Pulse signal generating apparatus, method, and medical ablation system with adjustable pulse waveform

Abstract

The application discloses a pulse signal generation device, a method and a medical ablation system with adjustable pulse waveform. The pulse signal generation device comprises a pulse setting module, a main control module, an output control module, a pulse generation module and a load module. The pulse setting module is configured to configure the technical parameters of the pulse electric field. The main control module is configured to generate the first pulse signal and the second pulse signal and the first control signal and the second control signal according to the configuration parameters. The output control module is configured to control the output of the first pulse signal and the second pulse signal in real time. The pulse generation module is configured to generate the third pulse signal of the target waveform according to the first pulse signal and the second pulse signal and output to the load module. The application can generate the high-intensity pulse electric field meeting the clinical requirements, effectively ablates the different lesion tissues and has significant clinical application value.

Description

Technical Field

[0001] This invention relates to a pulse signal generation device with adjustable pulse waveform, a corresponding pulse signal generation method, and a medical ablation system including the pulse signal generation device, belonging to the field of medical device technology. Background Technology

[0002] A pulse signal is a commonly used voltage or current signal in electronics, characterized by its instantaneous fluctuations and extremely short duration. Its waveform can be periodically repeating, non-periodic, or a single burst. Pulse signal technology is widely used in many technical fields, including computers, communications, automatic control, radio navigation, and measurement, and also has extensive applications in medical devices.

[0003] Pulsed electric field ablation is a technique that uses intermittent high-intensity pulsed electric fields applied over a very short period (milliseconds, microseconds, or nanoseconds) to cause electroporation of cell membranes, leading to apoptosis and necrosis, thus achieving the therapeutic goal of ablation. However, existing medical ablation devices generate a single, non-adjustable pulse waveform, which limits the depth to which the high-intensity pulsed electric field can reach human tissue and the effectiveness of treatment, failing to meet the appropriate ablation needs for different lesions.

[0004] To address this issue, Chinese utility model patent number ZL 202121712740.X discloses a pulse signal generation circuit. This circuit includes a pulse signal circuit unit and a load circuit unit; in the pulse signal circuit unit, two transistors are connected to form a first pulse signal circuit, and the other transistors are connected in pairs to form N second pulse signal circuits; the load circuit unit includes N resistors. This design solves the problems of numerous electronic components, high power consumption, large size, and inconvenience in corresponding medical devices. Summary of the Invention

[0005] The primary technical problem to be solved by this invention is to provide a pulse signal generation device with adjustable pulse waveform;

[0006] Another technical problem to be solved by the present invention is to provide a method for generating pulse signals with adjustable pulse waveforms;

[0007] Another technical problem to be solved by the present invention is to provide a medical ablation system including the pulse signal generating device.

[0008] To achieve the above objectives, the present invention adopts the following technical solution:

[0009] According to a first aspect of the present invention, a pulse signal generation device with adjustable pulse waveform is provided, comprising a pulse setting module, a main control module, an output control module, a pulse generation module, and a load module; wherein,

[0010] The input and output terminals of the pulse setting module, the main control module, the output control module, the pulse generation module, and the load module are connected in series in sequence.

[0011] The pulse setting module is used to configure the technical parameters of the third pulse signal and send the configuration parameters to the main control module;

[0012] The main control module is used to generate a first pulse signal and a second pulse signal, as well as a first control signal and a second control signal, according to the configuration parameters, and output them to the output control module;

[0013] The output control module is used to control the output of the first pulse signal and the second pulse signal in real time according to the first control signal and the second control signal, respectively.

[0014] The pulse generation module is used to generate the third pulse signal of the target waveform based on the received first pulse signal and second pulse signal, and output it to the load module;

[0015] The load module is used to apply the pulsed electric field formed by the third pulse signal to the cell tissue that needs to be ablated.

[0016] Preferably, the technical parameters configured for the third pulse signal include frequency multiplication, pulse waveform, pulse width, polarity, dead time, number of pulses in a single pulse train, and number of pulse trains.

[0017] Preferably, the main control module is implemented using a microcontroller, and the first pulse signal and the second pulse signal output by the module are a set of complementary PWM pulses.

[0018] Preferably, the output control module is composed of a first AND gate and a second AND gate; wherein...

