An acne-removing composition, use thereof, and cosmetic

Abstract

The application relates to a kind of acne-removing compositions and its application, cosmetics. The acne-removing composition includes the following components by weight: white willow bark extract 2 parts, magnolia bark extract 0.1-10 parts, centella asiatica extract 0.1-5 parts, and composite acne-removing extract 0.5-20 parts. The composite acne-removing extract includes coptis root extract, costus root extract and Ilex asprella extract, and the mass ratio of the coptis root extract, costus root extract and Ilex asprella extract is 1:(1-4):(1-10). The acne-removing composition provided by the application can effectively inhibit the activity of 5alpha-reductase and has good acne-removing effect.

Description

Technical Field

[0001] This application relates to the field of cosmetic technology, specifically to an acne-removing composition and its application, and cosmetics. Background Technology

[0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit, commonly occurring during adolescence. Its clinical manifestations include facial acne, papules, pustules, nodules, and other polymorphic skin lesions. The pathogenesis of acne is as follows: keratinization of the hair follicle leads to blockage, hindering sebum drainage. Increased sebum secretion accumulates within the hair follicle and sebaceous gland, creating a breeding ground for Propionibacterium acnes. When pores are blocked, these bacteria proliferate, breaking down saturated fatty acids and producing large amounts of free fatty acids. These fatty acids seep into the skin through the pores, causing a skin stress response, resulting in comedones, redness, and swelling. Bacteria such as Staphylococcus aureus adhere to the skin through the expelled pus, damaging skin tissue and ultimately leading to bacterial overgrowth. This simultaneously induces inflammation of the hair follicle and sebaceous gland. Malassezia, in particular, can cause keratinocytes to secrete more IL-1β, IL-6, IL-8, and TNF-α, while reducing IL-10 secretion, exacerbating the inflammatory response and potentially leading to scarring, causing disfiguring effects. Therefore, how to effectively prevent and treat acne remains an urgent problem to be solved. Summary of the Invention

[0003] To address the problems existing in the prior art, this application provides an acne-removing composition and its application, as well as a cosmetic.

[0004] In a first aspect, embodiments of this application provide an acne-removing composition comprising the following components in parts by weight: 2 parts of white willow bark extract, 0.1-10 parts of magnolia bark extract, 0.1-5 parts of centella asiatica extract, and 0.5-20 parts of a compound acne-removing extract; wherein,

[0005] The compound acne-removing extract includes Coptis chinensis root extract, Aucklandia lappa extract and ginseng extract, and the mass ratio of Coptis chinensis root extract, Aucklandia lappa extract and ginseng extract is 1:(1-4):(1-10).

[0006] In some embodiments, the acne-removing composition comprises the following components in parts by weight: 2 parts of white willow bark extract, 2-4 parts of magnolia bark extract, 2-4 parts of centella asiatica extract, and 1-10 parts of compound acne-removing extract.

[0007] In some embodiments, the mass ratio of Coptis chinensis root extract, Aucklandia lappa extract, and ginseng extract in the compound acne-removing extract is 1:1:4.

[0008] Secondly, embodiments of this application provide the application of the acne-removing composition of the first aspect of this application in cosmetics.

[0009] In some embodiments, the acne-removing composition comprises 3% to 15% by weight, based on the total mass of the cosmetic product.

[0010] Thirdly, embodiments of this application provide a cosmetic product, including the acne-removing composition of the first aspect of this application.

[0011] In some embodiments, the cosmetic comprises the following components in weight percentages: 3%–15% acne-removing composition, 5%–10% excipients, and 75%–92% water.

[0012] In some embodiments, the cosmetic comprises the following components in weight percentages: 5%–8% acne-removing composition, 5%–10% excipients, and 82%–90% water.

[0013] In some embodiments, the excipients include one or more of the following: humectants, thickeners, preservatives, emulsifiers, chelating agents, pH adjusters, and antioxidants.

[0014] In some embodiments, the humectant includes one or more of glycerin, butylene glycol, glyceryl polyether-26, propylene glycol, hexanediol, pentanediol, and methylpropanediol.

[0015] In some embodiments, the thickener includes one or more of carbomer, xanthan gum, ammonium acryloyldimethyl taurate / VP copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, and sodium hyaluronate.

