A biological sample management method, device and system

Abstract

The application provides a biological sample management method, device and system. The biological sample management method comprises the following steps: sending a storage request to a management end through a user end; after the management end confirms the storage request, sending approval authentication information to the user end and sending authorization management information to an intelligent cabinet by using the management end; when the user sends a connection request including the approval authentication information to the intelligent cabinet through the user end, and the intelligent cabinet confirms that the connection request is legal, determining a storage space corresponding to the connection request as a target storage space according to the authorization management information, and showing the position information of the target storage space to the user; obtaining the identity information of the user by using an identity recognition device, determining the target state of the target storage space according to the identity information, and controlling the electronic lock of the target storage space to be opened when the target state is opened, so that the efficiency of the storage and management of biological samples in clinical trials can be improved.

Description

Technical Field

[0001] This application relates to the technical field of medical devices for clinical trials, and more particularly to a method, device, and system for managing biological samples. Background Technology

[0002] Clinical trial biosamples refer to any substance obtained or derived from subjects in accordance with the clinical trial protocol, including but not limited to tissues, plasma, serum, urine, feces, and bone marrow. They are typically used for safety evaluation, efficacy evaluation, and some exploratory scientific research. The quality and safety of the samples play a crucial role in the accuracy of the trial results and are also important evidence for ensuring the authenticity and reliability of test data and traceability. Therefore, strengthening the preservation and supervision of biosamples is a vital aspect of clinical trials. During the implementation of clinical trials, the handling, preservation, and delivery of clinical trial samples are often assisted by Clinical Research Coordinators (CRCs). Currently, most CRCs in China are dispatched to medical institutions by third-party Clinical Trial Site Management Organizations (SMOs) on a labor dispatch basis to provide research assistant services for clinical research. Hospitals, as the responsible entities for biosample management, have the responsibility to establish a management system for clinical trial biosamples and assign dedicated personnel for management.

[0003] Traditional preservation and management methods rely on manual operation, which is prone to errors or omissions and lacks effective tracking and monitoring mechanisms. In other words, the preservation and management of clinical trial biological samples currently suffers from low efficiency and insufficient safety.

[0004] Based on this, this application provides a biological sample management method, device and system to improve the existing technology and meet the needs of practical applications. Summary of the Invention

[0005] The purpose of this application is to provide a biological sample management method, device and system to solve the problems of low efficiency and insufficient safety in the preservation and management of biological samples in the above-mentioned clinical trials.

[0006] The objective of this application is achieved through the following technical solution:

[0007] In a first aspect, this application provides a biological sample management method, which is applied to a smart cabinet, the smart cabinet including an identification device, multiple storage spaces for storing clinical trial biological samples, and an electronic lock for controlling the opening of each storage space;

[0008] The biological sample preservation method includes:

[0009] The user sends a save request to the management terminal, and the save request includes the sample information of the biological sample to be saved and the user identification information of the user terminal.

[0010] After the management terminal confirms the save request, it sends approval authentication information to the user terminal and authorization management information to the smart cabinet.

[0011] When a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the storage space corresponding to the connection request based on the authorization management information, and uses it as the target storage space, and displays the location information of the target storage space to the user.

[0012] The identity recognition device is used to obtain the user's identity information, and the target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open.

[0013] The beneficial effects of this technical solution are as follows: By using identity recognition devices and approval authentication information, it ensures that only authorized users can access specific storage spaces, enhancing the security of biological samples. Users sending requests via smart devices and the management system processing them simplifies the storage process, reduces the complexity of manual operations, and thus improves the efficiency of clinical trial biological sample storage and management. The automated control of electronic locks and the real-time display of location information improve the efficiency of sample access. Before user identity verification, the location information of the storage space is confirmed and displayed. If the user deems the storage location unsuitable, they can promptly contact the management personnel for adjustments, increasing the flexibility and selectivity of user operations and avoiding repetitive and invalid operations of identity verification and storage after discovering an unsuitable location, reducing operational time and resource waste, and improving overall efficiency. In summary, this solution addresses the problems of low efficiency and insufficient security in the storage and management of clinical trial biological samples.

[0014] In some possible implementations, the biological sample management method further includes, before sending a save request from the user terminal to the management terminal:

[0015] By acquiring user input through the user terminal, the sample information of the biological sample to be saved is obtained. The sample information includes the biological sample preservation environment requirements, as well as at least one of the following: clinical trial project number, sample name, sample type, sample quantity, and physical image of the sample.

[0016] The beneficial effects of this technical solution are as follows: By recording detailed sample information, it ensures precise matching of the biological sample preservation environment, thereby improving the preservation quality of biological samples. The user-end input operation simplifies the process of generating preservation requests, reduces the need for manual filling and recording, improves work efficiency, and ensures the timeliness of data recording. Electronic information input reduces the possibility of errors in manual recording, improving the accuracy of sample information. The above methods can be used to submit requests and information in real time, enabling the management end to receive and process user preservation requests promptly, improving the efficiency and response speed of the entire operation process.

[0017] In some possible implementations, the approval and authentication information includes unlocking key information generated based on the sample information and user identification information, and the authorization management information includes authorization key information corresponding to the unlocking key information; the smart cabinet confirms the legitimacy of the connection request in the following ways:

[0018] The system detects whether any of the multiple authorization management messages sent from the management terminal to the smart cabinet can match the unlocking key information. If there is authorization management information that matches the unlocking key information, the connection request is considered legitimate, and the location information of the target storage space is displayed using the user terminal.

[0019] The beneficial effects of this technical solution are as follows: The smart locker quickly verifies the legitimacy of connection requests by matching unlocking key information and authorization management information, improving the efficiency of the verification process. The matching mechanism between authorization management information and unlocking key information ensures that only correct authorization can unlock the corresponding storage space, avoiding permission confusion or incorrect authorization. The user terminal immediately displays the location information of the target storage space after a legitimate connection request, enhancing the user experience and enabling users to quickly locate and access the required storage space. The unlocking key information and authorization key information can use symmetric or asymmetric encryption technologies.

[0020] In some possible implementations, the biological sample management method further includes:

[0021] If no authorized management information matching the unlocking key information is found, the connection request is considered invalid. The number of failures within a preset time period is incremented by one, and it is checked whether the number of failures is not less than a preset number.

[0022] When the number of failures is less than the preset number, the smart cabinet is used again to retrieve the connection request sent by the user.

[0023] When the number of failures is not less than a preset number, a connection failure message is generated based on the multiple invalid connection requests and sent to the management terminal.

[0024] The beneficial effects of this technical solution are as follows: verifying and counting the legitimacy of connection requests can effectively prevent malicious attacks or fraudulent activities, and the preset failure limit and reporting mechanism help to detect and respond to abnormal operations in a timely manner.

