An in vivo thrombus in-situ formation device

Abstract

This invention relates to the field of thrombus prosthesis formation technology, and more particularly to an in-situ thrombus formation device. It includes a catheter tip, which is fixedly connected to a mirror-distributed array of flexible rings. The catheter tip has an annular array of injection holes located between the mirror-distributed flexible rings. The catheter tip is slidably and rotatably connected to a sliding column. The catheter tip is fixedly connected to a fixing ring, and the sliding column has a flow hole. The catheter tip is fixedly connected to a fixed connecting cylinder, and the sliding column and the fixed connecting cylinder cooperate to form a first sealed cavity. An injection tube is fixedly connected to the catheter tip. This invention pre-blocks the injection holes with the sliding column, and then uses the driving force of injecting thrombin solution to connect the flow hole and the injection hole, allowing the thrombin solution to enter the blood vessel. This prevents the thrombin solution from leaking and mixing with the blood prematurely as the blood moves along the vessel, thus preventing thrombus formation at a specific location.

Description

Technical Field

[0001] This invention relates to the field of thrombus prosthesis formation technology, and more particularly to an in-situ thrombus formation device. Background Technology

[0002] Thrombotic diseases have become a major type of disease affecting human health, including myocardial infarction, cerebral infarction, peripheral blood embolism, arterial embolism, and pulmonary embolism. Currently, there are many innovative therapeutic devices for thrombotic diseases in China, such as thrombus aspiration catheters and thrombectomy stents. Before these devices enter clinical trials, they all need to undergo preclinical animal studies to verify the feasibility, safety, and effectiveness of the devices in treating thrombotic diseases in animals. Therefore, the prerequisite is that a suitable thromboembolic model can be created in animals.

[0003] There are two main technical approaches to establishing this type of model. The first is to create a thrombus outside the body and then introduce it into the body using certain equipment. The second approach is not to create a thrombus outside the body, but to make the thrombus form in situ in the target blood vessel inside the body. When the diameter of the target blood vessel to be obstructed is large, this type of thrombus cannot be formed outside the body, and its transport will also be very difficult. Therefore, we will use relevant tools to make the thrombus form in the body. This process requires using a microcatheter to move along the blood vessel to the target blood vessel, and then sealing both ends of the target blood vessel through two microballoons. Thrombin solution is then injected into the blood between the two microballoons, so that the blood in the target blood vessel can form a thrombus with the thrombin solution. However, when the microcatheter moves along the blood vessel, the thrombin solution waiting to be injected can easily enter the blood vessel during the movement, causing the thrombin solution to exchange and mix with the blood in advance, resulting in some thrombi not forming in the specific location. Summary of the Invention

[0004] In order to overcome the shortcomings mentioned in the background art, the present invention provides an in vivo thrombus in situ formation device.

[0005] The technical solution is as follows: An in vivo thrombus in situ formation device includes a catheter head, which is fixedly connected to a mirror-distributed flexible ring. The catheter head is provided with an annular array of injection holes, which are located between the mirror-distributed flexible rings, and the distance between the injection holes and the mirror-distributed flexible rings is consistent. A sliding column is slidably and rotatably connected inside the catheter head. A fixed ring is fixedly connected inside the catheter head. A first elastic element is provided between the sliding column and the fixed ring. The sliding column is provided with a flow hole. All injection holes in the annular array communicate and cooperate with the flow hole. A fixed connecting cylinder is fixedly connected inside the catheter head. The sliding column and the fixed connecting cylinder are sealed and slidably connected. The sliding column and the fixed connecting cylinder cooperate to form a first sealed cavity. The flow hole on the sliding column communicates with the first sealed cavity. An injection tube is fixedly connected inside the catheter head, and the first sealed cavity communicates with the injection tube. An air injection component for expanding the mirror-distributed flexible rings is provided inside the catheter head.

[0006] Preferably, the fixed ring is fixedly connected to a mirror-distributed limiting block on the side near the sliding post, and the mirror-distributed limiting block is in limiting cooperation with the sliding post.

[0007] Preferably, the distance between the limiting block and the sliding column is a, and the distance between the central axis of the flow hole and the central axis of the adjacent injection hole is b, where a=b, so that the flow hole and the adjacent injection hole are accurately connected.

