allows for uniform dispersion in the nicotine liquid, thus minimizing the impact on nicotine release.

[0007] However, during the research and development process, it was discovered that the aerosol produced after atomizing nicotine liquid pretreated with coral powder could irritate the skin, causing allergic reactions. Extensive research and experimentation revealed that adding magnolia flower extract to the nicotine liquid could alleviate the skin irritation caused by the aerosol produced after atomizing the coral powder-pretreated nicotine liquid, making the skin less prone to allergic reactions and beneficial for long-term use. This is because certain active ingredients in magnolia flower extract can inhibit the adhesion of eosinophils to vascular endothelial cells and act on vascular endothelial cells to achieve an anti-allergic effect.

[0008] Preferably, in step S2, the modified coral powder is obtained by passing it through a 20-40 mesh sieve.

[0009] By adopting the above technical solution, the coral powder has a specific particle size, which reduces the particle size of the generated aerosol. This improves the atomization effect of the nicotine liquid after coral powder pretreatment, thereby reducing the grainy feeling and giving people a better experience.

[0010] Preferably, the mass ratio of nicotine to modified coral powder is (1.2-1.6):1.

[0011] By employing the above technical solution, excessive coral powder can easily lead to aggregation, affecting its dispersibility in nicotine liquid; conversely, insufficient coral powder prevents nicotine from being properly adsorbed, thus impacting the persistence of nicotine release. Therefore, using a specific ratio of coral powder to nicotine can improve the persistence of nicotine release, thereby enhancing the user experience.

[0012] Preferably, the nicotine content of the magnolia flower extract is 40-50% by mass.

[0013] By adopting the above technical solution and using a specific ratio of nicotine and magnolia flower extract to work together, it is beneficial to further alleviate the irritation of human skin caused by the aerosol generated after the nicotine liquid is atomized after being pretreated with coral powder. This makes it less likely for human skin to experience allergic reactions, allowing the nicotine liquid to be used for a long time.

[0014] Preferably, the additives include sweeteners and tobacco flavorings.

[0015] Preferably, the sweetener includes one or more of sorbitol, mannitol, maltitol, and xylitol.

[0016] By adopting the above technical solution and adding sweeteners to nicotine liquid, the nicotine liquid becomes sweet and delicious, thereby giving people a higher quality experience during use.

[0017] Preferably, the flavoring for tobacco includes one or more of strawberry flavoring, passion fruit flavoring, and blueberry flavoring.

[0018] By adopting the above technical solution, by adding tobacco flavoring to nicotine liquid, the nicotine liquid has a pleasant and delightful aroma, which enhances the flavor and flavor, thereby relieving fatigue and providing a comfortable experience for users.

[0019] Secondly, this application provides a method for preparing nicotine liquid for aerosol devices, employing the following technical solution: A method for preparing nicotine liquid for an aerosol device includes the following steps: Step 1: Pre-treat nicotine; Step 2: Add the pretreated nicotine, magnolia flower extract, 1,3-propanediol and additives to a mixing tank and mix evenly to obtain the nicotine liquid formula.

[0020] By adopting the above technical solution, the nicotine liquid prepared by the above method has better performance, and the production process is simple, which is conducive to industrial production.

[0021] In summary, this application includes at least one of the following beneficial technical effects: 1. By pretreating nicotine with coral powder, nicotine is easily adsorbed within the layered and cage-like structures of the coral powder, making it less likely for nicotine to be released. This improves the duration of nicotine release, providing a better experience and potentially reducing cravings. Furthermore, the porosity of coral powder prevents nicotine from filling the internal pores. When the nicotine concentration decreases, the adsorbed nicotine is released, further enhancing the duration of nicotine release. Additionally, adding magnolia flower extract to the nicotine liquid can alleviate the skin irritation caused by the aerosol produced after atomizing the coral powder-pretreated nicotine liquid, reducing the likelihood of allergic reactions and promoting long-term use.

[0022] 2. By using coral powder with a specific particle size, the particle size of the generated aerosol is reduced, thereby improving the atomization effect of the nicotine liquid, reducing the grainy feeling, and thus providing people with a better experience.

[0023] 3. The use of a specific ratio of nicotine and magnolia flower extract helps to further alleviate the irritation of human skin caused by the aerosol generated after the nicotine liquid is atomized after being pretreated with coral powder, making human skin less prone to allergic reactions. Detailed Implementation

[0024] The present application will be further described in detail below with reference to the embodiments.

[0025] Example 1 This embodiment discloses a nicotine liquid for an aerosol device, comprising the following components by mass: Nicotine 2kg; Magnolia flower extract 8kg; 1,3-propanediol 40kg; Additives 1kg; wherein the additives include sweeteners and tobacco flavorings, the sweetener being sorbitol, used in an amount of 0.5kg; the tobacco flavoring being passion fruit flavoring, used in an amount of 0.5kg; Nicotine is pre-treated as follows: S1. Preparation of coral powder: Natural coral is crushed and added to sodium hydroxide solution, soaked and ultrasonically cleaned, taken out and dried to obtain coral powder. S2. Preparation of modified coral powder: After ball milling the coral powder, add it to an ethanol solution to mix into a suspension, then add polyethylene glycol, mix evenly, dry, take out, grind, and pass through a 40-mesh sieve. S3. Pretreatment of nicotine: Dissolve modified coral powder in water, then add nicotine, stir evenly at 60℃, and finally freeze-dry to obtain pretreated nicotine.

