Pharmaceutical composition for preventing, inhibiting or treating symptoms associated with pseudoanaphylaxis

Abstract

The present invention relates to a pharmaceutical composition for preventing, inhibiting or treating symptoms associated with pseudoanaphylaxis, containing, as an active ingredient, a compound having a P2X4 receptor antagonistic activity or a pharmaceutically acceptable salt thereof.

Description

Technical Field

[0001] The present invention relates to a pharmaceutical composition containing a compound having a P2X4 receptor antagonistic effect or a pharmaceutically acceptable salt thereof as an active ingredient for preventing, inhibiting or treating symptoms associated with pseudoallergic reaction. Background Art

[0002] Allergic diseases are a growing modern disease. Generally, the onset of immediate allergies requires the production of IgE antibodies against allergens such as pollen and food, which then bind to IgE receptors on mast cells. Subsequently, the allergen binds to the IgE antibodies, stimulating the IgE receptors. This activates mast cells and causes the release of intracellular granules such as histamine (degranulation), which in turn triggers allergic symptoms. These two steps are the process by which immediate allergies are induced.

[0003] On the other hand, certain cationic drugs, such as antibiotics and anesthetics, directly bind to mast cell receptors, activating mast cells and causing symptoms similar to those of immediate allergies in which IgE is involved. This phenomenon is known as pseudoallergy without IgE involvement and has become a serious medical problem as a side effect of drugs (Non-Patent Document 1).

[0004] It is suggested that pseudoallergy is mediated by the Mas-related G protein-coupled receptor (Mrgpr) X2, which activates MCs by recognizing a wide range of therapeutic drugs with cationic groups (Non-Patent Document 2). For example, MrgprX2 has been shown to be a receptor that mediates pseudoallergic reactions to peptide drugs (Icatibant, Cetrorelixm, Leuprolide, Octreotide, Sermorelin, Mastoparan, Atracurium, Ciprofloxcin, etc.) and non-peptide drugs (Atracurium, Tubocurarine, Rocuronium, Succinylcholine, Ciprofloxacin) (Patent Document 1, Non-Patent Document 3, etc.). Although mast cell responsiveness to signals mediated by MrgprX2 requires higher concentrations of stimuli than IgE antibody-dependent stimulation, it is possible that it is upregulated under specific conditions, but its mechanism is still unclear.

[0005] Disclosed is a diazepine having P2X4 receptor antagonist effect Diketone derivative compounds (Patent Document 2, Patent Document 3). In recent years, an aromatic sulfonamide derivative compound has been reported as a P2X4 receptor antagonist (Patent Document 4, Patent Document 5). Diazepines with P2X4 receptor antagonist activity Diketone derivative compounds inhibit degranulation from mast cells stimulated by IgE antibodies or prostaglandin E2, thereby suppressing cutaneous or systemic allergic reactions (Patent Document 6). However, no disclosure is made regarding the effect of any compound on drug-induced pseudoallergy.

[0006] Pseudoallergic reactions, a side effect of medications, not only hinder various treatments but can also lead to life-threatening conditions such as anaphylactic shock. Drugs for treating pseudoallergic reactions, such as MrgprB2 antagonists and lipid ceramides, which are ligands for the immune receptor CD300f, are attracting significant attention, with hopes for elucidating the pathology and achieving fundamental treatment.

[0007] Prior art literature

[0008] Patent Literature

[0009] Patent Document 1: International Publication No. 2016 / 019246

[0010] Patent Document 2: International Publication No. 2010 / 093061

[0011] Patent Document 3: International Publication No. 2013 / 105608

[0012] Patent Document 4: International Publication No. 2016 / 198374

[0013] Patent Document 5: International Publication No. 2017 / 191000

[0014] Patent Document 6: International Publication No. 2022 / 030428

[0015] Non-patent literature

[0016] Non-patent literature 1: Turner PJ et al., J. Allergy Clin. Immunoly: In Practice. 2017, 5, 1169

[0017] Non-patent literature 2: Bruhns P et al., J. Allergy Clin. Immunol. 2021, 147, 1133

[0018] Non-patent document 3: McNeil BD et al., Nature 2015, 519, 237 Summary of the Invention

[0019] An object of the present invention is to provide a pharmaceutical composition useful for preventing, suppressing or treating symptoms associated with pseudoallergic reactions, and in particular, to provide a pharmaceutical composition useful for preventing, suppressing or treating symptoms associated with pseudoallergic reactions caused by drugs.

[0020] Therefore, the present inventors conducted intensive studies to solve the above-mentioned problems and found that P2X4 receptor antagonists, for example, compounds represented by general formulas (A) to (D) or pharmaceutically acceptable salts thereof, are useful for preventing, suppressing or treating symptoms associated with pseudoallergic reactions, and in particular, for preventing, suppressing or treating symptoms associated with pseudoallergic reactions caused by drugs, thereby completing the present invention.

[0021] That is, the present invention relates to the following:

[0022] [1] A pharmaceutical composition for preventing, suppressing or treating symptoms associated with pseudoallergic reactions, comprising a compound having a P2X4 receptor antagonistic activity or a pharmaceutically acceptable salt thereof as an active ingredient.

[0023] [2] The pharmaceutical composition according to [1], wherein the symptoms associated with the pseudoallergic reaction are one or more selected from skin and mucous membrane symptoms (including rash, punctate erythema, urticaria, angioedema, eyelid edema, conjunctival edema, and pruritus), gastrointestinal symptoms (including throat and larynx edema, vomiting, abdominal pain, and diarrhea), respiratory symptoms (including wheezing and dyspnea), cardiovascular system symptoms (including arrhythmia, pallor, hypothermia, and hypotension), and central nervous system symptoms (including headache and loss of consciousness).

[0024] [3] The pharmaceutical composition according to [1] or [2], wherein the pseudoallergic reaction is caused by an allergen having a cationic group.

[0025] [4] The pharmaceutical composition according to [3], wherein the allergen is amorolfine hydrochloride, atracurium, β-defensin, bleomycin, cetrorelix, C48 / 80 (monomer or cyclized monomer), ciprofloxacin, cisatracurium, codeine, colistimethate, complanadine A, cortistatin-14, degarelix, enfuvirtide, exenatide, fluoroquinolone, ganirelix, gentamicin sulfate, Sulfate, Glatirame Racetate, Glucagon, Goserelin, Histrelin, Icatibant, Ketoconazole, Lanreotide, Leuprolide, Levofloxacin, Liraglutide, LL-37, Mafenide acetate, Mastoparan, Micronomicin sulfate Sulfate, mivacurium, morphine (Morfine), moxifloxacin, octreotide, ofloxacin, PAMP-12, PAMP-20, pasireotide, PMX-53, pramlintide, rocuronium, sermorelin, sisomicin sulfate, substance P, succinylcholine, sulfadoxine, sulfamethoxazole Sulfamethoxazole, Terbinafine Hydrochloride, Teriparatide, Tesamorelin, Triptorelin, Tubocurarine, or Vancomycin.

[0026] [5] The pharmaceutical composition according to any one of [1] to [4], wherein the compound is a compound represented by the following general formula (A):

[0027]

[0028] (Where R 1A represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, or an alkyl group having 1 to 3 carbon atoms substituted with a phenyl group,

[0029] R 2A and R 3A which may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkylsulfonylamino group having 1 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), a carbamoyl group, an alkylthio group having 1 to 8 carbon atoms, an alkylsulfinyl group having 1 to 8 carbon atoms, an alkylsulfonyl group having 1 to 8 carbon atoms, or a sulfamoyl group.

[0030] R 4A and R 5A may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, or an alkyl group having 1 to 3 carbon atoms substituted with a phenyl group,

[0031] Moreover, W A represents a five- or six-membered heterocyclic ring containing 1 to 4 nitrogen atoms as ring constituents which may have a substituent.

[0032] [6] The pharmaceutical composition according to any one of [1] to [4], wherein the compound is a compound represented by the following general formula (BI):

[0033]

[0034] (Where R 1B and R 2B which may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), a phenyl group which may have a substituent, a pyridyl group which may have a substituent, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), or

[0035] R 1B and R 2B Together with the benzene ring to which they are bonded, they can form a condensed ring selected from a naphthalene ring, a quinoline ring, an isoquinoline ring, a tetrahydronaphthalene ring, an indane ring, a tetrahydroquinoline ring or a tetrahydroisoquinoline ring, and R 1B and R 2B Together and R 1B and R 2B The ring composed of the independently bonded carbon atoms may be substituted by 1 to 4 substituents, which may be the same or different, selected from an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms).

[0036] R 3B and R 4BThe groups may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[0037] R 5B represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxyl group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[0038] R 6B and R 7B may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group or an amino group,

[0039] X B represents C, CH or N,

[0040] Y B represents N, NH or C(=O),

[0041] Among them, X B When N, Y B Not N, NH,

[0042] In addition, X B When it is C or CH, Y B Not C(=O),

[0043] A double line consisting of a solid line and a dashed line represents a single bond or a double bond.

[0044] Z B represents an oxygen atom or a sulfur atom,

[0045] A Brepresents a benzene ring, a pyridine ring, a thiophene ring, a pyrimidine ring, a naphthalene ring, a quinoline ring, or an indole ring which may have 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), a phenyl group, or a pyridyl group which may have the same or different substituents as substituents, or represents a bonding site,

[0046] B B N(R 8B )C(=O)、NHCONH、CON(R 9B )、NHC(=S)NH、N(R 10B )SO2、SO2N(R 11B ) or OSO2,

[0047] Here, R 8B 、R 9B 、R 10B and R 11B represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxy group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[0048] D B represents an alkylene chain having 1 to 6 carbon atoms, which may have 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms or an aralkyl group having 1 to 8 carbon atoms (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), which may be the same or different, as substituents, and further represents an alkylene chain having 1 to 6 carbon atoms, which may have a double bond, or a bonding site,

[0049] E B Indicates O, S, NR 12B , or bonding sites,

[0050] Here, R 12B represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxyl group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[0051] G B represents a group which may have 1 to 4 groups selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acyl group having 2 to 8 carbon atoms, a methylenedioxy group, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), a phenyl group which may have a substituent, a pyridyl group which may have a substituent, an imidazolyl group which may have a substituent, and an oxazolyl, or the same or different substituents in the thiazolyl group which may have a substituent as a substituent, piperazine, piperidine, morpholine, cyclohexane, benzene, naphthalene, quinoline, quinoxaline, benzimidazole, thiophene, imidazole, thiazole, azole, indole, benzofuran, pyrrole, pyridine or pyrimidine,

[0052] Moreover, m B Indicates an integer from 0 to 5.

[0053] Among them, R 1B and R 2B In the case of not forming a ring together, X is not included B C, Y B N, the double line consisting of solid and dotted lines is a double bond, Z B is an oxygen atom, A B is a benzene ring, m B 0, B B C(=O)NH, E B is the bonding site and G B is phenyl).

[0054] [7] The pharmaceutical composition according to any one of [1] to [4], wherein the compound or a pharmaceutically acceptable salt thereof is a compound or a pharmaceutically acceptable salt thereof selected from the following (A1) to (A21) and (B1) to (B214):

[0055] (A1) 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0056] (A2) 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[0057] (A3) 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone potassium salt;

[0058] (A4) 5-[4-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0059] (A5) 5-[4-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[0060] (A6) 1-Methyl-5-[3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0061] (A7) 1,3-Dimethyl-5-[3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0062] (A8) 5-[2-chloro-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0063] (A9) 5-[2-chloro-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[0064] (A10) 5-[2-methyl-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0065] (A11) 5-[2-methyl-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[0066] (A12) 5-[2-Bromo-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0067] (A13) 5-[3-(2-methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0068] (A14) 5-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0069] (A15)5-[3-(5-oxo-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0070] (A16)5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0071] (A17)5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[0072] (A18)5-[3-( oxazol-2-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; and

[0073] (A19) 5-[3-(1H-pyrazol-4-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0074] (A20) 5-[4-fluoro-3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; and

[0075] (A21) 5-[4-Fluoro-3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; and

[0076] (B1) 5-(4-Benzoylaminophenyl)-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0077] (B2) 5-[4-[2-(trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0078] (B3) 5-[4-(3-bromobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0079] (B4) 5-[4-[4-(trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0080] (B5) 5-[4-(2-methylbenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0081] (B6) 5-[4-(2,6-dimethylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0082] (B7) 5-[4-(2,6-dichlorobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0083] (B8) 5-[4-(3-chlorobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0084] (B9) 5[4-(2-phenylacetylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0085] (B10) 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-phenylthiourea;

[0086] (B11) 5-[4-(2,3-dimethoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0087] (B12) 5-[4-(2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0088] (B13) 5-[4-[(2-chlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0089] (B14) 5-[4-(2,3-dimethylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0090] (B15) 5-[4-(2,5-dimethylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0091] (B16) 5-[4-(5-bromo-2-chlorobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0092] (B17) 5-[4-(2,4-dichlorobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0093] (B18) 5-[4-(2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0094] (B19) 5-[4-(2,3-dihydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0095] (B20) 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-phenylurea;

[0096] (B21) 5-[4-[(2,6-dichlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0097] (B22) 5-[4-[(2-methoxyphenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0098] (B23) 5-[4-[(2-hydroxyphenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0099] (B24) 1-(2-chlorophenyl)-3-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]thiourea;

[0100] (B25) 5-[4-[3-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0101] (B26) 5-[4-[2-[2-(trifluoromethyl)phenyl]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0102] (B27) 1-(2-chlorophenyl)-3-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]urea;

[0103] (B28) 5-[4-[(2-phenylpropionyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0104] (B29) 5-[4-(2-chloro-3-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0105] (B30) 5-[4-(3-phenylpropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0106] (B31) 5-[4-[(1H-indole-3-carbonyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0107] (B32) 5-[4-(2-chloro-3-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0108] (B33) 5-[4-[(2-methyl-2-phenylpropionyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0109] (B34) 5-[4-(2-phenoxyacetylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0110] (B35) 5-[4-[2-(2-chloro-4-methoxyphenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0111] (B36) 5-[4-[(1-methyl-1H-imidazole-2-carbonyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0112] (B37) 5-[4-[2-(2,4-dichlorophenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0113] (B38) 5-[4-[2-(2-chloro-4-hydroxyphenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0114] (B39) 5-[4-(3-phenylpropenylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0115] (B40) 5-[4-[(3-pyridylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[0116] (B41) 5-[4-(1H-benzimidazole-2-carbonylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0117] (B42) 1-[4-(2,3-dimethylbenzoylamino)phenyl]-7-methoxy-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[0118] (B43) 5-[4-[(Benzoylamino)methyl]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0119] (B44) 5-[4-[(2-chlorobenzoylamino)methyl]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0120] (B45) 1-[4-(2,3-dimethylbenzoylamino)phenyl]-7-hydroxy-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[0121] (B46) 5-[4-(2-chlorobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0122] (B47) 5-[4-(2-bromobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0123] (B48) 5-[4-(2-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0124] (B49) 5-[4-(2,3-dimethylbenzoylamino)-3-fluorophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0125] (B50) 5-[4-[2-(2-methylphenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0126] (B51) 5-[4-[(quinoxalin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0127] (B52) 5-[4-[(5-methylthiophen-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0128] (B53) 5-[3-[(2-chlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0129] (B54) 5-[4-[(2,4,6-trimethylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0130] (B55) 5-[4-(cyclohexylcarbonylamino)phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0131] (B56) 1-[4-(2,3-dimethylbenzoyl)aminophenyl]-6-methyl-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[0132] (B57) 5-[4-[(2-ethylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0133] (B58) 5-[4-[(6-methylpyridin-2-yl)carbonylamino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0134] (B59) 5-[4-[(2-methylpyridin-3-yl)carbonylamino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0135] (B60) 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-(2-methylphenyl)thiourea;

