一种水凝胶及其制备方法和应用
By incorporating tricarboxylic acid cycle intermediate metabolites and methacrylated gelatin into the hydrogel, the problem of poor in vivo stability of exogenous ATP was solved, promoting the repair of articular cartilage damage and achieving efficient tissue energy metabolism and stable repair effects.
CN118986854BActive Publication Date: 2026-07-17HUAZHONG UNIV OF SCI & TECH
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HUAZHONG UNIV OF SCI & TECH
- Filing Date
- 2024-08-14
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Exogenous ATP added in existing technologies has poor stability in vivo, resulting in poor long-term repair effects on articular cartilage damage.
Method used
Hydrogels were prepared by using intermediate metabolites of the tricarboxylic acid cycle as energy-active substances and combining them with materials such as methacrylated gelatin. The hydrogel products were formed by photoinitiator and ultraviolet light irradiation, and the energy-active substances were encapsulated to improve their stability in vivo.
Benefits of technology
It promotes energy metabolism in damaged articular cartilage tissues, increases cellular bioenergy levels, enhances tissue repair, and maintains the stability of intermediate metabolites in the body, preventing the rapid degradation of ATP.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN118986854B_ABST
Abstract
本申请涉及凝胶材料技术领域，尤其涉及一种水凝胶及其制备方法和应用；所述水凝胶包括能量活性物和包覆能量活性物的凝胶材料，能量活性物为三羧酸循环的中间代谢产物；中间代谢产物的摩尔浓度≥0.1mol / L；通过在水凝胶材料内加入三羧酸循环的中间代谢产物充当能量活性物，可以加速关节软骨损伤组织部位的能量代谢水平，以促进关节软骨的组织修复；同时由于水凝胶材料的生物相容性较高，通过水凝胶包覆能量活性物可以使得中间代谢产物在机体内稳定降解，从而可以避免外源添加的ATP在体内稳定性较差的缺陷。
Need to check novelty before this filing date? Find Prior Art