[0025] In some possible implementations, after the user saves the biological sample to the target storage space, the biological sample management method further includes:

[0026] The smart cabinet generates storage information based on the connection request and the corresponding authorization management information; it then sends the storage information to a sample database on the cloud server, which is used by administrators to obtain the storage status of each storage space through the management terminal.

[0027] The beneficial effects of this technical solution are as follows: By uploading the preserved information to the sample database on the cloud server, centralized management and unified storage of biological sample data are achieved, avoiding the cumbersome and fragile nature of traditional paper records and improving data security and reliability. Through the cloud server and sample database, administrators can obtain real-time information on the storage space and the status of biological samples, thereby enabling remote monitoring of the biological samples. Any abnormalities or changes in storage conditions can be detected and reported promptly, ensuring the safe and stable preservation of biological samples.

[0028] In some possible implementations, the authorization management information may also include the storage time of the biological sample corresponding to the storage request and the requirements for the biological sample storage environment;

[0029] The biological sample management method further includes: when the storage conditions of any storage space are abnormal, sending an abnormal alarm notification to the management terminal and the user terminal corresponding to the biological sample stored in the storage space;

[0030] An abnormality in the storage conditions of any storage space refers to:

[0031] The sensing module of the smart cabinet is used to obtain environmental information of the storage space;

[0032] Based on the authorized management information of the biological samples in the preservation space and the environmental design information of the preservation space, the minimum preservation standard of the preservation space is determined;

[0033] When the environmental information does not meet the minimum preservation standard, the preservation conditions are considered abnormal.

[0034] Each of the storage spaces has independent environmental design information, and each environmental design information is used to indicate the temperature setting range of its corresponding storage space.

[0035] The beneficial effects of this technical solution are as follows: by monitoring the environmental information of the storage space in real time, abnormal conditions in the storage environment can be detected in a timely manner, preventing biological samples from being damaged or becoming invalid due to environmental problems. Abnormal alarm notifications enable managers and users to respond quickly to problems and take necessary measures to protect the safety of biological samples.

[0036] In some possible implementations, the biological sample management method further includes:

[0037] The user sends a retrieval request to the management terminal, and the retrieval request includes the sample information of the biological sample that has been saved and the user's identification information on the user terminal.

[0038] After the management terminal confirms the collection request, it sends approval and authentication information to the user terminal and authorization management information to the smart cabinet.

[0039] When a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the target storage space corresponding to the connection request based on the authorization management information and displays the location information of the target storage space to the user.

[0040] The identity recognition device is used to obtain the user's identity information, and the target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open.

[0041] The beneficial effects of this technical solution are as follows: Through dual verification of identity recognition devices and approval authentication information, it ensures that only authorized users can access specific biological samples, thereby enhancing sample security and confidentiality. Remote communication between the user terminal and the smart cabinet allows users to retrieve samples from different locations, improving flexibility and convenience.

[0042] Secondly, this application also provides a biological sample management device, which includes a memory and at least one processor. The memory stores a computer program, and the at least one processor is configured to execute the computer program to perform the following steps:

[0043] When a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the storage space corresponding to the connection request based on the authorization management information, and uses it as the target storage space, and displays the location information of the target storage space to the user.

[0044] The user's identity information is obtained using the smart cabinet's identity recognition device. The target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open.

[0045] The approval and authentication information is obtained by the user terminal sending a save request to the management terminal, and the management terminal sending the saved request back to the user terminal after confirming the save request; the authorization management information is obtained by the management terminal sending the saved request back to the user terminal after confirming the save request; the save request includes sample information of the biological sample to be saved and user identification information of the user terminal.

[0046] Thirdly, this application also provides a biological sample preservation system, the biological sample preservation system comprising:

[0047] The smart cabinet includes the biosample management equipment described in the second aspect, an identification device, multiple storage spaces for storing clinical trial biosamples, and an electronic lock for controlling the opening of each storage space;

[0048] User terminal equipment is used to install and run the user terminal for user use;

[0049] Management terminal equipment, used to install and run management terminals for administrators.

[0050] In some possible implementations, both the user terminal device and the smart cabinet include a Bluetooth communication module, used to establish a Bluetooth connection between the user terminal device and the smart cabinet when the user sends a connection request to the smart cabinet through the user terminal. Attached Figure Description

[0051] The present application will be further described below with reference to the accompanying drawings and embodiments.

[0052] Figure 1 This is a flowchart illustrating a biological sample management method provided in an embodiment of this application.

[0053] Figure 2 This is a partial flowchart of a biological sample management method provided in an embodiment of this application.

[0054] Figure 3 This is a flowchart illustrating a process for determining whether the storage space is abnormal, provided in an embodiment of this application.

[0055] Figure 4 This is a structural block diagram of a biological sample management device provided in an embodiment of this application. Detailed Implementation

[0056] The technical solutions in this application will be described below with reference to the accompanying drawings and specific embodiments. It should be noted that, without conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments.

[0057] In this application, the terms "exemplary" or "for example" are used to indicate that something is an example, illustration, or description. Any implementation or design described as "exemplary" or "for example" in this application should not be construed as being better or more advantageous than other implementations or designs. Specifically, the use of terms such as "exemplary" or "for example" is intended to present the relevant concepts in a specific manner.

[0058] The descriptions of "first," "second," etc., appearing in the embodiments of this application are for illustrative purposes and to distinguish the objects being described. They have no order and do not indicate any special limitation on the quantity in the embodiments of this application, nor do they constitute any limitation on the embodiments of this application.

[0059] CRC stands for Clinical Research Coordinator. It refers to personnel who, after professional learning and training, have mastered the necessary skills for clinical trials and have been authorized by research institutions and principal investigators, assist researchers in performing non-medical judgment and treatment in clinical trials.

[0060] Currently, most clinical research coordinators (CRCs) in China are dispatched to medical institutions by third-party organizations on a labor dispatch basis to assist researchers in completing clinical studies. This process is characterized by large numbers of personnel, high mobility, and difficulty in management. Furthermore, as the primary implementers of clinical trial biosample processing and preservation, hospitals, as the responsible entities for biosample management, must assign dedicated personnel to supervise and regularly inventory clinical trial biosamples. Traditional preservation methods suffer from problems such as cumbersome operation, lack of transparency, low security, and inadequate supervision. Although hospitals, based on their own needs, have provided some methods for biosample preservation and transportation using databases to improve preservation efficiency and management, such as the intelligent system and method for biosample preservation and transportation disclosed in application number CN202210585371.5, which provides an intelligent container, from the moment the sample is placed in it after removal from the body until the sample is removed, sample information (patient name, removal time, sample type, etc.), real-time temperature, sample storage and retrieval time, and sampler information are automatically recorded and stored, and synchronized on a server. This measure emphasizes the collection and transportation management of biosamples, with a primary focus on supervising the transportation process through the use of intelligent sample transportation containers.