[0136] (B61) 5-[4-(2-methoxy-3-methylbenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0137] (B62) 5-[4-(2,3-dichlorobenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0138] (B63) 5-[4-(2,3-dimethylbenzoylamino)-3-hydroxyphenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0139] (B64) 5-[4-(2-chloro-3-methoxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[0140] (B65) 5-[4-[(4-dimethylaminobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0141] (B66) 5-[4-[2-(2,4-dichlorophenoxy)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0142] (B67) 5-[4-[2-(2-methylphenoxy)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0143] (B68) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)butyl]-2-chloro-3-methoxybenzamide;

[0144] (B69) 5-[4-(2-chloro-3-hydroxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[0145] (B70) 5-[4-(2-acetylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0146] (B71) 5-[4-(2-tert-Butylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0147] (B72) 5-[2-(2-iodobenzoyl)aminoethyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0148] (B73) 5-[3-[(2-iodobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0149] (B74) 6,7-Dimethyl-1-[4-(2-iodobenzoyl)aminophenyl]-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[0150] (B75) 5-[4-[(1-methylpiperidin-4-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[0151] (B76) 5[4-[(Benzofuran-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0152] (B77) 5-[4-[(1-methyl-1H-indol-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0153] (B78) 5-[4-(2-propenylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0154] (B79) 5-[4-(2-propylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0155] (B80) 5-[3-Fluoro-4-(2-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0156] (B81) 5-[4-(2-hydroxy-3-methylbenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0157] (B82) 5-[4-[(2-isopropoxybenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0158] (B83) 5-[4-[(3-methylthiophen-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0159] (B84) 5-[4-(2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0160] (B85) 5-[4-[2-(4-chloro-2-methylphenoxy)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0161] (B86) 5-[4-[(4-fluoro-2-trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0162] (B87) 5-[4-(4-fluoro-2-methoxybenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0163] (B88) 5-[4-(4-fluoro-2-hydroxybenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0164] (B89) 5-[3-[(2-iodophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0165] (B90) 5-[4-(2-methyl-2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0166] (B91) 5-[4-(2-tert-Butylbenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[0167] (B92) 5-[4-[(3-dimethylaminobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0168] (B93) 5-[4-(4-iodo-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0169] (B94) 5-[4-(6-fluoro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0170] (B95) 5-[4-(2-hydroxy-4-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0171] (B96) 5-[4-(6-fluoro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0172] (B97) 5-[4-(2-Fluorobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0173] (B98) 5-[4-[(2-dimethylaminobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0174] (B99) 5-[4-(2-methoxy-6-methylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0175] (B100) 5-[4-(2-hydroxy-6-methylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0176] (B101) 5-[4-[3-(2-methylphenyl)propionylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0177] (B102) 5-(4-phenylcarbamoylphenyl)-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0178] (B103) 5-(4-Benzylcarbamoylphenyl)-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0179] (B104) 5-[4-[3-(2-methylphenyl)acryloylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0180] (B105) 5-[4-[3-(2-chlorophenyl)propionylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0181] (B106) 5-[4-(2-iodobenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0182] (B107) 5-[4-[(1-methyl-1H-pyrrol-2-ylacetyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0183] (B108) 5-[4-(2-chlorobenzyl)carbamoylphenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0184] (B109) 5-[4-[3-(2-chlorophenyl)acryloylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0185] (B110) 5-[4-(2-chlorophenyl)carbamoylphenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0186] (B111) 5-[4-(6-bromo-2,3-methylenedioxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0187] (B112) 5-[4-(6-bromo-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0188] (B113) 5-[4-[(2-tert-butylbenzoyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0189] (B114) 5-[2-(2-iodobenzoyl)aminopyridin-5-yl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0190] (B115) 5-[4-(6-bromo-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0191] (B116) 5-[4-(6-chloro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0192] (B117) 5-[4-(2-iodobenzoylamino)phenyl]-1H-[1,4]diazepine 2,3-h]quinoline-2,4(3H,5H)-dione;

[0193] (B118) 5-[4-(6-chloro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0194] (B119) 5-[4-(2-hydroxy-6-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0195] (B120) 5-[4-[2-methoxy-6-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0196] (B121) 5-[4-[2-hydroxy-6-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0197] (B122) 5-[4-[(2-Isopropenylbenzoyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0198] (B123) 5-[4-[(2-isopropylbenzoyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0199] (B124) 5-[4-[2-chloro-5-(methylthio)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0200] (B125) 5-[4-[2-(methylthio)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0201] (B126) 5-[4-[3-(methylthio)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0202] (B127) 5-[4-[2-ethyl-6-methoxybenzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0203] (B128) 5-[4-(3-methanesulfonylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0204] (B129) 6-ethyl-1-[4-(2-iodobenzoyl)aminophenyl]-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[0205] (B130) 5-[4-[2-ethyl-6-hydroxybenzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0206] (B131) 5-[4-(3-methanesulfinylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0207] (B132) 5-[4-(2-chloro-5-methanesulfinylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0208] (B133) 5-[4-(2-methanesulfinylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0209] (B134) 5-[4-[[2-(4-morpholinyl)acetyl]amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[0210] (B135) 5-[4-(2-chloro-6-methoxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[0211] (B136) 5-[4-[[(3-chloropyridin-2-yl)carbonyl]amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0212] (B137) 5-[4-(2-chloro-6-hydroxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[0213] (B138) 5-[4-(3-chloro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0214] (B139) 5-[4-[(3-methylpyridin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0215] (B140) 5-[4-[[(3-chloropyridin-2-yl)carbonyl]amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0216] (B141) 5-[4-(3-chloro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0217] (B142) 5-[4-[[(3-hydroxypyridin-2-yl)carbonyl]amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0218] (B143) 5-[4-[(3-vinylpyridin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0219] (B144) 5-[4-[(3-ethylpyridin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0220] (B145) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-2-nitrobenzenesulfonamide;

[0221] (B146) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]benzenesulfonamide;

[0222] (B147) 3-Bromo-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]benzenesulfonamide;

[0223] (B148) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-methoxybenzenesulfonamide;

[0224] (B149) N-[3-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepine] -5-amino)phenyl]benzenesulfonamide;

[0225] (B150)N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-2-nitrobenzenesulfonamide;

[0226] (B151)N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]-diazepine -5-amino)phenyl]-2-nitro-benzenesulfonamide;

[0227] (B152) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]-diazepine -5-amino)phenyl]-N-methyl-2-nitrobenzenesulfonamide;

[0228] (B153) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-N-methyl-2-nitrobenzenesulfonamide;

[0229] (B154) 4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)-N-phenylbenzenesulfonamide;

[0230] (B155) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b]-[1,4]diazepine -5-yl)phenyl]-2-naphthalenesulfonamide;

[0231] (B156) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b]-[1,4]diazepine -5-yl)phenyl]-1-naphthalenesulfonamide;

[0232] (B157) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]cyclohexanesulfonamide;

[0233] (B158) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-pyridinesulfonamide hydrochloride;

[0234] (B159) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-4-isopropylbenzenesulfonamide;

[0235] (B160) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]phenylmethanesulfonamide;

[0236] (B161) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-thiophene-sulfonamide;

[0237] (B162) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-naphthalenesulfonamide;

[0238] (B163) 4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine)-3-bromobenzenesulfonate -5-yl)phenyl ester;

[0239] (B164) N-benzyl-N-[4-(1-benzyl-2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-2-nitrobenzenesulfonamide;

[0240] (B165) N-benzyl-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine] -5-amino)phenyl]-2-nitrobenzenesulfonamide;

[0241] (B166) 3-Bromo-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-methylbenzenesulfonamide;

[0242] (B167) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-N-methyl-2-nitrobenzenesulfonamide;

[0243] (B168) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide;

[0244] (B169) N-[4-(7-chloro-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine] -1-yl)phenyl]benzenesulfonamide;

[0245] (B170) N-[4-(7-bromo-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine] -1-yl)phenyl]benzenesulfonamide;

[0246] (B171) N-[4-[(2,4-dioxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine -1-yl)]phenyl]benzenesulfonamide;

[0247] (B172) N-[4-(2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine] -1-yl)phenyl]benzenesulfonamide;

[0248] (B173) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[0249] (B174) 1-(3-bromophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[0250] (B175) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-trifluoromethylbenzenesulfonamide;

[0251] (B176) N-[4-(7-bromo-6-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine] -1-yl)phenyl]benzenesulfonamide;

[0252] (B177) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[0253] (B178) 3-Bromo-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]benzenesulfonamide;

[0254] (B179) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-methoxybenzenesulfonamide;

[0255] (B180) 1-(2-bromophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[0256] (B181) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-1-(2-methylphenyl)methanesulfonamide;

[0257] (B182) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-1-(2-nitrophenyl)methanesulfonamide;

[0258] (B183) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-phenylethanesulfonamide;

[0259] (B184) 1-(2,3-dichlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[0260] (B185) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-7-methoxy-1H-benzo[1,2-b][1,4]diazepine -1-yl)phenyl]methanesulfonamide;

[0261] (B186) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-7-hydroxy-1H-benzo[1,2-b][1,4]diazepine -1-yl)phenyl]methanesulfonamide;

[0262] (B187) 1-(4-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[0263] (B188) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)benzyl]methanesulfonamide;

[0264] (B189) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)-2-methoxyphenyl]methanesulfonamide;

[0265] (B190) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)-2-hydroxyphenyl]methanesulfonamide;

[0266] (B191) 1-(2,6-dichlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[0267] (B192) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-6-methyl-1H-benzo[1,2-b][1,4]diazepine -1-yl)phenyl]methanesulfonamide;

[0268] (B193) 1-(2-chlorophenyl)-N-[3-(2,4-dioxy-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)propyl]methanesulfonamide;

[0269] (B194) 1-(2-chlorophenyl)-N-[2-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)ethyl]methanesulfonamide;

[0270] (B195) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-1-(2-iodophenyl)methanesulfonamide;

[0271] (B196) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-methylmethanesulfonamide;

[0272] (B197) 1-(2-chlorophenyl)-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[0273] (B198) 1-[2-(trifluoromethyl)phenyl]-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[0274] (B199) 1-(2-ethylphenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[0275] (B200) 1-(2,3-dimethylphenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[0276] (B201) 2-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylethanesulfonamide;

[0277] (B202) 1-(2-nitrophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[0278] (B203) 1-(2-aminophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[0279] (B204) 1-(2-dimethylaminophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[0280] (B205) 5-[4-[(pyridin-4-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[0281] (B206) 5-[4-[2-[(pyridin-3-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[0282] (B207) 5-[4-[(pyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[0283] (B208) 5-[4-[(2-methylpyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[0284] (B209) 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0285] (B210) 5-[4-[2-[(pyridin-2-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0286] (B211) 5-[4-[[4-(Trifluoromethyl)pyridin-3-yl]carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[0287] (B212) 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-1H-[1,4]diazepine 2,3-f]isoquinoline-2,4(3H,5H)-dione;

[0288] (B213) 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-8,9,10,11-tetrahydro-1H-[1,4]diazepine 2,4(3H,5H)-dione; and

[0289] (B214) 5-[4-[(2-isopropylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione.

[0290] [8] The pharmaceutical composition according to any one of [1] to [4], wherein the compound is a compound selected from the following (C1) to (C297):

[0291] (C1) N-[4-(3-chloro-5-cyanophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0292] (C2) 2-(2-chlorophenyl)-N-4-[3-(dimethylamino)phenoxy]-3-sulfamoylphenylacetamide;

[0293] (C3) 2-(2-chlorophenyl)-N-4-[(2-chloropyridin-4-yl)oxy]-3-sulfamoylphenylacetamide;

[0294] (C4) 2-(2-chlorophenyl)-N-[4-(3-isopropylphenoxy)-3-sulfamoylphenyl]acetamide;

[0295] (C5) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(trifluoromethyl)phenoxy]phenylacetamide;

[0296] (C6) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(trifluoromethoxy)phenoxy]phenylacetamide;

[0297] (C7) N-[4-(3-acetylphenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0298] (C8)N-[4-(1,3-benzodibenzoylmethane) [5-(2-chlorophenyl)-3-sulfamoylphenyl)-2-(2-chlorophenyl)acetamide]

[0299] (C9) N-[4-(3-acetamidophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0300] (C10) 2-(2-chlorophenyl)-N-[4-(2-fluorophenoxy)-3-sulfamoylphenyl]acetamide;

[0301] (C11) 2-(2-chlorophenyl)-N-[4-(3-fluorophenoxy)-3-sulfamoylphenyl]acetamide;

[0302] (C12) 2-(2-chlorophenyl)-N-[4-(4-fluorophenoxy)-3-sulfamoylphenyl]acetamide;

[0303] (C13) 2-(2-chlorophenyl)-N-[4-(pyridin-2-yloxy)-3-sulfamoylphenyl]acetamide;

[0304] (C14) 2-(2-chlorophenyl)-N-(4-phenoxy-3-sulfamoylphenyl)acetamide;

[0305] (C15) 2-(2-chlorophenyl)-N-[4-(3-cyanophenoxy)-3-sulfamoylphenyl]acetamide;

[0306] (C16) 2-(2-chlorophenyl)-N-4-[3-(methylsulfonyl)phenoxy]-3-sulfamoylphenylacetamide;

[0307] (C17) 3-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)benzamide;

[0308] (C18) 2-(2-chlorophenyl)-N-[4-(3-methylphenoxy)-3-sulfamoylphenyl]acetamide;

[0309] (C19) 2-(2-chlorophenyl)-N-[4-(pyrimidin-5-yloxy)-3-sulfamoylphenyl]acetamide;

[0310] (C20) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(4H-1,2,4-triazol-4-yl)phenoxy]phenylacetamide;

[0311] (C21) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(1H-tetrazol-5-yl)phenoxy]phenylacetamide;

[0312] (C22) 2-(2-chlorophenyl)-N-[4-(3-methoxyphenoxy)-3-sulfamoylphenyl]acetamide;

[0313] (C23) 2-(2-chlorophenyl)-N-[4-(4-methoxyphenoxy)-3-sulfamoylphenyl]acetamide;

[0314] (C24) 2-(2-chlorophenyl)-N-4-[3-(difluoromethoxy)phenoxy]-3-sulfamoylphenylacetamide;

[0315] (C25) 2-(2-chlorophenyl)-N-[4-(3,4-dicyanophenoxy)-3-sulfamoylphenyl]acetamide;

[0316] (C26) 2-(2-chlorophenyl)-N-4-[3-(morpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0317] (C27) 2-(2-chlorophenyl)-N-[4-(3-4-[(2-chlorophenyl)acetyl]piperazin-1-ylphenoxy)-3-sulfamoylphenyl]acetamide;

[0318] (C28) 2-(2-chlorophenyl)-N-[4-(pyridin-3-yloxy)-3-sulfamoylphenyl]acetamide;

