Pyridinium onium salt derivative and application thereof in myocardial disease diagnosis

CN119119001APending Publication Date: 2024-12-13BEIJING NORMAL UNIVERSITY
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Patent Information

Application Number
CN202411255955.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-09
Publication Date
2024-12-13

AI Technical Summary

Technical Problem

The existing diagnostic methods for myocardial amyloidosis are insufficient in sensitivity and specificity, especially when using PET probes, liver uptake affects myocardial signal, and the SPECT imaging resolution is low, which cannot be absolutely quantified, making it difficult to meet clinical needs.

Method used

Develop a cationic molecular probe with high affinity and selectivity, using radioisotope labeling for nuclear medicine imaging by binding to pathological protein aggregates in myocardial mitochondria or amyloid disease, such as AL and ATTR, for use in nuclear medicine imaging, especially Suitable for myocardial perfusion imaging and diagnosis of myocardial amyloidosis.

Benefits of technology

It provides good water solubility and high affinity, can directly detect pathological protein amyloid deposition in biological tissues, significantly improves the sensitivity and specificity of diagnosis, and is suitable for the early detection and evaluation of myocardial amyloidosis, significantly improves Resolution and quantitativeness of myocardial perfusion imaging.

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Abstract

The invention relates to the field of medicinal chemistry and radiopharmaceuticals, in particular to pyridinium onium salt derivatives and application thereof in myocardial disease diagnosis, the pyridinium onium salt derivatives have a structure of a general formula (I), and Ar comprises # imgabs0 and optional counter ions. After the compound and the derivative thereof are labeled by radionuclide, pathological protein aggregate in myocardial amyloid lesion can be developed. Besides, the compound shown in the formula I and the derivative thereof can be used for directly realizing labeling detection of mitochondria in myocardial cells by virtue of the charged property of the compound and the derivative thereof, and are used for displaying functions of the myocardial cells. In addition, the molecules have fluorescence and can be directly used for in-vitro detection of cell mitochondria and myocardial amyloid samples. # imgabs1 #
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