Porous structure for implantation into a human body, implant and method of making a porous structure

Abstract

The application relates to a porous structure for implanting into a human body, an implant and a manufacturing method of the porous structure. The porous structure comprises a plurality of bone trabeculae which form a plurality of mutually connected tessellation polygon cells; each of the tessellation polygon cells is provided with mutually communicating micropores; and part of the tessellation polygon cells are provided with concave-convex structures on the surface of the porous structure. In this way, the structural strength of the surface of the porous structure is high, the surface of the porous structure is not easy to be damaged and deformed after the porous structure is filled, so that the stability between particles (between the porous structures) is improved, and the mutual constraint force between the particles is enhanced. In addition, the concave-convex structure can also increase the friction between the porous structure and the bone interface, thereby improving the stability of the filled porous structure.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a porous structure for implantation into the human body, an implant, and a method for manufacturing the porous structure. Background Technology

[0002] Bone loss caused by trauma or surgery is called a bone defect. The presence of a bone defect often leads to nonunion, delayed healing or nonunion, and local functional impairment. The main treatment for bone defects is bone grafting to repair the bone defect.

[0003] Currently, there are two main methods for repairing bone defects: implanting autologous bone and implanting bone substitutes. Autologous bone is not the most ideal choice for filling bone defects because it is scarce, and harvesting bone from other parts of the patient during surgery increases surgical time and can cause secondary trauma. Bone substitutes typically use porous artificial bone particles for implantation. However, current artificial bone particles suffer from insufficient inter-particle stability. Summary of the Invention

[0004] Therefore, it is necessary to provide a porous structure for implantation in the human body, an implant, and a method for manufacturing the porous structure, addressing at least one of the above-mentioned problems.

[0005] In a first aspect, embodiments of this application provide a porous structure for implantation in the human body. The porous structure includes multiple trabeculae, which constitute multiple interconnected Thiessen polygonal cell bodies; each Thiessen polygonal cell body has interconnected micropores.

[0006] In some of the Thiessen polygonal cells, an uneven structure is formed on the surface of the porous structure.

[0007] The porous structure for implantation in the human body provided in this application utilizes Thiessen polygonal cell bodies to form an uneven structure on the surface of the porous structure. This results in high structural strength on the surface of the porous structure, making it less susceptible to damage and deformation after filling, thereby improving the stability between particles (between porous structures) and enhancing the mutual restraint between particles. Furthermore, the uneven structure can increase the friction between the porous structure and the bone interface, further improving the stability of the filled porous structure.

[0008] In one embodiment, the trabecular bone has a radial dimension between 200 and 500 μm.

[0009] And / or, the trabecular bone has a dimension between 0.2 and 1 mm along its own axial direction.

[0010] In one embodiment, the pore size of the micropores is between 400-600 μm.

[0011] In one embodiment, the trabecular bone is made of at least one of the following: metal, tricalcium phosphate, hydroxyapatite, calcium sulfate, bioglass, and polycaprolactone.

[0012] Secondly, embodiments of this application provide an implant comprising the porous structure for implantation into the human body as described in any embodiment of the first aspect.

[0013] The implant provided in this application uses Thiessen polygonal cell bodies to form an uneven structure on the surface of a porous structure. This results in high structural strength on the surface of the porous structure, making it less susceptible to damage and deformation after filling. This improves the stability between particles (between porous structures) and enhances the mutual restraint between particles. Furthermore, the uneven structure increases the friction between the porous structure and the bone interface, further improving the stability after filling the porous structure.

[0014] Thirdly, embodiments of this application provide a method for fabricating a porous structure, the method comprising:

[0015] A seed matrix is ​​generated within a preset area; the seed matrix includes a preset number of randomly arranged seed points;

[0016] Generate Thiessen polygon cells based on the seed points;

[0017] Create the target spatial geometry within the preset area;

[0018] Spatial position calculations are performed on the target spatial geometry and the Thiessen polygon cell to form a porous structure model;

[0019] The porous structure is fabricated according to the porous structure model as described in any embodiment of the first aspect.

