Composite hydrogel with biological activity, scaffold and application of composite hydrogel

By adding PEGDA, collagen and hyaluronic acid to the hydrogel, and cell growth factors loaded on liposomes, combined with bio3D printing technology, the problem of poor printability and mechanical properties of traditional hydrogel bioinks is solved. , a composite hydrogel scaffold with biological activity and viscosity is achieved, supporting cell proliferation and differentiation, and is suitable for a variety of biological research.

CN119119709AInactive Publication Date: 2024-12-13BEOGENE BIOTECH GUANGZHOU
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Patent Information

Application Number
CN202411253413.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-09
Publication Date
2024-12-13
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Traditional hydrogel bioinks have problems such as poor printability, poor mechanical properties, and microenvironment that is not conducive to cell growth, making it difficult to effectively support cell proliferation and differentiation.

Method used

Polyethylene glycol diacrylate (PEGDA), collagen and hyaluronic acid (HA) and liposome-loaded cell growth factors are used as components of the composite hydrogel, supporting the hardness and biological activity of the material Cells proliferate, migrate and differentiate, and scaffolds are prepared by bio3D printing technology.

Benefits of technology

A composite hydrogel with biological activity and viscosity is achieved, which supports cell proliferation and differentiation, can match the microenvironment hardness of each tissue and organ, promote cell growth and differentiation, and is suitable for cell and tissue microenvironment research and drug screening models.

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Abstract

The invention relates to a composite hydrogel with biological activity, a scaffold and application thereof. The composite hydrogel is prepared from the following components: 5 to 25 weight percent of polyethylene glycol diacrylate, 2 to 20 weight percent of collagen, 1 to 6 weight percent of hyaluronic acid and cell growth factors. The composite hydrogel has biological activity and viscosity, and supports cell activities such as cell proliferation, migration and differentiation; the hardness in a material system can be adjusted to be matched with the actual hardness of the microenvironment of each tissue organ, so that the functions of further promoting cell growth and differentiation are achieved. The composite hydrogel with biological activity and the scaffold prepared from the composite hydrogel can be applied to various basic researches including interaction between cells and tissue microenvironments, intracellular molecular biological signals, organ reactions, drug screening models and the like.
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Citation Information

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