Mouth nicotine product and preparation method thereof

Abstract

The invention discloses a buccal nicotine product and a preparation method thereof, the buccal nicotine product comprises an active component and an adsorbent, the active component comprises at least one of nicotine and nicotine salt, the adsorbent comprises activated carbon, and the mass ratio of the activated carbon in the buccal nicotine product is 20-40%. According to the application, the activated carbon has strong adsorption capacity and a release control function, so that the stability of nicotine can be improved, and uniform release of nicotine is facilitated.

Description

Technical Field

[0001] The present application relates to the technical field of nicotine products, and in particular to an oral nicotine product and a preparation method thereof. Background Art

[0002] Oral nicotine products are products containing nicotine or its derivatives. They are usually placed in the mouth in the form of powder, tablets or sachets. Nicotine or its derivatives are absorbed through the oral mucosa. No smoke is produced during use. In recent years, they have gained increasing attention worldwide and are becoming increasingly popular among people seeking alternatives to traditional nicotine products.

[0003] At present, most oral nicotine products on the market use microcrystalline cellulose as a carrier. Microcrystalline cellulose is stable and relatively safe, but it also has some shortcomings: the adsorption effect of microcrystalline cellulose on nicotine products is general, and it is easy to reabsorb moisture in the air, which is not conducive to product consistency and long-term storage; the pore structure and physical properties of microcrystalline cellulose make it difficult to accurately control the nicotine release rate, resulting in large fluctuations in nicotine concentration in actual use, which may affect the user experience and the absorption effect of nicotine. The rapid release of nicotine may cause discomfort to some users, while the slow release may not meet the immediate needs of some customers.

[0004] Therefore, it is necessary to explore new carrier materials for oral nicotine products in order to improve the performance and user experience of oral nicotine products. Summary of the invention

[0005] The purpose of the present application is to provide an oral nicotine product and a preparation method thereof.

[0006] This application adopts the following technical solutions:

[0007] One aspect of the present application discloses an oral nicotine product, comprising an active ingredient and an adsorbent, wherein the active ingredient comprises at least one of nicotine and a nicotine derivative, and the adsorbent comprises activated carbon, wherein the activated carbon accounts for 20% to 40% by mass in the oral nicotine product.

[0008] In one implementation of the present application, the oral nicotine product includes a wrapping material, and the wrapping material wraps the active ingredient and the adsorbent therein.

[0009] In one implementation of the present application, the packaging material includes at least one of gelatin, polyvinyl alcohol, hydroxypropyl methylcellulose, chitosan and sodium alginate.

[0010] In one implementation of the present application, the pore size of the activated carbon is 1 to 5 μm, the particle size of the activated carbon is 2 to 10 μm; and / or the particle size of the oral nicotine product is 200 to 300 μm.

[0011] In one implementation of the present application, the pore size of the activated carbon is 5 to 40 μm, the particle size of the activated carbon is 10 to 50 μm; and / or the particle size of the oral nicotine product is 500 to 700 μm.

[0012] In one implementation of the present application, the packaging material includes at least one of hydroxypropyl methylcellulose, chitosan and sodium alginate.

[0013] In one implementation of the present application, the oral nicotine product further includes at least one of a sweetener, a flavor, a preservative, and a pH adjuster.

[0014] In one implementation of the present application, the pH adjuster includes at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and magnesium carbonate.

[0015] In one implementation of the present application, the sweetener includes at least one of xylitol, sorbitol, mannitol, iglesia, lactitol, maltitol, isomalt, hydrogenated starch hydrolysate, erythritol, maltotriitol, aspartame, acesulfame potassium, saccharin sodium, sucralose, neotame, cyclamate, alitame, steviol glycosides, arabitol and monk fruit sweetener.

[0016] In one implementation of the present application, the preservative includes at least one of benzalkonium chloride, parahydroxybenzoates, benzoic acid, sorbic acid, sorbates, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, parabens, sodium diacetate, calcium propionate, sodium lactate and calcium lactate.