[0061] Compared to hospital staff, (CRC) clinical researchers are more concerned with:

[0062] This application aims to provide a highly efficient and secure solution for the preservation and management of biological samples from clinical trials, particularly those requiring long-term storage and involving dozens or even hundreds of simultaneous clinical trials with varying environmental (temperature) requirements. Currently, existing biological sample management methods are insufficient to meet the needs of clinical researchers (CRCs) who are numerous, mobile, and largely non-hospital staff. Therefore, this application provides a biological sample management method, device, and system that simplifies the storage process by enabling the use of identification and approval authentication information and provides real-time location information to clinical researchers, offering a suitable approach for biological sample preservation in clinical trials. The following section will first describe the biological sample management method, followed by the biological sample management device and biological sample preservation system.

[0063] Method Implementation Examples

[0064] See Figure 1 , Figure 1 This is a flowchart illustrating a biological sample management method provided in an embodiment of this application.

[0065] This application provides a biological sample management method, which is applied to a smart cabinet. The smart cabinet includes an identification device, multiple storage spaces for storing clinical trial biological samples, and an electronic lock for controlling the opening of each storage space.

[0066] The biological sample management method includes:

[0067] S101, a save request is sent from the user terminal to the management terminal. The save request includes the sample information of the biological sample to be saved and the user identification information of the user terminal.

[0068] S102, after the management terminal confirms the save request, the management terminal sends approval authentication information to the user terminal and authorization management information to the smart cabinet.

[0069] S103, when a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the storage space corresponding to the connection request according to the authorization management information, and uses it as the target storage space, and displays the location information of the target storage space to the user.

[0070] S104, the identity recognition device is used to obtain the user's identity information, and the target state of the target storage space is determined according to the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open.

[0071] The client can be a program that provides services to users, or it can exist in the form of a page or webpage; this application does not impose any restrictions on it. It is generally installed on the user's terminal device, such as a tablet, laptop, desktop computer, mobile phone, or other smart terminal device with the client installed. In this embodiment, the user refers to a clinical researcher (CRC) in a medical system.

[0072] Accordingly, the server refers to the application used by administrators to manage the permissions of personnel storing biological samples and to respond to client requests. Similarly, the server can also exist in the form of a page or webpage; this application does not impose any restrictions on this. The detection terminal device is, for example, a smart terminal device such as a tablet, laptop, desktop computer, or mobile phone with a client installed, used by administrators. It can be assumed that the administrators are hospital employees who, compared to users, have a better understanding of the hospital's actual situation and possess more professional knowledge and skills, enabling them to comprehensively manage the storage of biological samples and provide corresponding storage instructions based on the usage of the smart cabinets. The described biological sample management method can run on electronic devices.

[0073] Smart cabinets are devices used to store and protect various biological samples, such as smart freezers that include multiple independent storage spaces or combinations of multiple smart freezers.

[0074] In the technical solution provided in this embodiment, after receiving a storage request, the management terminal confirms it. Once confirmed, the management terminal sends approval authentication information to the user terminal and authorization management information to the smart cabinet. The authorization management information can be considered to include indication information of the storage space allocated for the storage request and the user identification information in the storage request, while the approval authentication information includes the permission to open the allocated storage space. After receiving the approval authentication information, the user terminal sends a connection request to the smart cabinet. This request contains the approval authentication information for verifying the permission to access the allocated storage space. The smart cabinet confirms the legality of the connection request and determines the corresponding storage space based on the authorization management information, displaying the location information of that space to the user. This allows the user to know the specific location for storing the biological sample before proceeding with the next step of identity verification. If the user deems the location unsuitable, they can contact the management terminal for adjustment. The user verifies their identity using an identification device (such as fingerprint or facial recognition), and the smart cabinet determines the status of the target storage space based on the user's identity. If the target status is open, the electronic lock is opened, allowing the user to access the sample. The user identification information sent from the user terminal to the management terminal can be considered as including the user's name, ID, and biometric information, such as fingerprint or facial recognition data. The authorization management information includes the user identification information from the storage request. The advantage is that most users are not formal hospital employees, and the management terminal cannot directly obtain user identification information (from the database). By including user identification information in the authorization management information, this method can perform authentication and authorization independently of the hospital's employee database, ensuring accurate user identification and authorization even without access to the hospital's internal employee database. Since the management terminal does not need to directly obtain and store all user identification information, data redundancy and potential privacy issues can be avoided.

[0075] Therefore, by using identification devices and authorization information, access to specific storage spaces is ensured to be limited to authorized users, enhancing the security of biological samples. Users send requests via smart devices, and the management system processes them, simplifying the storage process and reducing the complexity of manual operations. The automated control of electronic locks and the real-time display of location information improve the efficiency of sample access. Before user verification, the location information of the storage space is confirmed and displayed. If the user deems the storage location unsuitable, they can contact the management personnel for adjustments, increasing the flexibility and selectivity of user operations and avoiding repetitive and invalid operations of identity verification and storage after discovering an unsuitable location, reducing time and resource waste and improving overall efficiency. Furthermore, given the large number of (CRC) clinical researchers with varying access times, all storage requests and authorization information can be centrally managed through the management system, facilitating centralized review and ensuring transparency and standardization. Management personnel can achieve these goals remotely without being physically present. This eliminates the need to purchase similar intelligent storage equipment as a sample bank or arrange for 24-hour staffing, reducing departmental expenses and human resource investment, resulting in good economic efficiency. The multiple storage spaces and their corresponding electronic locks prevent numerous projects from sharing a single refrigerator space, making it easier to count the number of specimens and avoiding overheating caused by frequent or prolonged refrigerator opening.

[0076] The storage request includes sample information of the biological sample to be stored and user identification information from the user's terminal. Failure to promptly close the target storage space after storage / retrieval can lead to overheating and affect the project. This application allows the smart cabinet to send a closing indicator to the user's terminal after the target storage space is closed. This closing indicator includes the opening and closing times of the target storage space. When the time between the opening and closing times exceeds a preset length (e.g., 3 minutes, 5 minutes, 7 minutes), the client associates the closing indicator with the user's terminal identification information and sends it to the management terminal. In practical applications, the closing indicator information received by the client and the user's terminal identification information can be used to criticize and retrain the corresponding user.

[0077] The technical solution of this embodiment takes into account the diverse storage environment (temperature) requirements of different biological samples, and the provided biological sample management method can meet the needs of dozens or even hundreds of clinical trials being conducted simultaneously. The diverse requirements refer to the fact that different samples may involve different temperature requirements in biological sample management, such as -80 degrees Celsius, -20 degrees Celsius, refrigerated 2-8 degrees Celsius, and room temperature 15-25 degrees Celsius. Correspondingly, multiple storage spaces can be set with different temperature ranges according to the specific requirements of the biological samples.