[0026] This embodiment also discloses a method for preparing nicotine liquid for aerosol devices, including the following steps: Step 1: Pre-treat nicotine; Step 2: Add the pretreated nicotine, magnolia flower extract, 1,3-propanediol and additives to a mixing tank and mix well to obtain nicotine liquid.

[0027] Example 2 The difference from Example 1 is as follows: A nicotine liquid for an aerosol device comprises the following components by mass: Nicotine 4kg; Magnolia flower extract 10kg; 1,3-propanediol 50kg; additives 3kg; wherein the additives include sweeteners and tobacco flavorings, the sweetener being sorbitol at a dosage of 1.5kg; the tobacco flavoring being passion fruit flavoring at a dosage of 1.5kg; the nicotine is pretreated as follows: S1. Preparation of coral powder: Natural coral is crushed and added to sodium hydroxide solution, soaked and ultrasonically cleaned, taken out and dried to obtain coral powder. S2. Preparation of modified coral powder: After ball milling the coral powder, add it to an ethanol solution to form a suspension, then add polyethylene glycol, mix evenly, dry, take out, grind, and pass through a 20-mesh sieve. S3. Pretreatment of nicotine: Dissolve modified coral powder in water, then add nicotine, stir evenly at 60℃, and finally freeze-dry to obtain pretreated nicotine.

[0028] Example 3 The difference from Example 1 is as follows: A nicotine liquid for an aerosol device comprises the following components by mass: Nicotine 3kg; Magnolia flower extract 9kg; 1,3-propanediol 45kg; Additives 2kg; Among them, the additives include sweeteners and tobacco flavorings, the sweetener is sorbitol, the amount is 1kg; the tobacco flavoring is passion fruit flavoring, the amount is 1kg; Nicotine is pre-treated as follows: S1. Preparation of coral powder: Natural coral is crushed and added to sodium hydroxide solution, soaked and ultrasonically cleaned, taken out and dried to obtain coral powder. S2. Preparation of modified coral powder: After ball milling the coral powder, add it to an ethanol solution to mix into a suspension, then add polyethylene glycol, mix evenly, dry, take out, grind, and pass through a 30-mesh sieve. S3. Pretreatment of nicotine: Dissolve modified coral powder in water, then add nicotine, stir evenly at 60℃, and finally freeze-dry to obtain pretreated nicotine.

[0029] Example 4 The difference from Example 3 is that the mass ratio of nicotine to modified coral powder is 1.2:1; that is, 3.6 kg of nicotine and 3 kg of modified coral powder. Nicotine accounts for 40% of the mass of the magnolia flower extract, i.e., 3.6 kg of nicotine and 9 kg of magnolia flower extract.

[0030] Example 5 The difference from Example 3 is that the mass ratio of nicotine to modified coral powder is 1.6:1; that is, 4 kg of nicotine and 2.5 kg of modified coral powder. Nicotine accounts for 50% of the mass of the magnolia flower extract, that is, 4 kg of nicotine and 8 kg of magnolia flower extract.

[0031] Example 6 The difference from Example 5 is that the mass ratio of nicotine to modified coral powder is 1:1; and the mass ratio of nicotine to magnolia flower extract is 30%.

[0032] Comparative Example 1 The difference from Example 3 is that no nicotine pretreatment is performed.

[0033] Comparative Example 2 The difference from Example 3 is that an equal amount of chamomile extract is used instead of magnolia flower extract.

[0034] Comparative Example 3 The difference from Example 3 is that in step S2, the material is ground and passed through a 16-mesh sieve.

[0035] Comparative Example 4 The difference from Example 3 is as follows: A nicotine liquid for an aerosol device comprises the following components by mass: Nicotine 1kg; Magnolia flower extract 5kg; 1,3-propanediol 30kg; Additives 0.8kg.

[0036] Comparative Example 5 The difference from Example 3 is as follows: A nicotine liquid for an aerosol device comprises the following components by mass: Nicotine 6kg; Magnolia flower extract 12kg; 1,3-propanediol 55kg; Additives 4kg.

[0037] Experiment 1 In this experiment, the particle size of the nicotine liquid aerosols prepared in Examples 1-6 and Comparative Examples 1-5 was detected. Smoking was simulated using a smoking cycle simulator, and then the particle size of the exhaled smoke was detected using a rapid particle size analyzer system. The median particle size CMD (nm) was taken.

[0038] Experiment 2 The nicotine liquids prepared in Examples 1-6 and Comparative Examples 1-5 were placed in an aerosol device for irritation testing.

[0039] Fifty volunteers were randomly selected and inhaled the nicotine liquids prepared in Examples 1-6 and Comparative Examples 1-5, respectively. The condition of their skin after use was observed, and the results were scored. The arithmetic mean of the scores from the 50 volunteers was taken. See Table 1 for details.