[0016] In some embodiments, the preservative includes one or more of phenoxyethanol, chlorphenesin, p-hydroxyacetophenone, glyceryl caprylate, and ethylhexylglycerin.

[0017] In some embodiments, the emulsifier includes one or more of polyglycerol-6 distearate, glyceryl stearate, cetearyl oleate, sorbitan oleate, lecithin, hydrogenated lecithin, and phosphatidylcholine.

[0018] In some embodiments, the chelating agent includes one or both of disodium ethylenediaminetetraacetate and octanoyl hydroxamic acid.

[0019] In some embodiments, the pH adjuster includes one or more of arginine, sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, and sodium citrate.

[0020] In some embodiments, the antioxidant includes one or more of ascorbic acid, tocopheryl acetate, and sodium metabisulfite. Attached Figure Description

[0021] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments of this application will be briefly introduced below. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is a comparison chart of the inhibition rates of 5α-reductase by the samples of Example 1 and Comparative Examples 1-3.

[0023] Figure 2 This is a comparison chart of the inhibition rates of 5α-reductase by samples from Examples 1 to 7. Detailed Implementation

[0024] The features and exemplary embodiments of various aspects of this application will now be described in detail. Numerous specific details are set forth in the following detailed description to provide a comprehensive understanding of this application. However, it will be apparent to those skilled in the art that this application can be implemented without requiring some of these specific details. The following description of embodiments is merely intended to provide a better understanding of this application by illustrating examples. In the following description, at least some well-known structures and techniques are not shown to avoid unnecessarily obscuring the application; and, for clarity, the dimensions of some structures may be exaggerated. Furthermore, the features, structures, or characteristics described below can be combined in any suitable manner in one or more embodiments.

[0025] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. In the description of this application, it should be noted that, unless otherwise stated, "a plurality of" means two or more. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising..." does not exclude the presence of additional identical elements in the process, method, article, or apparatus that includes said element.

[0026] An embodiment of the first aspect of this application provides an acne-removing composition comprising the following components in parts by weight: 2 parts of white willow bark extract, 0.1-10 parts of magnolia bark extract, 0.1-5 parts of centella asiatica extract, and 0.5-20 parts of a compound acne-removing extract; wherein the compound acne-removing extract comprises coptis root extract, costus root extract, and kidney tea extract, and the mass ratio of coptis root extract, costus root extract, and kidney tea extract is 1:(1-4):(1-10).

[0027] Coptis chinensis, belonging to the Ranunculaceae family, is bitter and cold in nature, entering the heart, liver, stomach, and large intestine meridians. It has the effects of clearing heat and drying dampness, purging fire and detoxifying. Aucklandia lappa, belonging to the Asteraceae family, is bitter, pungent, and warm in nature, entering the liver, spleen, and stomach meridians. It has the effects of aromatic stomachic, qi-regulating, and pain-relieving properties. Kidney tea, belonging to the Lamiaceae family, is sweet and slightly bitter in taste, cool in nature, and enters the kidney meridian. It has the effects of clearing heat and removing dampness, expelling stones and promoting urination. The inventors discovered that when Coptis chinensis root extract, Aucklandia lappa extract, and kidney tea extract are combined in a certain proportion, it has a good inhibitory effect on 5α-reductase, which can effectively inhibit excessive sebum secretion, reduce skin inflammation and infection, and thus prevent and treat acne. Furthermore, the above compositions are all derived from natural plants, have low irritation and few side effects, can reduce infections and complications caused by long-term use of hormones, and can repair the skin barrier.

[0028] Furthermore, this application embodiment provides an acne-removing composition incorporating white willow bark extract, magnolia bark extract, and centella asiatica extract. White willow bark extract can accelerate the renewal of the stratum corneum and unclog keratin plugs; magnolia bark extract can have antibacterial, anti-inflammatory, and skin-inflammation-relieving effects; and centella asiatica extract can repair skin damage, fade acne scars, and accelerate wound healing. Through the combined use of white willow bark extract, magnolia bark extract, and centella asiatica extract with the compound acne-removing extract, skin inflammation and infection can be reduced, acne can be prevented, and skin damage can be effectively repaired, resulting in a significant improvement in skin condition.