[0020] In one embodiment, the step of performing spatial position calculations on the target spatial geometry and the Thiessen polygon cell to form a porous structure model includes:

[0021] Based on the spatial relationship between the target spatial geometry and the Thiessen polygon cell, a portion of the Thiessen polygon cell is deleted within the preset area, while another portion of the Thiessen polygon cell is retained.

[0022] Bone trabeculae are generated on the edges of the retained Thiessen polygonal cells to form a porous structure model.

[0023] In one embodiment, the Thiessen polygon cells that have overlapping regions with the target spatial geometry are retained, while the Thiessen polygon cells that do not have overlapping regions with the target spatial geometry are deleted.

[0024] In one embodiment, the Thiessen polygon cell includes a first Thiessen polygon cell and a second Thiessen polygon cell;

[0025] The ratio of the volume of the overlapping region of the first Thiessen polygon cell and the target spatial geometry to the volume of the first Thiessen polygon cell itself is not less than a preset threshold; the ratio of the volume of the overlapping region of the second Thiessen polygon cell and the target spatial geometry to the volume of the second Thiessen polygon cell itself is less than a preset threshold.

[0026] Specifically, the first Thiessen polygon cell is retained, while the second Thiessen polygon cell is deleted.

[0027] In one embodiment, the preset threshold is between 0.5 and 0.7.

[0028] In one embodiment, the method for fabricating the porous structure further includes:

[0029] A preset region is created for generating the porous structure; the preset region is a cubic space.

[0030] In one embodiment, the volume of the cubic space is N cubic millimeters, and the ratio of the preset quantity to N is between 1 and 4.

[0031] The method for fabricating porous structures provided in this application involves using Thiessen polygonal cells to form an uneven structure on the surface of the porous structure. This results in high structural strength on the surface of the porous structure, making it less susceptible to damage and deformation after filling. This improves the stability between particles (between porous structures) and enhances the mutual constraint between particles. Furthermore, the uneven structure increases the friction between the porous structure and the bone interface, further improving the stability of the filled porous structure. Attached Figure Description

[0032] Figure 1 This is a schematic flowchart illustrating a method for fabricating a porous structure according to an embodiment of this application.

[0033] Figure 2 for Figure 1 The diagram illustrates the model generation process during the fabrication process shown in the illustration.

[0034] Figure 3 for Figure 1 The flowchart of the manufacturing method shown is a schematic diagram of S400.

[0035] Figure 4 This is a schematic diagram of a porous structure provided in an embodiment of this application.

[0036] Explanation of reference numerals in the attached figures:

[0037] 10. Porous structure; 11. Thiessen polygonal cell body; 111. Bone trabeculae; 112. Micropores; 12. Concave-convex structure. Detailed Implementation

[0038] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0039] In the description of this application, it should be understood that if terms such as "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential" appear, these terms indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0040] Furthermore, where the terms "first" and "second" appear, these terms are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined with "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, where the term "multiple" appears, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0041] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0042] In this application, unless otherwise expressly specified and limited, the use of descriptions such as "above" or "below" the second feature indicates that the first and second features are in direct contact or indirect contact via an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. Similarly, "below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0043] It should be noted that if an element is referred to as being "fixed to" or "set on" another element, it can be directly on the other element or there may be an intervening element. If an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intervening element. If so, the terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used in this application are for illustrative purposes only and do not represent the only possible implementation.

[0044] As described in the background art, porous artificial bone particles are commonly used as bone substitutes for implantation in related technologies. However, the surface of these artificial bone particles (hereinafter referred to as particles) has multiple independent filaments protruding from it. Since the particle surface does not form a bent void structure, the surface structure strength of the particles is low. After the particles are filled, the filaments on the particle surface are prone to deformation or damage, resulting in problems such as insufficient filling stability between particles, poor constraint between particles, and insufficient bonding force between particles and bone.