[0319] (C29) 2-(2-chlorophenyl)-N-4-[(5-chloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0320] (C30) 2-(2-chlorophenyl)-N-[4-(4-cyanophenoxy)-3-sulfamoylphenyl]acetamide;

[0321] (C31) 2-(2-chlorophenyl)-N-4-[3-(difluoromethyl)phenoxy]-3-sulfamoylphenylacetamide;

[0322] (C32) 2-(2-chlorophenyl)-N-[4-(2-methoxyphenoxy)-3-sulfamoylphenyl]acetamide;

[0323] (C33) 2-(2-chlorophenyl)-N-[4-(3,5-dicyanophenoxy)-3-sulfamoylphenyl]acetamide;

[0324] (C34) 2-(2-chlorophenyl)-N-[4-(5-cyano-2-methoxyphenoxy)-3-sulfamoylphenyl]acetamide;

[0325] (C35) 2-(2-chlorophenyl)-N-4-[(2,5-dichloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0326] (C36) 2-(2-chlorophenyl)-N-4-[(5,6-dichloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0327] (C37) 3-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)-N-cyclopropylbenzamide;

[0328] (C38) 2-(2-chlorophenyl)-N-4-[(3-chloropyridin-2-yl)oxy]-3-sulfamoylphenylacetamide;

[0329] (C39) 2-(2-chlorophenyl)-N-4-[(4-chloropyridin-2-yl)oxy]-3-sulfamoylphenylacetamide;

[0330] (C40) 2-(2-chlorophenyl)-N-4-[(6-chloropyridin-2-yl)oxy]-3-sulfamoylphenylacetamide;

[0331] (C41) 2-(2-chlorophenyl)-N-4-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0332] (C42) 2-(2-chlorophenyl)-N-4-[4-(1H-imidazol-1-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0333] (C43) 2-(2-chlorophenyl)-N-4-[4-(2-oxopyrrolidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0334] (C44) 2-(2-chlorophenyl)-N-4-[4-(morpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0335] (C45) 2-(2-chlorophenyl)-N-[4-(5-cyano-2-methylphenoxy)-3-sulfamoylphenyl]acetamide;

[0336] (C46) 2-(2-chlorophenyl)-N-[4-(3-cyano-2-methylphenoxy)-3-sulfamoylphenyl]acetamide;

[0337] (C47) 2-(2-chlorophenyl)-N-[4-(3-cyano-4-fluorophenoxy)-3-sulfamoylphenyl]acetamide;

[0338] (C48) N-4-[(5-chloro-2-cyanopyridin-3-yl)oxy]-3-sulfamoylphenyl-2-(2-chlorophenyl)acetamide;

[0339] (C49) 2-(2-chlorophenyl)-N-4-[3-(piperidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0340] (C50) 2-(2-chlorophenyl)-N-4-[3-(2-oxopyrrolidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0341] (C51) 2-(2-chlorophenyl)-N-4-[3-(2-oxo-1,3- Oxazolidin-3-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0342] (C52) 2-(2-chlorophenyl)-N-4-[3-(morpholin-4-ylcarbonyl)phenoxy]-3-sulfamoylphenylacetamide;

[0343] (C53) 2-(2-chlorophenyl)-N-4-[(4-methyltetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide;

[0344] (C54) 2-(2-chlorophenyl)-N-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide;

[0345] (C55) 2-(2-chlorophenyl)-N-4-[(4-cyanotetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide;

[0346] (C56) 2-(2-chlorophenyl)-N-(3-sulfamoyl-4-[2-(trifluoromethyl)pyrimidin-5-yl]oxyphenyl)acetamide;

[0347] (C57) 2-(2-chlorophenyl)-N-4-[(2-isopropylpyrimidin-5-yl)oxy]-3-sulfamoylphenylacetamide;

[0348] (C58) 2-(2-chlorophenyl)-N-4-[(2-cyclopropyl-4-methylpyrimidin-5-yl)oxy]-3-sulfamoylphenylacetamide;

[0349] (C59) N-[4-(3-bromophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0350] (C60) N-[4-(4-bromophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0351] (C61) 2-(2-chlorophenyl)-N-4-[3-(2-methyl-1,3-thiazol-4-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0352] (C62) 2-(2-chlorophenyl)-N-4-[4-(5-oxopyrrolidin-2-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0353] (C63) 2-(2-chlorophenyl)-N-4-[4-(2-oxo-1,3- Oxazolidin-3-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0354] (C64) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[4-(1,3-thiazol-2-yl)phenoxy]phenylacetamide;

[0355] (C65) N-[4-(2-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0356] (C66) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0357] (C67) 2-(2-chlorophenyl)-N-4-[3-(piperidin-1-ylcarbonyl)phenoxy]-3-sulfamoylphenylacetamide;

[0358] (C68) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[4-(tetrahydrofuran-3-yl)phenoxy]phenylacetamide;

[0359] (C69) 2-(2-chlorophenyl)-N-[4-(3-cyano-5-fluorophenoxy)-3-sulfamoylphenyl]acetamide;

[0360] (C70) N-[4-(2-methoxyphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0361] (C71) N-[4-(2-methoxyphenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide;

[0362] (C72) N-3-sulfamoyl-4-[2-(trifluoromethoxy)phenoxy]phenyl-2-[4-(trifluoromethyl)phenyl]acetamide;

[0363] (C73) N-[4-(2-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide;

[0364] (C74) 2-phenyl-N-3-sulfamoyl-4-[2-(trifluoromethoxy)phenoxy]phenylacetamide;

[0365] (C75) 2-(2-chlorophenyl)-N-4-[(2-oxo-1,2-dihydropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0366] (C76) N-[4-(2-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0367] (C77) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0368] (C78) N-4-[(5-chloropyridin-3-yl)oxy]-3-sulfamoylphenyl-2-phenylacetamide;

[0369] (C79) 2-(2-chlorophenyl)-N-4-[(2-chloropyrimidin-5-yl)oxy]-3-sulfamoylphenylacetamide;

[0370] (C80) 2-(2-chlorophenyl)-N-4-[(5-fluoropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0371] (C81) 2-(2-chlorophenyl)-N-4-[(6-chloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0372] (C82) N-[2-chloro-4-(3-chlorophenoxy)-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0373] (C83) N-[2-chloro-4-(3-chlorophenoxy)-5-sulfamoylphenyl]-2-(2-chloro-3-fluorophenyl)acetamide;

[0374] (C84) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-fluorophenyl)acetamide;

[0375] (C85) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide;

[0376] (C86) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide;

[0377] (C87) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-isopropylphenyl)acetamide;

[0378] (C88) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-ethoxyphenyl)acetamide;

[0379] (C89) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(difluoromethyl)phenyl]acetamide;

[0380] (C90) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[(trifluoromethyl)thio]phenylacetamide;

[0381] (C91) 2-(2-bromophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0382] (C92) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methylpyridin-3-yl)acetamide;

[0383] (C93) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chloropyridin-3-yl)acetamide;

[0384] (C94) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)-2,2-difluoroacetamide;

[0385] (C95) 2-(2-chloro-4-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0386] (C96) 2-(2-chloro-6-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0387] (C97) 2-(2-chloro-5-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0388] (C98) 2-(2-chloro-3-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0389] (C99) 2-(2-chloro-5-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0390] (C100) 2-(2-chloro-6-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0391] (C101) 2-(2-chloro-6-methoxyphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0392] (C102) 2-(2-chloro-5-methoxyphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0393] (C103) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3-dichlorophenyl)acetamide;

[0394] (C104) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichlorophenyl)acetamide;

[0395] (C105) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide;

[0396] (C106) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2,2-difluoro-2-phenylacetamide;

[0397] (C107) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-3-(trifluoromethyl)phenyl]acetamide;

[0398] (C108) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-6-(trifluoromethyl)phenyl]acetamide;

[0399] (C109) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-5-(trifluoromethyl)phenyl]acetamide;

[0400] (C110) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,4-dichlorophenyl)acetamide;

[0401] (C111) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4,6-dichloropyridin-3-yl)acetamide;

[0402] (C112) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-chloropyridin-2-yl)acetamide;

[0403] (C113) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(difluoromethoxy)phenyl]acetamide;

[0404] (C114) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,5-dichlorophenyl)acetamide;

[0405] (C115) 2-[6-chloro-2,3-difluoro-4-(trifluoromethyl)phenyl]-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0406] (C116) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide;

[0407] (C117) 2-(5-bromo-2-chlorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0408] (C118) 2-(4-bromo-2-chloro-5-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0409] (C119) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-chloropyridin-4-yl)acetamide;

[0410] (C120) 2-(2-chloro-6-fluoro-3-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0411] (C121) 2-(6-chloro-2-fluoro-3-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0412] (C122) 2-(2-chloro-3,6-difluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0413] (C123) 2-(2-chloro-4,5-difluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0414] (C124) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3-dichloro-6-fluorophenyl)acetamide;

[0415] (C125) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3,6-trichlorophenyl)acetamide;

[0416] (C126) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichloro-4-methylphenyl)acetamide;

[0417] (C127) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2,3-dichloro-6-(trifluoromethyl)phenyl]acetamide;

[0418] (C128) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichloro-3-methylphenyl)acetamide;

[0419] (C129) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichloro-3-cyclopropylphenyl)acetamide;

[0420] (C130) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2,6-dichloro-3-(trifluoromethyl)phenyl]acetamide;

[0421] (C131) 2-(3-bromo-2,6-dichlorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0422] (C132) 2-(3-bromo-2-chloro-6-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0423] (C133) 2-(3-bromo-6-chloro-2-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0424] (C134) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide;

[0425] (C135) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-4-(trifluoromethyl)phenyl]acetamide;

[0426] (C136) 2-(2-chlorophenyl)-N-(4-[3-(methylsulfonyl)benzyl]oxy-3-sulfamoylphenyl)acetamide;

[0427] (C137) 2-(2-chlorophenyl)-N-4-[(2-fluorobenzyl)oxy]-3-sulfamoylphenylacetamide;

[0428] (C138) 2-(2-chlorophenyl)-N-4-[(4-cyanobenzyl)oxy]-3-sulfamoylphenylacetamide;

[0429] (C139) N-4-[(3-chlorobenzyl)oxy]-3-sulfamoylphenyl-2-(2-chlorophenyl)acetamide;

[0430] (C140) 2-(2-chlorophenyl)-N-4-[(3-methoxybenzyl)oxy]-3-sulfamoylphenylacetamide;

[0431] (C141) N-[4-(Benzyloxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0432] (C142) 2-(2-chlorophenyl)-N-4-[(3-cyanobenzyl)oxy]-3-sulfamoylphenylacetamide;

[0433] (C143) 2-(2-chlorophenyl)-N-4-[(4-fluorobenzyl)oxy]-3-sulfamoylphenylacetamide;

[0434] (C144) N-4-[(2-chlorobenzyl)oxy]-3-sulfamoylphenyl-2-(2-chlorophenyl)acetamide;

[0435] (C145) 2-(2-chlorophenyl)-N-4-[(2-cyanobenzyl)oxy]-3-sulfamoylphenylacetamide;

[0436] (C146) N-[4-(Benzyloxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0437] (C147) 2-(2-chlorophenyl)-N-(4-[4-(methylsulfonyl)benzyl]oxy-3-sulfamoylphenyl)acetamide;

[0438] (C148) 2-(2-chlorophenyl)-N-[4-(1-phenylethoxy)-3-sulfamoylphenyl]acetamide;

[0439] (C149) 2-(2-chlorophenyl)-N-[4-(1-phenylethoxy)-3-sulfamoylphenyl]acetamide;

[0440] (C150) 2-(2-chlorophenyl)-N-[4-(pyridin-3-ylmethoxy)-3-sulfamoylphenyl]acetamide;

[0441] (C151) 2-(2-chlorophenyl)-N-[4-(pyridin-2-ylmethoxy)-3-sulfamoylphenyl]acetamide;

[0442] (C152) 2-(2-chlorophenyl)-N-[4-(pyridin-4-ylmethoxy)-3-sulfamoylphenyl]acetamide;

[0443] (C153) N-[4-(pyridin-2-ylmethoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide;

[0444] (C154) 2-(2-chlorophenyl)-N-[4-(pyrimidin-4-ylmethoxy)-3-sulfamoylphenyl]acetamide;

[0445] (C155) 2-(2-chlorophenyl)-N-[4-(pyrimidin-2-ylmethoxy)-3-sulfamoylphenyl]acetamide;

[0446] (C156) 2-(2-chlorophenyl)-N-[4-(2-phenylethoxy)-3-sulfamoylphenyl]acetamide;

[0447] (C157) 2-(2-chlorophenyl)-N-4-[2-(3-chlorophenyl)ethoxy]-3-sulfamoylphenylacetamide;

[0448] (C158) 2-(2-chlorophenyl)-N-[4-(cyclobutylmethoxy)-3-sulfamoylphenyl]acetamide;

[0449] (C159) 2-(2-chlorophenyl)-N-[4-(oxetan-2-ylmethoxy)-3-sulfamoylphenyl]acetamide;

[0450] (C160) 2-(2-chlorophenyl)-N-[4-(oxetan-3-ylmethoxy)-3-sulfamoylphenyl]acetamide;

[0451] (C161) 2-(2-chlorophenyl)-N-[4-(cyclopentylmethoxy)-3-sulfamoylphenyl]acetamide;

[0452] (C162) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydrofuran-2-ylmethoxy)phenyl]acetamide;

[0453] (C163) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydrofuran-3-ylmethoxy)phenyl]acetamide;

[0454] (C164) 2-(2-Chloro-5-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide;

[0455] (C165) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide;

[0456] (C166) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-3-ylmethoxy)phenyl]acetamide;

[0457] (C167) 2-(2-Chloro-6-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide;

[0458] (C168) 2-(2-Chloro-3-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide;

[0459] (C169) 2-(2-chlorophenyl)-N-5-sulfamoyl-6-[3-(trifluoromethyl)phenoxy]pyridin-3-ylacetamide;

[0460] (C170) 2-phenyl-N-5-sulfamoyl-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl acetamide;

[0461] (C171) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-phenylacetamide;

[0462] (C172) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(2-methylphenyl)acetamide;

[0463] (C173) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(3-methylphenyl)acetamide;

[0464] (C174) 2-(2-chlorophenyl)-N-4-[3-(3-oxomorpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0465] (C175) 2-(2-chlorophenyl)-N-4-[4-(3-oxomorpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0466] (C176) 2-(2-chlorophenyl)-N-4-[4-(2-oxopiperidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0467] (C177) 2-(2-chlorophenyl)-N-4-[3-(2-oxopiperidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0468] (C178) 2-(2-chlorophenyl)-N-4-[3-(prop-1-en-2-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0469] (C179) 2-(2-chlorophenyl)-N-4-[2-(prop-1-en-2-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0470] (C180) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide;

[0471] (C181) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-chlorophenyl)acetamide;

[0472] (C182) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(pyridin-3-yl)acetamide;

[0473] (C183) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide;

[0474] (C184) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-methylphenyl)acetamide;

[0475] (C185) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylpropionamide;

[0476] (C186) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(pyridin-2-yl)acetamide;

[0477] (C187) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-chlorophenyl)acetamide;

[0478] (C188) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0479] (C189) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(pyridin-4-yl)acetamide;

[0480] (C190) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(6-methylpyridin-2-yl)acetamide;

[0481] (C191) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide;