[0029] In some embodiments, the acne-removing composition may include the following components in weight percentages: 2 parts white willow bark extract, 2-4 parts magnolia bark extract, 2-4 parts centella asiatica extract, and 1-10 parts compound acne-removing extract. By limiting the content of each component in the acne-removing composition to the above range, it is beneficial to further enhance the acne-removing effect of the acne-removing composition, while the combination of each component is gentler and can better improve the skin effect.

[0030] In some embodiments, the mass ratio of Coptis chinensis root extract, Aucklandia lappa extract, and gentiana oleracea extract in the compound acne-removing composition is 1:1:4. The inventors have discovered through experimental research that when the proportions of Coptis chinensis root extract, Aucklandia lappa extract, and gentiana oleracea extract are further limited to the above range, it exhibits better inhibitory effects on 5α-reductase, enhances the inhibitory effect on excessive sebum secretion, further reduces skin inflammation and infection, and improves the acne-removing effect.

[0031] In some embodiments, extracts of white willow bark, magnolia bark, centella asiatica, coptis root, costus root, and kidney tea can all be obtained by methods commonly used in the art. For example, a preliminary extraction can be performed using thermal dissolution extraction, followed by a secondary extraction using supercritical fluid extraction.

[0032] Optionally, the solvent for preliminary extraction can be one or more of water, glycerol, butanediol, ethanol, and propylene glycol.

[0033] Optionally, the initial extraction temperature can be 45℃ to 65℃.

[0034] Optionally, the extraction method may include:

[0035] S110: Take the crushed plant raw material powder and filter it using a 100-200 mesh filter to remove larger particles;

[0036] S120: Mix the filtered powder with the solvent at a ratio of 1:9, heat to 40℃~65℃, stir at a speed of 45rpm~60rpm for 5h~10h, and homogenize at 3000rpm~3500rpm for 10min~20min during the stirring process.

[0037] S130, after the mixing time is reached, pour the material into the high-pressure micro-jet equipment, set the pressure to 6000 bar, and pass it through the high-pressure micro-jet 5-10 times;

[0038] S140, the material after preliminary extraction is added to the reactor of the supercritical carbon dioxide extraction equipment for secondary gas extraction. The specific method is as follows: add supercritical carbon dioxide, control the pressure at 25 MPa to extract the active ingredients, and after extraction, reduce the pressure to separate the carbon dioxide and separate the supernatant.

[0039] S150: The supernatant is purified by passing it through an ion exchange column to obtain the extract.

[0040] The purified extract can be tested for the content of active ingredients. After passing the test, it is sterilized and stored in a sealed container.

[0041] The embodiments of the second aspect of this application provide for the application of the embodiments of the first aspect of this application in cosmetics.

[0042] An embodiment of the third aspect of this application provides a cosmetic product, including the acne-removing composition of the first aspect of this application.

[0043] In some embodiments, the cosmetic may include the following components in weight percentages: 3%–15% acne-fighting composition, 5%–10% excipients, and 75%–92% water.

[0044] By adding the acne-removing composition of the first aspect of this application to a cosmetic and limiting the content of its components within the above-mentioned range, it can effectively inhibit the activity of 5α-reductase, thereby enabling the cosmetic to have a good acne-removing effect.

[0045] Optionally, the cosmetic may include the following components in weight percentages: 5%–8% acne-fighting composition, 5%–10% excipients, and 82%–90% water. By limiting the content of the acne-fighting composition in the cosmetic to within the above-mentioned units, the acne-fighting effect of the cosmetic can be further improved.

[0046] In some embodiments, excipients may include one or more of the following: humectants, thickeners, preservatives, emulsifiers, chelating agents, pH adjusters, and antioxidants.

[0047] In some embodiments, the humectant may include one or more of glycerin, butylene glycol, glyceryl polyether-26, propylene glycol, hexanediol, pentanediol, and methylpropanediol.

[0048] In some embodiments, the thickener may include one or more of carbomer, xanthan gum, ammonium acryloyldimethyl taurate / VP copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, and sodium hyaluronate.

[0049] In some embodiments, the preservative may include one or more of phenoxyethanol, chlorphenesin, p-hydroxyacetophenone, glyceryl caprylate, and ethylhexylglycerin.