[0078] In some embodiments, before sending a save request to the management terminal via the user terminal, the biological sample management method further includes:

[0079] The system obtains user input via a client-side interface, acquiring sample information for the biological samples to be preserved. This sample information includes biological sample preservation environment requirements, and at least one of the following: clinical trial project number, sample name, sample type, sample quantity, and a photograph of the sample. The biological sample preservation environment requirements are temperature requirements. The clinical trial project number is, for example, an identifier for a clinical trial related to the biological sample, used for tracking and management. The sample name refers to the name or description of the biological sample for easy identification. The sample type refers to the type of biological sample, such as blood type, tissue type, etc. The sample quantity refers to the number of samples to be preserved. The photograph of the sample refers to an image of the sample for visual confirmation and recording.

[0080] By meticulously recording sample information, precise matching of the biological sample preservation environment is ensured, thereby improving the preservation quality of the biological samples. The user-end input process simplifies the generation of preservation requests, reduces the need for manual filling and recording, improves work efficiency, and ensures the timeliness of data recording. Electronic information input reduces the possibility of errors in manual recording, improving the accuracy of sample information. These methods can be used to submit requests and information in real time, enabling the management end to receive and process user preservation requests promptly, improving the efficiency and response speed of the entire operation process.

[0081] It is worth noting that this application considers that researchers should ensure all clinical trial data is obtained from the source documents and trial records of the clinical trial, and is accurate, complete, readable, and timely. Source data should be attributable, readable, synchronic, original, accurate, complete, consistent, and durable. Modifications to source data should be documented, should not obscure the initial data, and the reasons for the modifications should be recorded. The technical solution of this application, through user-side input, eliminates the need for manual filling and recording, enabling detailed record-keeping of sample information and achieving timeliness in data recording.

[0082] In addition, since biological specimens have storage temperature requirements and are not suitable for counting after being taken out, the technical solution provided in this embodiment can use the sample information of the biological samples to be preserved to automatically calculate the sample quantity and remind users to send it out or destroy it in a timely manner.

[0083] In some embodiments, the approval and authentication information includes unlocking key information generated based on the sample information and user identification information, and the authorization management information includes authorization key information corresponding to the unlocking key information; the smart cabinet confirms the legitimacy of the connection request in the following ways:

[0084] The system detects whether any of the multiple authorization management messages sent from the management terminal to the smart cabinet can match the unlocking key information. If there is authorization management information that matches the unlocking key information, the connection request is considered legitimate, and the location information of the target storage space is displayed using the user terminal.

[0085] The management terminal generates authorization management information, including authorization key information corresponding to the unlocking key information, for use in smart cabinet access verification and operation authorization. After receiving the approval authentication information, the user can send a connection request containing the unlocking key information to the smart cabinet. The smart cabinet stores multiple authorization management information messages sent by the management terminal and searches for authorization management information that matches the unlocking key information sent by the user. If the smart cabinet finds a matching authorization management information, it confirms that the connection request is legitimate. The smart cabinet then sends the location information of the target storage space to the user to display the location of the target storage space to the user.

[0086] Therefore, the smart locker quickly verifies the legitimacy of connection requests by matching unlocking key information and authorization management information, improving the efficiency of the verification process. The matching mechanism between authorization management information and unlocking key information ensures that only correct authorization can unlock the corresponding storage space, avoiding permission confusion or incorrect authorization. Upon receiving a legitimate connection request, the user terminal immediately displays the location information of the target storage space, enhancing the user experience and enabling users to quickly locate and access the required storage space. The unlocking key information and authorization key information can use symmetric or asymmetric encryption technologies.

[0087] See Figure 2 , Figure 2 This is a partial flowchart of a biological sample management method provided in an embodiment of this application.

[0088] In some embodiments, the biological sample management method further includes:

[0089] S105, if there is no authorized management information that can match the unlocking key information, the connection request is considered invalid, the number of failures within a preset time period is incremented by one, and it is checked whether the number of failures is not less than the preset number;

[0090] S106, when the number of failures is less than a preset number, the smart cabinet is used again to obtain the connection request sent by the user terminal; at this time, the user sends a connection request including approval and authentication information to the smart cabinet through the user terminal.

[0091] S107, when the number of failures is not less than a preset number, a connection failure message is generated based on the multiple invalid connection requests and sent to the management terminal.

[0092] This application does not restrict the selection of preset duration and preset number of times. The preset duration is, for example, 2 minutes, 3 minutes, or 10 minutes. The preset number of times is, for example, 4 times, 5 times, or 7 times.

[0093] If no matching unlocking key is found, the connection request is considered invalid. In this case, the smart locker will perform the following operations: increment the failure count within a preset time period and record the current failure count. Check if the failure count has reached or exceeded the preset maximum. If the failure count is less than the preset maximum, the smart locker will wait again and acquire the next connection request from the user, continuing the verification process. If the failure count reaches or exceeds the preset maximum, the smart locker will generate a connection failure message and send it to the management terminal, reporting the invalid connection request.

[0094] Therefore, verifying and counting the legitimacy of connection requests can effectively prevent malicious attacks or fraudulent activities. Preset failure count limits and reporting mechanisms help to detect and respond to abnormal operations in a timely manner.

[0095] In some embodiments, after the user saves the biological sample to the target storage space, the biological sample management method further includes:

[0096] The smart cabinet generates storage information based on the connection request and the corresponding authorization management information; it then sends the storage information to a sample database on the cloud server, which is used by administrators to obtain the storage status of each storage space through the management terminal.

[0097] The intelligent cabinet generates preservation information based on successful preservation operations. This information includes, but is not limited to: the specific location of the sample and the preservation space number, the operator's identification information and timestamp, and the environmental conditions during preservation (such as the temperature within the preservation space). This ensures the transparency and traceability of the preservation process. The generated preservation information is sent to a sample database on a cloud server. The sample database manages and stores the preservation status of biological samples in all preservation spaces. Administrators can access the sample database through a management terminal to obtain the real-time preservation status and historical records of each preservation space. Simultaneously, through the management terminal, administrators can monitor the usage of each preservation space and the preservation status of biological samples in real time.

[0098] Therefore, by uploading the stored information to the sample database on the cloud server, centralized management and unified storage of biological sample data are achieved, avoiding the cumbersome and fragile nature of traditional paper records and improving data security and reliability. Through the cloud server and sample database, administrators can obtain real-time information on the storage space and the status of biological samples, enabling remote monitoring. Any abnormalities or changes in storage conditions can be detected and reported promptly, ensuring the safe and stable preservation of biological samples.

[0099] In practical applications, the sample database provides management with functions including but not limited to: providing real-time updated storage information, including the location, quantity, and storage conditions of the samples; and allowing managers to query and analyze historical data to support decision-making and auditing needs.

