An electronic atomizing liquid containing 6-chloronicotine or a salt thereof and a preparation method thereof

Abstract

The application discloses an electronic atomizing liquid containing 6-chloronicotine or a salt thereof and a preparation method thereof, and relates to the technical field of electronic atomizing liquids. The electronic atomizing liquid containing 6-chloronicotine or a salt thereof is composed of the following components in percentage by weight: 6-chloronicotine or 6-chloronicotine salt 0.1-2.5%, nicotine salt 7.5-15%, glycerol 35-40%, perfume and flavor base liquid 35-45%, and the balance propylene glycol. The electronic atomizing liquid containing 6-chloronicotine or a salt thereof uses 6-chloronicotine or 6-chloronicotine salt as raw material, and can produce the feeling of wanting to quit smoking and the feeling of wanting to hit the throat brought by high inhaled nicotine in the case of less inhaled amount by virtue of the unique physiological activity, so that the inhaled amount of users can be reduced, and the purpose of increasing efficiency and reducing harm is achieved.

Description

Technical Field

[0001] This invention relates to the field of electronic atomizing liquid technology, and in particular to an electronic atomizing liquid containing 6-chloronicotine or its salt and a method for preparing the same. Background Technology

[0002] Nicotine is a naturally occurring alkaloid found in tobacco. Extracted from tobacco, it is used to prepare e-liquids for inhalation via vaporization. Currently, many e-liquid products contain varying concentrations of nicotine. E-liquids with lower nicotine content tend to have a weaker throat hit, leading users to unconsciously inhale more nicotine to enhance the throat hit experience. This results in nicotine dependence. Therefore, there is an urgent need for a nicotine substitute to replace the nicotine in e-liquids.

[0003] Reports indicate that nicotine binds to nicotine acetylcholine receptors, which can relax the mind and alleviate addiction. Nicotine enters the brain through the respiratory system and bloodstream, where it binds to nicotine acetylcholine receptors and increases their concentration. Over time, a person becomes increasingly dependent on the pleasure derived from nicotine inhalation, which is nicotine addiction.

[0004] The throat hit during vaping refers to the stimulation of the back of the throat caused by the vapor after it is inhaled. A strong throat hit refers to a rapid and intense stimulation of the back of the throat after the vapor enters the mouth. It is well known that nicotine content plays a crucial role in the perception of the throat hit. Generally, the higher the nicotine concentration, the greater the irritation to the throat and the stronger the throat hit, and vice versa. Limitations on nicotine concentration may result in insufficient craving relief. Therefore, creating a better throat hit and vaping experience within the standard concentration range has become the key to overcoming these limitations.

[0005] Ferretti and Hong Xing et al. (Bioorganic & Medicinal Chemistry Letters 13(2003)733-735; Mol Pharmacol 98:168-180, August 2020) summarized the relationship between nicotine derivatives and nAChRs. 6-chloronicotine is a class of compounds formed by chlorination at the 6-position of the nicotine pyridine ring. Due to its unique structure, it exhibits better lipophilicity than nicotine and displays superior agonist properties in response to nicotine α7 receptors, showing activity similar to nicotine α4β2 receptors. Compared to nicotine, 6-chloronicotine shows improved nAChR titer and balanced binding affinity to human receptors. Bachir Latli and Kevin D'Amour et al. (Novel and Potent 6-Chloro-3-pyridinyl Ligands for the alpha4beta2 Neuronal Nicotinic Acetylcholine Receptor, J.Med.Chem.1999, 42, 2227-2234) reported that 6-chloro nicotine products have excellent agonistic properties with alpha4β2 and can enhance their binding ability to nicotine acetylcholine receptors. Therefore, applying 6-chloronicotine to e-liquids can enhance the throat hit and improve the nicotine's ability to relieve addiction. Summary of the Invention

[0006] Currently, there are no effective additives on the market to enhance the throat hit or craving sensation of e-cigarette liquids. To improve these sensations, most commercially available e-cigarette liquids increase nicotine concentration or add free nicotine. However, this approach can result in a strong odor and irritation due to excessively high nicotine concentrations. The unpleasant smell of free nicotine can also severely impact the vaping experience, and high concentrations of nicotine can cause significant harm to the body.