[0040] Table 1 Experiment 3 Fifty smokers were randomly selected to inhale the nicotine liquids prepared in Examples 1-6 and Comparative Examples 1-5 and rate their experience. The rating results are shown in Table 2. Six evaluation indicators were selected: smoke, tobacco flavor, taste, aftertaste, smoothness in the throat, and satisfaction. Each indicator had a maximum score of 3 points, and the arithmetic mean of the scores from the 50 smokers was taken.

[0041] Table 2 Sensory Evaluation The experimental results of Experiments 1-3 are shown in Table 3.

[0042] Table 3 Comparing the experimental data of Comparative Example 1 and Example 3 in Table 3, it can be seen that in Comparative Example 1, without pretreatment of nicotine, the aerosol generated by the nicotine liquid was somewhat irritating to the skin. This is because magnolia flower extract could not effectively alleviate the skin irritation caused by nicotine aerosol. In Comparative Example 2, replacing the magnolia flower extract with an equal amount of chamomile extract increased the skin irritation caused by the aerosol generated by the nicotine liquid. In Example 3, the aerosol generated by the nicotine liquid was not irritating to the skin. This is because certain active ingredients in the magnolia flower extract could effectively alleviate the skin irritation caused by the aerosol generated after the nicotine liquid was pretreated with coral powder, making the skin less prone to allergic reactions. Therefore, only by pretreating the nicotine and then adding the magnolia flower extract can the skin irritation caused by the aerosol generated after the nicotine liquid was pretreated with coral powder be effectively alleviated.

[0043] Comparing Comparative Example 3 and Example 3, the coral powder in Comparative Example 3 passed through a 16-mesh sieve, and the aerosol generated by the nicotine liquid in Comparative Example 3 had a certain degree of skin irritation. In contrast, Examples 1-3 specified that the coral powder passed through a 20-40 mesh sieve, and the aerosol generated in Examples 1-3 did not irritate the skin. Furthermore, the taste scores in Examples 1-3 were significantly higher than those in Comparative Examples 1-3. This is because the coral powder uses a specific particle size, resulting in a smaller aerosol particle size, which improves the atomization effect of the nicotine liquid after coral powder pretreatment, thereby reducing the grainy feel and providing a better user experience.

[0044] Comparing the data from Comparative Examples 4-5 in Table 3 with those from Example 3, it can be seen that the amounts of each component in Comparative Examples 4-5 are outside the scope protected by this application. The aerosols generated in Comparative Examples 4-5 are somewhat irritating to the skin, which is because the amount of each component also affects its performance. In contrast, the amounts of each component in the nicotine liquid in Example 3 are all within the scope of this application, and the aerosols generated in Example 3 are not irritating to the skin. Therefore, not any arbitrary ratio can achieve the technical effects of this application.

[0045] Comparing the data from Examples 4-6 in Table 3 with Example 3, it can be seen that Examples 4-5 specified the mass ratio of nicotine to modified coral powder and the mass ratio of nicotine to magnolia flower extract. The aerosols generated in Examples 4-5 showed reduced skin irritation, and the sensory scores in Examples 4-5 were higher than those in Example 3. This indicates that using specific proportions of nicotine and magnolia flower extract, and specific proportions of coral powder and nicotine, not only helps to further alleviate the irritation of human skin caused by the aerosols generated after the nicotine liquid is atomized after coral powder pretreatment, making human skin less prone to allergic reactions, but also helps to improve the persistence of nicotine release, thereby improving the user experience.

[0046] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A nicotine liquid for an aerosol device, characterized in that: The components include the following parts by mass: Nicotine 2-4 parts; Magnolia flower extract 8-10 parts; 40-50 parts of 1,3-propanediol; 1-3 parts of additives; The nicotine content of the magnolia flower extract is 40-50% by mass. The additives include sweeteners and tobacco flavorings; The method for preparing the nicotine liquid for the aerosol device includes the following steps: Step 1: Pre-treat the nicotine, as follows: S1. Preparation of coral powder: Natural coral is crushed and added to sodium hydroxide solution, soaked and ultrasonically cleaned, taken out and dried to obtain coral powder. S2. Preparation of modified coral powder: After ball milling the coral powder, it is added to an ethanol solution and mixed into a suspension. Then, polyethylene glycol is added, mixed evenly, dried, taken out, ground, and sieved to obtain modified coral powder. S3. Pre-treatment of nicotine: Dissolve modified coral powder in water, then add nicotine, stir evenly, and finally freeze-dry to obtain pre-treated nicotine. Step 2: Add the pretreated nicotine, magnolia flower extract, 1,3-propanediol and additives to a mixing tank and mix well to obtain nicotine liquid. In step S2, modified coral powder is obtained by passing it through a 20-40 mesh sieve; the mass ratio of nicotine to modified coral powder is (1.2-1.6):

1.

2. The nicotine liquid for an aerosol device according to claim 1, characterized in that: The sweetener includes mannitol.

3. The nicotine liquid for an aerosol device according to claim 1, characterized in that: The flavorings used in tobacco products include one or more of strawberry flavoring, passion fruit flavoring, and blueberry flavoring.

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