[0045] In view of at least one of the above-mentioned problems, embodiments of this application provide a porous structure for implantation into the human body, an implant, and a method for fabricating a porous structure. By using Thiessen polygonal cells to form an uneven structure on the surface of the porous structure, the surface of the porous structure has high structural strength. After filling the porous structure, the surface is not easily damaged or deformed, thereby improving the stability between particles (between porous structures) and enhancing the mutual restraint between particles. In addition, the uneven structure can also increase the friction between the porous structure and the bone interface, improving the stability of the porous structure after filling.

[0046] Firstly, referring to Figure 1 As shown in the figure, this application provides a method for fabricating a porous structure, the method comprising:

[0047] S100: Generate a seed matrix within a preset area. The seed matrix includes a preset number of randomly arranged seed points.

[0048] It should be noted that, according to the basic principle of Thiessen polygons, the cell size of a Thiessen polygon is mainly determined by the seed lattice that generates the polygon. The number and distribution of the seed lattice are two key factors affecting the cell size of the Thiessen polygon. The denser the seed lattice, the denser the generated Thiessen polygon cell size; conversely, the sparser the seed lattice, the sparser the generated Thiessen polygon cell size.

[0049] Specifically, refer to Figure 2 In step a, random seed points are generated within the preset area by generating random spatial point coordinates. At the same time, the number of random point coordinates generated is controlled by inputting a preset number, thus completing the generation of seed point lattice within the preset area and preparing for the construction of the Thiessen polygon cell.

[0050] S200: Generates Thiessen polygon cells based on seed points.

[0051] It should be noted that the generation and division of Thiessen polygon cells is a crucial step in creating porous structure models. In one example, such as... Figure 2 As shown in step b, the Thiessen polygon cell can be constructed with various sub-points as the center. In another example, the Thiessen polygon cell can also be constructed without centering on a seed point.

[0052] Specifically, after generating the Thiessen polygon cells, all Thiessen polygon cells can be numbered to facilitate selection of Thiessen polygon cells in subsequent steps.

[0053] S300: Creates a target spatial geometry within a preset area. For example, the target spatial geometry can be any spatial geometry such as a sphere, cone, cylinder, or cube. (See reference...) Figure 2As shown in step c, in this embodiment of the application, a sphere is used as the target spatial geometry.

[0054] It should be noted that if the expected porous structure has a general outline of a sphere, then the target spatial geometry is a sphere; if the expected porous structure has a general outline of a cone, then the target spatial geometry is a cone.

[0055] S400: Performs spatial position calculations on the target spatial geometry and the Thiessen polygon cell to form a porous structure model.

[0056] In this embodiment, a porous structure model with a surface featuring unevenness and convexity can be formed by performing spatial position calculations on the target spatial geometry and the Thiessen polygon cells. It should be noted that here, "spatial position calculation" can be considered as selecting all Thiessen polygon cells within a preset area. In this embodiment, the generated porous structure model is as follows: Figure 2 As shown in step d.

[0057] S500: Fabricate a porous structure based on a porous structure model. (Refer to...) Figure 2 Step e in the middle and Figure 3 As shown, the porous structure 10 includes multiple trabeculae 111, which constitute multiple interconnected Thiessen polygonal cells 11. Each Thiessen polygonal cell 11 has interconnected micropores 112. Some of the Thiessen polygonal cells 11 have irregular or irregular structures 12 formed on the surface of the porous structure 10.

[0058] The method for fabricating porous structures provided in this application involves using Thiessen polygonal cells to form an uneven structure on the surface of the porous structure. This results in high structural strength on the surface of the porous structure, making it less susceptible to damage and deformation after filling. This improves the stability between particles (between porous structures) and enhances the mutual constraint between particles. Furthermore, the uneven structure increases the friction between the porous structure and the bone interface, further improving the stability of the filled porous structure.

