Dendritic polymer microcapsule drug carrier as well as preparation method and application thereof
CN119113126APending Publication Date: 2024-12-13THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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Patent Information
- Application Number
- CN202411269707.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-11
- Publication Date
- 2024-12-13
AI Technical Summary
Technical Problem
Existing gene therapy drug carriers are difficult to achieve stable load and targeted delivery in tumor treatment, which affects the therapeutic effect.
Method used
Hyperbranched polyamide-amine (PAMAM) was modified by room temperature amidation method and heat-initiated mercaptogram method, and combined with ion interaction enrichment method, dendrimer microcapsules with amphiphilicity and sialic acid targeting were prepared. Drug carriers to achieve stable loading and targeted delivery of anti-tumor drugs.
Benefits of technology
It improves the therapeutic effect of anti-tumor drugs, achieves the stability and targeted delivery of drugs, and can load both hydrophobic and hydrophilic drugs at the same time, improving the biocompatibility and therapeutic effect of drugs.
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Figure CN119113126A_ABST
Abstract
The invention discloses a preparation method of a dendritic polymer microcapsule drug carrier. The preparation method comprises the following steps: (1) preparing maleated PAMAM through a normal-temperature amidation method; adding dodecanethiol through a thermal initiation-mercapto-ene click method, carrying out phenylboronic acid modification, and synthesizing a PAMAM microcapsule drug carrier, namely PAMBC; and (2) synthesizing the PAMAM microcapsule drug carrier loaded with the antitumor drug through an ion interaction enrichment method. The invention also discloses the dendritic polymer microcapsule drug carrier obtained by the preparation method and application of the dendritic polymer microcapsule drug carrier in preparation of antitumor drugs. The carrier provided by the invention has amphipathicity and sialic acid targeting property, can realize stable loading of the anti-tumor drug, and can improve the treatment effect of the anti-tumor drug.
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