[0482] (C192) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-methoxyphenyl)acetamide;

[0483] (C193) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-methoxyphenyl)acetamide;

[0484] (C194) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(5-methylpyridin-2-yl)acetamide;

[0485] (C195)(2S)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylpropionamide;

[0486] (C196)(2R)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylpropionamide;

[0487] (C197) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)propionamide;

[0488] (C198) 2-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-(2-methoxyethyl)-N-methylbenzamide;

[0489] (C199) 2-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N,N-dimethylbenzamide;

[0490] (C200) N-[4-(cyclohexyloxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0491] (C201) 2-(2-chlorophenyl)-N-[4-(cyclohexyloxy)-3-sulfamoylphenyl]acetamide;

[0492] (C202) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-(2-methoxyethyl)benzamide;

[0493] (C203) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N,N-dimethylbenzamide;

[0494] (C204) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-methylbenzamide;

[0495] (C205) N-[4-(cyclobutyloxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0496] (C206) 2-(2-chlorophenyl)-N-[4-(cyclobutyloxy)-3-sulfamoylphenyl]acetamide;

[0497] (C207) 2-phenyl-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]acetamide;

[0498] (C208) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]acetamide;

[0499] (C209) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-(2-methoxyethyl)-N-methylbenzamide;

[0500] (C210) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(5-chloropyridin-2-yl)acetamide;

[0501] (C211) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[3-(2-methoxyethoxy)phenyl]acetamide;

[0502] (C212) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(2-methoxyethoxy)phenyl]acetamide;

[0503] (C213) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[3-(2-hydroxyethoxy)phenyl]acetamide;

[0504] (C214) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(2-hydroxyethoxy)phenyl]acetamide;

[0505] (C215) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0506] (C216) N-[4-(oxetan-3-yloxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0507] (C217) 2-(2-chlorophenyl)-N-[4-(oxetan-3-yloxy)-3-sulfamoylphenyl]acetamide;

[0508] (C218) N-[4-(cyclopentyloxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0509] (C219) 2-(2-chlorophenyl)-N-[4-(cyclopentyloxy)-3-sulfamoylphenyl]acetamide;

[0510] (C220) N-4-[(1-methylpiperidin-3-yl)oxy]-3-sulfamoylphenyl-2-phenylacetamide;

[0511] (C221) 2-(2-chlorophenyl)-N-4-[(1-methylpiperidin-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0512] (C222) N-4-[(1-methylpyrrolidin-3-yl)oxy]-3-sulfamoylphenyl-2-phenylacetamide;

[0513] (C223) 2-(2-chlorophenyl)-N-4-[(1-methylpyrrolidin-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0514] (C224) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide;

[0515] (C225) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-cyanophenyl)acetamide;

[0516] (C226) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-cyanophenyl)acetamide;

[0517] (C227) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-cyanophenyl)acetamide;

[0518] (C228) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide;

[0519] (C229) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-chlorophenyl)acetamide;

[0520] (C230) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide;

[0521] (C231) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0522] (C232) 2-(2-chloro-4-fluorophenyl)-N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0523] (C233) 2-(2-chlorophenyl)-N-4-[(1,1-dioxidotetrahydrothiophen-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0524] (C234) 2-(2-chlorophenyl)-N-4-[(1-methyl-1H-pyrazol-4-yl)oxy]-3-sulfamoylphenylacetamide;

[0525] (C235) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide;

[0526] (C236) 2-(2-chloro-4-methoxyphenyl)-N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0527] (C237) 2-(2-chlorophenyl)-N-4-[(1-methyl-1H-pyrazol-3-yl)oxy]-3-sulfamoylphenylacetamide;

[0528] (C238) 2-(2-chlorophenyl)-N-4-[(1-methyl-1H-pyrazol-5-yl)oxy]-3-sulfamoylphenylacetamide;

[0529] (C239) 2-(2-chlorophenyl)-N-4-[(1-methylpiperidin-4-yl)oxy]-3-sulfamoylphenylacetamide;

[0530] (C240) 2-(2-chlorophenyl)-N-(4-[5-methyl-2-(pyridin-3-yl)-1,3-thiazol-4-yl]oxy-3-sulfamoylphenyl)acetamide;

[0531] (C241) N-[4-(3-chlorophenoxy)-2-methyl-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0532] (C242) 2-(2-Chlorophenyl)-N-{4-[(1-oxytetrahydrothiophen-3-yl)oxy]-3-sulfamoylphenyl}acetamide;

[0533] (C243) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-[2,6-dichloro-4-(trifluoromethyl)phenyl]acetamide;

[0534] (C244) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,5-dichloro-4-cyanophenyl)acetamide;

[0535] (C245) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0536] (C246) N-[4-(cyclopropylmethoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0537] (C247) N-[4-(3,5-dimethylphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0538] (C248) N-[4-(2,4-difluorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0539] (C249) N-[4-(4-fluorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0540] (C250) N-[4-(3-fluorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0541] (C251) N-[4-(3-methoxyphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0542] (C252) N-[4-(2-fluoro-5-methylphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0543] (C253) 2-phenyl-N-3-sulfamoyl-4-[4-(trifluoromethoxy)phenoxy]phenylacetamide;

[0544] (C254) 2-phenyl-N-3-sulfamoyl-4-[3-(trifluoromethyl)phenoxy]phenylacetamide;

[0545] (C255) N-[4-(3,5-dimethoxyphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0546] (C256) N-[4-(3-cyanophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide;

[0547] (C257) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-hydroxyphenyl)acetamide;

[0548] (C258) 2-(2-chloro-6-methoxy-4-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0549] (C259) 2-(2-chloro-6-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]propionamide;

[0550] (C260) 2-(2-chloro-4,6-difluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0551] (C261) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichlorophenyl)propionamide;

[0552] (C262) 2-(2-chlorophenyl)-N-4-[(2H5)phenyloxy]-3-sulfamoylphenylacetamide;

[0553] (C263) 2-(2-chlorophenyl)-N-(4-{[4-chloro(2H4)phenyl]oxy}-3-sulfamoylphenyl)acetamide;

[0554] (C264) 2-(2-chlorophenyl)-N-(4-{[2-chloro(2H4)phenyl]oxy}-3-sulfamoylphenyl)acetamide;

[0555] (C265) 2-(2-chlorophenyl)-N-4-[4-(2-hydroxypropan-2-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0556] (C266) 2-(2-chlorophenyl)-N-4-[(2,2-dimethyltetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide;

[0557] (C267) 2-(2-Chlorophenyl)-N-{4-[(1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-ylmethoxy]-3-sulfamoylphenyl}acetamide;

[0558] (C268) 2-(2-Chlorophenyl)-N-4-[(4-chlorotetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide;

[0559] (C269) 2-(2-chlorophenyl)-N-[4-(1,4-di ... [2-alkylmethoxy)-3-sulfamoylphenyl]acetamide;

[0560] (C270) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)oxy]phenylacetamide;

[0561] (C271) N-[4-(3-chlorophenoxy)-3-methyl-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0562] (C272) N-[4-(3-chlorophenoxy)-3-methyl-5-sulfamoylphenyl]-2-phenylacetamide;

[0563] (C273) methyl 2-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)benzoate;

[0564] (C274) methyl 4-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)benzoate;

[0565] (C275) 2-(2-chlorophenyl)-N-4-[3-(2-hydroxypropan-2-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0566] (C276) 2-(2-chlorophenyl)-N-4-[2-(2-hydroxypropan-2-yl)phenoxy]-3-sulfamoylphenylacetamide;

[0567] (C277) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3-dihydro-1,4-benzodihydrophenoxy)-3-sulfamoylphenyl 6-oxo-1,2-dioxane-2-yl)acetamide;

[0568] (C278) 2-(7-chloro-2,3-dihydro-1,4-benzodihydrogen) 6-in-1-yl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0569] (C279) 2-(5-chloro-2,3-dihydro-1-benzofuran-4-yl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide;

[0570] (C280) 2-(2-Fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide;

[0571] (C281) N-[3-Sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]-2-[2-(trifluoromethyl)phenyl]acetamide;

[0572] (C282) 2-[2-(Difluoromethyl)phenyl]-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide;

[0573] (C283) 2-(2-Chloro-4-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide;

[0574] (C284) 2-(2-Chlorophenyl)-N-(3-sulfamoyl-4-{[6-(trifluoromethyl)pyridin-3-yl]oxy}phenyl)-acetamide;

[0575] (C285) 2-(2-chlorophenyl)-N-(4-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]oxy}-3-sulfamoyl-phenyl)acetamide;

[0576] (C286) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenyl(2H2)acetamide;

[0577] (C287) N-{4-[(6-chloro-5-fluoropyridin-3-yl)oxy]-3-sulfamoylphenyl}-2-(2-chlorophenyl)-acetamide;

[0578] (C288) 2-(2-Chlorophenyl)-N-{4-[(4,4-difluoro-1-hydroxycyclohexyl)methoxy]-3-sulfamoyl-phenyl}acetamide;

[0579] (C289) 2-(2-chlorophenyl)-N-{4-[(1-hydroxycyclohexyl)methoxy]-3-sulfamoylphenyl}-acetamide;

[0580] (C290) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0581] (C291) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-[2-(difluoromethyl)-phenyl]acetamide;

[0582] (C292) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0583] (C293) 2-(2-chloro-5-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoyl-phenyl]acetamide;

[0584] (C294) N-[6-(3-chlorophenoxy)-5-sulfamoylpyridin-3-yl]-2-(2-fluorophenyl)acetamide;

[0585] (C295) N-[6-(3-chlorophenoxy)-5-sulfamoylpyridin-3-yl]-2-[2-(trifluoromethyl)phenyl]-acetamide;

[0586] (C296) N-[6-(3-chlorophenoxy)-5-sulfamoylpyridin-3-yl]-2-[2-(difluoromethyl)phenyl]-acetamide; and

[0587] (C297) 2-(2-Chloro-5-fluorophenyl)-N-[6-(3-chlorophenoxy)-5-sulfamoylpyridin-3-yl]-acetamide.

[0588] [9] The pharmaceutical composition according to any one of [1] to [4], wherein the compound is a compound selected from the following (D1) to (D558):

[0589] (D1) 2-(2-chlorophenyl)-N-[4-(2-oxopyridin-1(2H)-yl)-3-sulfamoylphenyl]acetamide;

[0590] (D2) N-[4-(4-chloro-2-oxopyridin-1(2H)-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0591] (D3) 2-(2-chlorophenyl)-N-[4-(3,5-dichloro-2-oxopyridin-1(2H)-yl)-3-sulfamoylphenyl]acetamide;

[0592] (D4) N-[4-(3-chloro-2-oxopyridin-1(2H)-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0593] (D5) 2-(2-chlorophenyl)-N-[4-(3-methyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0594] (D6) 2-(2-chlorophenyl)-N-[4-(5-methyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0595] (D7) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0596] (D8) 2-(2-chlorophenyl)-N-{4-[5-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0597] (D9) 2-(2-chlorophenyl)-N-[4-(1H-imidazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0598] (D10) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-imidazol-1-yl]phenyl}acetamide;

[0599] (D11) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0600] (D12) 2-(2-chlorophenyl)-N-{4-[3-(difluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0601] (D13) 2-(2-chlorophenyl)-N-{4-[5-cyclopropyl-3-(difluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0602] (D14) 2-(2-chlorophenyl)-N-{4-[4-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0603] (D15) 2-(2-chlorophenyl)-N-{4-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0604] (D16) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(1H-1,2,4-triazol-1-yl)phenyl]acetamide;

[0605] (D17) 2-(2-chlorophenyl)-N-{4-[3-(difluoromethyl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0606] (D18) N-{4-[3-(difluoromethyl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}-2-(2-fluorophenyl)acetamide;

[0607] (D19) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0608] (D20) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0609] (D21) 2-[2-(difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0610] (D22) N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[2-(trifluoromethyl)phenyl]acetamide;

[0611] (D23) N-[4-(3-tert-butyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0612] (D24) 2-(2-chlorophenyl)-N-[4-(3-chloro-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0613] (D25) 2-(2-chlorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0614] (D26) 2-(2-chlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0615] (D27) 2-(2-chlorophenyl)-N-[4-(4-isopropoxy-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0616] (D28) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0617] (D29) 2-(2-chlorophenyl)-N-[4-(3-isobutyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0618] (D30) 2-(2-chlorophenyl)-N-{4-[4-(methylthio)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0619] (D31) 2-(2-chlorophenyl)-N-[4-(4-methoxy-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0620] (D32) N-[4-(1H-benzimidazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0621] (D33) N-[4-(4-chloro-1H-imidazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0622] (D34) 2-(2-chlorophenyl)-N-{4-[3-(dimethylamino)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0623] (D35) 2-(2-chlorophenyl)-N-[4-(3-ethyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0624] (D36)(2-chlorophenyl)-N-[4-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0625] (D37) 2-(2-chlorophenyl)-N-[4-(5-cyclopropyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0626] (D38) 2-(2-chlorophenyl)-N-{4-[3-(methoxymethyl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0627] (D39) 2-(2-chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0628] (D40) N-[4-(4-tert-butyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0629] (D41) 2-(2-chlorophenyl)-N-[4-(3-cyano-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0630] (D42) N-[4-(4-bromo-1H-imidazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0631] (D43) 2-(2-chlorophenyl)-N-[4-(3H-imidazo[4,5-b]pyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0632] (D44) 2-(2-chlorophenyl)-N-[4-(1H-imidazo[4,5-b]pyridin-1-yl)-3-sulfamoylphenyl]acetamide;

[0633] (D45) 2-(2-chlorophenyl)-N-[4-(1H-imidazo[4,5-c]pyridin-1-yl)-3-sulfamoylphenyl]acetamide;

[0634] (D46) 2-(2-chlorophenyl)-N-[4-(3H-imidazo[4,5-c]pyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0635] (D47) 2-(2-chlorophenyl)-N-[4-(2,4-dimethyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0636] (D48) 2-(2-Fluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0637] (D49) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(difluoromethyl)phenyl]acetamide;

[0638] (D50) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0639] (D51) 2-[2-(Difluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0640] (D52) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0641] (D53) 2-(2-Methoxyphenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0642] (D54) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0643] (D55) 2-(3-Fluorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0644] (D56) 2-(2-Chloro-4-fluorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0645] (D57) 2-[2-(difluoromethoxy)phenyl]-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0646] (D58) 2-(2-Chloro-5-fluorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0647] (D59) 2-(3-chloropyridin-4-yl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0648] (D60) 2-[4-(difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0649] (D61) 2-(2-Chlorophenyl)-2,2-difluoro-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0650] (D62) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)-2,2-difluoroacetamide;

[0651] (D63) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0652] (D64) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide;

[0653] (D65) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-fluorophenyl)acetamide;

[0654] (D66) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide;

[0655] (D67) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chloropyridin-3-yl)acetamide;

[0656] (D68) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chloro-4-fluorophenyl)acetamide;

[0657] (D69) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(difluoromethoxy)phenyl]acetamide;

[0658] (D70) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide;

[0659] (D71) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chloro-4,5-difluorophenyl)acetamide;

[0660] (D72) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-chloropyridin-4-yl)acetamide;

[0661] (D73) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide;

[0662] (D74) 2-(2-Bromophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0663] (D75) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methoxyphenyl)acetamide;