[0050] In some embodiments, the emulsifier may include one or more of polyglycerol-6 distearate, glyceryl stearate, cetearyl oleate, sorbitan oleate, lecithin, hydrogenated lecithin, and phosphatidylcholine.

[0051] In some embodiments, the chelating agent may include one or both of disodium ethylenediaminetetraacetate and octanoyl hydroxamic acid.

[0052] In some embodiments, the pH adjuster may include one or more of arginine, sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, and sodium citrate.

[0053] In some embodiments, antioxidants may include one or more of ascorbic acid, tocopheryl acetate, and sodium metabisulfite.

[0054] Example

[0055] The following specific embodiments illustrate the present invention. It should be noted that the embodiments described below are exemplary and are only used to explain this application, and should not be construed as limiting this application. Where specific techniques or conditions are not specified in the embodiments, they shall be performed in accordance with the techniques or conditions described in the literature in the art or according to the product instructions. Reagents or instruments used, unless otherwise specified, are all conventional products that can be obtained commercially.

[0056] Example 1

[0057] An acne-removing composition comprising the following components in parts by weight: 2 parts white willow bark extract, 2 parts magnolia bark extract, 0.2 parts centella asiatica extract, 1 part coptis root extract, 1 part costus root extract, and 4 parts kidney tea extract.

[0058] The excipients were designated as phase A, and the above-mentioned acne-removing composition was designated as phase B. The components of phase A were mixed, heated to 80°C, and stirred until homogeneous and free of particles. The mixture was then cooled to 25°C, and phase B was added and stirred until homogeneous before being discharged. Performance testing was then conducted. The ratio of phase A to phase B is detailed in Table 1.

[0059] Table 1

[0060]

[0061] Example 2

[0062] The allocation ratios for each group in Example 2 are detailed in Table 2.

[0063] Table 2

[0064]

[0065]

[0066] Example 3

[0067] The allocation ratios for each group in Example 3 are detailed in Table 3.

[0068] Table 3

[0069]

[0070] Example 4

[0071] The allocation ratios for each group in Example 4 are detailed in Table 4.

[0072] Table 4

[0073]

[0074] Example 5

[0075] The allocation ratios of each group in Example 5 are detailed in Table 5.

[0076] Table 5

[0077]

[0078] Example 6

[0079] The allocation ratios for each group in Example 6 are detailed in Table 6.

[0080] Table 6

[0081]

[0082] Example 7

[0083] The allocation ratios for each group in Example 7 are detailed in Table 7.

[0084] Table 7

[0085]

[0086]

[0087] Comparative Example 1

[0088] The allocation ratios for each group in Comparative Example 1 are detailed in Table 8.

[0089] Table 8

[0090]

[0091] Comparative Example 2

[0092] The allocation ratios for each group in Comparative Example 2 are detailed in Table 9.

[0093] Table 9

[0094]

[0095] Comparative Example 3

[0096] The allocation ratios for each group in Comparative Example 3 are detailed in Table 10.

[0097] Table 10

[0098]

[0099] The samples from Examples 1-7 and Comparative Examples 1-3 were diluted with water at a mass ratio of 5:95 to a concentration of 5%, and then added dropwise to a 5α-reductase source at a concentration of 0.25 wt% of the 5α-reductase source. After complete reaction, the products were separated and then quantitatively analyzed. The analytical results are as follows: Figure 1 and Figure 2 As shown.

[0100] Figure 1 The inhibition rates of 5α-reductase by the samples in Example 1 and Comparative Examples 1-3 are shown. It can be seen that the compound acne-reducing extract, comprising Coptis chinensis root extract, Aucklandia lappa extract, and Tea jasminoides extract, exhibits a significant inhibitory effect on 5α-reductase, and this effect is significantly superior to the sum of the inhibitory effects of using Coptis chinensis root extract, Aucklandia lappa extract, or Tea jasminoides extract alone in the formulation. This demonstrates that the use of the compound acne-reducing extract comprising Coptis chinensis root extract, Aucklandia lappa extract, and Tea jasminoides extract in the formulation has a synergistic effect in promoting 5α-reductase inhibition.