[0007] To address the aforementioned technical problems, this invention provides an electronic atomizing liquid containing 6-chloronicotine or its salt, and a method for preparing the same. 6-chloronicotine salt is prepared by combining 6-chloronicotine with organic acids, or it can be added directly to the electronic atomizing liquid in free form. Utilizing its unique physiological activity, it can produce the craving sensation and desired throat hit associated with high nicotine intake with a relatively small inhalation volume, thus reducing user absorption and achieving the goal of maximizing efficacy while minimizing harm.

[0008] Specifically, the following technical solutions are included:

[0009] In a first aspect, an electronic atomizing liquid containing 6-chloronicotine or its salt is provided, comprising the following components by weight percentage: 0.1-2.5% 6-chloronicotine or 6-chloronicotine salt, 7.5-15% nicotine salt, 35-40% glycerin, 35-45% flavoring base liquid, and the balance being propylene glycol; wherein the 6-chloronicotine accounts for 0.1-0.3% of the electronic atomizing liquid containing 6-chloronicotine or its salt by weight, and the 6-chloronicotine salt accounts for 1.5-2.5% of the electronic atomizing liquid containing 6-chloronicotine or its salt by weight.

[0010] Furthermore, the 6-chloronicotine salt is prepared from 6-chloronicotine, organic acids, and glycerol.

[0011] Furthermore, the organic acid is selected from a variety of benzoic acid, lactic acid, acetic acid, propionic acid, levulinic acid, DL-tartaric acid, malic acid, and citric acid.

[0012] Furthermore, the molar ratio of the organic acid to 6-chloronicotine is (0.7-1.4):1.

[0013] Preferably, the nicotine salt is composed of the following raw materials in weight percentages: nicotine 20%, benzoic acid 6.0%, levulinic acid 5.3%, lactic acid 7.4%, and glycerol 61.3%.

[0014] Preferably, the flavoring base liquid is one or more of grape flavoring, tobacco flavoring, oolong tea flavoring, sweet orange flavoring, apple flavoring, and blueberry flavoring.

[0015] Furthermore, the preparation method of the 6-chloronicotine salt includes the following steps: placing organic acid, 6-chloronicotine and glycerol into a reactor and stirring for 3-5 hours, then cooling to room temperature of 25-28°C to obtain the 6-chloronicotine salt.

[0016] Furthermore, in the preparation method of the 6-chloronicotine salt, the stirring temperature is 40-65℃ and the stirring speed is 200-500 r / min.

[0017] The preparation of 6-chloronicotine salt involves stirring and reacting organic acid, 6-chloronicotine, and glycerol. The process is simple, convenient, and safe.

[0018] Preferably, 6-chloronicotine salt is stored at a temperature of 2-8°C.

[0019] Among them, 6-chloronicotine salt is not easily degraded at 2-8℃ and does not easily change color.

[0020] Furthermore, the 6-chloronicotine salt is composed of the following raw materials in weight percentages: 20% 6-chloronicotine, 5-10% benzoic acid, 0.3-0.8% propionic acid, 1.5-3% lactic acid, and the balance being glycerol.

[0021] Preferably, when the organic acid is composed of benzoic acid, propionic acid and lactic acid, the molar ratio of the organic acid to 6-chloronicotine is (0.7-0.9):1.

[0022] In this process, benzoic acid, propionic acid, and lactic acid are mixed and reacted with 6-chloronicotine to form a salt. Benzoic acid mainly enhances the throat hit and stimulation, while propionic acid and lactic acid are acidic substances produced during tobacco fermentation. The special fermentation aroma can better blend with the e-liquid without affecting the original aroma of the e-liquid.

[0023] Furthermore, the 6-chloronicotine salt is composed of the following raw materials in weight percentage: 20% 6-chloronicotine, 4-6% benzoic acid, 8-12% lactic acid, 0.5-1.5% acetic acid, 0.5-1.5% DL-tartaric acid, and the balance being glycerol.