[0059] In one example, porous structures can be fabricated using additive manufacturing. Additive manufacturing (3D printing), as a highly flexible manufacturing process with excellent compatibility with complex shapes, can realize the fabrication of the porous structures described in this application. By using additive manufacturing to print porous structures, parts of any shape can be directly generated from computer graphics data without machining or any molds, thereby greatly shortening the product development cycle, increasing productivity, and reducing production costs.

[0060] In one example, the printing material can be a biocompatible metallic material, such as titanium alloy, tantalum alloy, cobalt-chromium alloy, 316L stainless steel, tantalum metal, magnesium alloy, etc. Alternatively, depending on the purpose, materials such as ceramics, polymers, and composite materials can be selected, including tricalcium phosphate, hydroxyapatite, calcium sulfate, bioglass, and polycaprolactone. Depending on the material selection, the printing process that can be used can be powder bed fusion, fused deposition modeling, photopolymerization, etc.

[0061] In one embodiment, reference Figure 3 As shown, S400: The steps for performing spatial position calculations on the target spatial geometry and the Thiessen polygon cell to form a porous structure model include:

[0062] S410: Based on the spatial relationship between the target spatial geometry and the Thiessen polygon cells, delete a portion of the Thiessen polygon cells within a preset area and retain another portion of the Thiessen polygon cells.

[0063] It should be noted here that the spatial positional relationship can include the following: one is that a portion of the Thiessen polygon cells completely coincide with the target spatial geometry; another is that a portion of the Thiessen polygon cells do not coincide with the target spatial geometry; and yet another is that a portion of the Thiessen polygon cells partially coincide with the target spatial geometry. In this embodiment, by considering the spatial positional relationship between the target spatial geometry and the Thiessen polygon cells, a portion of the Thiessen polygon cells can be selected to form a porous structure model.

[0064] S420: Generate bone trabeculae on the edges of the preserved Thiessen polygonal cells to form a porous structure model.

[0065] Specifically, the edges of the retained Thiessen polygon cells are extracted, duplicate edges are merged, and the edges are given a certain cross-sectional shape to form trabeculae. For example, a circular cross-section with a diameter of 300 μm is given to the edges.

[0066] In one embodiment, Thiessen polygon cells that have overlapping regions with the target spatial geometry are retained, while Thiessen polygon cells that do not have overlapping regions with the target spatial geometry are deleted.

[0067] Here, overlapping area refers to overlapping areas in three-dimensional space.

[0068] In one embodiment, the Thiessen polygon cell includes a first Thiessen polygon cell and a second Thiessen polygon cell. The ratio of the volume of the overlapping region of the first Thiessen polygon cell and the target spatial geometry to the volume of the first Thiessen polygon cell itself is not less than a preset threshold. The ratio of the volume of the overlapping region of the second Thiessen polygon cell and the target spatial geometry to the volume of the second Thiessen polygon cell itself is less than a preset threshold.

[0069] Specifically, the first Thiessen polygon cell is retained, while the second Thiessen polygon cell is deleted.

[0070] This is equivalent to retaining the Thiessen polygon cells with a larger overlap area with the target spatial geometry, while deleting the Thiessen polygon cells with a smaller overlap area with the target spatial geometry.

[0071] In one example, the specific steps for selecting Thiessen polygonal cells to form a porous structure model are as follows:

[0072] The volume of the overlapping region between the Thiessen polygon cell and the target spatial geometry is calculated. The first Thiessen polygon cell with a ratio not less than a preset threshold is retained, while the second Thiessen polygon cell with a ratio less than the preset threshold and the Thiessen polygon cell that do not have an overlapping region with the target spatial geometry are deleted.

[0073] In another example, when selecting Thiessen polygonal cells to form a porous structure model, two selections can be made, as follows:

[0074] First, a "coarse selection" is performed on the Thiessen polygon cells, that is, Thiessen polygon cells that have overlapping areas with the target spatial geometry are retained, and Thiessen polygon cells that do not have overlapping areas with the target spatial geometry are deleted.

[0075] Secondly, the Thiessen polygon cells are "selected": among the retained Thiessen polygon cells, the first Thiessen polygon cells that meet the preset threshold are retained, and the second Thiessen polygon cells that do not meet the preset threshold are deleted.