[0100] In some embodiments, the authorization management information may also include the storage time of the biological sample corresponding to the storage request and the biological sample storage environment requirements;

[0101] The biological sample management method further includes: when the storage conditions of any storage space are abnormal, sending an abnormal alarm notification to the management terminal and the user terminal corresponding to the biological sample stored in the storage space.

[0102] See Figure 3 , Figure 3 This is a flowchart illustrating a process for determining whether the storage space is abnormal, provided in an embodiment of this application.

[0103] An abnormality in the storage conditions of any storage space refers to:

[0104] S201, the environmental information of the storage space is obtained using the sensing module of the smart cabinet; the sensing module includes a temperature sensing unit;

[0105] S202, Based on the authorized management information of the biological samples in the storage space and the environmental design information of the storage space, determine the minimum storage standard of the storage space;

[0106] S203, when the environmental information does not meet the minimum preservation standard, it is considered that the preservation conditions are abnormal;

[0107] Each of the storage spaces has independent environmental design information, and each environmental design information is used to indicate the temperature setting range of its corresponding storage space.

[0108] Storage time and biological sample preservation environment requirements are used to determine the storage conditions of biological samples in the intelligent cabinet. These requirements determine the preservation period and necessary environmental conditions for the biological samples. These requirements include temperature range requirements. The intelligent cabinet monitors the environmental information of each storage space through sensor modules and determines the minimum preservation standard for each space based on the authorized management information of the biological samples within that space and pre-set environmental design information. It can be assumed that the minimum preservation standard may differ for different biological samples stored in the same storage space; similarly, the minimum preservation standard may differ for different storage spaces. The minimum preservation standard is determined based on the characteristics of the biological samples and the environmental design information of the storage space. Once the system detects an abnormal storage condition, it immediately sends an abnormality alarm notification to the management terminal and the user terminal corresponding to the storage space. The abnormality alarm notification may include a detailed description of the abnormal situation, such as the location information of the storage space and the contents of the biological sample. The environmental design information of the storage space can be determined by engineers during the design process of the intelligent cabinet.

[0109] Therefore, by monitoring the environmental information of the storage space in real time, abnormal storage conditions can be detected promptly, preventing biological samples from being damaged or becoming invalid due to environmental problems. Anomaly alarm notifications enable managers and users to respond quickly to issues and take necessary measures to protect the safety of biological samples.

[0110] In some embodiments, the minimum preservation standard of the storage space includes a temperature storage range, and determining the minimum preservation standard of the storage space based on the authorized management information of the biological samples within the storage space and the environmental design information of the storage space includes:

[0111] Obtain the set of storage standard values ​​that meet the minimum storage criteria for the storage space, wherein the storage standard values ​​in the set of storage standard values ​​conform to the following formula:

[0112] f min (T min K1)≤T≤f max (T max K2)

[0113] f min (f min K1) = K1 × T min

[0114] f max (T max K2) = K2 × T max

[0115] Where T is the minimum storage standard value required to meet the storage space requirements, and T is the temperature value. minThe minimum environmental requirement corresponding to T in the biological sample preservation environment requirements for authorized management information of biological samples, T max The highest environmental requirement corresponding to T in the biological sample preservation environment requirements for authorized management information of biological samples is defined as T. K1 and K2 are the first range coefficient and the second range coefficient corresponding to T, and their initial values ​​are 1.

[0116] The minimum storage standard for the storage space is determined based on the set of storage standard values ​​for the temperature storage range.

[0117] Therefore, more precise minimum preservation standards are obtained for both biological samples and preservation space, which not only ensures high safety during the biological sample preservation process, but also ensures high safety during long-term preservation.

[0118] In some embodiments, the range coefficients (first range coefficient and second range coefficient) are obtained in the following ways:

[0119] Obtain the target range coefficient correspondence, which is used to indicate the first range coefficient, second range coefficient, minimum standard ratio, and maximum standard ratio under the target environment type (temperature type). The minimum standard ratio is the ratio of the minimum design range value of the environmental design information of the target environment type to the minimum environmental requirement value of the biological sample preservation environment. The maximum standard ratio is the ratio of the maximum design range value of the environmental design information of the target environment type to the maximum environmental requirement value of the biological sample preservation environment. The first range coefficient is not greater than 1, and the second range coefficient is not less than 1.

[0120] Based on the actual minimum standard ratio and the actual maximum standard ratio between the storage space and the biological samples stored therein, the first range coefficient and the second range coefficient corresponding to the target environment type are obtained using the target range coefficient correspondence relationship.

[0121] The minimum standard ratio is defined as the ratio between the minimum design range value for a specific target environment type and the minimum requirement for biological sample preservation environment. The maximum standard ratio is defined as the ratio between the maximum design range value for a specific target environment type and the maximum requirement for biological sample preservation environment. Since the target preservation space is designated by the administrator to the user, and the environmental requirements for biological samples are within the design range of the target preservation space, this embodiment allows for adjustment of the range coefficient based on the degree of difference between the environmental requirements range of the biological samples and the design range of the target preservation space. This provides customized minimum preservation standards, meaning that adjustments can be made based on actual circumstances when different biological samples are placed in the same preservation space or when the same biological sample is placed in different preservation spaces.

[0122] In some embodiments, the identification device is a fingerprint recognition device, and the identification information is fingerprint identification information. Using a fingerprint recognition device as the identification device effectively prevents unauthorized operation of the smart cabinet, improving the security of the biometric sample preservation process. Users do not need to remember or carry additional identification documents or passwords; they only need to use their fingerprints for authentication, simplifying the operation process and enhancing the user experience.

[0123] In some embodiments, the biological sample management method further includes:

[0124] The user sends a retrieval request to the management terminal, and the retrieval request includes the sample information of the biological sample that has been saved and the user's identification information on the user terminal.

[0125] After the management terminal confirms the collection request, it sends approval and authentication information to the user terminal and authorization management information to the smart cabinet.

[0126] When a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the target storage space corresponding to the connection request based on the authorization management information and displays the location information of the target storage space to the user.

[0127] The identity recognition device is used to obtain the user's identity information, and the target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open.

[0128] Therefore, through dual verification of identity recognition devices and approval authentication information, it is ensured that only authorized users can access specific biological samples, thereby enhancing the security and confidentiality of the samples. Remote communication between the user terminal and the smart locker allows users to retrieve samples from different locations, improving flexibility and convenience.

[0129] Meanwhile, the sample information includes the clinical trial project number, so the remaining quantity of each biological sample in the clinical trial project can be automatically calculated and updated based on the number of samples retrieved, thereby achieving precise management of sample quantity.

[0130] In a specific application scenario, this application embodiment also provides a biological sample management method, which is applied to a smart cabinet. The smart cabinet includes an identification device, multiple storage spaces for storing clinical trial biological samples, and an electronic lock for controlling the opening of each storage space.