[0008] Preferably, the flexible ring is recessed inside the catheter tip to reduce contact between the flexible ring and the thrombus.

[0009] Preferably, the gas injection assembly includes a first gas injection tube, which is fixedly connected to the inside of the guide tube head. The guide tube head, the flexible ring near the injection tube, the sliding column, and the fixed connecting cylinder cooperate to form a second sealed cavity. The guide tube head, the flexible ring away from the injection tube, and the sliding column cooperate to form a third sealed cavity. The sliding column is provided with mirror-distributed gas injection channels, which connect the second sealed cavity and the third sealed cavity.

[0010] Preferably, the injection channels and the flow holes are misaligned in a mirror-image distribution.

[0011] Preferably, the system further includes a rotating assembly for rotating the sliding column. The rotating assembly is disposed inside the fixed connecting cylinder. The rotating assembly includes a sliding shaft, which is splinedly connected to the inside of the sliding column. A retaining shaft is fixedly connected to the sliding shaft inside the fixed connecting cylinder. A rotating groove is provided on the inner wall of the fixed connecting cylinder. The retaining shaft is slidably connected to the rotating groove. A driving assembly for moving the sliding shaft is provided inside the fixed connecting cylinder. An adaptation assembly for maintaining the volume of the first sealed cavity is provided on the sliding column.

[0012] Preferably, the drive assembly includes a fixed cylinder, which is fixedly connected to the inside of the fixed connecting cylinder. A first piston shaft is slidably connected inside the fixed cylinder and is fixedly connected to the sliding shaft. A second elastic element is provided between the fixed cylinder and the first piston shaft. The first piston shaft and the fixed cylinder cooperate to form a fourth sealed cavity. A second air injection tube is fixedly connected to the guide tube head. The second air injection tube passes through the fixed connecting cylinder and communicates with the fourth sealed cavity.

[0013] Preferably, the adaptation component includes an adjusting cylinder, which is fixedly connected to the sliding column, and the sliding shaft is fixedly connected to a second piston shaft, with the adjusting cylinder and the second piston shaft being in a sealed sliding connection.

[0014] Preferably, the sliding column is fixedly connected with uniformly distributed stirring shafts for stirring the solution inside the sliding column.

[0015] The beneficial effects of this invention are: 1. By pre-blocking the injection hole with a sliding column, and then using the injection force of thrombin solution to connect the flow hole and the injection hole, the thrombin solution enters the blood vessel, preventing the thrombin solution from leaking and mixing with the blood in advance when the blood moves along the blood vessel, thus preventing the thrombin solution from forming at a specific location.

[0016] 2. The sliding shaft drives the sliding column to rotate synchronously, and the sliding column drives the flow hole on it to rotate synchronously. The rotation of the flow hole connects with the other injection holes in sequence, changing the direction of thrombin solution entering the blood vessel, causing thrombus to form in different locations in the target blood vessel, and increasing the types of thrombus formation.

[0017] 3. By sliding the second piston shaft along the adjusting cylinder, the reduced volume of the sealed cavity formed by the sliding column and the fixed connecting cylinder is compensated, so that the thrombin solution in the sealed cavity is replenished into the adjusting cylinder, thus preventing the thrombin solution content in the blood vessels from increasing. Attached Figure Description

[0018] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2This is a three-dimensional cross-sectional view of the catheter tip of the present invention; Figure 3 This is a three-dimensional cross-sectional view of the catheter tip and flexible ring of the present invention; Figure 4 This is a schematic diagram of the three-dimensional structure of the injection channel of the present invention; Figure 5 This is a three-dimensional cross-sectional view of the fixed connecting tube of the present invention; Figure 6 This is a three-dimensional cross-sectional view of the fixing cylinder of the present invention; Figure 7 This is a three-dimensional cross-sectional view of the adjusting cylinder and sliding column of the present invention.

[0019] Explanation of reference numerals in the attached drawings: 1-Conduit head, 2-Flexible ring, 3-Injection hole, 4-Sliding column, 5-Fixing ring, 6-First elastic element, 7-Flow hole, 8-Fixing connecting cylinder, 9-Injection tube, 10-Limiting block, 201-First air injection tube, 202-Air injection channel, 301-Sliding shaft, 302-Clamping shaft, 303-Rotating groove, 304-Fixing cylinder, 305-First piston shaft, 306-Second elastic element, 307-Second air injection tube, 401-Adjusting cylinder, 402-Second piston shaft, 403-Stirring shaft. Detailed Implementation

[0020] The following description is only a preferred embodiment of the present invention and does not limit the scope of protection of the present invention.