[0017] In one implementation of the present application, the oral nicotine product includes, by weight: 25 to 35 parts of the adsorbent, 2 to 4 parts of the active ingredient, 15 to 25 parts of the packaging material, 1 to 3 parts of the sweetener, 0.5 to 2 parts of the flavor, 0.1 to 0.5 parts of the preservative and 0.3 to 1 part of the pH adjuster.

[0018] In one implementation of the present application, the nicotine derivative includes at least one of nicotine salt, nicotine containing a substituent, and nicotine salt containing a substituent.

[0019] Another aspect of the present application discloses a method for preparing an oral nicotine product, comprising: mixing materials including the active ingredient and the adsorbent to obtain a mixed material; preparing the coating material into a coating solution, coating and granulating the mixed material with the coating solution, and drying and sieving to obtain the oral nicotine product.

[0020] The beneficial effects of this application are:

[0021] In the oral nicotine product and preparation method of the present application, activated carbon is used as a carrier for adsorbing active ingredients (nicotine and / or nicotine derivatives), which has the following advantages:

[0022] Effective adsorption of active ingredients: Activated carbon has good porosity and a large specific surface area, and has a high adsorption capacity, which can effectively adsorb active ingredient molecules. Activated carbon can adsorb active ingredients more saturatedly, thereby reducing the adsorption of water molecules in the air, reducing the moisture of the product, and improving the stability of the product.

[0023] Controllable release of active ingredients: The active ingredient molecules adsorbed in the pores of activated carbon are gradually released through the diffusion mechanism, and the release is more uniform and predictable. That is, the pore structure of activated carbon can control the release rate of active ingredients to a certain extent. By adjusting the pore structure of activated carbon, the release rate of chemical ingredients can be controlled to design oral nicotine products that can meet the needs of people with different needs. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 1 is the release curve of the oral nicotine product of each embodiment of the present application.

[0025] Figure 2 It is the peak time of release of the oral nicotine products of various embodiments involved in this application. DETAILED DESCRIPTION

[0026] The present invention is further described in detail below by specific embodiments in conjunction with the accompanying drawings. In the following embodiments, many detailed descriptions are intended to enable the present application to be better understood. However, those skilled in the art can effortlessly recognize that some of the features can be omitted in different situations, or can be replaced by other materials and methods. In some cases, some operations related to the present application are not shown or described in the specification, in order to avoid the core part of the present application being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations according to the description in the specification and the general technical knowledge in the art.

[0027] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be interchanged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for the purpose of clearly describing a certain embodiment and are not meant to be a required sequence, unless otherwise specified that a certain sequence must be followed.

[0028] The serial numbers assigned to the components in this article, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning.

[0029] Most of the oral nicotine products on the market currently use microcrystalline cellulose as a carrier. Although this material has a certain effect in controlling nicotine release, it has problems such as strong hygroscopicity and difficulty in finely controlling the nicotine release rate. The strong hygroscopicity may cause the product to become damp and deteriorate in a high humidity environment. The damp carrier material not only affects the taste, but may also accelerate the decomposition of nicotine and other active ingredients, leading to premature release of nicotine, which is not conducive to maintaining product consistency and long-term storage. The nicotine release process is difficult to accurately control, which may lead to large fluctuations in nicotine concentration in actual use, thereby limiting the product's performance in providing a stable nicotine release experience, which may lead to inconsistent consumer experience.

[0030] In view of this, the present application creatively proposes an oral nicotine product and a preparation method thereof, using porous activated carbon as a new type of carrier. Through the high specific surface area of ​​activated carbon, it can efficiently adsorb and stably release active ingredients, provide a more stable and predictable active ingredient release curve, and achieve more precise release control. In addition, compared with microcrystalline cellulose, activated carbon has a stronger adsorption capacity and can adsorb more raw materials (nicotine and nicotine derivatives, etc.). When the activated carbon is saturated with adsorption, water can no longer enter in large quantities. The adsorption effect of microcrystalline cellulose on nicotine and nicotine derivatives is poor. Microcrystalline cellulose is unsaturated adsorption, and there are more vacancies to accommodate water molecules. It can absorb water molecules in the air, causing the product to become damp, affecting the taste and product quality.

