一种抗氧化降解聚碳酸酯聚氨酯及其制备方法与应用

Antioxidant-degradable polycarbonate polyurethane was prepared by a two-step bulk synthesis method, which improved the compatibility of hard and soft segments and formed an antioxidant protective layer. This method solves the problems of insufficient antioxidant degradation and mechanical properties of existing polycarbonate-based polyurethane materials and is suitable for long-term implantation in biomaterials.

CN119219883BActive Publication Date: 2026-07-17SICHUAN UNIV

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN UNIV
Filing Date
2024-09-13
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing polycarbonate-based polyurethane materials suffer from poor compatibility between hard and soft segments, resulting in poor resistance to oxidative degradation and mechanical properties, which limits their application in long-term implant materials.

Method used

Antioxidant degradable polycarbonate polyurethane was prepared by a two-step bulk synthesis method. Modified polycarbonate diol and hydroxyl-terminated polydimethylsiloxane were used as soft segments, and diisocyanate and chain extender were used as hard segments. By controlling the reaction conditions and adding chain extender, the interaction between hard and soft segments was enhanced to form an antioxidant protective layer.

Benefits of technology

It improves the antioxidant degradation resistance and mechanical properties of polyurethane materials, enhances biocompatibility, makes them suitable for long-term implantation in biomaterials, and reduces solvent recovery and treatment costs.

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Abstract

本发明公开了一种抗氧化降解聚碳酸酯聚氨酯及其制备方法与应用,属于医用聚合物材料技术领域。本发明采用两步本体合成法制备抗氧化降解聚碳酸酯聚氨酯,首先将聚碳酸酯二元醇和二异氰酸酯在催化剂作用下反应生成改性聚碳酸酯二元醇,然后将改性聚碳酸酯二元醇、羟基封端的聚二甲基硅氧烷和二异氰酸酯在催化剂作用下进行预聚反应,反应结束后,向反应液中加入扩链剂,固化后即得。本发明中所制备的抗氧化降解聚碳酸酯聚氨酯是以改性聚碳酸酯二元醇和羟基封端的聚二甲基硅氧烷作为软链段,以二异氰酸酯和扩链剂作为硬链段组成的嵌段聚合物,其具有优异的力学性能、抗氧化降解性能及生物相容性,可应用于制备长期医用植入材料。
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