[0021] When the microcatheter moves along the blood vessel, the thrombin solution waiting to be injected can easily enter the blood vessel during the movement, causing the thrombin solution to exchange and mix with the blood in advance, resulting in the thrombus not forming at the specific location.

[0022] Example 1: An in vivo thrombus formation device, such as Figures 1-4As shown, the device includes a catheter head 1, with two mirror-distributed flexible rings 2 fixedly connected to it. The flexible rings 2 can expand and stretch into a spherical shape to contact and block the target blood vessel. In the unexpanded state, the flexible rings 2 are recessed inside the catheter head 1 to reduce contact between the flexible rings 2 and the thrombus after thrombus formation and withdrawal, preventing the thrombus from moving synchronously due to adhesion of the flexible rings 2. The catheter head 1 is provided with a ring-shaped array of injection holes 3, located between the mirror-distributed flexible rings 2, with the distance between the injection holes 3 and the mirror-distributed flexible rings 2 being consistent, ensuring the thrombin injection site... The catheter head 1 is positioned between two flexible rings 2. A sliding post 4 is slidably and rotatably connected inside the catheter head 1. A fixed ring 5 is fixedly connected inside the catheter head 1. A first elastic element 6, which is a spring, is provided between the sliding post 4 and the fixed ring 5. The first elastic element 6 is used to drive the sliding post 4 to reset. The sliding post 4 is provided with a flow hole 7. The injection holes 3 in the annular array all communicate and cooperate with the flow hole 7. A fixed connecting cylinder 8 is fixedly connected inside the catheter head 1. The sliding post 4 and the fixed connecting cylinder 8 are sealed and slidably connected, forming a first sealed cavity. The flow hole 7 on the sliding post 4 is connected to the first sealed cavity. The catheter head 1 is internally connected to an injection tube 9. A first sealed cavity is connected to the injection tube 9. Thrombin solution is injected into the first sealed cavity through the injection tube 9, causing the thrombin solution to push the sliding column 4 along the fixed connecting cylinder 8. This, in turn, causes the flow hole 7 on the sliding column 4 to connect with the adjacent injection hole 3, allowing the thrombin solution to enter the blood vessel. Two mirror-distributed limiting blocks 10 are fixedly connected to the lower side of the fixing ring 5. Both mirror-distributed limiting blocks 10 engage with the sliding column 4, preventing the sliding of the sliding column 4. The distance between the limiting blocks 10 and the sliding column 4 is 'a'. The distance between the central axis of the through hole 7 and the central axis of the adjacent injection hole 3 is b, where a=b. This is used to ensure precise connection between the through hole 7 and the adjacent injection hole 3, preventing the thrombin solution from pushing the sliding column 4 too far and causing it to block the injection hole 3 again. The catheter head 1 is equipped with an air-injection assembly for the expansion of the flexible ring 2 for mirror distribution. The injection hole 3 is blocked in advance by the sliding column 4, and then the through hole 7 is connected to the injection hole 3 by the injection force of the thrombin solution, allowing the thrombin solution to enter the blood vessel. This prevents the thrombin solution from leaking and mixing with the blood in advance when the blood moves along the blood vessel, thus preventing the thrombin solution from forming at a specific location.

[0023] like Figures 2-4As shown, the gas injection assembly includes a first gas injection tube 201, which is connected to an external gas injection device. The catheter head 1, the lower flexible ring 2, the sliding column 4, and the fixed connecting cylinder 8 cooperate to form a second sealed cavity. The catheter head 1, the upper flexible ring 2, and the sliding column 4 cooperate to form a third sealed cavity. Two mirror-distributed gas injection channels 202 are provided on the sliding column 4. The two mirror-distributed gas injection channels 202 are staggered with the flow hole 7. The two mirror-distributed gas injection channels 202 connect the second sealed cavity and the third sealed cavity, which are used to expand the two flexible rings 2 to block the blood vessels.