[0019] The first input terminal and the second input terminal of the first AND gate are respectively input to the first pulse signal and the first control signal, and the output terminal is the first output terminal of the output control module;

[0020] The first and second input terminals of the second AND gate are respectively input to the second pulse signal and the second control signal, and the output terminal is the second output terminal of the output control module.

[0021] Preferably, when the first control signal is a high-level signal, the first AND gate outputs the first pulse signal; when the first control signal is a low-level signal, the first AND gate outputs a low-level signal, and at this time, the output of the first pulse signal is turned off.

[0022] When the second control signal is a high-level signal, the second AND gate outputs the second pulse signal; when the second control signal is a low-level signal, the second AND gate outputs a low-level signal, and at this time, the output of the second pulse signal is turned off.

[0023] Preferably, the pulse generation module is implemented using an H-bridge circuit; the H-bridge circuit includes a first MOS transistor, a second MOS transistor, a third MOS transistor, and a fourth MOS transistor, as well as a first diode, a second diode, a third diode, a fourth diode, and a resistor-capacitor series branch.

[0024] Preferably, the gates of the first MOS transistor and the fourth MOS transistor are both connected to the first output terminal of the output control module; the gates of the second MOS transistor and the third MOS transistor are both connected to the second output terminal of the output control module.

[0025] According to a second aspect of the present invention, a method for generating a pulse signal with an adjustable pulse waveform is provided, comprising the following steps:

[0026] (1) Configure the technical parameters of the third pulse, including frequency multiplication, pulse waveform, pulse width, polarity, dead time, number of pulses in a single pulse train and number of pulse trains;

[0027] (2) The main control module configures a first pulse signal and a second pulse signal, as well as a first control signal and a second control signal, according to the aforementioned technical parameters; wherein, the first pulse signal and the second pulse signal are a set of complementary PWM pulses;

[0028] (3) Upon receiving the pulse output command, the main control module initializes the IO port and simultaneously turns on the power supply of the pulse generation module.

[0029] (4) Make the first control signal or the second control signal a high level signal. At this time, the first pulse signal or the second pulse signal is output to the pulse generation module.

[0030] (5) Count the pulses of the third pulse signal output by the pulse generation module;

[0031] (6) Determine whether the number of the third pulse signal has reached the set value of the number of single pulses; if it has, increment the count value of the number of pulses by 1 and proceed to step (9); if it has not reached, proceed to the next step.

[0032] (7) Determine whether the polarity of the first pulse signal or the second pulse signal meets the set standard; if it does, proceed to step (4); if it does not, proceed to the next step.

[0033] (8) Switch the polarity of the first pulse signal or the second pulse signal, and then proceed to step (4);

[0034] (9) Determine whether the number of pulse trains has reached the set value; if it has, proceed to step (11); if it has not, proceed to the next step.

[0035] (10) The count of the third pulse signal is cleared, and then the process proceeds to step (4);

[0036] (11) Set the first control signal and the second control signal to low level to end pulse output.

[0037] According to a third aspect of the present invention, a medical ablation system is provided, including the pulse signal generating device with the adjustable pulse waveform described above.

[0038] Compared with existing technologies, the adjustable pulse waveform pulse signal generation device provided by this invention, through its innovative design, achieves flexible configuration and real-time control of pulse electric field related technical parameters. This not only improves adaptability and safety but also ensures excellent pulse electric field performance, meeting the stringent requirements of the medical field for high precision, narrow pulse width, short release time, and controllable adjustment. Using this pulse signal generation device, high-intensity pulse electric fields that meet clinical requirements can be generated for effective ablation treatment of different lesions, demonstrating significant clinical application value. Therefore, the adjustable pulse waveform pulse signal generation device provided by this invention has the advantages of ingenious and reasonable structural design, low design cost, flexible control, and excellent pulse electric field performance. Attached Figure Description

[0039] Figure 1 This is a schematic diagram of the pulse waveform used in existing medical ablation devices;

[0040] Figure 2 A structural block diagram of an adjustable pulse waveform pulse signal generation system provided by the present invention;

[0041] Figure 3 This is a pin wiring diagram of the MCU chip in an embodiment of the present invention;

[0042] Figure 4(a) is a circuit diagram of the output control module in an embodiment of the present invention;

[0043] Figure 4(b) is a wiring diagram of the output control module in an embodiment of the present invention;

[0044] Figure 5 This is a circuit schematic diagram of the H-bridge circuit in an embodiment of the present invention;

[0045] Figure 6 The waveform diagram of the third pulse signal is shown in this embodiment of the invention. Figure 1 ;

[0046] Figure 7 The waveform diagram of the third pulse signal is shown in this embodiment of the invention. Figure 2 ;

[0047] Figure 8 The flowchart illustrates a pulse signal generation method for an adjustable pulse waveform provided by the present invention. Detailed Implementation

[0048] The technical content of the present invention will now be described in detail with reference to the accompanying drawings and specific embodiments.

