Mdm2 / mdmx inhibiting peptides, compositions, and methods of making and use

By self-assembling nanoparticles from a complex of MDM2/MDMX inhibitory peptides, human serum albumin, and verteporfen, the MDM2/MDMX protein is targeted and degraded, activating the p53 pathway and enhancing the efficacy of photodynamic therapy. This solves the targeting problem of photodynamic therapy in the treatment of retinoblastoma and achieves a significant inhibitory effect on cancer cells.

CN118955647BActive Publication Date: 2026-07-03THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
Filing Date
2024-07-31
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Existing photodynamic therapy is not effective in treating retinoblastoma (RB), with targeting issues leading to insignificant treatment outcomes.

Method used

The complex formed by MDM2/MDMX inhibitory peptide, human serum albumin and verteporfen through hydrophobic and hydrogen bonds, combined with gold ion coordination and thiol modification, is self-assembled into nanoparticles. These nanoparticles target ubiquitination and degradation of MDM2/MDMX protein, enhance the expression of p53 protein and ROS, and synergize with photodynamic therapy.

Benefits of technology

It enhanced the sensitivity of retinoblastoma to photodynamic therapy by targeting and degrading MDM2/MDMX proteins, activating the wild-type p53 pathway, increasing the cell's sensitivity to ROS, and significantly inhibiting cancer cell growth.

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Abstract

This invention belongs to the field of biomedical technology, and relates to MDM2 / MDMX inhibitory peptides, compositions, preparation methods, and applications. This invention provides an MDM2 / MDMX inhibitory peptide, the amino acid sequence of which is shown in SEQ ID NO: 1. This invention also provides a complex for improving the photodynamic therapy effect of the MDM2 / MDMX inhibitory peptide, a composition of the complex and the MDM2 / MDMX inhibitory peptide, and a method for preparing the same. This invention solves the technical problem of the difficulty in treating retinoblastoma.
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