[0024] When staff need to create a thrombus in an animal's blood vessel, they place the device in the blood vessel via vascular intervention. The staff then moves the device into the blood vessel until the catheter tip 1 reaches the desired thrombus formation location. Once this is achieved, the staff stops moving the device and activates an external gas injection device. This device injects gas into the first gas injection tube 201, which then enters the second sealed cavity. The gas in the second sealed cavity then flows into the third sealed cavity through two mirror-distributed gas injection channels 202. As gas gradually enters, the gas content in both the second and third sealed cavities gradually increases, causing the two mirror-distributed flexible rings 2 to expand. This continues until the flexible rings 2 expand to contact and adhere to the inner wall of the blood vessel, thus sealing the vessel. Finally, the external gas injection device is turned off.

[0025] After the blood vessel is blocked, the staff begins to inject thrombin solution into the injection tube 9. The thrombin solution then flows along the injection tube 9 into the fixed connecting cylinder 8, and then along the fixed connecting cylinder 8 into the sliding column 4. This continues until the first sealed cavity is gradually filled with thrombin solution. Once the first sealed cavity is full, thrombin solution continues to be injected into it. As the thrombin solution enters the first sealed cavity, it pushes the sliding column 4 to slide along the fixed connecting cylinder 8, while the first elastic element 6 is compressed. This continues until the sliding column 4 slides to contact the two mirror-distributed limiting blocks 10, which then limit the sliding column 4 to prevent it from sliding further. The movable column 4 continues to slide along the fixed connecting cylinder 8. At this time, the sliding column 4 drives the flow hole 7 on it to connect with the adjacent injection hole 3. At this time, the thrombin solution in the first sealed cavity enters the blood vessel through the flow hole 7 and the connected injection hole 3, so that the thrombin solution mixes with the blood in the blood vessel, and the blood in the blood vessel begins to coagulate to form a thrombus. This continues until the thrombus is formed. The injection hole 3 is blocked in advance by the sliding column 4. Then, the flow hole 7 is connected with the injection hole 3 by the driving force of the injection of thrombin solution, so that the thrombin solution enters the blood vessel. This prevents the thrombin solution from leaking and mixing with the blood in advance when the blood in the blood vessel moves along the blood vessel, so that the thrombus does not form in the specific location.

[0026] Once a thrombus forms, the staff stops injecting thrombin solution into the injection tube 9. At this time, the first elastic element 6 resets and pushes the sliding column 4 to reset synchronously. The sliding column 4 causes the flow hole 7 on it to misalign with the injection hole 3. At this time, the thrombin solution in the first sealed cavity cannot enter the blood vessel. Then, the external gas injection device is turned on to extract the gas from the second and third sealed cavities. At this time, the gas in the second and third sealed cavities flows back to the outside along the first gas injection tube 201, causing the two flexible rings 2 to contract to their initial state. Then, the staff removes the device from the blood vessel. At this time, the thrombus preparation in the blood vessel is complete. When it is necessary to prepare a thrombus in the blood vessel again, the above steps are repeated.

[0027] Example 2: Based on Example 1, such as Figure 5 and Figure 6 As shown, it also includes a rotating assembly for rotating the sliding column 4. The rotating assembly is located inside the fixed connecting cylinder 8. The rotating assembly includes a sliding shaft 301, which is splined to the inside of the sliding column 4 and is initially located inside the fixed connecting cylinder 8. A retaining shaft 302 is fixedly connected to the sliding shaft 301 inside the fixed connecting cylinder 8. A rotating groove 303 is provided on the inner wall of the fixed connecting cylinder 8. The rotating groove 303 is a spiral groove. The retaining shaft 302 is slidably connected to the rotating groove 303. The sliding shaft 301 drives the retaining shaft 302 to slide along the groove 303, causing the sliding column 4 to drive the flow hole 7 to rotate and connect with the injection holes 3 of the annular array in sequence. This changes the direction of thrombin solution entering the blood vessel, causing thrombi to form at different locations in the target blood vessel and increasing the types of thrombi formed. A driving assembly for moving the sliding shaft 301 is provided inside the fixed connecting cylinder 8. An adaptation assembly for maintaining the volume of the first sealed cavity is provided on the sliding column 4.