[0049] like Figure 2 As shown in the figure, an adjustable pulse signal waveform pulse generation device provided by an embodiment of the present invention includes a pulse setting module, a main control module, an output control module, a pulse generation module, and a load module. The input and output terminals of the pulse setting module, the main control module, the output control module, the pulse generation module, and the load module are connected in series sequentially.

[0050] The pulse setting module is used to configure the relevant technical parameters of the third pulse signal and send the configuration parameters to the main control module. The technical parameters that need to be configured for the third pulse signal, depending on the actual situation, include frequency multiplication, pulse waveform, pulse width, polarity, dead time, number of pulses in a single burst, and number of pulse bursts. The pulse setting module is implemented using computer program software with a user interface.

[0051] The main control module is used to generate a first pulse signal and a second pulse signal, as well as a first control signal and a second control signal, based on the received configuration parameters, and output them to the output control module.

[0052] The output control module is used to control the output of the first pulse signal and the second pulse signal in real time according to the first control signal and the second control signal, respectively.

[0053] The pulse generation module is used to generate a third pulse signal of the target waveform based on the received first pulse signal and second pulse signal, and output it to the load module.

[0054] The load module is used to apply the pulsed electric field formed by the third pulse signal to the cell tissue that needs to be ablated; the load module usually consists of one or more electrodes.

[0055] In one embodiment of the present invention, the main control module is implemented using an STM32F103 microcontroller (MCU), but is not limited thereto. Other 16-bit, 32-bit, or 64-bit microcontrollers and other similar control chips, such as the PIC32 series, N32G435 series, and FPGA chips, can also be used to implement the technical solution of the present invention.

[0056] like Figure 3 As shown, pins 36 and 26 of the MCU chip are configured as a set of complementary PWM (Pulse Width Modulation) pulse output ports; the complementary PWM pulses are the first pulse signal PWM1 and the second pulse signal PWM2. Pins 35 and 25 of the MCU chip are configured as general-purpose I / O ports, used to output the first control signal KX1 and the second control signal KX2, respectively.

[0057] The output control module, as shown in Figure 4(a), consists of a first AND gate AND 1 and a second AND gate AND 2. The first and second input terminals of the first AND gate AND 1 are connected to pins 36 and 35, respectively, and its output is the first output terminal out1 of the output control module. The first and second input terminals of the second AND gate AND 2 are connected to pins 26 and 25, respectively, and its output is the second output terminal out2 of the output control module. The pin wiring of the output control module is shown in Figure 4(b). Pins 1 and 2 of the first AND gate AND 1 and the second AND gate AND 2 are the first and second input terminals, respectively. Pin 3 is the ground terminal, pin 5 is the power supply terminal, and pin 4 is the output terminal.

[0058] When the MCU chip's Pin35 is high, i.e., the first control signal KX1 is high, the output terminal out1 of the first AND gate AND 1 outputs the corresponding first pulse signal PWM 1; when the MCU chip's Pin35 is low, i.e., the first control signal KX1 is low, the output terminal out1 of the first AND gate AND 1 outputs a low signal, and at this time, the output of the first pulse signal PWM 1 is turned off.

[0059] When the MCU chip's Pin25 pin is high, i.e., the second control signal KX2 is high, the output terminal out2 of the second AND gate AND2 outputs the corresponding second pulse signal PWM2; when the MCU chip's Pin25 pin is low, i.e., the second control signal KX2 is low, the output terminal out2 of the second AND gate AND2 outputs a low signal, and at this time, the output of the second pulse signal PWM2 is turned off.