[0031] In general, the oral nicotine product and preparation method thereof of the present application uses activated carbon as a carrier for adsorbing active ingredients (nicotine and / or nicotine salt), which has the following advantages:

[0032] (1) Effective adsorption of active ingredients: Because activated carbon has good porosity and a large specific surface area, it has a high adsorption capacity and can effectively adsorb active ingredients.

[0033] (2) Controllable release of active ingredients: The active ingredient molecules adsorbed in the pores of activated carbon are gradually released through a diffusion mechanism, and the release is more uniform and predictable. In other words, the pore structure of activated carbon can control the release rate of active ingredients to a certain extent. By adjusting the pore structure of activated carbon, the release rate of chemical ingredients can be controlled to design oral nicotine products that can meet the needs of different groups of people.

[0034] (3) Protecting active ingredients: Compared with the high water absorption and swelling of microcrystalline cellulose, the main function of activated carbon is to adsorb organic molecules and gases. When activated carbon is saturated with adsorption, its adsorption capacity for water molecules is relatively limited, and the pores of activated carbon can serve as a physical barrier to reduce the direct contact between nicotine and the external environment (such as oxygen and moisture). This physical barrier helps prevent nicotine from oxidizing and hydrolyzing, thereby enhancing the stability of the product. In addition, activated carbon can adsorb other impurities or harmful substances that may cause the decomposition of active ingredients, such as heavy metals and other organic pollutants, which also helps to improve the overall stability and safety of nicotine products.

[0035] In one embodiment, the oral nicotine product may include an active ingredient and an adsorbent.

[0036] In a specific embodiment, the active ingredient may include at least one of nicotine and a nicotine derivative.

[0037] In a specific embodiment, the nicotine derivative may include at least one of nicotine salt, nicotine containing a substituent, and nicotine salt containing a substituent. Among them, the nicotine salt may include at least one of nicotine benzoate, nicotine lactate, nicotine citrate, nicotine malate, nicotine maleate, nicotine succinate, nicotine alicyclic carboxylate, nicotine levulinate, nicotine gentisate, and nicotine tartrate. The nicotine containing a substituent may be 6-methyl nicotine. The nicotine salt containing a substituent may be a 6-methyl nicotine salt, such as 6-methyl nicotine benzoate, etc.

[0038] In a specific embodiment, the mass proportion of the active ingredient in the oral nicotine product may be 1% to 5%. For example, the mass proportion of the active ingredient in the oral nicotine product may be 1%, 2%, 3%, 3.5%, 4%, 4.5% or 5%.

[0039] In one embodiment, the adsorbent includes activated carbon.

[0040] In a specific embodiment, the pore size of the activated carbon may be 1 to 50 μm, and the particle size of the activated carbon may be 2 to 100 μm.

[0041] In a specific embodiment, in an oral nicotine product designed for relatively fast release, the pore size of the activated carbon may be 1 to 5 μm, and the particle size of the activated carbon may be 2 to 10 μm. It should be noted that relatively fast release oral nicotine products are suitable for users who seek instant gratification.

[0042] In a specific embodiment, in an oral nicotine product designed for slower release, the pore size of the activated carbon may be 5 to 40 μm, and the particle size of the activated carbon may be 10 to 50 μm. It should be noted that the oral nicotine product with slower release is suitable for users or occasions that need to experience nicotine for a long time, and is conducive to maintaining a more stable nicotine absorption level.

[0043] In a specific embodiment, the mass proportion of the adsorbent in the oral nicotine product may be 20% to 40%. For example, the mass proportion of the adsorbent in the oral nicotine product may be 20%, 25%, 30%, 35% or 40%.

