一种愈创薁脂质体及其制备方法和应用
By preparing guaiac liposomes composed of glycerol, liquid oil, diol, guaiac, phospholipids, tocopheryl acetate, and kavalactone, the problems of water solubility, alcohol solubility, and stability of guaiac were solved, enabling the application of nano-sized guaiac liposomes in transparent skin care products.
CN119033623BActive Publication Date: 2026-07-17JIANGMEN POLYTECHNIC +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JIANGMEN POLYTECHNIC
- Filing Date
- 2024-08-29
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Guaiacin has poor water and alcohol solubility, and insufficient permeability and stability, which limits its application and bioavailability in skin tissues.
Method used
Guaiac liposomes, composed of glycerol, liquid oil, diol, guaiac, phospholipids, tocopheryl acetate, kavalactone, and stabilizers, were prepared into nanoliposomes with a particle size ≤30nm through high-shear homogenization and microfluidic high-pressure homogenization, thereby improving stability, permeability, and antioxidant properties.
Benefits of technology
It achieves nanoscale guaiazoline liposomes, exhibiting excellent stability, permeability, antioxidant properties, and a pleasant skin feel, making it suitable for transparent skincare products.
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Figure CN119033623B_ABST
Abstract
本发明属于脂质体制备技术领域，具体涉及一种愈创薁脂质体及其制备方法和应用。所述愈创薁脂质体，原料包括：甘油、液态油脂、二元醇、愈创薁、磷脂、生育酚乙酸酯、卡瓦内酯、稳定剂和纯化水。本发明解决了愈创薁的水溶性、醇溶性差，渗透性差，光、热稳定性差的问题，提供的愈创薁脂质体具有纳米尺寸，优异的稳定性、渗透性、抗氧化性、舒缓性和肤感，能够应用于透明体系的护肤品。
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