[0101] Figure 2 The inhibition rates of 5α-reductase by the samples in Examples 1 to 7 are shown. A comparison of Examples 1, 2, and 3 reveals that the inhibitory effect on 5α-reductase gradually strengthens with increasing proportion of kidney tea extract. Comparing Examples 3 and 4, increasing the proportion of kidney tea extract from 8% to 10% does not significantly improve the inhibitory effect on 5α-reductase; therefore, approximately 8% kidney tea extract is the optimal proportion. A comparison of Examples 3, 5, 6, and 7 shows that increasing the proportions of Coptis chinensis root extract and Aucklandia lappa root extract enhances the inhibitory effect on 5α-reductase; the best effect is achieved when each extract is added at 4%.

[0102] Although this application has been described with reference to preferred embodiments, various modifications can be made thereto and components can be replaced with equivalents without departing from the scope of this application. In particular, the technical features mentioned in the various embodiments can be combined in any manner, provided there is no structural conflict. This application is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. An acne-removing composition, characterized in that, It includes the following components in parts by weight: White willow bark extract 2 parts, magnolia bark extract 0.1-10 parts, centella asiatica extract 0.1-5 parts, compound acne-fighting extract 0.5-20 parts; among which, The compound acne-removing extract includes Coptis chinensis root extract, Aucklandia lappa extract and ginseng extract, wherein the mass ratio of Coptis chinensis root extract, Aucklandia lappa extract and ginseng extract is 1:(1~4):(1~10). The preparation methods of the Coptis chinensis root extract, the Aucklandia lappa extract, and the kidney tea extract include: performing a preliminary extraction by thermal dissolution extraction, followed by a secondary extraction by supercritical extraction, wherein the solvent for the preliminary extraction is one or more of water, glycerol, butylene glycol, ethanol, and propylene glycol, and the extraction temperature for the preliminary extraction is 45℃~65℃.

2. The acne-removing composition according to claim 1, characterized in that, The acne-removing composition comprises the following components in parts by weight: 2 parts of white willow bark extract, 2-4 parts of magnolia bark extract, 2-4 parts of centella asiatica extract, and 1-10 parts of compound acne-removing extract.

3. The acne-removing composition according to claim 1 or 2, characterized in that, In the compound acne-removing extract, the mass ratio of Coptis chinensis root extract, Aucklandia lappa extract, and ginseng extract is 1:1:

4.

4. The use of the acne-removing composition according to any one of claims 1 to 3 in the preparation of cosmetics.

5. The application according to claim 4, characterized in that, Based on the total mass of the cosmetic product, the weight percentage of the acne-removing composition is 3% to 15%.

6. A cosmetic product, characterized in that, Includes the acne-removing composition according to any one of claims 1 to 3.

7. The cosmetic product according to claim 6, characterized in that, The cosmetic comprises the following components in weight percentage: 3%~15% acne-removing composition, 5%~10% excipients, and 75%~92% water.

8. The cosmetic product according to claim 6, characterized in that, The cosmetic product comprises the following components in weight percentage: 5%~8% acne-removing composition, 5%~10% excipients, and 82%~90% water.

9. The cosmetic product according to claim 7 or 8, characterized in that, The excipients include one or more of the following: humectants, thickeners, preservatives, emulsifiers, chelating agents, pH adjusters, and antioxidants.

10. The cosmetic product according to claim 9, characterized in that, The moisturizer includes one or more of glycerin, butylene glycol, glyceryl polyether-26, propylene glycol, hexanediol, pentanediol, and methylpropylene glycol; and / or The thickener includes one or more of carbomer, xanthan gum, ammonium acryloyl dimethyl taurate / VP copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, and sodium hyaluronate; and / or The preservative includes one or more of phenoxyethanol, chlorphenesin, p-hydroxyacetophenone, glyceryl caprylate, and ethylhexylglycerin; and / or The emulsifier comprises one or more of polyglycerol-6 distearate, glyceryl stearate, cetearyl oleate, sorbitan oleate, lecithin, hydrogenated lecithin, and phosphatidylcholine; and / or The chelating agent includes one or two of disodium ethylenediaminetetraacetate and octanoyl hydroxamic acid; and / or The pH adjuster includes one or more of arginine, sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, and sodium citrate; and / or The antioxidants include one or more of ascorbic acid, tocopheryl acetate, and sodium metabisulfite.

Images