[0076] In one embodiment, the preset threshold is between 0.5 and 0.7. For example, the preset threshold can be 0.5, 0.55, 0.6, 0.65, 0.7, etc. It is understood that the preset threshold can be selected according to the required shape of the porous structure, and this application embodiment does not limit this selection.

[0077] In one embodiment, the method for fabricating the porous structure further includes:

[0078] S090: Creates a preset region for generating porous structures. The preset region is a cubic space.

[0079] Specifically, a preset region for generating a porous structure model is created centered on the origin of the coordinate system and using the boundary coordinates of the input spatial region. Figure 2As shown in step a. In this embodiment, a 6mm×6mm×6mm cube space is selected as the preset region, and a seed lattice is generated within this preset region to lay the foundation for the subsequent generation of the Thiessen polygon. It is understood that the space of the preset region should be larger than the space occupied by the porous structure model.

[0080] In one embodiment, the volume of the cubic space is N cubic millimeters, and the ratio of the preset quantity to N is between 1 and 4.

[0081] In this embodiment, the volume of the cubic space is 216 cubic millimeters, and the number of seed points can be 216, 432, 648, or 864.

[0082] In one embodiment, after the porous structure is fabricated, the following steps may also be included:

[0083] S600: Cleaning and sterilization treatment for porous structures.

[0084] It should be understood that, in the embodiments of this application, although the steps in the flowcharts of the accompanying drawings are shown sequentially according to the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless explicitly stated herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least some of the steps in the accompanying drawings may include multiple steps or multiple stages, which are not necessarily completed at the same time, but may be executed at different times. The execution order of these steps or stages is not necessarily sequential, but may be performed alternately or in turn with other steps or at least a portion of the steps or stages of other steps.

[0085] Secondly, referring to Figure 4 As shown, this application provides a porous structure 10 for implantation in the human body, which can be manufactured by the manufacturing method of any embodiment in the first aspect.

[0086] Specifically, the porous structure 10 includes multiple trabeculae 111, which constitute multiple interconnected Thiessen polygonal cells 11. Each Thiessen polygonal cell 11 has interconnected micropores 112. Some of the Thiessen polygonal cells 11 have irregular or irregular structures 12 formed on the surface of the porous structure 10.

[0087] In this embodiment, the edges of the Thiessen polygonal cell 11 are formed by trabeculae 111. The phrase "a portion of the Thiessen polygonal cell 11 has an uneven structure 12 formed on the surface of the porous structure 10" can be understood as: the Thiessen polygonal cell 11 located on the surface of the porous structure 10 has an uneven structure 12 formed on the surface of the porous structure 10. That is, a portion of the Thiessen polygonal cell 11 is located inside the porous structure 10, and a portion is located on the surface of the porous structure 10.

[0088] The porous structure 10 for implantation in the human body provided in this application embodiment uses Thiessen polygonal cell bodies 11 to form an uneven structure 12 on the surface of the porous structure 10. This allows the trabeculae 111 on the surface of the Thiessen polygonal cell bodies 11 to connect with each other, improving the structural strength of the porous structure 10 surface. This makes the surface of the porous structure 10 less susceptible to damage and deformation, thereby improving the stability between particles (between porous structures 10) and enhancing the mutual restraint between particles. In addition, the uneven structure 12 can also increase the friction between the porous structure 10 and the bone interface, improving the stability of the porous structure 10 after filling. Furthermore, by adopting a trabeculae 111 structure design for the porous structure 10 and setting interconnected micropores 112 in the porous structure 10, the mechanical properties of the porous structure 10 are better matched with the patient's own bone structure, which is conducive to bone ingrowth into the porous structure 10.

[0089] In one embodiment, the trabecular bone 111 has a radial dimension between 200 and 500 μm.

