Terahertz metasurface resonance chip and rapid PCR detection system and method

Through terahertz metasurface resonance chip and terahertz wave technology, the use of optical resonance cavity and terahertz probes to quickly melt RNA base fragments at low temperatures, solving the low accuracy and detection caused by high-temperature denaturation in PCR detection technology. The high cost problem achieves fast and accurate PCR detection.

CN119125061APending Publication Date: 2024-12-13UNIV OF SHANGHAI FOR SCI & TECH
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Patent Information

Application Number
CN202411333281.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-24
Publication Date
2024-12-13

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Abstract

The invention provides a terahertz metasurface resonance chip and a rapid PCR detection system and method.The terahertz metasurface resonance chip comprises a substrate and a metasurface unit array structure arranged on the substrate, and the metasurface unit array structure comprises a plurality of metal multi-opening ring units; every two metal multi-opening ring units form a group, and the metal multi-opening ring units are arranged on the surface of the substrate in an aligned mode in the transverse direction and the longitudinal direction, and an optical resonant cavity is formed between every two metal multi-opening ring units. The invention has the following beneficial effects: the terahertz technology is combined with the metasurface, and rapid melting of RNA base fragments is realized through terahertz waves transmitted by the terahertz wave transmitting module; the terahertz metasurface resonance chip and the terahertz probe in the terahertz detection module are used for observing light and the resonance effect of the metasurface to detect the melting process, and rapid PCR detection is achieved, so that rapid PCR detection is achieved, and the system and the method are applied to detection and diagnosis of various molecules.
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