[0664] (D76) 2-(4-chlorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0665] (D77) 2-(2-Chloro-6-fluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0666] (D78) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-nitrophenyl)acetamide;

[0667] (D79) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,4-dichlorophenyl)acetamide;

[0668] (D80) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,6-dichlorophenyl)acetamide;

[0669] (D81) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3,4-difluorophenyl)acetamide;

[0670] (D82) 2-(3-Chlorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0671] (D83) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3,5-difluorophenyl)acetamide;

[0672] (D84) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide;

[0673] (D85) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-hydroxyphenyl)acetamide;

[0674] (D86) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-hydroxyphenyl)acetamide;

[0675] (D87) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,3-difluorophenyl)acetamide;

[0676] (D88) 2-(2-chloro-4-fluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0677] (D89) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chloropyridin-3-yl)acetamide;

[0678] (D90) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-chloro-3-(trifluoromethyl)phenyl]acetamide;

[0679] (D91) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(difluoromethoxy)phenyl]acetamide;

[0680] (D92) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide;

[0681] (D93) 2-(2-chloro-4,5-difluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0682] (D94) 2-(2-chloro-4-methoxyphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0683] (D95) 2-(2-Chloro-6-fluoro-3-methylphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0684] (D96) 2-(2-chloro-3,6-difluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0685] (D97) 2-(2-chloro-5-methylphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0686] (D98) 2-(2-Chloro-5-fluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0687] (D99) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,5-dichlorophenyl)acetamide;

[0688] (D100) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-isopropylphenyl)acetamide;

[0689] (D101) 2-(2-chloro-5-methoxyphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0690] (D102) 2-(2-chloro-4,6-difluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0691] (D103) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-chloro-6-(trifluoromethyl)phenyl]acetamide;

[0692] (D104) 2-(5-Bromo-4-fluoro-2-methylphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0693] (D105) 2-(2-chloro-6-methoxyphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0694] (D106) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,6-difluorophenyl)propionamide;

[0695] (D107) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide;

[0696] (D108) 2-(4-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0697] (D109) 2-(2-chlorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2,2-difluoroacetamide;

[0698] (D110) 2-(2-nitrophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0699] (D111) 2-(2,4-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0700] (D112) 2-(2-Methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0701] (D113) 2-(2-Chloro-6-fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0702] (D114) 2-(3-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0703] (D115) 2-(3,5-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0704] (D116) 2-(2,6-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0705] (D117) 2-(2-Bromophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0706] (D118) 2-(3,4-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0707] (D119) 2-(4-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0708] (D120) 2-(3-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0709] (D121) 2-(4-Methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0710] (D122) 2-(2,3-Difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0711] (D123) 2-(2-Methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0712] (D124) 2-(3-Methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0713] (D125) 2-[2-(difluoromethoxy)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0714] (D126) 2-(2-chloropyridin-3-yl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0715] (D127) 2-(2-Chloro-4-fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0716] (D128) 2-(2-chloro-5-methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0717] (D129) N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[2-(trifluoromethoxy)phenyl]acetamide;

[0718] (D130) 2-(2-chloro-4,5-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0719] (D131) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0720] (D132) 2-(2-chloro-6-fluoro-3-methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0721] (D133) 2-(2-chloro-3,6-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0722] (D134) 2-[2-Chloro-6-(trifluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0723] (D135) 2-(2-Chloro-4-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0724] (D136) 2-(2,5-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0725] (D137) 2-(2-Isopropylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0726] (D138) 2-(2-Chloro-5-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0727] (D139) 2-(2-Chloro-5-fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0728] (D140) N-[4-(4-Fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide;

[0729] (D141) 2-(5-Bromo-4-fluoro-2-methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0730] (D142) 2-(2-Chloro-6-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0731] (D143) 2-(2-Chloro-4,6-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0732] (D144) 2-(3-Fluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0733] (D145) 2-(3,4-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0734] (D146) 2-(3,5-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0735] (D147) N-[4-(4-Fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-hydroxyphenyl)acetamide;

[0736] (D148) 2-(3-Chlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0737] (D149) 2-(4-Fluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0738] (D150) N-[4-(4-Fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-hydroxyphenyl)acetamide;

[0739] (D151) N-[4-(4-Fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-methylphenyl)acetamide;

[0740] (D152) N-[4-(4-Fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide;

[0741] (D153) N-[4-(4-Fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide;

[0742] (D154) N-[4-(4-Fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide;

[0743] (D155) 2-(2,3-Difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0744] (D156) 2-(2-Ethoxyphenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0745] (D157) 2-[2-(Difluoromethoxy)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0746] (D158) 2-(2-chloropyridin-3-yl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0747] (D159) 2-(2-chloro-6-fluoro-3-methylphenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0748] (D160) N-[4-(4-Fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide;

[0749] (D161) 2-(2-Chloro-4,5-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0750] (D162) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0751] (D163) 2-(2,5-dichlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0752] (D164) 2-(2-chloro-3,6-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0753] (D165) 2-(2-chloro-5-methylphenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0754] (D166) 2-(5-Bromo-4-fluoro-2-methylphenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0755] (D167) N-[4-(4-Fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-isopropylphenyl)acetamide;

[0756] (D168) 2-(2-Chloro-5-fluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0757] (D169) 2-[2-Chloro-6-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0758] (D170) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide;

[0759] (D171) 2-(2,6-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]propionamide;

[0760] (D172) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide;

[0761] (D173) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide;

[0762] (D174) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-methylphenyl)acetamide;

[0763] (D175) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-ethoxyphenyl)acetamide;

[0764] (D176) 2-(2-Ethoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0765] (D177) 2-(2-Bromophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0766] (D178) 2-(2,4-Dichlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0767] (D179) 2-(2,6-dichlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0768] (D180) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-nitrophenyl)acetamide;

[0769] (D181) 2-(4-chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0770] (D182) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methoxyphenyl)acetamide;

[0771] (D183) 2-(2-Chloro-6-fluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0772] (D184) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide;

[0773] (D185) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-fluorophenyl)acetamide;

[0774] (D186) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,4-dichlorophenyl)acetamide;

[0775] (D187) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,6-dichlorophenyl)acetamide;

[0776] (D188) 2-(2-Bromophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0777] (D189) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3,4-difluorophenyl)acetamide;

[0778] (D190) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3,5-difluorophenyl)acetamide;

[0779] (D191) 2-(3-chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0780] (D192) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide;

[0781] (D193) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-hydroxyphenyl)acetamide;

[0782] (D194) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-hydroxyphenyl)acetamide;

[0783] (D195) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide;

[0784] (D196) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide;

[0785] (D197) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide;

[0786] (D198) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-methylphenyl)acetamide;

[0787] (D199) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-ethoxyphenyl)acetamide;

[0788] (D200) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,3-difluorophenyl)acetamide;

[0789] (D201) 2-(2-chloropyridin-3-yl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0790] (D202) 2-(2-Chloro-4-fluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0791] (D203) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(difluoromethoxy)phenyl]acetamide;

[0792] (D204) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide;

[0793] (D205) 2-(2-Chloro-4,5-difluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0794] (D206) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0795] (D207) 2-(2-Chloro-6-fluoro-3-methylphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0796] (D208) 2-(2-Chloro-3,6-difluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0797] (D209) 2-(2-chloro-5-methylphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0798] (D210) 2-(2-chloro-4-methoxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0799] (D211) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,5-dichlorophenyl)acetamide;

[0800] (D212) 2-(5-chloro-2-methoxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0801] (D213) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(propan-2-yl)phenyl]acetamide;

[0802] (D214) 2-(2-Chloro-5-fluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0803] (D215) 2-[2-Chloro-6-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0804] (D216) 2-(2-Chloro-6-methoxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0805] (D217) 2-(2-Chloro-4,6-difluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0806] (D218) 2-(3-chloropyridin-4-yl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0807] (D219) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide;

[0808] (D220) 2-(2-chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2,2-difluoroacetamide;

[0809] (D221) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[0810] (D222) N-{3-Sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}-2-[2-(trifluoromethoxy)phenyl]acetamide;

[0811] (D223) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(2-methylphenyl)acetamide;

[0812] (D224) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-[2-(trifluoromethyl)phenyl]acetamide;

[0813] (D225) 2-[2-(Difluoromethyl)phenyl]-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0814] (D226) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(2-methoxyphenyl)acetamide;

[0815] (D227) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(4-fluorophenyl)acetamide;

[0816] (D228) 2-(2-Chloro-5-fluorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0817] (D229) 2-(2,3-Dichlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0818] (D230) 2-(3-chloropyridin-4-yl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0819] (D231) 2-(2-chlorophenyl)-N-[4-(3-cyclobutyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0820] (D232) N-[4-(4-acetyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0821] (D233) 2-(2-chlorophenyl)-N-[4-(3-isopropyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0822] (D234) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide;

[0823] (D235) 1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazole-4-carboxylic acid ethyl ester;

[0824] (D236) 1-(4-{[(2-fluorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazole-4-carboxylic acid ethyl ester;

[0825] (D237) 2-(2-Fluorophenyl)-N-{4-[4-(2-hydroxypropan-2-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0826] (D238) 2-(2-Chlorophenyl)-N-{4-[4-(2-hydroxypropan-2-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0827] (D239) 2-(2-chloropyridin-3-yl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide;

[0828] (D240) 2-(2-Chlorophenyl)-N-methyl-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0829] (D241) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide;

[0830] (D242) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide;

[0831] (D243) 2-(2-Chloro-5-cyanophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0832] (D244) 2-(2-Chlorophenyl)-N-{3-cyano-5-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0833] (D245) 2-(5-Bromo-2-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[0834] (D246) N-[4-(3-chloro-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0835] (D247) 2-(2-Chlorophenyl)-N-[3-cyano-4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoylphenyl]acetamide;

[0836] (D248) 2-(2-Chlorophenyl)-N-[4-(4-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0837] (D249) 2-(2-Chlorophenyl)-N-[4-(3-methoxy-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0838] (D250) 2-(2-chlorophenyl)-N-[4-(4-cyclopropyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0839] (D251) 2-(2-chlorophenyl)-N-[4-(4-methyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0840] (D252) 2-(2-Chlorophenyl)-N-[4-(3-cyclopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0841] (D253) 2-(2-chlorophenyl)-N-[4-(2H-pyrazolo[3,4-b]pyridin-2-yl)-3-sulfamoylphenyl]acetamide;

[0842] (D254) 2-(2-chlorophenyl)-N-[4-(2H-pyrazolo[3,4-c]pyridin-2-yl)-3-sulfamoylphenyl]acetamide;

[0843] (D255) 2-(2-Chlorophenyl)-N-[4-(2H-pyrazolo[4,3-b]pyridin-2-yl)-3-sulfamoylphenyl]acetamide;

[0844] (D256) 2-(2-chlorophenyl)-N-{4-[4-(2-methoxyethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0845] (D257) 2-(2-Chlorophenyl)-N-[4-(3-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0846] (D258) 2-(2-chlorophenyl)-N-(4-{4-[(2,2-difluoroethyl)amino]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide;

[0847] (D259) 2-(2-Chlorophenyl)-N-{4-[4-(2,2-difluoroethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0848] (D260) 2-(2-chlorophenyl)-N-[4-(4-{[(2,2-difluoroethyl)amino]methyl}-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0849] (D261) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)-1,2,4- oxadiazol-3-yl]phenyl}acetamide;

[0850] (D262) 2-(2-Fluorophenyl)-N-[4-(4-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0851] (D263) N-[4-(4-cyclopropyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0852] (D264) N-[4-(3-cyclopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0853] (D265) 2-(2-Fluorophenyl)-N-{4-[4-(2-methoxyethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0854] (D266) 2-(2-chlorophenyl)-N-(2-sulfamoylbiphenyl-4-yl)acetamide;

[0855] (D267) 2-(2-Chlorophenyl)-N-{4-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0856] (D268) 2-(2-Chlorophenyl)-N-{4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0857] (D269) 2-(2-Chlorophenyl)-N-{4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0858] (D270) 2-(2-Fluorophenyl)-N-{4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0859] (D271) N-{4-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(2-chlorophenyl)acetamide;

[0860] (D272) 2-(3-chlorophenyl)-N-(2-sulfamoylbiphenyl-4-yl)acetamide;

[0861] (D273) 2-(2-chlorophenyl)-N-[4-(3-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0862] (D274) 2-(2-chlorophenyl)-N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0863] (D275) 2-(2-chlorophenyl)-N-[4-(3,5-dimethyl-1,2- [4-oxazol-3-yl)-3-sulfamoylphenyl]acetamide;

[0864] (D276) 2-(2-chlorophenyl)-N-(4-{1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide;

[0865] (D277) 2-(2-Chloro-4-fluorophenyl)-N-{4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0866] (D278) 2-(2-Chloro-4-fluorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0867] (D279) 2-(2-chlorophenyl)-N-(3-sulfamoyl-4-{1-[2-(trifluoromethoxy)ethyl]-1H-pyrazol-4-yl}phenyl)acetamide;

[0868] (D280) 2-(2-chlorophenyl)-N-[4-(1-cyclobutyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0869] (D281) 2-(2-chlorophenyl)-N-(4-{1-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide;

[0870] (D282) 2-(2-chlorophenyl)-N-[4-(5-cyanopyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0871] (D283) 2-(2-chlorophenyl)-N-(4-{1-[oxetan-2-ylmethyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide;

[0872] (D284) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl]phenyl}acetamide;

[0873] (D285) 2-(2-chlorophenyl)-N-[4-(2-methoxypyrimidin-5-yl)-3-sulfamoylphenyl]acetamide;

[0874] (D286) 2-(2-chlorophenyl)-N-(4-{1-[2-(propan-2-yloxy)ethyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide;

[0875] (D287) 2-(2-Chlorophenyl)-N-{4-[1-(3-hydroxy-3-methylbutyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0876] (D288) 2-(2-Chlorophenyl)-N-{4-[5-(2-hydroxypropan-2-yl)-1-methyl-1H-pyrazol-3-yl]-3-sulfamoylphenyl}acetamide;

[0877] (D289) 2-(2-chlorophenyl)-N-{4-[5-(difluoromethoxy)pyridin-3-yl]-3-sulfamoylphenyl}acetamide;

[0878] (D290) N-[4-(2-chloro-5-methoxypyridin-3-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0879] (D291) 2-(2-Chlorophenyl)-N-{4-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0880] (D292) N-[4-(5-tert-butyl-1H-pyrazol-3-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0881] (D293) N-[4-(1-Benzyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0882] (D294) 2-(2-chlorophenyl)-N-[4-(6-methylpyridazin-4-yl)-3-sulfamoylphenyl]acetamide;

[0883] (D295) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[6-(trifluoromethyl)pyridin-2-yl]phenyl}acetamide;

[0884] (D296) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(2-fluorophenyl)acetamide;

[0885] (D297) 2-(2-Chlorophenyl)-N-{6-[1-(difluoromethyl)-1H-pyrazol-4-yl]-5-sulfamoylpyridin-3-yl}acetamide;

[0886] (D298) N-[4-(6-chloro-5-methylpyridin-3-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0887] (D299) 2-(2-Chlorophenyl)-N-{4-[2-(cyclopropylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide;

[0888] (D300) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl]phenyl}acetamide;

[0889] (D301) 2-(2-chlorophenyl)-N-{4-[2-(methylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide;