[0090] Specifically, the shape of the trabeculae 111 can be cylindrical or prismatic. If the shape of the trabeculae 111 is cylindrical, the radial dimension of the trabeculae 111 is the diameter of the trabeculae 111. If the shape of the trabeculae 111 is prismatic, the radial dimension of the trabeculae 111 is the distance between the two opposite side surfaces of the prismatic trabeculae 111.

[0091] By ensuring that the dimensions of the trabecular bone 111 along its own radial direction are within the aforementioned range, the structural strength of the trabecular bone 111 can be improved.

[0092] For example, the trabeculae 111 are cylindrical, and the diameter of the cylindrical trabeculae 111 can be 200 μm, 300 μm, 400 μm or 500 μm.

[0093] In one embodiment, the trabecular bone 111 has a dimension between 0.2 and 1 mm along its own axial direction.

[0094] Specifically, the dimension of the trabecular bone 111 along its own axial direction refers to the length of the trabecular bone 111. By keeping the length of the trabecular bone 111 within the aforementioned range, the structural strength of the trabecular bone 111 can be better. For example, the length of the trabecular bone 111 can be 0.2 mm, 0.4 mm, 0.5 mm, 0.7 mm, 0.9 mm, or 0.2 mm.

[0095] In one embodiment, the pore size of the micropore 112 is between 400-600 μm.

[0096] For example, if the micro-hole 112 is a circular hole, then the diameter of the micro-hole 112 is the diameter of the circular hole. If the micro-hole 112 is an irregularly shaped through hole, then the diameter of the micro-hole 112 is the maximum inner diameter of the irregular micro-hole 112.

[0097] In one embodiment, the average pore diameter of the micropore 112 is between 400 and 600 μm. Specifically, if the micropore 112 is a non-circular hole, the average pore diameter of the micropore 112 can be within the above range. For example, if the micropore 112 is a rectangular hole, then the average pore diameter of the micropore 112 is equal to the average of the maximum and minimum inner diameters of the rectangular hole. If the micropore 112 is an irregularly shaped through hole, then the pore diameter of the micropore 112 is the average of all the inner diameters of the through hole.

[0098] It should be noted that the numerical values ​​and ranges involved in the embodiments of this application are approximate values. Due to the influence of the manufacturing process, there may be a certain range of errors, which can be considered negligible by those skilled in the art.

[0099] In one embodiment, the trabecular bone 111 is made of at least one of metal, tricalcium phosphate, hydroxyapatite, calcium sulfate, bioglass, and polycaprolactone.

[0100] For example, the metal can be titanium alloy, tantalum alloy, cobalt-chromium alloy, 316L stainless steel, tantalum metal, magnesium alloy, etc.

[0101] Thirdly, embodiments of this application provide an implant comprising the porous structure described in any embodiment of the second aspect.

[0102] Specifically, the implant surface has a porous layer composed of a porous structure. Examples of implants include acetabular cup prostheses, femoral stem prostheses, femoral prostheses, tibial prostheses, etc.

[0103] The implant provided in this application embodiment uses Thiessen polygonal cell bodies to form an uneven structure on the surface of a porous structure. This results in high structural strength on the porous surface, making it less susceptible to damage and deformation, thereby improving interparticle stability and enhancing the mutual restraint between particles. Furthermore, the uneven structure increases the friction between the porous structure and the bone interface, further improving the implant's stability.

[0104] It should be noted that the method for making the above-mentioned implants specifically includes the following steps:

[0105] S10: Generate a seed matrix within a preset area. The seed matrix includes a preset number of randomly arranged seed points. For example, a cuboid space of 60mm × 60mm × 30mm is generated, and 108,000 seed points are generated within this cuboid space.

[0106] S20: Generate Thiessen polygon cells based on seed points.

[0107] S30: Create the target spatial geometry within the preset area. For example, create a sphere with a diameter of 52mm.