[0044] In one embodiment, the oral nicotine product may include a wrapping material.

[0045] In a specific embodiment, the encapsulation material encapsulates the active ingredient and the adsorbent to form a microcapsule. It should be noted that the oral nicotine product is encapsulated in the form of microcapsules, which can help protect the active ingredient.

[0046] In a specific embodiment, the weight proportion of the wrapping material in the oral nicotine product may be 15% to 30%. For example, the weight proportion of the wrapping material in the oral nicotine product may be 15%, 20%, 25% or 30%.

[0047] In a specific embodiment, the encapsulating material includes at least one of gelatin, polyvinyl alcohol, hydroxypropyl methylcellulose (HPMC), chitosan and sodium alginate.

[0048] In one embodiment, in an oral nicotine product designed for faster release, the coating material may be gelatin and / or polyvinyl alcohol.

[0049] In a specific embodiment, in an oral nicotine product designed for slower release, the wrapping material may be at least one of hydroxypropyl methylcellulose, chitosan and sodium alginate. It should be noted that, as wrapping materials, hydroxypropyl methylcellulose, chitosan and sodium alginate can also serve as sustained-release agents and adhesives while providing protection. Specifically: through physical barriers (such as gels formed by HPMC), chemical stability (such as pH sensitivity of chitosan) or structural properties (such as the gel network of sodium alginate), these mechanisms work together to make the release of active ingredients more stable and controllable. These ingredients can also facilitate the bonding of materials and improve the formability of materials. It should be noted that in an oral nicotine product designed for faster release, the wrapping material may also include at least one of hydroxypropyl methylcellulose, chitosan and sodium alginate as an excipient to regulate the release rate.

[0050] In a specific embodiment, the oral nicotine product may include a sweetener, thereby improving the taste.

[0051] In a specific embodiment, the sweetener may include at least one of xylitol, sorbitol, mannitol, igloo, lactitol, maltitol, isomalt, hydrogenated starch hydrolysate, erythritol, maltotriitol, aspartame, acesulfame potassium, saccharin sodium, sucralose, neotame, cyclamate, alitame, steviol glycosides, arabitol and monk fruit sweetener.

[0052] In a specific embodiment, the oral nicotine product may include flavors, thereby improving the taste. Generally speaking, edible flavors can be added to the oral nicotine product as flavors.

[0053] In a specific embodiment, the flavor may include at least one of vanilla flavor, fruit flavor (such as strawberry flavor, banana flavor, pineapple flavor, grape flavor, watermelon flavor, etc.), flower flavor (such as rose flavor, jasmine flavor, etc.), herbal flavor (such as mint flavor, etc.) and chocolate flavor.

[0054] In a specific embodiment, the oral nicotine product may include a preservative. It should be noted that preservatives are additives used in the food industry to extend the shelf life of food and prevent the growth of microorganisms. They can inhibit the growth of bacteria, molds and yeasts, thereby ensuring the safety and quality of food.

[0055] In a specific embodiment, the preservative may include at least one of benzalkonium chloride, parabens, benzoic acid, sorbic acid, sorbate, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, parabens, sodium diacetate, calcium propionate, sodium lactate and calcium lactate.

[0056] In one embodiment, the oral nicotine product may include a pH adjusting agent.

[0057] In a specific embodiment, a pH adjuster is used to adjust the acidity and alkalinity of an oral nicotine product. The pH adjuster can be acidic or alkaline. In some embodiments, the pH adjuster is acidic, such as citric acid. In some embodiments, the pH adjuster is alkaline, and alkaline pH adjusters have the following advantages: alkaline pH conditions help convert nicotine from its salt form to a free base form, thereby increasing the bioavailability of nicotine. In the oral environment, nicotine is more easily absorbed by the oral mucosa into the blood circulation in the form of a free base; adjusting the pH can improve the taste of oral nicotine products and reduce irritation or discomfort. Alkaline pH can neutralize some acidic components, making the product milder; by adjusting the pH value, the stability of oral products can be improved to prevent the decomposition or deterioration of the components; an appropriate pH value can help inhibit the growth of microorganisms, thereby extending the shelf life of the product.