[0024] Preferably, when the organic acid is composed of benzoic acid, lactic acid, acetic acid and DL-tartaric acid, the molar ratio of the organic acid to 6-chloronicotine is (1.2-1.4):1.

[0025] The mixture uses benzoic acid, lactic acid, acetic acid, and DL-tartaric acid to react with 6-chloronicotine to form a salt. Benzoic acid mainly enhances the throat hit and stimulation, lactic acid is an acid produced when fruits ripen, acetic acid is the sour taste of fruits, and DL-tartaric acid, commonly known as grape acid, is an acid found in fruits. The combination of these four acids can well express the characteristics of electronic atomizing liquid without affecting the original aroma.

[0026] Furthermore, the 6-chloronicotine salt is composed of the following raw materials in weight percentages: 20% 6-chloronicotine, 10-12% benzoic acid, 2-4% lactic acid, and the balance being glycerol.

[0027] Preferably, when the organic acid is composed of benzoic acid and lactic acid, the molar ratio of the organic acid to 6-chloronicotine is (0.9-1.1):1.

[0028] Among them, benzoic acid and lactic acid have different and complementary functions in 6-chloronicotine salt. Benzoic acid mainly enhances the throat hit and stimulation, while the special fermented aroma of lactic acid can harmonize the aroma of benzoic acid and 6-chloronicotine with the fragrance in the e-liquid.

[0029] In a second aspect, a method for preparing an electronic atomizing liquid containing 6-chloronicotine or its salt as described in the first aspect is provided, comprising the following steps: stirring 6-chloronicotine or 6-chloronicotine salt, nicotine salt, glycerin, flavoring base liquid and propylene glycol at 25-28°C until homogeneous to obtain an electronic atomizing liquid containing 6-chloronicotine or its salt.

[0030] The beneficial effects of this invention are as follows:

[0031] This invention provides an e-liquid containing 6-chloronicotine or its salt, and a method for preparing the same. Using 6-chloronicotine or its salt as a raw material, and leveraging its unique physiological activity, it can produce the craving and throat hit of a high dose of nicotine with a relatively small inhalation amount, thus reducing user absorption and achieving the goal of maximizing efficacy and minimizing harm. The prepared e-liquid containing 6-chloronicotine or its salt has a smooth taste, does not affect the characteristic aroma of the original e-liquid, and provides a strong throat hit and rapid craving relief. Detailed Implementation

[0032] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] It should be understood that, when used in this specification and the appended claims, the terms "comprising" and "including" indicate the presence of the described features, integrals, steps, operations, elements and / or components, but do not exclude the presence or addition of one or more other features, integrals, steps, operations, elements, components and / or collections thereof.

[0034] It should also be understood that the terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the invention. As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” are intended to include the plural forms unless the context clearly indicates otherwise.

[0035] It should also be further understood that the term "and / or" as used in this specification and the appended claims refers to any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0036] To better understand the technical content of the present invention, the technical solution of the present invention will be further introduced and explained below with reference to specific embodiments.

[0037] Preferably, the nicotine salt described in the embodiments and comparative examples of the present invention is composed of the following raw materials in weight percentage: nicotine 20%, benzoic acid 6.0%, levulinic acid 5.3%, lactic acid 7.4%, and glycerol 61.3%.

[0038] Preferably, the lactic acid described in the embodiments and comparative examples of the present invention is specifically composed of 80% lactic acid by weight and 20% water by weight.

[0039] Preparation method of 6-chloronicotine salt:

[0040] Organic acid, 6-chloronicotine, and glycerol are placed in a reactor and stirred at a temperature of 40-65℃ and a stirring speed of 200-500 r / min for 3-5 hours. After stirring, the mixture is cooled to room temperature of 25-28℃ to obtain 6-chloronicotine salt.