[0060] In one embodiment of the present invention, the pulse generation module is implemented using an H-bridge circuit, such as... Figure 5 As shown, the H-bridge circuit includes a first MOSFET M1, a second MOSFET M2, a third MOSFET M3, and a fourth MOSFET M4, as well as a first diode D1, a second diode D2, a third diode D3, a fourth diode D4, and a resistor-capacitor series branch. The gates of the first MOSFET M1 (first input terminal in1) and the fourth MOSFET M4 (fourth input terminal in4) are both connected to the first output terminal out1 of the output control module; the gates of the second MOSFET M2 (second input terminal in2) and the third MOSFET M3 (third input terminal in3) are both connected to the second output terminal out2 of the output control module. The first output terminal out3 and the second output terminal out4 of the H-bridge circuit are respectively connected to the load module.

[0061] The pulse signal generation device provided in this embodiment of the invention can configure the relevant technical parameters of the third pulse signal according to the actual needs of the pulse electric field. The first pulse signal, the second pulse signal, the first control signal, and the second control signal generated by the main control module are provided to the H-bridge circuit through the output control module. After high-voltage commutation of the H-bridge circuit, the third pulse signal of the target waveform is finally output and provided to the load module.

[0062] In one embodiment of the present invention, an example of the waveform of the third pulse signal is as follows: Figure 6 As shown, in Figure 6 In this diagram, T1 represents the duration of a single pulse train of the third pulse signal, which typically consists of two or more monopole pulses and / or bipole pulses; T2 represents the duration of a bipole pulse (if the bipole pulse is periodic, then T2 is called the period); T3 represents the width of a positive monopole pulse; T4 represents the dead time between positive and negative pulses; T5 represents the width of a negative monopole pulse; T6 represents the total duration of several single pulse trains; V1 represents the amplitude of the positive monopole pulse; and V2 represents the amplitude of the negative monopole pulse. The various durations, widths, waveform combinations, and number of pulses of the third pulse signal can all be configured using the pulse setting module to obtain third pulse signals with different waveforms. Some examples of third pulse signal waveforms are shown below. Figure 7 As shown.

[0063] This invention provides a pulse signal generation device for an adjustable pulse waveform, wherein the method for generating a third pulse signal of a target waveform is as follows: Figure 8 As shown, it includes the following steps:

[0064] S1: Configure the relevant technical parameters of the third pulse signal according to the actual needs of the pulse electric field, including but not limited to frequency doubling, pulse waveform, pulse width, polarity, dead time, number of pulses in a single string, and number of pulse trains.

[0065] S2: The main control module configures the first pulse signal and the second pulse signal, as well as the first control signal and the second control signal, according to the relevant technical parameters; wherein, the first pulse signal and the second pulse signal are a set of complementary PWM pulses.

[0066] S3: Upon receiving the pulse output command, the MCU initializes the IO ports, configuring pins 36 and 26 as a set of complementary PWM pulse output ports; and configuring pins 25 and 35 as general IO output ports. At the same time, the power supply of the H-bridge circuit is turned on.

[0067] S4: Set the first control signal or the second control signal to a high level. At this time, the first pulse signal or the second pulse signal is output to the pulse generation module.

[0068] S5: Perform pulse counting on the third pulse signal output by the pulse generation module.

[0069] S6: Determine whether the number of the third pulse signal has reached the set value of the number of pulses in a single series; if it has, increment the count value of the number of pulse series by 1 and proceed to step S9; if it has not reached the set value, proceed to the next step.

[0070] S7: Determine whether the polarity of the first pulse signal or the second pulse signal meets the set standard; if it does, proceed to step S4; if it does not, proceed to the next step.

[0071] S8: Switch the polarity of the first pulse signal or the second pulse signal, and then proceed to step S4.

[0072] It should be noted that during the output of a third pulse signal with a defined waveform, steps S4-S8 can be cyclically set once or multiple times depending on the specific waveform. For example, in step S4, the first control signal is set to a high level and the second control signal to a low level for the first time, at which point the first pulse signal is output to the pulse generation module; the second time, the first control signal is set to a low level and the second control signal to a high level, at which point the second pulse signal is output to the pulse generation module. This cyclical setting method can achieve changes in the polarity of the third pulse signal waveform, as detailed in the specific embodiments below.

[0073] S9: Determine whether the number of pulse trains has reached the set value; if it has, proceed to step S11; if it has not, proceed to the next step.