[0890] (D302) 2-(2-Chlorophenyl)-N-[6-(1-methyl-1H-pyrazol-4-yl)-5-sulfamoylpyridin-3-yl]acetamide;

[0891] (D303) 2-(2-chlorophenyl)-N-{4-[1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0892] (D304) N-{3-Sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}-2-[2-(trifluoromethyl)phenyl]acetamide;

[0893] (D305) 2-(2-chlorophenyl)-N-[3-sulfamoyl-5'-(trifluoromethyl)-2,3'-bipyridin-5-yl]acetamide;

[0894] (D306) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[2-(trifluoromethyl)pyrimidin-5-yl]phenyl}acetamide;

[0895] (D307) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethoxy)pyridin-3-yl]phenyl}acetamide;

[0896] (D308) 2-(2-chlorophenyl)-N-[4-(2-cyclopropylpyrimidin-5-yl)-3-sulfamoylphenyl]acetamide;

[0897] (D309) 2-(2-chlorophenyl)-N-[4-(2-ethoxypyrimidin-5-yl)-3-sulfamoylphenyl]acetamide;

[0898] (D310) 2-(2-chlorophenyl)-N-{4-[2-(propan-2-ylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide;

[0899] (D311) 2-(2-chlorophenyl)-N-{4-[2-(propan-2-yloxy)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide;

[0900] (D312) 2-(2-chlorophenyl)-N-{4-[2-(ethylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide;

[0901] (D313) 2-(2-chlorophenyl)-N-[4-(2-methylpyrimidin-5-yl)-3-sulfamoylphenyl]acetamide;

[0902] (D314) 2-(2-chlorophenyl)-N-{4-[2-(propylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide;

[0903] (D315) 2-(2-chlorophenyl)-N-(3-sulfamoyl-4-{2-[(2,2,2-trifluoroethyl)amino]pyrimidin-5-yl}phenyl)acetamide;

[0904] (D316) 2-(2-chlorophenyl)-N-{4-[2-(cyclobutyloxy)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide;

[0905] (D317) N-[4-(2-chloro-4-methylpyrimidin-5-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0906] (D318) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)pyridin-2-yl]phenyl}acetamide;

[0907] (D319) 2-(2-chlorophenyl)-N-[4-(5-chloropyridin-2-yl)-3-sulfamoylphenyl]acetamide;

[0908] (D320) 2-(2-chlorophenyl)-N-[4-(1,2-dimethyl-1H-imidazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0909] (D321) N-{6-[1-(difluoromethyl)-1H-pyrazol-4-yl]-5-sulfamoylpyridin-3-yl}-2-(2-fluorophenyl)acetamide;

[0910] (D322) 2-(2-Chlorophenyl)-N-{4-[5-(pyrrolidin-1-yl)pyridin-3-yl]-3-sulfamoylphenyl}acetamide;

[0911] (D323) 2-(2-chlorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-hydroxyethaneamide;

[0912] (D324) 2-(2-chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-hydroxyethaneamide;

[0913] (D325) 2-(2-chlorophenyl)-N-[4-(5-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0914] (D326) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0915] (D327) 2-(2-chlorophenyl)-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0916] (D328) 2-(2-chlorophenyl)-N-{4-[1-(2-methylpropyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0917] (D329) 2-(2-chlorophenyl)-N-[4-(1-cyclopentyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0918] (D330) 2-(2-chlorophenyl)-N-[2'-fluoro-3'-(propan-2-yloxy)-2-sulfamoylbiphenyl-4-yl]acetamide;

[0919] (D331) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[0920] (D332) N-[4-(6-chloro-5-methoxypyridin-3-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0921] (D333) 2-(2-Chloro-6-fluorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0922] (D334) 2-(2-Chloro-3-fluorophenyl)-N-[4-(1-methyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0923] (D335) N-[4-(1-tert-butyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0924] (D336) 2-(2-chlorophenyl)-N-{4-[2-(propan-2-yloxy)pyridin-3-yl]-3-sulfamoylphenyl}acetamide;

[0925] (D337) 2-(2-chloro-3-fluorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0926] (D338) 2-(2-Fluorophenyl)-N-[4-(pyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0927] (D339) 2-(2-Chloro-6-fluorophenyl)-N-[4-(1-methyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0928] (D340) 2-(2-chlorophenyl)-N-[3'-fluoro-5'-(2-hydroxypropan-2-yl)-2-sulfamoylbiphenyl-4-yl]acetamide;

[0929] (D341) 2-(2-chlorophenyl)-N-[4-(5-methoxypyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0930] (D342) 2-(2-chlorophenyl)-N-[3'-(2-hydroxypropan-2-yl)-2-sulfamoylbiphenyl-4-yl]acetamide;

[0931] (D343) 2-(2-Fluorophenyl)-N-{4-[1-(propan-2-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0932] (D344) N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0933] (D345) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenyl}acetamide;

[0934] (D346) N-[4-(1-tert-butyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0935] (D347) N-[3'-Fluoro-5'-(2-hydroxypropane-2-yl)-2-sulfamoylbiphenyl-4-yl]-2-(2-fluorophenyl)acetamide;

[0936] (D348) N-[4-(1-cyclopentyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0937] (D349) 2-(2-chlorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0938] (D350) 2-(2-Chloro-6-fluorophenyl)-N-{4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0939] (D351) 2-(2-chlorophenyl)-N-[4-(1,3-dimethyl-1H-pyrazol-5-yl)-3-sulfamoylphenyl]acetamide;

[0940] (D352) 2-(2-chlorophenyl)-N-(4'-chloro-2-sulfamoylbiphenyl-4-yl)acetamide;

[0941] (D353) 2-(2-chlorophenyl)-N-{4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-sulfamoylphenyl}acetamide;

[0942] (D354) 2-(2-chlorophenyl)-N-[4-(pyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0943] (D355) 2-(2-Chlorophenyl)-N-{4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0944] (D356) 2-(2-chlorophenyl)-N-(3'-chloro-2-sulfamoylbiphenyl-4-yl)acetamide;

[0945] (D357) 2-(2-chlorophenyl)-N-(4-{1-[(2,2-dichlorocyclopropyl)methyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide;

[0946] (D358) 2-(2-chlorophenyl)-N-[4-(1,3-dimethyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0947] (D359) 2-(2-Chlorophenyl)-N-{4-[1-(propan-2-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0948] (D360) 2-(2-chlorophenyl)-N-[4-(1-methyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0949] (D361) 2-(2-chlorophenyl)-N-{4-[1-(2-hydroxy-3,3-dimethylbutyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0950] (D362) 2-(2-Fluorophenyl)-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0951] (D363) 2-(2-chlorophenyl)-N-[4-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0952] (D364) 4'-{[(2-chlorophenyl)acetyl]amino}-N-[2-(dimethylamino)ethyl]-2'-sulfamoylbiphenyl-3-carboxamide;

[0953] (D365) 2-(2-chlorophenyl)-N-[4-(pyrazolo[1,5-a]pyrimidin-3-yl)-3-sulfamoylphenyl]acetamide;

[0954] (D366) 2-(2-Chlorophenyl)-N-{4-[5-(pyrrolidin-1-ylcarbonyl)pyridin-3-yl]-3-sulfamoylphenyl}acetamide;

[0955] (D367) 2-(2-Chlorophenyl)-N-[4-(1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0956] (D368) 2-(2-Fluorophenyl)-N-{4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-sulfamoylphenyl}acetamide;

[0957] (D369) 2-(2-Fluorophenyl)-N-{4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0958] (D370) 2-(2-chlorophenyl)-N-{4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0959] (D371) 2-(5-chloro-2-fluorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0960] (D372) 2-(2-chlorophenyl)-N-[4-(6-methylpyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[0961] (D373) 2-(2-chlorophenyl)-N-{4-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[0962] (D374) 2-(2-Fluorophenyl)-N-[4-(1-methyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide;

[0963] (D375) N-[4-(1,3-dimethyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0964] (D376) N-[4-(5-cyclopropyl-1,3,4- oxadiazole-2-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[0965] (D377) 2-(2-chlorophenyl)-N-[4-(5-cyclopropyl-1,3,4- oxadiazol-2-yl)-3-sulfamoylphenyl]acetamide;

[0966] (D378) N-{4-[4-(difluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}-2-(2-fluorophenyl)acetamide;

[0967] (D379) 2-(2-Chlorophenyl)-N-{4-[4-(difluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0968] (D380) 2-(2-Chlorophenyl)-N-{5-sulfamoyl-6-[4-(trifluoromethyl)-1H-pyrazol-1-yl]pyridin-3-yl}acetamide;

[0969] (D381) 2-(2-Fluorophenyl)-N-{5-sulfamoyl-6-[4-(trifluoromethyl)-1H-pyrazol-1-yl]pyridin-3-yl}acetamide;

[0970] (D382) N-[6-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]-2-(2-fluorophenyl)acetamide;

[0971] (D383) 2-(2-Chlorophenyl)-N-[6-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]acetamide;

[0972] (D384) 2-(2-Fluorophenyl)-N-[6-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]acetamide;

[0973] (D385) 2-(2-Chlorophenyl)-N-[6-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]acetamide;

[0974] (D386) N-[6-(4-Bromo-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]-2-(2-fluorophenyl)acetamide;

[0975] (D387) 2-(2-Chlorophenyl)-N-[6-(4-chloro-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]acetamide;

[0976] (D388) N-[6-(4-chloro-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]-2-(2-fluorophenyl)acetamide;

[0977] (D389) N-[6-(4-Bromo-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]-2-(2-chlorophenyl)acetamide;

[0978] (D390) 2-(2-fluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)-1,3,4- oxadiazol-2-yl]phenyl}acetamide;

[0979] (D391) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)-1,3,4- oxadiazol-2-yl]phenyl}acetamide;

[0980] (D392) 2-(2-Chlorophenyl)-N-{4-[3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0981] (D393) 2-(2-Fluorophenyl)-N-[4-(1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0982] (D394) N-[4-(4-tert-butyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[0983] (D395) 2-(2-chlorophenyl)-N-[4-(1H-indazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0984] (D396) 2-(2-chlorophenyl)-N-[4-(2H-indazol-2-yl)-3-sulfamoylphenyl]acetamide;

[0985] (D397) 2-(2-Fluorophenyl)-N-[4-(2H-indazol-2-yl)-3-sulfamoylphenyl]acetamide;

[0986] (D398) 2-(2-Fluorophenyl)-N-[4-(1H-indazol-1-yl)-3-sulfamoylphenyl]acetamide;

[0987] (D399) 1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-N,N-dimethyl-1H-pyrazole-4-carboxamide;

[0988] (D400) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]cyclopropanecarboxamide;

[0989] (D401) 2-(2-chlorophenyl)-N-{4-[4-(pyrazin-2-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0990] (D402) 2-(2-chlorophenyl)-N-{4-[4-(pyridin-2-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0991] (D403) 2-(2-Chlorophenyl)-N-{4-[4-(pyridin-3-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0992] (D404) 2-(2-Chlorophenyl)-N-{4-[4-(pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0993] (D405) 2-(2-Fluorophenyl)-N-{4-[4-(pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[0994] (D406) 2-(4-Methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide;

[0995] (D407) 2-(4-Methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide;

[0996] (D408) 2-(4-Methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-(D)2-yl]phenyl}acetamide;

[0997] (D409) 2-(4-Methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide;

[0998] (D410) 2-[4-(difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide;

[0999] (D411) 2-[4-(difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide;

[1000] (D412) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide;

[1001] (D413) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide;

[1002] (D414) 2-[2-Chloro-4-(trifluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide;

[1003] (D415) 2-[2-Chloro-4-(trifluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide;

[1004] (D416) 2-(2,4-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide;

[1005] (D417) 2-(2,4-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide;

[1006] (D418) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(1,3-thiazol-5-yl)phenyl]acetamide;

[1007] (D419) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(1,2-thiazol-3-yl)phenyl]acetamide;

[1008] (D420) 2-(2-chlorophenyl)-N-[4-(2-methyl-1,3-thiazol-4-yl)-3-sulfamoylphenyl]acetamide;

[1009] (D421) 2-(2-chlorophenyl)-N-[4-(2-methoxy-1,3-thiazol-4-yl)-3-sulfamoylphenyl]acetamide;

[1010] (D422) 2-(2-chlorophenyl)-N-[4-(2-methoxy-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide;

[1011] (D423) 2-(2-chlorophenyl)-N-[4-(2-methyl-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide;

[1012] (D424) 2-(2-chlorophenyl)-N-[4-(3-methyl-1,2-thiazol-5-yl)-3-sulfamoylphenyl]acetamide;

[1013] (D425) 2-(2-chlorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-3-sulfamoylphenyl]acetamide;

[1014] (D426) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(1,2-thiazol-4-yl)phenyl]acetamide;

[1015] (D427) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(1,3-thiazol-2-yl)phenyl]acetamide;

[1016] (D428) 2-(2-chlorophenyl)-N-[4-(4-cyano-1,3-thiazol-2-yl)-3-sulfamoylphenyl]acetamide;

[1017] (D429) 2-(2-chlorophenyl)-N-{4-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3-sulfamoylphenyl}acetamide;

[1018] (D430) 2-(2-chlorophenyl)-N-[4-(2-cyclopropyl-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide;

[1019] (D431) 2-(2-chlorophenyl)-N-[4-(2-cyclopropyl-1,3-thiazol-4-yl)-3-sulfamoylphenyl]acetamide;

[1020] (D432) 2-(2-chlorophenyl)-N-[4-(4-methyl-1,3- [oxazol-2-yl)-3-sulfamoylphenyl]acetamide;

[1021] (D433) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[2-(trifluoromethyl)-1,3-thiazol-4-yl]phenyl}acetamide;

[1022] (D434) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl}acetamide;

[1023] (D435) 2-(2-chlorophenyl)-N-{4-[2-(2-hydroxypropan-2-yl)-1,3-thiazol-5-yl]-3-sulfamoylphenyl}acetamide;

[1024] (D436) 2-(2-chlorophenyl)-N-{4-[2-(2-hydroxypropan-2-yl)-1,3-thiazol-4-yl]-3-sulfamoylphenyl}acetamide;

[1025] (D437) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(1,3-thiazol-4-yl)phenyl]acetamide;

[1026] (D438) 2-(2-chlorophenyl)-N-[4-(5-cyclopropyl-1,2- oxazol-3-yl)-3-sulfamoylphenyl]acetamide;

[1027] (D439) ​​2-(2-chlorophenyl)-N-[4-(2-cyclopropyl-1,3- oxazol-5-yl)-3-sulfamoylphenyl]acetamide;

[1028] (D440) 2-(2-chlorophenyl)-N-(4-{4-[(3,3-difluoroazetidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide;

[1029] (D441) N-{4-[4-(azetidin-1-ylcarbonyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}-2-(2-chlorophenyl)acetamide;

[1030] (D442) 2-(2-Chlorophenyl)-N-{4-[4-(pyrrolidin-1-ylcarbonyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[1031] (D443) 2-(2-chlorophenyl)-N-(4-{4-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide;

[1032] (D444) 2-(4-Chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1033] (D445) 2-(2-Chloro-6-fluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1034] (D446) N-{3-Sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}-2-[4-(trifluoromethyl)phenyl]acetamide;

