Anti-CD28 nano antibody, method for screening CD28 nano antibody based on natural library and application of CD28 nano antibody

CN119101160AActive Publication Date: 2024-12-10BIOINTRON (JIANGSU) BIOLOGICAL INC
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Patent Information

Application Number
CN202411496798.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-25
Publication Date
2024-12-10
Estimated Expiration
2044-10-25

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Abstract

The invention relates to an anti-CD28 nano antibody, a method for screening the CD28 nano antibody based on a natural library and application of the CD28 nano antibody, and belongs to the technical field of biology. The anti-CD28 nano antibody disclosed by the invention is composed of a heavy chain, and the heavy chain comprises three complementary determining regions, namely CDR1, CDR2 and CDR3; the amino acid sequence of the CDR1 is as shown in SEQ ID NO: 3; the amino acid sequence of the CDR2 is as shown in SEQ ID NO: 4; the amino acid sequence of the CDR3 is as shown in SEQ ID NO: 5. The nano antibody targeting CD28 is obtained through an alpaca nano antibody natural library and a phage display technology, can specifically recognize CD28, and has application prospects in preparation of tumor treatment drugs and tumor detection.
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Citation Information

Patent Citations

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  • Anti-human CD28 engineering antibody and application

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  • Anti-CD28 nano antibody as well as preparation method and application thereof

    CN117534761A

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