[0041] Preparation method of electronic atomizing fluid containing 6-chloronicotine or its salt:

[0042] An electronic atomizing liquid containing 6-chloronicotine or its salt is obtained by stirring 6-chloronicotine or its salt, nicotine salt, glycerin, flavor base liquid and propylene glycol at 25-28℃.

[0043] Performance Testing—Sensory Evaluation

[0044] Twenty professional e-liquid sensory evaluators were selected to evaluate the e-liquid samples in the following categories, and the average score was taken. The evaluation indicators are shown in Table 1:

[0045] Table 1 Sensory Effect Evaluation Indicators for Electronic Atomizing Fluids

[0046]

[0047]

[0048] Example

[0049] Example 1

[0050] An e-liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 2.25% 6-chloronicotine salt, 8.5% nicotine salt, 38% glycerin, 40% flavoring base (tobacco flavoring), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-liquid containing 6-chloronicotine or its salt is 4.5 mg / g, and the weight content of nicotine in the e-liquid containing 6-chloronicotine or its salt is 17 mg / g.)

[0051] The 6-chloronicotine salt is prepared from 6-chloronicotine, organic acids, and glycerol, wherein the organic acids are composed of benzoic acid, lactic acid, and propionic acid. The 6-chloronicotine salt is composed of the following raw materials in weight percentages: 20% 6-chloronicotine, 7.6% benzoic acid, 0.5% propionic acid, 1.9% lactic acid, with the balance being glycerol. The molar ratio of the organic acids to 6-chloronicotine is 0.84:1.

[0052] Specifically, the preparation method of the 6-chloronicotine salt includes the following steps:

[0053] Organic acid, 6-chloronicotine, and glycerol were placed in a reactor and stirred at a temperature of 55°C and a stirring speed of 350 r / min for 4 hours. The mixture was then cooled to room temperature of 25°C to obtain 6-chloronicotine salt.

[0054] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Example 1 includes the following steps: stirring 6-chloronicotine salt with nicotine salt, glycerin, flavor base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0055] Example 2

[0056] An e-cigarette liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 1.5% 6-chloronicotine salt, 15% nicotine salt, 35% glycerin, 35% flavor base (grape flavor), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 3 mg / g, and the weight content of nicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 30 mg / g.)

[0057] The 6-chloronicotine salt is prepared from 6-chloronicotine, organic acids, and glycerol. The organic acids consist of benzoic acid, lactic acid, acetic acid, and DL-tartaric acid. The 6-chloronicotine salt is composed of the following raw materials in weight percentages: 20% 6-chloronicotine, 4.3% benzoic acid, 10.5% lactic acid, 0.5% acetic acid, 0.6% DL-tartaric acid, with the balance being glycerol. The molar ratio of the organic acids to 6-chloronicotine is 1.38:1.

[0058] Specifically, the preparation method of the 6-chloronicotine salt includes the following steps:

[0059] Organic acid, 6-chloronicotine, and glycerol were placed in a reactor and stirred at a temperature of 40°C and a stirring speed of 200 r / min for 3 hours. The mixture was then cooled to room temperature of 25°C to obtain 6-chloronicotine salt.

[0060] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Example 2 includes the following steps: stirring 6-chloronicotine salt with nicotine salt, glycerin, flavor base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0061] Example 3

[0062] An e-cigarette liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 1.75% 6-chloronicotine salt, 10% nicotine salt, 40% glycerin, 45% flavoring base (oolong tea flavoring), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 3.5 mg / g, and the weight content of nicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 20 mg / g.)

[0063] The 6-chloronicotine salt is prepared from 6-chloronicotine, organic acids, and glycerol, wherein the organic acids are composed of benzoic acid and lactic acid. The 6-chloronicotine salt is composed of the following raw materials in weight percentages: 20% 6-chloronicotine, 10.5% benzoic acid, 2.4% lactic acid, and the balance being glycerol. The molar ratio of the organic acid to 6-chloronicotine is 1.05:1.