[0131] The biological sample management method includes:

[0132] The user's input is obtained through the user terminal to obtain the sample information of the biological sample to be saved. The sample information includes the biological sample preservation environment requirements, as well as at least one of the following: clinical trial project number, sample name, sample type, sample quantity, and sample physical image.

[0133] The user sends a save request to the management terminal, and the save request includes the sample information of the biological sample to be saved and the user identification information of the user terminal.

[0134] After the management terminal confirms the save request, it sends approval authentication information to the user terminal and authorization management information to the smart cabinet.

[0135] When a user sends a connection request including approval and authentication information to the smart cabinet via the user terminal, and the smart cabinet confirms the connection request is legitimate, it determines the storage space corresponding to the connection request based on the authorization management information, and uses this as the target storage space, displaying the location information of the target storage space to the user. The approval and authentication information includes unlocking key information generated based on the sample information and user identification information. The authorization management information includes authorization key information corresponding to the unlocking key information, the storage time of the biological sample corresponding to the storage request, and the biological sample storage environment requirements. The smart cabinet confirms the legitimacy of the connection request by: detecting whether there is any authorization management information among the multiple authorization management information sent by the management terminal to the smart cabinet that can match the unlocking key information; if there is authorization management information that can match the unlocking key information, the connection request is considered legitimate, and the location information of the target storage space is displayed using the user terminal.

[0136] The identity recognition device is used to obtain the user's identity information, and the target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open.

[0137] The smart cabinet generates storage information based on the connection request and the corresponding authorization management information; it then sends the storage information to a sample database on the cloud server, which is used by administrators to obtain the storage status of each storage space through the management terminal.

[0138] If no authorized management information matching the unlocking key information is found, the connection request is considered invalid. The number of failures within a preset time period is incremented by one, and it is checked whether the number of failures is not less than a preset number.

[0139] When the number of failures is less than the preset number, the smart cabinet is used again to retrieve the connection request sent by the user.

[0140] When the number of failures is not less than a preset number, a connection failure message is generated based on the multiple invalid connection requests and sent to the management terminal.

[0141] When the storage conditions of any storage space become abnormal, an abnormal alarm notification is sent to the management terminal and the user terminal corresponding to the biological sample stored in the storage space.

[0142] An abnormality in the storage conditions of any storage space refers to:

[0143] The sensing module of the smart cabinet is used to obtain environmental information of the storage space;

[0144] Based on the authorized management information of the biological samples in the preservation space and the environmental design information of the preservation space, the minimum preservation standard of the preservation space is determined;

[0145] When the environmental information does not meet the minimum preservation standard, the preservation conditions are considered abnormal.

[0146] Each of the storage spaces has independent environmental design information, and each environmental design information is used to indicate the temperature setting range of its corresponding storage space.

[0147] As an example, clinical researcher A inputs sample information for the biological sample to be preserved via the user terminal, including sample type (blood), sample quantity (1), clinical trial project number (CT-2023-001), storage time (3 days), and environmental requirements (temperature set between 2°C and 8°C). Clinical researcher A sends a preservation request to the management terminal via the user terminal, including the aforementioned sample information, fingerprint information entered by clinical researcher A using the user terminal device, and clinical researcher A's ID (ID1001). Upon receiving the preservation request, the management personnel verify the information and approve the request. The management terminal generates approval authentication information based on the sample information and user identifier, sends the approval authentication information to the user terminal, and simultaneously sends authorization management information to the smart cabinet.

[0148] Clinical researcher A establishes a Bluetooth connection between their user terminal device and the smart locker, sending a connection request containing approval and authentication information to the locker. The smart locker verifies the matching of the unlocking key based on the received authorization management information. After confirming the connection request is legitimate, the smart locker displays the location information of the target storage space (storage space D01) through its client. After verifying the target storage space is correct, clinical researcher A uses a fingerprint recognition device on the smart locker to verify their identity. The locker determines the status of the target storage space based on clinical researcher A's identity information and authorization management information. If the fingerprint verification is successful (the space needs to be open), the electronic lock is opened. The smart locker generates storage information, such as storage time and temperature records, based on the connection request and authorization management information, and sends it to the sample database on the cloud server. If the environmental information of a storage space does not meet the preset storage standards (e.g., the temperature exceeds the range), the smart locker uses sensors to detect this and sends an abnormal alarm notification to the management terminal and the user terminal.

[0149] Equipment Implementation Examples

[0150] This application provides a biological sample management device, the specific implementation of which is consistent with the implementation method and the technical effects achieved in the above-described method implementation, and some contents will not be repeated.

[0151] The biological sample management device includes a memory and at least one processor. The memory stores a computer program, and the at least one processor is configured to execute the computer program to perform the following steps:

[0152] When a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the storage space corresponding to the connection request based on the authorization management information, and uses it as the target storage space, and displays the location information of the target storage space to the user.

[0153] The user's identity information is obtained using the smart cabinet's identity recognition device. The target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open.

[0154] The approval and authentication information is obtained by the user terminal sending a save request to the management terminal, and the management terminal sending the saved request back to the user terminal after confirming the save request; the authorization management information is obtained by the management terminal sending the saved request back to the user terminal after confirming the save request; the save request includes sample information of the biological sample to be saved and user identification information of the user terminal.

[0155] In some embodiments, before sending a save request to the management terminal via the user terminal, the at least one processor is further configured to perform the following steps when executing the computer program:

[0156] By acquiring user input through the user terminal, the sample information of the biological sample to be saved is obtained. The sample information includes the biological sample preservation environment requirements, as well as at least one of the following: clinical trial project number, sample name, sample type, sample quantity, and physical image of the sample.

[0157] In some embodiments, the approval and authentication information includes unlocking key information generated based on the sample information and user identification information, and the authorization management information includes authorization key information corresponding to the unlocking key information; the smart cabinet confirms the legitimacy of the connection request in the following ways:

[0158] The system detects whether any of the multiple authorization management messages sent from the management terminal to the smart cabinet can match the unlocking key information. If there is authorization management information that matches the unlocking key information, the connection request is considered legitimate, and the location information of the target storage space is displayed using the user terminal.

[0159] In some embodiments, the at least one processor is further configured to perform the following steps when executing the computer program:

[0160] If no authorized management information matching the unlocking key information is found, the connection request is considered invalid. The number of failures within a preset time period is incremented by one, and it is checked whether the number of failures is not less than a preset number.

[0161] When the number of failures is less than the preset number, the smart cabinet is used again to retrieve the connection request sent by the user.

[0162] When the number of failures is not less than a preset number, a connection failure message is generated based on the multiple invalid connection requests and sent to the management terminal.