[0074] S10: The count of the third pulse signal is cleared, and then proceed to step S4.

[0075] S11: Set the first control signal and the second control signal to low level to end pulse output.

[0076] According to the above specific operating procedures and steps, the third pulse signal of the target waveform can be configured and output in real time, and then provided to the ablation device to form the required pulse electric field for reasonable ablation treatment of different lesions.

[0077] The following specific embodiment illustrates the operation of the adjustable pulse waveform pulse signal generation device provided by the present invention in generating a third pulse signal of a target waveform. In this embodiment, the target waveform of the third pulse signal required by the pulse electric field is as follows: Figure 7 The waveform shown in the upper middle section requires a total of 20 pulse trains to be output. Each pulse train consists of 5 consecutive positive unipolar pulses and 5 consecutive negative unipolar pulses. The dead time T4 = 2us. The amplitude of the unipolar pulse V1 = 2000V and the pulse width T3 = 30us. The main control module uses an STM32F103 MCU with a main frequency of 64MHz.

[0078] S101: Input the aforementioned technical parameters of the third pulse signal into the system. The target waveform and its specific technical parameters can be input into the user interface of the system pulse setting module.

[0079] S102: Based on the analysis of relevant technical parameters, the MCU determines the relevant technical parameters of a set of complementary PWM pulses to be output: frequency multiplication (period) of 1472, duty cycle of 50%, output polarity of low, dead time of 2µs, number of pulses per string of 10, and number of pulse trains of 20. This set of complementary PWM pulses refers to the first pulse signal and the second pulse signal.

[0080] S103: Upon receiving the pulse output command, the MCU initializes the I / O ports, configuring pins 36 and 26 as a set of complementary PWM pulse output ports with opposite polarities; pins 25 and 35 are configured as general I / O output ports, with a default output level of low. Simultaneously, the 2000V high-voltage power supply to the H-bridge circuit is turned on.

[0081] At this time, the output terminals of the first AND gate AND 1 and the second AND gate AND 2 in the output control module are both at a low level. Therefore, the four input terminals of the H-bridge circuit in the pulse generation module are all at a low level, and there is no pulse signal output.

[0082] S104: Set the MCU's pin 25 to output a high level and pin 35 to output a low level, that is, set the second control signal KX2 to a high level and the first control signal KX1 to a low level, so that the output of the first pulse signal PWM1 is turned off, and the second pulse signal PWM2 is output to the first input terminal and the fourth input terminal of the H-bridge circuit, and the corresponding MOSFETs are turned on. At this time, the H-bridge circuit outputs the third pulse signal.

[0083] Based on the target waveform setting, the first to fifth third pulse signals output are positive unipolar pulses.

[0084] S105: Perform pulse counting on the output third pulse signal.

[0085] S106: Determine if the count value of the third pulse signal is equal to 5; if the count value is equal to 5, proceed to step S204; otherwise, proceed to the next step.

[0086] In this embodiment, the polarity of the unipolar pulse needs to be switched after the fifth unipolar pulse in each single pulse train.

[0087] S107: Determine whether the polarity of the second pulse signal PWM2 meets the set standard; if it does, proceed to step S104; if it does not, input the next step.

[0088] Since the first five pulses in the target waveform's single-pulse sequence are all positive unipolar pulses, and the second pulse signal PWM2 corresponding to the second positive unipolar pulse is low for half a cycle, the polarity of the second pulse signal PWM2 needs to be switched. It should be noted that after the polarity switch, the polarity of the second pulse signal PWM2 corresponding to the third positive unipolar pulse still does not meet the requirements, so it needs to be switched again. In each single-pulse generation process of this embodiment, only the first and sixth unipolar pulses do not require polarity switching; the polarity of either the second pulse signal PWM2 or the first pulse signal PWM1 must be switched for the rest.

[0089] S108: Switch the polarity of the second pulse signal PWM2, and then proceed to step S104.

[0090] S204: Set the MCU's pin 25 to output a low level and pin 35 to output a high level, that is, set the second control signal KX2 to a low level and the first control signal KX1 to a high level, so that the output of the second pulse signal PWM2 is turned off, and the first pulse signal PWM1 is output to the second and third input terminals of the H-bridge circuit, and the corresponding MOSFETs are turned on. At this time, the H-bridge circuit outputs the third pulse signal.