[0064] Specifically, the preparation method of the 6-chloronicotine salt includes the following steps:

[0065] Organic acid, 6-chloronicotine, and glycerol were placed in a reactor and stirred at a temperature of 65°C and a stirring speed of 500 r / min for 5 hours. After stirring, the mixture was cooled to room temperature of 28°C to obtain 6-chloronicotine salt.

[0066] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Example 3 includes the following steps: stirring 6-chloronicotine salt with nicotine salt, glycerin, flavor base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0067] Example 4

[0068] An e-cigarette liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 0.25% 6-chloronicotine, 8.5% nicotine salt, 38% glycerin, 40% flavoring base (tobacco flavoring), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 2.5 mg / g, and the weight content of nicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 17 mg / g.)

[0069] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Example 4 includes the following steps: 6-chloronicotine is stirred evenly with nicotine salt, glycerin, flavoring base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0070] Example 5

[0071] An e-cigarette liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 0.2% 6-chloronicotine, 15% nicotine salt, 35% glycerin, 35% flavor base (grape flavor), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 2 mg / g, and the weight content of nicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 30 mg / g.)

[0072] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Example 5 includes the following steps: 6-chloronicotine is stirred evenly with nicotine salt, glycerin, flavor base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0073] Example 6

[0074] An e-cigarette liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 0.15% 6-chloronicotine, 10% nicotine salt, 40% glycerin, 45% flavoring base (oolong tea flavoring), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 1.5 mg / g, and the weight content of nicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 20 mg / g.)

[0075] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Example 6 includes the following steps: 6-chloronicotine is stirred evenly with nicotine salt, glycerin, flavor base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0076] Comparative Example 1

[0077] The difference between Comparative Example 1 and Example 1 is that the electronic atomizing liquid does not contain 6-chloronicotine salt, while all other conditions are the same.

[0078] Comparative Example 2

[0079] An e-cigarette liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 0.05% 6-chloronicotine, 8.5% nicotine salt, 38% glycerin, 40% flavoring base (tobacco flavoring), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 0.5 mg / g, and the weight content of nicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 17 mg / g.)

[0080] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Comparative Example 2 includes the following steps: stirring 6-chloronicotine with nicotine salt, glycerin, flavor base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0081] Comparative Example 3

[0082] An e-cigarette liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 0.4% 6-chloronicotine, 8.5% nicotine salt, 38% glycerin, 40% flavoring base (tobacco flavoring), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 4 mg / g, and the weight content of nicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 17 mg / g.)

[0083] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Comparative Example 3 includes the following steps: 6-chloronicotine is stirred evenly with nicotine salt, glycerin, flavor base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0084] Comparative Example 4

[0085] An e-cigarette liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 1.0% 6-chloronicotine salt, 8.5% nicotine salt, 38% glycerin, 40% flavoring base (tobacco flavoring), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 2 mg / g, and the weight content of nicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 17 mg / g.)

[0086] The 6-chloronicotine salt is prepared from 6-chloronicotine, organic acids, and glycerol, wherein the organic acids are composed of benzoic acid, lactic acid, and propionic acid. The 6-chloronicotine salt is composed of the following raw materials in weight percentages: 20% 6-chloronicotine, 7.6% benzoic acid, 0.5% propionic acid, 1.9% lactic acid, with the balance being glycerol. The molar ratio of the organic acids to 6-chloronicotine is 0.84:1.

[0087] Specifically, the preparation method of the 6-chloronicotine salt includes the following steps:

[0088] Organic acid, 6-chloronicotine, and glycerol were placed in a reactor and stirred at a temperature of 55°C and a stirring speed of 350 r / min for 4 hours. The mixture was then cooled to room temperature of 25°C to obtain 6-chloronicotine salt.

[0089] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Comparative Example 4 includes the following steps: stirring 6-chloronicotine salt with nicotine salt, glycerin, flavor base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0090] Comparative Example 5

[0091] An e-cigarette liquid containing 6-chloronicotine or its salt comprises the following components by weight percentage: 3.0% 6-chloronicotine salt, 8.5% nicotine salt, 38% glycerin, 40% flavoring base (tobacco flavoring), and the balance being propylene glycol. (The weight content of 6-chloronicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 6 mg / g, and the weight content of nicotine in the e-cigarette liquid containing 6-chloronicotine or its salt is 17 mg / g.)