[0163] In some embodiments, after the user saves the biological sample to a target storage space, the at least one processor is further configured to perform the following steps when executing the computer program:

[0164] The smart cabinet generates storage information based on the connection request and the corresponding authorization management information; it then sends the storage information to a sample database on the cloud server, which is used by administrators to obtain the storage status of each storage space through the management terminal.

[0165] In some embodiments, the authorization management information further includes the storage time of the biological sample corresponding to the storage request and the biological sample storage environment requirements; the at least one processor is also configured to perform the following steps when executing the computer program:

[0166] When the storage conditions of any storage space become abnormal, an abnormal alarm notification is sent to the management terminal and the user terminal corresponding to the biological sample stored in the storage space.

[0167] An abnormality in the storage conditions of any storage space refers to:

[0168] The sensing module of the smart cabinet is used to obtain environmental information of the storage space;

[0169] Based on the authorized management information of the biological samples in the preservation space and the environmental design information of the preservation space, the minimum preservation standard of the preservation space is determined;

[0170] When the environmental information does not meet the minimum preservation standard, the preservation conditions are considered abnormal.

[0171] Each of the storage spaces has independent environmental design information, and each environmental design information is used to indicate the temperature setting range of its corresponding storage space.

[0172] In some embodiments, the identity recognition device is a fingerprint recognition device, and the identity information is fingerprint identity information.

[0173] In some embodiments, the at least one processor is further configured to perform the following steps when executing the computer program: sending a retrieval request to the management terminal via a user terminal, the retrieval request including sample information of the already stored biological sample and user identification information of the user terminal;

[0174] After the management terminal confirms the collection request, it sends approval and authentication information to the user terminal and authorization management information to the smart cabinet.

[0175] When a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the target storage space corresponding to the connection request based on the authorization management information and displays the location information of the target storage space to the user.

[0176] The identity recognition device is used to obtain the user's identity information, and the target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open.

[0177] See Figure 4 , Figure 4This is a structural block diagram of a biological sample management device provided in an embodiment of this application.

[0178] The biological sample management device 10 may include, for example, at least one memory 11, at least one processor 12, and a bus 13 connecting different platform systems.

[0179] The memory 11 may include a (computer) readable medium in the form of volatile memory, such as random access memory (RAM) 111 and / or cache memory 112, and may further include read-only memory (ROM) 113.

[0180] The memory 11 also stores a computer program, which can be executed by the processor 12 to enable the processor 12 to implement the steps of any of the above methods.

[0181] The memory 11 may also include a utility 114 having at least one program module 115, including but not limited to: an operating system, one or more application programs, other program modules, and program data, each or some combination of these examples may include an implementation of a network environment.

[0182] Accordingly, processor 12 can execute the aforementioned computer program, and can also execute utility 114.

[0183] The processor 12 may employ one or more application-specific integrated circuits (ASICs), programmable logic devices (PLDs), complex programmable logic devices (CPLDs), field-programmable gate arrays (FPGAs), or other electronic components.

[0184] Bus 13 can represent one or more types of bus structures, including a memory bus or memory controller, peripheral bus, graphics acceleration port, processor, or a local bus using any bus structure with multiple bus structures.

[0185] The biosample management device 10 can also communicate with one or more external devices, such as a keyboard, pointing device, Bluetooth device, etc., and with one or more devices capable of interacting with the biosample management device 10, and / or with any device (e.g., a router, modem, etc.) that enables the biosample management device 10 to communicate with one or more other computing devices. This communication can be performed through the input / output interface 14. Furthermore, the biosample management device 10 can also communicate with one or more networks (e.g., local area networks (LANs), wide area networks (WANs), and / or public networks, such as the Internet) via the network adapter 15. The network adapter 15 can communicate with other modules of the biosample management device 10 via the bus 13. It should be understood that, although not shown in the figures, in practical applications, other hardware and / or software modules can be used in conjunction with the biosample management device 10, including but not limited to: microcode, device drivers, redundant processors, external disk drive arrays, RAID systems, tape drives, and data backup storage platforms.

[0186] System Implementation Examples

[0187] This application provides a biological sample preservation system, the biological sample preservation system comprising:

[0188] The smart cabinet includes the biosample management device, the identification device, multiple storage spaces for storing clinical trial biosamples, and an electronic lock for controlling the opening of each storage space, as described in the equipment embodiment.

[0189] User terminal equipment is used to install and run the user terminal for user use;

[0190] Management terminal equipment, used to install and run management terminals for administrators.

[0191] The specific implementation method of the biological sample management device is consistent with the implementation method and the technical effect achieved as described in the above-mentioned device implementation method, and some contents will not be repeated.

[0192] In some embodiments, both the user terminal device and the smart cabinet include a Bluetooth communication module, used to establish a Bluetooth connection between the user terminal device and the smart cabinet when the user sends a connection request to the smart cabinet through the user terminal. Additionally, the user terminal device and the management terminal device may each include a wireless module for enabling long-distance wireless connectivity between them.

[0193] On the one hand, Bluetooth connectivity provides a short-range, point-to-point secure communication method, reducing security risks during data transmission. On the other hand, the Bluetooth communication module makes it more convenient for user terminal devices to connect to the smart cabinet, allowing users to complete biological sample preservation operations without relying on Wi-Fi or wired connections.

[0194] It should be noted that in the embodiments of this application, "at least one" refers to one or more, and "more than one" refers to two or more. "And / or" describes the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A alone, A and B simultaneously, or B alone, where A and B can be singular or plural. The character " / " generally indicates that the preceding and following related objects are in an "or" relationship. "At least one of the following" or similar expressions refer to any combination of these items, including any combination of single or plural items. For example, at least one of a, b, or c can represent: a, b, c, a and b, a and c, b and c, or a and b and c, where a, b, and c can be single or multiple. It is worth noting that "at least one" can also be interpreted as "one or more".

[0195] The terms "first," "second," etc., used in the specification, claims, and accompanying drawings of this application are configured to distinguish similar objects and are not necessarily configured to describe a particular order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of this application described herein can be implemented in orders other than those illustrated or described herein. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover a non-exclusive inclusion; for example, a process, method, system, product, or apparatus that comprises a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units not explicitly listed or inherent to such processes, methods, products, or apparatus.

[0196] This application describes the invention from the perspectives of purpose, performance, progress, and novelty, and it meets the functional enhancement and use requirements emphasized by the Patent Law. The above description and drawings are merely preferred embodiments of this application and are not intended to limit this application. Therefore, all structures, devices, features, etc., that are similar to or identical to those of this application, i.e., all equivalent substitutions or modifications made in accordance with the scope of this patent application, shall fall within the scope of protection of this patent application.

