A non-canonical ferroptosis inhibitor and preparation method and use thereof
CN119219619BActive Publication Date: 2026-08-28SICHUAN UNIV
Patent Information
- Application Number
- CN202411353338.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-26
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2044-09-26
AI Technical Summary
Technical Problem
此外，铁是生物体中必需的微量元素，也是许多生物酶的活性中心，铁螯合剂的使用会不可避免地导致贫血和许多代谢性疾病的副作用
Benefits of technology
[0084]实验结果表明，本发明制备的化合物对Ferroptosis具有良好的抑制作用，且抑制Ferroptosis不通过还原机制和螯合机制，可用于制备非螯合、非还原的非经典铁死亡抑制剂。因此，本发明的化合物可以用于制备预防和/或治疗与铁死亡相关的神经退行性疾病、组织缺血再灌注损伤、脑卒中、心血管、肾衰竭、炎症、心脏毒性、急性器官损伤、慢性萎缩性胃炎或糖尿病并发症等疾病的药物，具有广阔的市场前景。实验结果也进一步验证了本发明化合物可以用于治疗慢性萎缩性胃炎，可以缓解对乙酰氨基酚诱导的急性肝损伤。
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Abstract
The application provides a non-classical ferroptosis inhibitor and a preparation method and application thereof, and belongs to the technical field of chemical synthetic drugs. The application synthesizes a compound with good inhibitory effect on ferroptosis, and the compound can be used for preparing a ferroptosis inhibitor, and the structure of the compound is shown as formula I. The compound can be used for preparing a drug for preventing and / or treating diseases related to ferroptosis, such as neurodegenerative diseases, tissue ischemia-reperfusion injury, stroke, cardiovascular, renal failure, inflammation, cardiotoxicity, acute organ injury, chronic atrophic gastritis or diabetes complications, and has a wide market prospect.
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Citation Information
Patent Citations
Fungicidal oxadiazoles
WO2018118781A1