[0108] S40: Perform spatial position calculations on the target spatial geometry and the Thiessen polygon cell to form a porous structure model. For example, if the volume of the overlapping region between the Thiessen polygon cell and the target spatial geometry is not less than 60% of the Thiessen polygon cell's own volume, the Thiessen polygon cell is retained. If the volume of the overlapping region between the Thiessen polygon cell and the target spatial geometry is less than 60% of the Thiessen polygon cell's own volume, the Thiessen polygon cell is deleted. Further, the edges of the retained Thiessen polygon cells are extracted, duplicate edges are merged, and the edges are given a circular cross-section with a diameter of 200 μm, forming trabeculae.

[0109] S50: Combine the porous structure with the solid part of the implant, remove the excess part of the porous structure, and form an implant model.

[0110] S60: Fabricate the implant based on the implant model. For example, the implant can be fabricated using tantalum metal as the material using an additive manufacturing process.

[0111] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0112] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A method for fabricating a porous structure, characterized in that, include: Generate a seed matrix within the preset area; The seed dot matrix includes a preset number of randomly arranged seed dots; Generate Thiessen polygon cells based on the seed points; Create the target spatial geometry within the preset area; Spatial position calculations are performed on the target spatial geometry and the Thiessen polygon cell to form a porous structure model; A porous structure is fabricated based on the porous structure model; The step of performing spatial position calculations on the target spatial geometry and the Thiessen polygon cell to form a porous structure model includes: Based on the spatial relationship between the target spatial geometry and the Thiessen polygon cell, a portion of the Thiessen polygon cell is deleted within the preset area, while another portion of the Thiessen polygon cell is retained. Bone trabeculae are generated on the edges of the retained Thiessen polygonal cells to form the porous structure model; wherein, the edges of the retained Thiessen polygonal cells are extracted, duplicate edges are merged, and the edges are given a certain cross-sectional shape so that the edges form the bone trabeculae. The Thiessen polygon cell includes a first Thiessen polygon cell and a second Thiessen polygon cell; the volume of the overlapping region of the first Thiessen polygon cell and the target spatial geometry is not less than a preset threshold in ratio to the volume of the first Thiessen polygon cell itself; the volume of the overlapping region of the second Thiessen polygon cell and the target spatial geometry is less than a preset threshold in ratio to the volume of the second Thiessen polygon cell itself; wherein, the first Thiessen polygon cell is retained and the second Thiessen polygon cell is deleted; the preset threshold is between 0.5 and 0.

7. The method for fabricating the porous structure further includes: A preset region for generating the porous structure is created; the preset region is a cubic space; wherein, the preset region for generating the porous structure model is created with the origin of the coordinate system as the center and the boundary coordinates of the input spatial region are used, and a seed lattice is generated within the preset region; the space of the preset region is larger than the space occupied by the porous structure model.

2. The method for fabricating a porous structure according to claim 1, characterized in that, The volume of the cubic space is N cubic millimeters, and the ratio of the preset quantity to N is between 1 and 4.

3. A porous structure for implantation in the human body, characterized in that, The porous structure (10) is manufactured using the manufacturing method described in any one of claims 1-2; The porous structure (10) includes multiple trabeculae (111), which constitute multiple interconnected Thiessen polygonal cells (11); each Thiessen polygonal cell (11) has interconnected micropores (112). In this process, some of the Thiessen polygonal cells (11) have an uneven structure (12) formed on the surface of the porous structure (10).

4. The porous structure for implantation in the human body according to claim 3, characterized in that, The trabecular bone (111) has a radial dimension between 200-500 μm; And / or, the trabecular bone (111) has a dimension between 0.2 and 1 mm along its own axial direction.

5. The porous structure for implantation in the human body according to claim 3, characterized in that, The pore size of the micropore (112) is between 400-600 μm.

6. The porous structure for implantation in the human body according to any one of claims 3-5, characterized in that, The material of the trabecular bone (111) includes at least one of the following: metal, tricalcium phosphate, hydroxyapatite, calcium sulfate, bioglass, and polycaprolactone.

7. An implant, characterized in that, Includes a porous structure (10) for implantation in the human body as described in any one of claims 3-5.

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