[0028] like Figure 5 and Figure 6 As shown, the drive assembly includes a fixed cylinder 304, which is fixedly connected to the inside of the fixed connecting cylinder 8. A first piston shaft 305 is slidably connected inside the fixed cylinder 304. A second elastic element 306, which is a spring, is provided between the fixed cylinder 304 and the first piston shaft 305. The second elastic element 306 is used to drive the first piston shaft 305 to reset. The first piston shaft 305 and the fixed cylinder 304 cooperate to form a fourth sealed cavity. A second air injection pipe 307 is fixedly connected to the conduit head 1. The second air injection pipe 307 is connected to an external air injection device. The second air injection pipe 307 passes through the fixed connecting cylinder 8 and is connected to the fourth sealed cavity. It is used to inject gas into the fourth sealed cavity, thereby pushing the first piston shaft 305 to drive the sliding shaft 301 to move.

[0029] like Figure 3 , Figure 5 and Figure 7As shown, the adaptation component includes an adjusting cylinder 401, which is fixedly connected to the sliding column 4. A second piston shaft 402 is fixedly connected to the sliding shaft 301. The adjusting cylinder 401 and the second piston shaft 402 are slidably connected in a sealed manner. The sliding shaft 301 drives the second piston shaft 402 to slide synchronously, compensating for the reduced volume of the first sealed cavity, so that the thrombin solution in the first sealed cavity is replenished into the adjusting cylinder 401, avoiding an increase in the content of thrombin solution entering the blood vessels. A uniformly distributed stirring shaft 403 is fixedly connected inside the sliding column 4. The rotation of the sliding column 4 drives the uniformly distributed stirring shaft 403 inside to stir the thrombin solution, so that the thrombin in the thrombin solution is evenly distributed.

[0030] After the blood vessel is blocked by the two flexible rings 2, the external gas injection device is turned on, and the gas injection device begins to inject gas into the second gas injection tube 307. At this time, the gas enters the fourth sealed cavity along the second gas injection tube 307. After the gas enters the fourth sealed cavity, the gas pushes the first piston shaft 305 to slide along the fixed cylinder 304. At the same time, the second elastic element 306 is compressed. The first piston shaft 305 drives the sliding shaft 301 to slide along the sliding column 4. The first piston shaft 305 drives the locking shaft 302 on it to move synchronously. The locking shaft 302 slides along the rotating slide groove 303. The rotating slide groove 303 drives the sliding shaft 301 to rotate by squeezing the locking shaft 302. The sliding shaft 301 drives... The sliding column 4 rotates synchronously, causing the flow hole 7 on it to rotate synchronously, so that the flow hole 7 rotates to below the target injection hole 3. Then, thrombin solution is injected into the first sealed cavity, causing the flow hole 7 to rotate and align with the target injection hole 3, changing the direction of the thrombin solution entering the blood vessel, causing the thrombus to form in different locations in the target blood vessel, increasing the types of thrombus formation. This continues until the required amount of thrombin solution is injected. Then, the external gas injection device is turned on to extract the gas from the fourth sealed cavity. At this time, the second elastic element 306 resets and drives the first piston shaft 305 to reset. When it is necessary to change the injection direction of thrombin, the above steps are repeated.

[0031] When the first piston shaft 305 drives the sliding shaft 301 to slide along the sliding column 4, the volume of the first sealed cavity gradually decreases. At this time, the solution in the first sealed cavity will be further injected into the blood vessel, resulting in an excessive amount of thrombin solution injected. At this time, the sliding shaft 301 drives the second piston shaft 402 to move synchronously. The second piston shaft 402 slides along the regulating cylinder 401. The reduced volume of the first sealed cavity allows the thrombin solution in the first cavity to be replenished into the regulating cylinder 401, preventing an increase in the content of thrombin solution entering the blood vessel. At the same time, when the sliding column 4 rotates, it drives the stirring shaft 403, which is evenly distributed inside, to rotate, stirring the thrombin solution located inside the sliding column 4, improving the uniformity of the thrombin solution and improving the quality of subsequent thrombi.

[0032] The above description is merely an embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural or procedural transformations made based on the content of the present invention specification, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of the present invention.