Claims

1. A method for managing biological samples, characterized in that, The biological sample management method is applied to a smart cabinet, which includes an identification device, multiple storage spaces for storing clinical trial biological samples, and an electronic lock for controlling the opening of each storage space. The biological sample management method includes: The user sends a save request to the management terminal, and the save request includes the sample information of the biological sample to be saved and the user identification information of the user terminal. After the management terminal confirms the save request, it sends approval and authentication information to the user terminal and authorization management information to the smart cabinet. The approval and authentication information includes unlocking key information generated based on the sample information and user identification information, and the authorization management information includes authorization key information corresponding to the unlocking key information. When a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the storage space corresponding to the connection request based on the authorization management information, and uses it as the target storage space, then displays the location information of the target storage space to the user. The smart cabinet confirms the legitimacy of the connection request by: detecting whether there is any authorization management information among the multiple authorization management information sent by the management terminal to the smart cabinet that can match the unlocking key information; if there is authorization management information that can match the unlocking key information, the connection request is considered legitimate, and the location information of the target storage space is displayed using the user terminal. The identity recognition device is used to obtain the user's identity information, and the target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open. The authorization management information also includes the storage time of the biological sample corresponding to the storage request and the requirements for the biological sample storage environment; The biological sample management method further includes: when the storage conditions of any storage space are abnormal, sending an abnormal alarm notification to the management terminal and the user terminal corresponding to the biological sample stored in the storage space; An abnormality in the storage conditions of any storage space refers to: The sensing module of the smart cabinet is used to obtain environmental information of the storage space; Based on the authorized management information of the biological samples in the preservation space and the environmental design information of the preservation space, the minimum preservation standard of the preservation space is determined; When the environmental information does not meet the minimum preservation standard, the preservation conditions are considered abnormal. Each of the storage spaces has independent environmental design information, and each environmental design information is used to indicate the temperature setting range of its corresponding storage space; the minimum storage standard of the storage space includes the temperature storage range, and determining the minimum storage standard of the storage space based on the authorized management information of the biological samples in the storage space and the environmental design information of the storage space includes: Obtain a set of storage standard values ​​that meet the minimum storage standard for the storage space; determine the minimum storage standard for the storage space based on the set of storage standard values ​​for the temperature storage range.

2. The biological sample management method according to claim 1, characterized in that, Before sending a save request from the user terminal to the management terminal, the biological sample management method further includes: By acquiring user input through the user terminal, the sample information of the biological sample to be saved is obtained. The sample information includes the biological sample preservation environment requirements, as well as at least one of the following: clinical trial project number, sample name, sample type, sample quantity, and physical image of the sample.

3. The biological sample management method according to claim 1, characterized in that, The biological sample management method also includes: If no authorized management information matching the unlocking key information is found, the connection request is considered invalid. The number of failures within a preset time period is incremented by one, and it is checked whether the number of failures is not less than a preset number. When the number of failures is less than the preset number, the smart cabinet is used again to retrieve the connection request sent by the user. When the number of failures is not less than a preset number, a connection failure message is generated based on the multiple invalid connection requests and sent to the management terminal.

4. The biological sample management method according to claim 1, characterized in that, After the user saves the biological sample to the target storage space, the biological sample management method further includes: The smart cabinet generates storage information based on the connection request and the corresponding authorization management information; it then sends the storage information to a sample database on the cloud server, which is used by administrators to obtain the storage status of each storage space through the management terminal.

5. The biological sample management method according to claim 1, characterized in that, The biological sample management method also includes: The user sends a retrieval request to the management terminal, and the retrieval request includes the sample information of the biological sample that has been saved and the user's identification information on the user terminal. After the management terminal confirms the collection request, it sends approval and authentication information to the user terminal and authorization management information to the smart cabinet. When a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the target storage space corresponding to the connection request based on the authorization management information and displays the location information of the target storage space to the user. The identity recognition device is used to obtain the user's identity information, and the target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open.

6. A biological sample management device, characterized in that, The biological sample management device includes a memory and at least one processor. The memory stores a computer program, and the at least one processor is configured to execute the computer program to perform the following steps: When a user sends a connection request including approval and authentication information to the smart cabinet through the user terminal, and the smart cabinet confirms that the connection request is legitimate, it determines the storage space corresponding to the connection request based on the authorization management information, and uses it as the target storage space, and displays the location information of the target storage space to the user. The user's identity information is obtained using the smart cabinet's identity recognition device. The target state of the target storage space is determined based on the identity information. When the target state is open, the electronic lock of the target storage space is controlled to open. The approval and authentication information is obtained by sending a save request from the user terminal to the management terminal, and the management terminal sends the saved request back to the user terminal after confirming the saved request; the authorization management information is obtained by sending the saved request back to the user terminal after the management terminal confirms the saved request; the save request includes sample information of the biological sample to be saved and user identification information of the user terminal. The approval and certification information includes unlocking key information generated based on the sample information and user identification information; the authorization management information includes authorization key information corresponding to the unlocking key information; the smart cabinet confirms the legitimacy of the connection request in the following ways: The system detects whether any of the multiple authorization management messages sent by the management terminal to the smart cabinet can match the unlocking key information. If there is authorization management information that can match the unlocking key information, the connection request is considered legitimate, and the location information of the target storage space is displayed using the user terminal. The authorization management information also includes the storage time of the biological sample corresponding to the storage request and the biological sample storage environment requirements; the at least one processor is further configured to perform the following steps when executing the computer program: When the storage conditions of any storage space become abnormal, an abnormal alarm notification is sent to the management terminal and the user terminal corresponding to the biological sample stored in the storage space. An abnormality in the storage conditions of any storage space refers to: The sensing module of the smart cabinet is used to obtain environmental information of the storage space; Based on the authorized management information of the biological samples in the preservation space and the environmental design information of the preservation space, the minimum preservation standard of the preservation space is determined; When the environmental information does not meet the minimum preservation standard, the preservation conditions are considered abnormal. Each of the storage spaces has independent environmental design information, and each environmental design information is used to indicate the temperature setting range of its corresponding storage space; The minimum preservation standards for the preservation space include a temperature preservation range. Determining the minimum preservation standards for the preservation space based on the authorized management information of the biological samples within the preservation space and the environmental design information of the preservation space includes: Obtain a set of storage standard values ​​that meet the minimum storage standard for the storage space; determine the minimum storage standard for the storage space based on the set of storage standard values ​​for the temperature storage range.

7. A biological sample preservation system, characterized in that, The biological sample preservation system includes: The smart cabinet includes the biosample management device as described in claim 6, an identification device, multiple storage spaces for storing clinical trial biosamples, and an electronic lock for controlling the opening of each storage space; User terminal equipment is used to install and run the user terminal for user use; Management terminal equipment, used to install and run management terminals for administrators.

8. The biological sample preservation system according to claim 7, characterized in that, Both the user terminal device and the smart cabinet include a Bluetooth communication module, which is used to establish a Bluetooth connection between the user terminal device and the smart cabinet when the user sends a connection request to the smart cabinet through the user terminal.

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