[1035] (D447) 2-(3-Fluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1036] (D448) 2-(2,4-Dichlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1037] (D449) 2-(2-Bromophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1038] (D450) 2-(2,4-difluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1039] (D451) 2-(3,4-difluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1040] (D452) 2-(3,5-difluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1041] (D453) 2-(3-Chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1042] (D454) 2-(4-Methylphenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1043] (D455) 2-(4-Methoxyphenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1044] (D456) 2-(2-Fluoro-4-methylphenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1045] (D457) 2-(2-Fluoro-4-methoxyphenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1046] (D458) 2-[4-(Difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide;

[1047] (D459) 2-(4-chlorophenyl)-N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[1048] (D460) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[1049] (D461) 2-(2-Chloro-6-fluorophenyl)-N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[1050] (D462) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide;

[1051] (D463) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide;

[1052] (D464) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(3-fluorophenyl)acetamide;

[1053] (D465) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2,4-dichlorophenyl)acetamide;

[1054] (D466) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2,4-difluorophenyl)acetamide;

[1055] (D467) 2-(2-Bromophenyl)-N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[1056] (D468) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(3,4-difluorophenyl)acetamide;

[1057] (D469) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide;

[1058] (D470) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide;

[1059] (D471) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2-fluoro-4-methylphenyl)acetamide;

[1060] (D472) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2-fluoro-4-methoxyphenyl)acetamide;

[1061] (D473) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide;

[1062] (D474) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-[2-chloro-4-(trifluoromethyl)phenyl]acetamide;

[1063] (D475) 2-(2,4-dichlorophenyl)-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[1064] (D476) 2-(2-Fluoro-4-methylphenyl)-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[1065] (D477) 2-[4-(Difluoromethyl)phenyl]-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide;

[1066] (D478) 2-(2-Chlorophenyl)-N-[4-(4-cyclopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1067] (D479) N-[4-(4,6-difluoro-2H-benzotriazol-2-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[1068] (D480) N-[4-(4,6-difluoro-1H-benzotriazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide;

[1069] (D481) 2-(2-Chlorophenyl)-N-[4-(4,6-difluoro-1H-benzotriazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1070] (D482) 2-(2-Chlorophenyl)-N-[4-(4,6-difluoro-2H-benzotriazol-2-yl)-3-sulfamoylphenyl]acetamide;

[1071] (D483) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[2-(trifluoromethyl)-1,3-thiazol-5-yl]phenyl}acetamide;

[1072] (D484) 2-(2-Chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide;

[1073] (D485) 2-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1074] (D486) 2-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide;

[1075] (D487) 2-(2-Chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide;

[1076] (D488) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide;

[1077] (D489) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoyl-2-(trifluoromethyl)phenyl}acetamide;

[1078] (D490) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[1079] (D491) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-5-sulfamoyl-2-(trifluoromethyl)phenyl}acetamide;

[1080] (D492) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide;

[1081] (D493) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-2-fluoro-3-sulfamoylphenyl}acetamide;

[1082] (D494) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-2-fluoro-5-sulfamoylphenyl}acetamide;

[1083] (D495) 2-(2-chlorophenyl)-N-{4-[2-(dimethylamino)-1,3-thiazol-4-yl]-3-sulfamoylphenyl}acetamide;

[1084] (D496) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(1,2-thiazol-5-yl)phenyl]acetamide;

[1085] (D497) 1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-N-cyclopropyl-N-methyl-1H-pyrazole-4-carboxamide;

[1086] (D498) 2-(2-Chlorophenyl)-2-hydroxy-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[1087] (D499) 2-(2-Chlorophenyl)-N-{3-chloro-5-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[1088] (D500) 2-(2-chlorophenyl)-N-[4-(4-cyano-3-hydroxy-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1089] (D501) 2-(2-chlorophenyl)-N-[4-(1H-pyrazolo[4,3-c]pyridin-1-yl)-3-sulfamoylphenyl]acetamide;

[1090] (D502) 2-(2-chlorophenyl)-N-[4-(4,5-dimethyl-1,3-thiazol-2-yl)-3-sulfamoylphenyl]acetamide;

[1091] (D503) 2-(2-chlorophenyl)-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide;

[1092] (D504) 2-(2-chlorophenyl)-N-[4-(4-methyl-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide;

[1093] (D505) N-{4-(4-amino-1H-pyrazol-1-yl)-3-[(2,4-dimethoxybenzyl)sulfamoyl]phenyl}-2-(2-chlorophenyl)acetamide;

[1094] (D506) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-2,2-difluoroacetamide;

[1095] (D507) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-3,3,3-trifluoropropionamide;

[1096] (D508) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-3,3,3-trifluoro-2-methylpropionamide (racemic);

[1097] (D509) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-3,3,3-trifluoro-2-methylpropionamide (Enantiomer A);

[1098] (D510) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-3,3,3-trifluoro-2-methylpropionamide (Enantiomer B);

[1099] (D511) 2-(2-chlorophenyl)-N-(4-{4-[(cis)-2,5-dimethylpyrrolidin-1-yl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide;

[1100] (D512) 2-(2-chlorophenyl)-N-(4-{4-[(trans)-2,5-dimethylpyrrolidin-1-yl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide (Enantiomer A);

[1101] (D513) 2-(2-chlorophenyl)-N-(4-{4-[(trans)-2,5-dimethylpyrrolidin-1-yl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide (Enantiomer B);

[1102] (D514) N-(4-{4-[(2,2-difluoroethyl)amino]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)-2-(2-fluorophenyl)acetamide;

[1103] (D515) 2-(2-chlorophenyl)-N-(3-sulfamoyl-4-{4-[(2,2,2-trifluoroethyl)amino]-1H-pyrazol-1-yl}phenyl)acetamide;

[1104] (D516) 2-(2-Chlorophenyl)-N-[4-(4-isopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1105] (D517) 2-(2-Fluorophenyl)-N-[4-(4-isopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1106] (D518) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(2,2,2-trifluoroethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[1107] (D519) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(2,2,2-trifluoroethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[1108] (D520) 2-(2-chlorophenyl)-N-[4-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-3-sulfamoylphenyl]acetamide;

[1109] (D521) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1,2,4- oxadiazol-5-yl]phenyl}acetamide;

[1110] (D522) 2-(2-chlorophenyl)-N-{4-[5-(difluoromethyl)-1,3,4- oxadiazol-2-yl]-3-sulfamoylphenyl}acetamide;

[1111] (D523)N-{4-[5-(difluoromethyl)-1,3,4- oxadiazol-2-yl]-3-sulfamoylphenyl}-2-(2-fluorophenyl)acetamide;

[1112] (D524) 2-(2-chlorophenyl)-N-[4-(5-methyl-1,3,4- oxadiazol-2-yl)-3-sulfamoylphenyl]acetamide;

[1113] (D525) 2-(2-fluorophenyl)-N-[4-(5-methyl-1,3,4- oxadiazol-2-yl)-3-sulfamoylphenyl]acetamide;

[1114] (D526)N-[4-(5-methyl-1,3,4- oxadiazole-2-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide;

[1115] (D527) 2-(2-chlorophenyl)-N-[4-(1H-pyrrol-3-yl)-3-sulfamoylphenyl]acetamide;

[1116] (D528) 2-(2-Chlorophenyl)-N-{4-[5-(difluoroacetyl)-1H-pyrrol-3-yl]-3-sulfamoylphenyl}acetamide;

[1117] (D529) 2-(2-chlorophenyl)-N-[4-(1-methyl-1H-pyrrol-3-yl)-3-sulfamoylphenyl]acetamide;

[1118] (D530) 2-(2-chlorophenyl)-N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)-3-sulfamoylphenyl]acetamide;

[1119] (D531) 2-(2-chlorophenyl)-N-{3-sulfamoyl-2-(trifluoromethyl)-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[1120] (D532) 2-(2-chlorophenyl)-N-{5-sulfamoyl-2-(trifluoromethyl)-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[1121] (D533) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-{5-sulfamoyl-2-(trifluoromethyl)-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[1122] (D534) 2-[2-Chloro-5-(trifluoromethyl)phenyl]-N-{5-sulfamoyl-2-(trifluoromethyl)-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

[1123] (D535) 2-[2-Chloro-6-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide;

[1124] (D536) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide;

[1125] (D537) 2-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide;

[1126] (D538) 2-[2-Chloro-4-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide;

[1127] (D539) N-[4-(3-tert-butyl-4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[1128] (D540) N-[4-(3-Bromo-4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[1129] (D541) 2-(2-Chlorophenyl)-N-{4-[4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide;

[1130] (D542) 2-(2-chlorophenyl)-N-[4-(3,4-dimethyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1131] (D543) N-[4-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide;

[1132] (D544) 2-(2-Chlorophenyl)-N-[4-(1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1133] (D545) 2-(2-Chlorophenyl)-N-[4-(3-cyano-5-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1134] (D546) 2-(2-Chlorophenyl)-N-[4-(3-hydroxy-5-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1135] (D547) 2-(2-Chlorophenyl)-N-[4-(4-cyano-5-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1136] (D548) 2-(2-Chlorophenyl)-N-[4-(4-cyano-3-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1137] (D549) 2-(2-chlorophenyl)-N-{4-[4-(morpholin-4-yl)-1,3-thiazol-2-yl]-3-sulfamoylphenyl}acetamide;

[1138] (D550) 2-(2-chlorophenyl)-N-{4-[5-(morpholin-4-yl)-1,3-thiazol-2-yl]-3-sulfamoylphenyl}acetamide;

[1139] (D551) 2-(2-chlorophenyl)-N-[4-(5-methyl-1,3-thiazol-2-yl)-3-sulfamoylphenyl]acetamide;

[1140] (D552) 2-(2-chlorophenyl)-N-[4-(pyridin-4-yl)-3-sulfamoylphenyl]acetamide;

[1141] (D553) 1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazole-4-carboxamide;

[1142] (D554) 2-(2-Chloro-3-hydroxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1143] (D555) 2-(2-Chloro-4-hydroxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1144] (D556) 2-(2-Chloro-5-hydroxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide;

[1145] (D557) 2-(2-chloro-6-hydroxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; and

[1146] (D558) 2-(2-Chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-hydroxyacetamide.

[1147] The pharmaceutical composition of the present invention is useful as a pharmaceutical composition useful for preventing, suppressing, or treating symptoms associated with anaphylaxis. In particular, it is useful as a pharmaceutical composition useful for preventing, suppressing, or treating symptoms associated with anaphylaxis caused by a drug. The drug is not particularly limited as long as it is a compound that stimulates MrgprX2, and high efficacy is expected regardless of the severity of the symptoms associated with anaphylaxis. BRIEF DESCRIPTION OF THE DRAWINGS

[1148] Figure 1 This study demonstrates that P2X4 receptor deletion alleviates pseudoallergy. Administration of C48 / 80 alleviates (A) passive systemic anaphylaxis and (B) passive cutaneous anaphylaxis induced by P2X4 receptor gene deletion. Data are mean ± SEM, and Student's t-tests were performed (*: p < 0.05, **: p < 0.01, NS: not significantly different).

[1149] Figure 2 The involvement of mast cells in pseudoallergy was shown. W－sh / W－sh Mast cells were reconstituted by transplanting BMMCs from wild-type mice or P2X4 receptor-deficient mice. Mice reconstituted with mast cells from P2X4 receptor-deficient mice attenuated C48 / 80-induced pseudoallergy (mean ± SEM). Data are mean ± SEM, and Student's t-test was performed (*: p < 0.05).

[1150] Figure 3 Figure 2 shows gene expression in PMCs. Quantitative PCR was used to analyze the expression of P2 receptors (left: P2Xn receptors, center: P2Yn receptors) and MrgprB2 genes, which use purine nucleotides derived from wild-type mice or P2X4 receptor-deficient mice as endogenous ligands. Data are mean ± SEM, and Student's t-test was performed (**: p < 0.01).

[1151] Figure 4 ATP promotes PMC degranulation. ATP promotes PMC degranulation (A) induced by IgE receptor stimulation and (B) induced by MrgprB2 stimulation via C48 / 80. Data are mean ± SEM, and Student's t-test was performed (**: p < 0.01). ATP-induced degranulation was not observed in PMCs derived from P2X4 receptor-deficient mice.

[1152] Figure 5 Figure 2 shows PMC degranulation induced by various MrgprB2-stimulating substances. ATP promotes PMC degranulation induced by (A) substance P (Sub P) and PAMP-12 (PAMP), and (B) vancomycin. Data are mean ± SEM, and Student's t-test was performed (**: p < 0.01). ATP-induced degranulation was not enhanced in PMCs derived from P2X4 receptor-deficient mice.

[1153] Figure 6 This figure shows the dose-dependence of PMC degranulation on allergens. Degranulation was measured when wild-type mouse-derived PMCs were stimulated with various concentrations of (A) DNP-HSA and (B) C48 / 80 in the presence or absence of ATP. (A) PMCs were pre-sensitized with IgE (SPE-7). Data are mean ± SEM, and Student's t-tests were performed (*: p < 0.05, **: p < 0.01). ATP increases sensitivity to allergens stimulated by IgE receptors, while correspondingly enhancing the maximum response to MrgprB2 stimulation.

[1154] Figure 7 This figure shows the treatment of pseudoanaphylaxis using a P2X4 receptor antagonist. Compound B, which inhibits the P2X4 receptor, inhibits (A) ATP-dependent PMC degranulation and (B) C48 / 80-induced passive anaphylaxis. Data are mean ± SEM, and Student's t-test was performed (*: p < 0.05, **: p < 0.01). DETAILED DESCRIPTION

[1155] The pharmaceutical composition of the present invention can be used as a pharmaceutical composition useful for preventing, suppressing, or treating symptoms associated with pseudoallergic reactions. As used herein, "pseudoallergic reaction" refers to an allergic reaction that, while similar to true allergies, does not necessarily involve IgE antibodies. In other words, pseudoallergic reactions do not require IgE to induce an allergic reaction. Therefore, pseudoallergic reactions may be caused by a single exposure to an allergen.

[1156] The symptoms of pseudoallergic reactions are similar to those occurring in true allergies due to the degranulation of mast cells, and include rash, punctate erythema, urticaria, angioedema, eyelid edema, conjunctival edema, itching and other skin and mucous membrane symptoms, throat and laryngeal edema, vomiting, abdominal pain, diarrhea and other digestive tract symptoms, wheezing, respiratory symptoms such as dyspnea, arrhythmia, pallor, hypothermia, hypotension and other cardiovascular system symptoms, or headache, loss of consciousness and other central nervous system symptoms. For example, the facial and neck flushing that occurs when vancomycin is given is called red man syndrome. As the symptoms of pseudoallergic reactions, these symptoms occur rapidly in multiple organs and also include allergic reactions that can threaten life.

[1157] As another aspect of the present invention, the pharmaceutical composition of the present invention can be used to suppress the extracellular release of secretory granules in mast cells accompanying the symptoms of pseudoallergic reaction. The pharmaceutical composition of the present invention can be used to prevent, suppress or treat the symptoms of the above-mentioned pseudoallergic reaction accompanying the extracellular release of secretory granules in mast cells. These symptoms accompanying pseudoallergic reaction all become the applicable subjects of the pharmaceutical composition of the present invention. However, the applicable subjects of the pharmaceutical composition of the present invention are not limited thereto.