[0092] The 6-chloronicotine salt is prepared from 6-chloronicotine, organic acids, and glycerol, wherein the organic acids are composed of benzoic acid, lactic acid, and propionic acid. The 6-chloronicotine salt is composed of the following raw materials in weight percentages: 20% 6-chloronicotine, 7.6% benzoic acid, 0.5% propionic acid, 1.9% lactic acid, with the balance being glycerol. The molar ratio of the organic acids to 6-chloronicotine is 0.84:1.

[0093] Specifically, the preparation method of the 6-chloronicotine salt includes the following steps:

[0094] Organic acid, 6-chloronicotine, and glycerol were placed in a reactor and stirred at a temperature of 55°C and a stirring speed of 350 r / min for 4 hours. The mixture was then cooled to room temperature of 25°C to obtain 6-chloronicotine salt.

[0095] The preparation method of the electronic atomizing liquid containing 6-chloronicotine or its salt in Comparative Example 5 includes the following steps: stirring 6-chloronicotine salt with nicotine salt, glycerin, flavor base liquid and propylene glycol at 25°C to obtain the electronic atomizing liquid containing 6-chloronicotine or its salt.

[0096] Comparative Example 6

[0097] Compared with Example 1, Comparative Example 6 differs in that the 6-chloronicotine salt in the electronic atomizing liquid containing 6-chloronicotine or its salt is prepared from 6-chloronicotine, organic acid and glycerol, wherein the organic acid is cinnamic acid, and the molar ratio of the organic acid to 6-chloronicotine is 0.84:1, and all other conditions are the same.

[0098] Comparative Example 7

[0099] Compared with Example 1, Comparative Example 7 differs in that the 6-chloronicotine salt in the electronic atomizing liquid containing 6-chloronicotine or its salt is prepared from 6-chloronicotine, organic acid and glycerol, wherein the organic acid is a single benzoic acid, and the molar ratio of the organic acid to 6-chloronicotine is 0.84:1, and all other conditions are the same.

[0100] Comparative Example 8

[0101] Compared with Example 1, Comparative Example 8 differs in that the 6-chloronicotine salt in the electronic atomizing liquid containing 6-chloronicotine or its salt is prepared from 6-chloronicotine, organic acid and glycerol, wherein the organic acid is a single lactic acid, and the molar ratio of the organic acid to 6-chloronicotine is 0.84:1, and all other conditions are the same.

[0102] Comparative Example 9

[0103] Compared with Example 1, Comparative Example 9 differs in that the 6-chloronicotine salt in the electronic atomizing liquid containing 6-chloronicotine or its salt is prepared from 6-chloronicotine, an organic acid and glycerol, wherein the organic acid is a single propionic acid, and the molar ratio of the organic acid to 6-chloronicotine is 0.84:1, and all other conditions are the same.

[0104] Sensory evaluation tests were conducted on the e-liquids containing 6-chloronicotine or its salts from Examples 1-6, as well as the e-liquid from Comparative Example 1. The test results are shown in Table 2 below:

[0105] Table 2. Sensory effect evaluation test results of Examples 1-6 and Comparative Example 1

[0106]

[0107] As shown in Table 2, the e-liquid with added 6-chloronicotine salt significantly improved the throat hit and craving sensation compared to the original e-liquid, while the aroma and comfort remained unaffected. Although the added 6-chloronicotine salt resulted in a slightly increased irritation, the vaping experience remained good, and comfort was not significantly affected.

[0108] The sensory effects of the electronic atomizing liquids from Comparative Examples 2 to 9 were evaluated, and the results are shown in Table 3 below.