[0058] In a specific embodiment, the pH adjuster may include at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and magnesium carbonate.

[0059] In a specific embodiment, the encapsulating material encapsulates the active ingredient, the adsorbent, and at least one of a sweetener, a flavor, a preservative, and a pH adjuster to form a microcapsule.

[0060] In one embodiment, the oral nicotine product may be substantially in powder form.

[0061] In a specific embodiment, the particle size of the oral nicotine product may be 100-1000 μm. For example, the particle size of the oral nicotine product may be 100 μm, 200 μm, 300 μm, 400 μm, 500 μm, 600 μm, 700 μm, 800 μm, 900 μm or 1000 μm.

[0062] In a specific embodiment, the particle size of the oral nicotine product designed for faster release may be 200-300 μm. For example, the particle size of the oral nicotine product designed for faster release may be 200 μm, 250 μm or 300 μm.

[0063] In a specific embodiment, the particle size of the buccal nicotine product designed for slower release may be 500-700 μm. For example, the particle size of the buccal nicotine product designed for slower release may be 500 μm, 550 μm, 600 μm, 650 μm or 700 μm.

[0064] In a specific embodiment, the oral nicotine product may include, by weight, 25 to 35 parts of an adsorbent, 2 to 4 parts of an active ingredient, and 15 to 25 parts of a packaging material.

[0065] In a specific embodiment, the oral nicotine product may further include, by weight, 1 to 3 parts of a sweetener, 0.5 to 2 parts of a flavor, 0.1 to 0.5 parts of a preservative, and 0.3 to 1 parts of a pH adjuster.

[0066] In a specific embodiment, the preparation method of the oral nicotine product may include: mixing materials including active ingredients and adsorbents to obtain a mixed material; and coating and granulating the mixed material.

[0067] In a specific embodiment, the method for preparing an oral nicotine product may include: mixing an active ingredient, an adsorbent, a sweetener, a flavor, a preservative, a pH adjuster, and an adjuvant.

[0068] In a specific embodiment, the preparation method of the oral nicotine product may include: preparing the encapsulating material into a coating solution, and coating and granulating the mixed material with the coating solution, wherein the solvent of the coating solution may be water.

[0069] In a specific embodiment, the formula for preparing the oral nicotine product can be shown in the following table:

[0070] Element Mass parts (parts) Adsorbent 25～35 Active ingredients 2～4 Sweeteners 1～3 essence 0.5～2 preservative 0.1～0.5 pH Adjusters 0.3～1 Packing materials 15～25 Solvents 5～10

[0071] In a specific embodiment, during the coating process, the coating temperature can be 30-50°C.

[0072] In a specific embodiment, during the coating process, the spray rate may be 0.5-2 ml / min.

[0073] In a specific embodiment, in the coating process, the coating time can be 20 to 60 minutes.

[0074] In a specific embodiment, during the granulation process, the temperature may be 50-80°C.

[0075] In one embodiment, during the granulation process, the spray pressure may be 120-180 psi.

[0076] In a specific embodiment, in the granulation process, the granulation time may be 15 to 30 minutes.

[0077] In a specific embodiment, the method for preparing an oral nicotine product may include: drying and sieving after granulation.

[0078] In a specific embodiment, in the drying process, the drying temperature may be 50-80°C.

[0079] In a specific embodiment, in the drying process, the drying time may be 30 to 60 minutes.

[0080] In a specific embodiment, in the screening process, for an oral nicotine product designed for faster release, the mesh size may be 60. It should be noted that a finer mesh size can facilitate rapid dissolution and ensure rapid release of the active ingredient.

[0081] In a specific embodiment, in the screening process, for an oral nicotine product designed for slower release, the mesh size of the screen may be 30. It should be noted that a coarser screen can be beneficial for prolonging the release of the active ingredient.

