一种宣肺败毒中药组合物在制备抗肿瘤药物中的应用
By screening the active substances in the blood-entering components of Xuanfei Baidu Granules, regulating the MAPK signaling pathway and inhibiting the expression of key proteins, the Xuanfei Baidu traditional Chinese medicine composition has shown significant effects in treating pulmonary fibrosis, anti-tumor activity, and regulating insulin resistance, thus expanding its clinical application.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANDONG BUCHANG PHARMA
- Filing Date
- 2024-08-08
- Publication Date
- 2026-07-17
AI Technical Summary
Existing antibiotics are ineffective in treating pneumonia and pulmonary fibrosis. The traditional Chinese medicine composition Xuanfei Baidu Granules has been found to have potential uses in clinical applications, including anti-inflammatory, anti-tumor, insulin resistance, and hypoglycemic effects, thus expanding its clinical treatment scope.
By screening the active substances in the blood-entering components of Xuanfei Baidu Granules, such as decaffeoyl mucoside, baicalin, luteolin, and apigenin, the MAPK signaling pathway was regulated, inflammatory factor expression was inhibited, and pulmonary fibrosis was suppressed. At the same time, amygdalin inhibited the expression of FN protein and α-SMA protein, thus preventing and treating pulmonary fibrosis. It also showed inhibitory effects on tumor cells HCT-116 and PC3, and promoted glucose uptake and regulated insulin resistance in HepG-2 cells.
The traditional Chinese medicine composition for clearing the lungs and eliminating toxins significantly inhibits pulmonary fibrosis and tumor cell growth, lowers blood sugar levels, regulates inflammatory responses, and expands its clinical application indications.
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Figure CN118903335B_ABST