[0109] Table 3. Sensory effect evaluation test results of comparative examples 2-9

[0110]

[0111]

[0112] As shown in Table 3, the e-liquids containing 6-chloronicotine or its salts, prepared using 6-chloronicotine which is not within the scope of this invention (Comparative Examples 2-3), have poor throat hit and craving sensation. The e-liquids containing 6-chloronicotine or its salts, prepared using 6-chloronicotine salts which are not within the scope of this invention (Comparative Examples 4-5), also have poor throat hit and craving sensation. Furthermore, the e-liquid containing 6-chloronicotine or its salts (Comparative Example 6), which uses 6-chloronicotine salts made from organic acids not within the scope of this invention, has poor sensory evaluation results. The e-liquids containing 6-chloronicotine or its salts (Comparative Examples 7-9), which use 6-chloronicotine salts made from single organic acids within the scope of this invention, have poor sensory evaluation results.

[0113] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in the present invention, and these modifications or substitutions should all be covered within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. An electronic atomizing liquid containing 6-chloronicotine or its salt, characterized in that, It is composed of the following components by weight percentage: 0.1-2.5% 6-chloronicotine or 6-chloronicotine salt, 7.5-15% nicotine salt, 35-40% glycerin, 35-45% flavor and fragrance base liquid, and the balance being propylene glycol; wherein the 6-chloronicotine accounts for 0.1-0.3% of the weight percentage of the e-liquid containing 6-chloronicotine or its salt, and the 6-chloronicotine salt accounts for 1.5-2.5% of the weight percentage of the e-liquid containing 6-chloronicotine or its salt.

2. The electronic atomizing liquid containing 6-chloronicotine or its salt as described in claim 1, characterized in that, The 6-chloronicotine salt is prepared from 6-chloronicotine, organic acids and glycerol.

3. The electronic atomizing liquid containing 6-chloronicotine or its salt as described in claim 2, characterized in that, The organic acid is selected from a variety of benzoic acid, lactic acid, acetic acid, propionic acid, levulinic acid, DL-tartaric acid, malic acid, and citric acid.

4. The electronic atomizing liquid containing 6-chloronicotine or its salt as described in claim 2, characterized in that, The molar ratio of the organic acid to 6-chloronicotine is (0.7-1.4):

1.

5. The electronic atomizing liquid containing 6-chloronicotine or its salt as described in claim 1, characterized in that, The preparation method of the 6-chloronicotine salt includes the following steps: organic acid, 6-chloronicotine and glycerol are put into a reactor and stirred for 3-5 hours, and then cooled to room temperature of 25-28°C to obtain 6-chloronicotine salt.

6. The electronic atomizing liquid containing 6-chloronicotine or its salt as described in claim 5, characterized in that, In the preparation method of the 6-chloronicotine salt, the stirring temperature is 40-65℃ and the stirring speed is 200-500 r / min.

7. The electronic atomizing liquid containing 6-chloronicotine or its salt as described in claim 1, characterized in that, The 6-chloronicotine salt is composed of the following raw materials in weight percentage: 20% 6-chloronicotine, 5-10% benzoic acid, 0.3-0.8% propionic acid, 1.5-3% lactic acid, and the balance being glycerol.

8. The electronic atomizing liquid containing 6-chloronicotine or its salt as described in claim 1, characterized in that, The 6-chloronicotine salt is composed of the following raw materials in weight percentage: 20% 6-chloronicotine, 4-6% benzoic acid, 8-12% lactic acid, 0.5-1.5% acetic acid, 0.5-1.5% DL-tartaric acid, and the balance being glycerol.

9. The electronic atomizing liquid containing 6-chloronicotine or its salt as described in claim 1, characterized in that, The 6-chloronicotine salt is composed of the following raw materials in weight percentage: 20% 6-chloronicotine, 10-12% benzoic acid, 2-4% lactic acid, and the balance being glycerol.

10. The method for preparing the electronic atomizing liquid containing 6-chloronicotine or its salt as described in any one of claims 1-9, characterized in that, The process includes the following steps: stirring 6-chloronicotine or 6-chloronicotine salt, nicotine salt, glycerin, flavor base liquid and propylene glycol at 25-28°C until homogeneous to obtain an electronic atomizing liquid containing 6-chloronicotine or its salt.

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