[0082] The present application is further described in detail below by specific experimental process and experimental data examples. The following examples only further illustrate the present application and should not be construed as limiting the present application. In the present embodiment, unless otherwise specified, the reagents and instruments used are all commercially available, and the experimental operation is carried out in accordance with the product specification and conventional experimental specifications.

[0083] Embodiment 1:

[0084] Example 1 is a mint-flavored rapid-release nicotine oral product, which uses fine-pored activated carbon as an adsorbent. The particle size of the activated carbon is in the range of 2 to 10 μm, and the pore size is in the range of 1 to 5 μm.

[0085] The specific formula is shown in the table below:

[0086]

[0087] Follow the following process steps:

[0088]

[0089] Embodiment 2:

[0090] Example 2 is a watermelon-flavored rapid-release nicotine oral product, which uses fine-pored activated carbon as an adsorbent. The particle size of the activated carbon ranges from 2 to 10 μm, and the pore size ranges from 1 to 5 μm.

[0091] The specific formula is shown in the table below:

[0092]

[0093] The process steps are the same as those in Example 1.

[0094] Embodiment 3:

[0095] Example 3 is a mint-flavored slow-release nicotine oral product, which uses coarse-pore activated carbon as an adsorbent. The particle size of the activated carbon ranges from 10 to 50 μm, and the pore size ranges from 5 to 40 μm.

[0096] The specific formula is shown in the table below:

[0097]

[0098] The process steps are the same as those in Example 1 except that the mesh size of the sieve is 30 mesh.

[0099] Embodiment 4:

[0100] Example 4 is a pineapple-flavored slow-release nicotine oral product, which uses coarse-pore activated carbon as an adsorbent. The particle size of the activated carbon ranges from 10 to 50 μm, and the pore size ranges from 5 to 40 μm.

[0101] The specific formula is shown in the table below:

[0102]

[0103] The process steps are the same as those in Example 1 except that the mesh size of the sieve is 30 mesh.

[0104] Dissolution curve experiment:

[0105] The dissolution curve experiments were conducted on the oral nicotine products prepared in Examples 1 to 4. The specific experimental methods are as follows:

[0106] Equipment: Dissolution apparatus - paddle method.

[0107] Samples: 1 g of each of the four oral nicotine products of Example 1, Example 2, Example 3 and Example 4.

[0108] Dissolution medium: artificial saliva (preparation method: 1 liter of 0.8 g / L potassium chloride aqueous solution, add 1 mL of 50 mM sodium bicarbonate solution), pH 6.8.

[0109] Sampling points: 0.5min, 1min, 2min, 5min, 10min, 15min, 20min, 30min, 40min, 60min.

[0110] Test conditions: heating temperature 37°C, speed 100r / min.

[0111] Analysis method: High performance liquid chromatography was used to detect nicotine content. The specific parameters are as follows:

[0112]

[0113] Test results:

[0114]

[0115]

[0116] The above results were used to make a nicotine release curve, and the release dynamic function was fitted: y = 100a (1-e-bt ), Figure 1 is the release curve of the oral nicotine product of each embodiment of the present application, wherein the release curve of embodiment 1 has a=0.30, b=0.26, the release curve of embodiment 2 has a=0.29, b=0.23, the release curve of embodiment 3 has a=0.16, b=0.14, and the release curve of embodiment 4 has a=0.16, b=0.11. Figure 1 It can be seen that Examples 1 and 2 show a rapidly rising dissolution curve, approaching the maximum release of nicotine within 8 minutes, which meets the design goal of rapid release. This shows that the rapid release of active ingredients can quickly reach the peak of oral absorption, which is suitable for consumers who need immediate effects. The dissolution curves of Examples 3 and 4 are relatively gentle, gradually approaching the maximum release within 14 minutes, reflecting the characteristics of the slow-release formula. This release characteristic is suitable for nicotine release that requires a longer duration, helping users maintain a more stable nicotine absorption level.