[0091] It should be noted that the polarity of the third pulse signal output at this time has changed to negative.

[0092] S205: Continue counting pulses on the output third pulse signal.

[0093] S206: Determine if the count value of the third pulse signal is equal to 10; if the count value is equal to 10, increment the count value of the pulse train count by 1 and proceed to step S109; otherwise, proceed to the next step.

[0094] S207: Determine whether the polarity of the first pulse signal PWM1 meets the set standard; if it does, proceed to step S204; if it does not, input the next step.

[0095] S208: Switch the polarity of the first pulse signal PWM1, and then proceed to step S204.

[0096] S109: Determine whether the number of pulse trains has reached the set value of 20; if it has, proceed to step S111; if it has not, proceed to the next step.

[0097] S110: The count of the third pulse signal is cleared, and then the process proceeds to step S104 to start the output and counting of the next pulse train.

[0098] S111: Set the first control signal and the second control signal to low level to end pulse output.

[0099] At this time, pins 25 and 35 are set to output low level, stopping the output of complementary PWM pulses. All four inputs of the H-bridge are low level, the H-bridge output is cut off, and the 2000V high-voltage power supply of the H-bridge circuit is turned off.

[0100] Through the cyclic operation of steps S101 to S111 above, the pulse signal generating device outputs the third pulse signal of 20 target waveforms according to the set requirements. Then the system is in a state of waiting for user instructions, and the user can perform the next output or shut down as needed.

[0101] Compared to pulse waveforms used in general industrial control, the various pulse waveforms required in the medical field are characterized by high precision requirements, narrow pulse widths, short overall release times, and the need for constant controllability and adjustment. For example, in medical applications, the release of high-voltage pulses must be completed within the refractory period of the heartbeat; therefore, the release time must be strictly controlled. Too short a time may fail to achieve the desired effect, while too long a time may lead to medical accidents. Therefore, the adjustable pulse signal waveform generation device provided in this invention can flexibly and conveniently realize the output of various pulse waveforms required in medical applications.

[0102] Based on the aforementioned pulse signal generation device, this embodiment of the invention further provides a medical ablation system, including the aforementioned adjustable pulse waveform pulse signal generation device, used to generate a third pulse signal with a pulse waveform that can be adjusted in real time, forming a high-intensity pulse electric field that meets clinical requirements, and performing corresponding ablation treatment on different lesion tissues.

[0103] In summary, compared with existing technologies, the adjustable pulse waveform pulse signal generation device provided by this invention, through its innovative design, achieves flexible configuration and real-time control of pulse electric field related technical parameters. This not only improves adaptability and safety but also ensures excellent pulse electric field performance, meeting the stringent requirements of the medical field for high precision, narrow pulse width, short release time, and controllable adjustment. Using this pulse signal generation device, high-intensity pulse electric fields that meet clinical requirements can be generated for effective ablation treatment of different lesions, demonstrating significant clinical application value. Therefore, the adjustable pulse waveform pulse signal generation device provided by this invention has the advantages of ingenious and reasonable structural design, low design cost, flexible control, and excellent pulse electric field performance.

[0104] It should be noted that the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0105] The above provides a detailed description of the adjustable pulse waveform pulse signal generation device, method, and medical ablation system provided by this invention. Any obvious modifications made by those skilled in the art without departing from the essence of this invention will constitute an infringement of the patent rights of this invention and will incur corresponding legal liability.