Claims

1. An in vivo thrombus in situ formation device, characterized in that, The device includes a catheter head (1), which is fixedly connected to a mirror-distributed flexible ring (2). The catheter head (1) is provided with an annular array of injection holes (3), which are located between the mirror-distributed flexible rings (2) and the distance between the injection holes (3) and the mirror-distributed flexible rings (2) is consistent. A sliding column (4) is slidably and rotatably connected inside the catheter head (1). A fixed ring (5) is fixedly connected inside the catheter head (1). A first elastic element (6) is provided between the sliding column (4) and the fixed ring (5). The sliding column (4) is provided with a flow hole. 7) The injection holes (3) of the ring array are all connected and cooperate with the flow holes (7). A fixed connecting cylinder (8) is fixedly connected inside the catheter head (1). The sliding column (4) is sealed and slidably connected to the fixed connecting cylinder (8). The sliding column (4) and the fixed connecting cylinder (8) cooperate to form a first sealed cavity. The flow holes (7) on the sliding column (4) are connected to the first sealed cavity. An injection tube (9) is fixedly connected inside the catheter head (1). The first sealed cavity is connected to the injection tube (9). An air injection assembly for expanding the flexible ring (2) in a mirror distribution is provided inside the catheter head (1). It also includes a rotating assembly for rotating the sliding column (4), the rotating assembly being disposed inside the fixed connecting cylinder (8), the rotating assembly including a sliding shaft (301), the sliding shaft (301) being splinedly connected to the inside of the sliding column (4), the sliding shaft (301) being fixedly connected to a retaining shaft (302) inside the fixed connecting cylinder (8), the inner wall of the fixed connecting cylinder (8) being provided with a rotating groove (303), the retaining shaft (302) being slidably connected to the rotating groove (303), the fixed connecting cylinder (8) being provided with a driving assembly for moving the sliding shaft (301), and the sliding column (4) being provided with an adaptation assembly for maintaining the volume of the first sealed cavity; The adaptation component includes an adjusting cylinder (401), which is fixedly connected to the sliding column (4), and the sliding shaft (301) is fixedly connected to the second piston shaft (402). The adjusting cylinder (401) and the second piston shaft (402) are in a sealed sliding connection.

2. The in vivo thrombus formation device according to claim 1, characterized in that, The fixed ring (5) is fixedly connected to a mirror-distributed limiting block (10) on the side near the sliding column (4), and the mirror-distributed limiting block (10) is in limiting cooperation with the sliding column (4).

3. The in vivo thrombus formation device according to claim 2, characterized in that, The distance between the limiting block (10) and the sliding column (4) is a, and the distance between the central axis of the flow hole (7) and the central axis of the adjacent injection hole (3) is b, a=b, which is used to make the flow hole (7) and the adjacent injection hole (3) accurately connected.

4. The in vivo thrombus formation device according to claim 3, characterized in that, The flexible ring (2) is recessed inside the catheter tip (1) to reduce the contact between the flexible ring (2) and the thrombus.

5. The in vivo thrombus formation device according to claim 4, characterized in that, The gas injection assembly includes a first gas injection tube (201), which is fixedly connected to the inside of the catheter head (1). The catheter head (1), the flexible ring (2) near the injection tube (9), the sliding column (4), and the fixed connecting cylinder (8) cooperate to form a second sealed cavity. The catheter head (1), the flexible ring (2) away from the injection tube (9), and the sliding column (4) cooperate to form a third sealed cavity. The sliding column (4) is provided with mirror-distributed gas injection channels (202), which connect the second sealed cavity and the third sealed cavity.

6. The in vivo thrombus formation device according to claim 5, characterized in that, The injection channels (202) and the flow holes (7) are misaligned in a mirror-image distribution.

7. The in vivo thrombus formation device according to claim 1, characterized in that, The drive assembly includes a fixed cylinder (304), which is fixedly connected to the inside of the fixed connecting cylinder (8). A first piston shaft (305) is slidably connected inside the fixed cylinder (304). The first piston shaft (305) is fixedly connected to the sliding shaft (301). A second elastic element (306) is provided between the fixed cylinder (304) and the first piston shaft (305). The first piston shaft (305) and the fixed cylinder (304) cooperate to form a fourth sealed cavity. The guide head (1) is fixedly connected to a second air injection tube (307). The second air injection tube (307) passes through the fixed connecting cylinder (8) and communicates with the fourth sealed cavity.

8. The in vivo thrombus formation device according to claim 1, characterized in that, The sliding column (4) is fixedly connected to a uniformly distributed stirring shaft (403) for stirring the solution inside the sliding column (4).

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