A strain of Lactobacillus paracasei CCFM1367 capable of converting multiple flavonoids from Pueraria lobata to enhance the anti-alcohol and liver-protective effects and its postbiotics

Abstract

The present invention discloses a strain of Lactobacillus paracasei CCFM1367 and its postbiotics that can convert multiple kudzu root flavonoids to enhance the effect of sobering up and protecting the liver, and belongs to the field of microbial technology. The Lactobacillus paracasei CCFM1367 provided by the present invention and the kudzu root extract fermentation liquid, synbiotic preparation, viable bacteria or postbiotics prepared therefrom have at least one of the following effects: (1) improving liver tissue pathology; (2) enhancing antioxidant enzyme activity in liver tissue; (3) alleviating inflammatory response; (4) improving alcohol metabolism enzyme activity and enhancing alcohol metabolism; (5) upregulating the expression of tight junction-associated protein-1 and occludin in the intestine, and repairing intestinal barrier damage. The Lactobacillus paracasei CCFM1367 provided by the present invention and the kudzu root extract fermentation liquid, synbiotic preparation, viable bacteria and postbiotics prepared therefrom can be used to prepare functional foods and / or dietary supplements with the potential for sobering up and protecting the liver, and have huge application prospects.

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