Claims

1. A pulse signal generation device with adjustable pulse waveform, characterized in that... It includes a pulse setting module, a main control module, an output control module, a pulse generation module, and a load module; among which, The input and output terminals of the pulse setting module, the main control module, the output control module, the pulse generation module, and the load module are connected in series in sequence. The pulse setting module is used to configure the technical parameters of the third pulse signal and send the configured technical parameters to the main control module; the technical parameters include at least polarity, dead time, number of pulse trains, and number of pulses in a single pulse train; The main control module is used to generate a first pulse signal and a second pulse signal, as well as a first control signal and a second control signal, according to the configured technical parameters, and output them to the output control module; wherein, the first pulse signal and the second pulse signal are a set of complementary PWM pulses; The main control module is further configured to: count the third pulse signal output by the pulse generation module; determine whether the number of the third pulse signal reaches the set value of the number of pulses in a single string; if not, determine whether the polarity of the first pulse signal or the second pulse signal meets the set standard; if not, switch the polarity of the first pulse signal or the second pulse signal and continue outputting; if it reaches the set value, increment the count value of the number of pulse strings by 1 and determine whether the number of pulse strings reaches the set value; if the number of pulse strings does not reach the set value, clear the count of the third pulse signal and continue outputting the next single pulse string; if the number of pulse strings reaches the set value, set the first control signal and the second control signal to low level signals and end pulse output. The output control module consists of a first AND gate and a second AND gate. The first AND gate selects or turns off the first pulse signal in real time according to the first control signal; the second AND gate selects or turns off the second pulse signal in real time according to the second control signal. The pulse generation module includes an H-bridge circuit. The gates of the first MOS transistor and the fourth MOS transistor in the H-bridge circuit are both connected to the output of the first AND gate. The gates of the second MOS transistor and the third MOS transistor in the H-bridge circuit are both connected to the output of the second AND gate. The H-bridge circuit is used to perform high-voltage commutation based on the received first pulse signal and second pulse signal to generate the third pulse signal with configured technical parameters, and output it to the load module. The load module is used to apply the pulsed electric field formed by the third pulse signal to the cell tissue that needs to be ablated.

2. The pulse signal generation device for adjustable pulse waveforms as described in claim 1, characterized in that: The technical parameters for configuring the third pulse signal also include frequency multiplication, pulse waveform, and pulse width.

3. The pulse signal generation device for adjustable pulse waveforms as described in claim 1, characterized in that: The first input terminal and the second input terminal of the first AND gate are respectively input to the first pulse signal and the first control signal, and the output terminal is the first output terminal of the output control module; The first and second input terminals of the second AND gate are respectively input to the second pulse signal and the second control signal, and the output terminal is the second output terminal of the output control module.

4. The pulse signal generation device for adjustable pulse waveforms as described in claim 3, characterized in that: When the first control signal is a high-level signal, the first AND gate outputs the first pulse signal; when the first control signal is a low-level signal, the first AND gate outputs a low-level signal, and at this time, the output of the first pulse signal is turned off. When the second control signal is a high-level signal, the second AND gate outputs the second pulse signal; when the second control signal is a low-level signal, the second AND gate outputs a low-level signal, and at this time, the output of the second pulse signal is turned off.

5. The pulse signal generation device for adjustable pulse waveforms as described in claim 1, characterized in that: The H-bridge circuit also includes a first diode, a second diode, a third diode, a fourth diode, and a resistor-capacitor series branch.

6. A method for generating pulse signals of adjustable pulse waveforms, implemented based on the pulse signal generation device of adjustable pulse waveforms according to any one of claims 1 to 5, characterized in that... Includes the following steps: (1) Configure the technical parameters of the third pulse, including frequency multiplication, pulse waveform, pulse width, polarity, dead time, number of pulses in a single pulse and number of pulse trains; (2) The main control module configures the first pulse signal and the second pulse signal, as well as the first control signal and the second control signal, according to the aforementioned technical parameters; wherein the first pulse signal and the second pulse signal are a set of complementary PWM pulses; (3) Upon receiving the pulse output command, the main control module initializes the IO port and simultaneously turns on the working power of the pulse generation module; (4) Make the first control signal or the second control signal a high-level signal. At this time, the first pulse signal or the second pulse signal is output to the pulse generation module. (5) Count the pulses of the third pulse signal output by the pulse generation module; (6) Determine whether the number of the third pulse signal has reached the set value of the number of single pulses; if it has, increment the count value of the number of pulses by 1 and proceed to step (9); if it has not reached, proceed to the next step. (7) Determine whether the polarity of the first pulse signal or the second pulse signal meets the set standard; if it does, proceed to step (4); if it does not, proceed to the next step. (8) Switch the polarity of the first pulse signal or the second pulse signal, and then proceed to step (4); (9) Determine whether the number of pulse trains has reached the set value; if it has, proceed to step (11); if it has not, proceed to the next step. (10) The count of the third pulse signal is cleared, and then the process proceeds to step (4). (11) Set the first control signal and the second control signal to low level to end pulse output.

7. A medical ablation system, characterized in that... The pulse signal generating device includes the adjustable pulse waveform described in any one of claims 1 to 5.

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