[0117] The time when nicotine is released by 80% is taken as the peak time. Figure 2 is the peak time of release of the oral nicotine products of each embodiment of the present application. Figure 2 It can be seen that the peak time of Example 1 and Example 2 is relatively short, about 4 to 6 minutes, which meets the design requirements of rapid release. The peak time of Example 3 and Example 4 is relatively long, close to 14 minutes, which is consistent with the design goal of slow release.

[0118] These data clearly show that the fast and slow release systems achieve the expected release dynamics. The above experimental data show that the formula has a good release effect and meets the requirements of different gradient designs.

[0119] In summary, in the present application, by adjusting the parameters of activated carbon powder, the release rate of nicotine can be effectively controlled to meet the needs of different consumers.

[0120] The above contents are further detailed descriptions of the present application in combination with specific implementation methods, and it cannot be determined that the specific implementation of the present application is limited to these descriptions. For ordinary technicians in the technical field to which the present application belongs, several simple deductions or substitutions can be made without departing from the concept of the present application.

Claims

1. An oral nicotine product, characterized in that: The oral nicotine product comprises an active ingredient and an adsorbent, wherein the active ingredient comprises at least one of nicotine and a nicotine derivative, and the adsorbent comprises activated carbon, wherein the activated carbon accounts for 20% to 40% by weight of the oral nicotine product.

2. The oral nicotine product according to claim 1, wherein: The oral nicotine product comprises a wrapping material, wherein the wrapping material wraps the active ingredient and the adsorbent.

3. The oral nicotine product according to claim 2, wherein: The packaging material includes at least one of gelatin, polyvinyl alcohol, hydroxypropyl methylcellulose, chitosan and sodium alginate.

4. The oral nicotine product according to claim 1, wherein: The pore size of the activated carbon is 1 to 5 μm, the particle size of the activated carbon is 2 to 10 μm; and / or the particle size of the oral nicotine product is 200 to 300 μm.

5. The oral nicotine product according to claim 1, wherein: The pore size of the activated carbon is 5 to 40 μm, the particle size of the activated carbon is 10 to 50 μm; and / or the particle size of the oral nicotine product is 500 to 700 μm.

6. The oral nicotine product according to claim 2, wherein: The oral nicotine product further comprises at least one of a sweetener, a flavor, a preservative, and a pH adjuster.

7. The oral nicotine product according to claim 6, wherein: The pH regulator comprises at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and magnesium carbonate; and / or, The sweetener comprises at least one of xylitol, sorbitol, mannitol, igletol, lactitol, maltitol, isomalt, hydrogenated starch hydrolysate, erythritol, maltotriitol, aspartame, acesulfame potassium, saccharin sodium, sucralose, neotame, sodium cyclamate, alitame, steviol glycosides, arabitol and monk fruit sweetener; and / or, The preservative includes at least one of benzalkonium chloride, p-hydroxybenzoic acid esters, benzoic acid, sorbic acid, sorbate, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, parabens, sodium diacetate, calcium propionate, sodium lactate and calcium lactate.

8. The oral nicotine product according to claim 6, wherein: The oral nicotine product includes, by weight, 25 to 35 parts of the adsorbent, 2 to 4 parts of the active ingredient, 15 to 25 parts of the packaging material, 1 to 3 parts of the sweetener, 0.5 to 2 parts of the flavor, 0.1 to 0.5 parts of the preservative and 0.3 to 1 part of the pH adjuster.

9. The oral nicotine product according to any one of claims 1 to 8, characterized in that The nicotine derivative includes at least one of nicotine salt, nicotine containing a substituent, and nicotine salt containing a substituent.

10. A method for preparing an oral nicotine product according to any one of claims 1 to 9, characterized in that: include: Mixing materials including the active ingredient and the adsorbent to obtain a mixed material; The coating material is prepared into a coating solution, the coating solution is used to coat and granulate the mixed material, and the mixed material is dried and sieved to obtain the oral nicotine product.

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