[1158] Mast cells (also known as mastocytes or labrocytes) are derived from bone marrow stem cells. They are part of the immune system and contain numerous granules rich in histamine and heparin. Although best known for their role in allergies and anaphylaxis, mast cells also play important protective roles and are closely involved in wound healing, including angiogenesis, and defense against pathogens.

[1159] Mast cells are characteristically present in most of tissues around blood vessels and nerves, and are especially obvious near the boundary between the external worlds such as skin, lung mucosa and digestive tract and internal environment and mouth, conjunctiva and nose. Mast cells in organism are sometimes divided into two types according to staining, stimulus responsiveness. That is, in rodents, they are classified as tissue-bound mast cells (CTMC) distributed in skin, peritoneal cavity etc. and mucosal mast cells (MMC) induced in digestive tract when parasitic infection. CTMC has the heparin-rich granules of safranin staining positive, demonstrates high histamine content, and the sulfation level of proteoglycans, the histamine content of the granules of MMC are lower.

[1160] Mast cells play a central role in inflammatory processes. Upon activation, mast cells rapidly release their characteristic granules and various hormonal mediators into the interstitium. Mast cells can undergo degranulation in response to direct injury (e.g., physical or chemical (opioids, alcohol, and certain antibiotics such as polymyxins), coupled binding to immunoglobulin E (IgE) receptors, MrgprX2 agonists, or stimulation with complement proteins.

[1161] In anaphylactic and pseudoanaphylactic reactions, mast cells remain inactive until allergens bind to IgE or MrgprX2 already coated on the cells. Molecules released into the extracellular environment in response to allergen stimulation include preformed mediators (from granules) (e.g., serine proteases such as tryptase, histamine (2-5 pg / cell), serotonin, proteoglycans, and heparin (active as an anticoagulant)), newly formed lipid mediators (eicosanoids) (e.g., thromboxane, prostaglandin D2, leukotriene C4, platelet-activating factor), and cytokines (e.g., eotaxin).

[1162] Histamine dilates postcapillary venules, activates the endothelium, and increases vascular permeability. This leads to local edema (swelling), warmth, and redness, as well as the recruitment of additional inflammatory cells to the site of release. Histamine also depolarizes nerve endings (causing itching or pain). Skin symptoms of histamine release include a "redness and swelling" reaction. The redness and swelling immediately following a mosquito bite is a good example of this reaction, which occurs within seconds of mast cell overload caused by the allergen.

[1163] In this specification, "prevention" is a concept that includes avoiding "pathological" or "abnormal" symptoms, conditions or the onset of a disease, as well as actions or means for achieving the above purpose.

[1164] In this specification, "treatment" refers to the elimination, recovery, cure or alleviation of "morbid" or "abnormal" symptoms, states or diseases, as well as the behavior or means used to achieve the above-mentioned purpose, including the suppression of the deterioration of "morbid" or "abnormal" symptoms, states or diseases, as well as the behavior or means used to achieve the above-mentioned purpose, and the concept of improvement. Here, "improvement" refers to the bringing "morbid" or "abnormal" symptoms, states or diseases close to a "healthy" or "normal" state or the behavior or means used to achieve the above-mentioned purpose, as well as the concept of bringing "morbid" or "abnormal" symptoms, states or diseases to a "healthy" or "normal" state or the behavior or means used to achieve the above-mentioned purpose. Therefore, in one embodiment, "improvement" includes that the numerical value of an indicator of "morbid" or "abnormal" symptoms or states becomes smaller or larger as the above-mentioned "improvement" approaches a normal value or reaches a normal value. In addition, "inhibition" refers to the stopping or slowing down of the deterioration or development of symptoms, states or diseases, as well as the behavior or means used to achieve the above-mentioned purpose, as well as the concept of improving the above-mentioned symptoms, states or diseases or the behavior or means used to achieve the above-mentioned purpose. Here, "improve" has the above meaning. The above-mentioned "worsening or development of symptoms, conditions or diseases" includes the worsening or development of "pathological" or "abnormal" symptoms, conditions or diseases, as well as the worsening or development from a "healthy" or "normal" state to a "pathological" or "abnormal" symptom, condition or disease. In one embodiment, "inhibit" refers to stopping or slowing the worsening or development of symptoms, conditions or diseases, or the behavior or means used to achieve this purpose. In another embodiment, "inhibit" refers to stopping or slowing the worsening or development of symptoms, conditions or diseases.

[1165] In one embodiment, "treatment" refers to eliminating, reversing, curing or alleviating "pathological" or "abnormal" symptoms, conditions or diseases, as well as actions or means used to achieve the above-mentioned purposes. In another embodiment, "treatment" refers to eliminating, reversing, curing or alleviating "pathological" or "abnormal" symptoms, conditions or diseases.

[1166] In this specification, the above-mentioned symptoms, conditions or diseases or the numerical values, conditions or functions serving as indicators thereof can be evaluated by comparing before and after administration of the pharmaceutical provided by the present invention, or by comparing a group administered with a placebo or a control product not containing the pharmaceutical provided by the present invention with a group administered with the pharmaceutical provided by the present invention.

[1167] The pseudoallergy of the present invention is caused by substances having cationic groups, such as cationic amphiphilic drugs, and endogenous or exogenous peptides composed of a cationic head group and a hydrophobic core. Examples of cationic groups include amino groups, imino groups, and various cyclic or chain functional groups having amine structures from primary to tertiary amines. The substance having the cationic group as the allergen of pseudoallergy can be induced as an endogenous substance (for example, substance P, PAMP-12), or can be introduced into the body as an exogenous substance (for example, melittin from wasp venom), or can be administered in the form of a drug. The method of administering the drug includes systemic administration and local administration, for example, oral administration, sublingual administration, intravenous administration, intramuscular administration, subcutaneous administration, transdermal administration, intradermal administration, nasal administration, pulmonary administration, intrarespiratory administration, intraperitoneal administration, intramedullary administration, eye drops, and ear drops.

[1168] The pseudoallergy of the present invention is caused by activation of MrgprX2. Mas-related G protein-coupled receptor X2 (MrgprX2) is a mast cell-specific receptor for substances with cationic groups, such as cationic amphiphilic drugs, and endogenous or exogenous peptides composed of a basic head group and a hydrophobic core. Please refer to McNeil BD, 2015 Nature, 519: 237-241, which is incorporated herein by reference. MrgprX2 recognizes and binds to small molecules containing cyclized tetrahydroisoquinoline (THIQ), such as nonsteroidal neuromuscular blocking drugs (NMBDs) including tubocurarine and atracurium. In response to these compounds, MrgprX2 mediates pseudoallergic reactions characterized by histamine release, inflammation, and airway constriction. As described herein, MrgprX2 also functions as a receptor for several other ligands, including peptides and alkaloids such as cortistatin-14 and adrenomedullin N-terminal peptide (PAMP-12), and to a lesser extent, PAMP-20, the antimicrobial protein LL-37, PMX-53 peptide, β-defensins, and complanadine A.

[1169] The amino acid sequence of human MrgprX2 is known (NP_001290544.1 (GI: 746816153), incorporated herein by reference (SEQ ID NO: 1). The nucleic acid sequence of human MrgprX2 is known (NM_001303615.1 (GI: 746816152), incorporated herein by reference (SEQ ID NO: 2).

[1170] The mouse ortholog of human MrgprX2 is MrgprB2 (amino acid sequence: for example, NP_780740.2 (GI: 229094244); nucleic acid sequence: for example, NM_175531.4 (GI: 229094243)).

[1171] The substance (allergen) that causes pseudoallergy in the present invention is a MrgprX2 agonist. Whether the allergen causing pseudoallergy is a MrgprX2 agonist can be investigated using known methods, for example, using recombinant cells expressing MrgprX2 (Patent Document 1). When evaluated using genetically recombinant HEK293 cells that functionally express MrgprX2 (MrgprX2-HEK), the EC50 of the allergen of the present invention as a MrgprX2 agonist is 50 μM or less, 10 μM or less, 5 μM or less, 1 μM or less, or 0.5 μM or less for peptides, and 500 μg / mL or less, 100 μg / mL or less, 50 μg / mL or less, 10 μg / mL or less, 5 μg / mL or less, or 1 μg / mL or less for compounds.

[1172] Examples of the pseudoallergens of the present invention include, but are not limited to, amorolfine hydrochloride, atracurium, β-defensin, bleomycin, cetrorelix, C48 / 80 (monomer or cyclized monomer), ciprofloxacin, cisatracurium, codeine, colistimethate, complanadine A, cortistatin-14, degarelix, enfuvirtide, exenatide, fluoroquinolone, ganirelix, gentamicin sulfate, and succinylcholine. sulfate), glatiramer acetate, glucagon, goserelin, histrelin, icatibant, ketoconazole, lanreotide, leuprolide, levofloxacin, liraglutide, LL-37, mafenide acetate, mastoparan, micronomicin sulfate sulfate), mivacurium, morphine, moxifloxacin, octreotide, ofloxacin, PAMP-12, PAMP-20, pasireotide, PMX-53, pramlintide, rocuronium, sermorelin, sisomicin sulfate, substance P, succinylcholine, sulfadoxine, sulfamethoxazole sulfamethoxazole, terbinafine hydrochloride, teriparatide, tesamorelin, triptorelin, tubocurarine, and vancomycin.

[1173] The pharmaceutical composition for pseudoallergy of the present invention contains a compound having a P2X4 receptor antagonistic activity or a pharmaceutically acceptable salt thereof as an active ingredient.

[1174] [Compound having P2X4 receptor antagonistic activity or a pharmaceutically acceptable salt thereof]

[1175] Compounds or pharmaceutically acceptable salts thereof that antagonize the P2X4 receptor (Genebank No. X87763, incorporated herein by reference (SEQ ID NO: 3)), a subtype of the P2X family of ATP receptors, and inhibit the action of ATP. Antagonistic activity can be investigated using conventional methods, such as those described in the Examples herein. Compounds or pharmaceutically acceptable salts thereof having P2X4 receptor antagonistic activity (also referred to herein as "P2X4 receptor antagonists") of the present invention have an IC50 of 10 μM or less, 5 μM or less, or 1 μM or less. Pharmaceutically acceptable salts include, for example, amine salts, alkali metal salts (such as lithium, potassium, and sodium), alkaline earth metal salts (such as barium, calcium, and magnesium), transition metal salts (such as zinc), inorganic acid salts (such as hydrochlorides and sulfates), and organic acid salts (such as acetates, lactates, malates, tartrates, citrates, ascorbates, succinates, butyrates, valerates, fumarates, and organic sulfonates).

[1176] As the active ingredient of the pharmaceutical composition of the present invention, compounds represented by the following general formulae (A) to (D) or pharmaceutically acceptable salts thereof can be used.

[1177] The abbreviations used in the following tables and the like are as follows: Me: methyl, Et: ethyl, Pr: n-propyl, iPr: isopropyl, tBu: tert-butyl, Ac: acetyl, Ph: phenyl.

[1178] In the following tables and the like, a substituent is sometimes listed together with the position number of the position where it is substituted. Furthermore, in chemical formulas, to distinguish apparently identical position numbers, a superscript "'" may be added to one position number for convenience. However, in compound names, such superscripts may not be used to indicate position numbers as long as the structure can be uniquely identified.

[1179] (A-1) A compound represented by the following general formula (A) or a pharmaceutically acceptable salt thereof:

[1180]

[1181] (Where R 1A represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, or an alkyl group having 1 to 3 carbon atoms substituted with a phenyl group,

[1182] R 2A and R 3A which may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkylsulfonylamino group having 1 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), a carbamoyl group, an alkylthio group having 1 to 8 carbon atoms, an alkylsulfinyl group having 1 to 8 carbon atoms, an alkylsulfonyl group having 1 to 8 carbon atoms, or a sulfamoyl group.

[1183] R 4A and R 5A may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, or an alkyl group having 1 to 3 carbon atoms substituted with a phenyl group,

[1184] Moreover, W A represents a heterocyclic ring containing a five- or six-membered ring having 1 to 4 nitrogen atoms as ring constituents which may have a substituent).

[1185] In the general formula (A), R 1A 、R 2A 、R 3A 、R 4A and R 5A Examples of the alkyl group having 1 to 8 carbon atoms include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl and hexyl.

[1186] As R 1A The alkenyl group having 2 to 8 carbon atoms includes allyl group and the like.

[1187] As R 1A 、R 2A 、R 3A、R 4A and R 5A or R 11A 、R 12A 、R 13A 、R 14A and R 15A The alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms includes methyl, ethyl, propyl, isopropyl, butyl or tert-butyl groups substituted by 1 to 3 halogen atoms such as fluorine atoms, chlorine atoms or bromine atoms, and preferably includes trifluoromethyl, chloromethyl, 2-chloroethyl, 2-bromoethyl or 2-fluoroethyl.

[1188] As R 1A 、R 4A and R 5A The alkyl group having 1 to 3 carbon atoms substituted by a phenyl group includes a benzyl group and the like.

[1189] As R 2A and R 3A The alkoxy group having 1 to 8 carbon atoms includes methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, tert-butoxy, pentyloxy and hexyloxy.

[1190] As R 2A and R 3A The alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms includes methyl, ethyl, propyl, isopropyl, butyl or tert-butyl groups substituted by 1 to 3 halogen atoms such as fluorine atoms, chlorine atoms or bromine atoms, and preferably includes trifluoromethoxy, 2-chloroethoxy, 2-bromoethoxy or 2-fluoroethoxy.

[1191] As R 2A and R 3A The halogen atom includes a fluorine atom, a chlorine atom, a bromine atom, and the like.

[1192] As R 2A and R 3A The alkylamino group having 1 to 8 carbon atoms includes methylamino and ethylamino.

[1193] As R 2A and R 3A The dialkylamino group having 1 to 8 carbon atoms includes dimethylamino and diethylamino.

[1194] As R 2A and R 3A The acylamino group having 2 to 8 carbon atoms includes acetylamino.

[1195] As R 2A and R 3AThe acylamino group having 2 to 8 carbon atoms and substituted by 1 to 3 halogen atoms includes trifluoromethylcarbonylamino.

[1196] As R 2A and R 3A The alkylsulfonylamino group having 1 to 8 carbon atoms includes methylsulfonylamino.

[1197] As R 2A and R 3A The acyl group having 2 to 8 carbon atoms includes acetyl.

[1198] As R 2A and R 3A Examples of the alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms) include methoxycarbonyl and ethoxycarbonyl.

[1199] As R 2A and R 3A Examples of the alkylthio group having 1 to 8 carbon atoms include methylthio.

[1200] As R 2A and R 3A The alkylsulfinyl group having 1 to 8 carbon atoms includes methylsulfinyl.

[1201] As R 2A and R 3A The alkylsulfonyl group having 1 to 8 carbon atoms includes methylsulfonyl.

[1202] As W A The five- or six-membered heterocyclic ring containing 1 to 4 nitrogen atoms as ring constituent elements which may have a substituent includes tetrazole, 1,2,4-triazole, 1,2,3-triazole, 1,2,4- Oxadiazole, pyrazole, imidazole, Azoles, isocyanates Azole, pyrrole, thiazole, pyridine, pyrrolidine.

[1203] As W A The substituents that the five- or six-membered heterocyclic ring containing 1 to 4 nitrogen atoms as ring constituents that may have a substituent include alkyl groups having 1 to 8 carbon atoms such as methyl and ethyl groups, alkyl groups having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms such as trifluoromethyl groups, halogen atoms such as fluorine atoms, cyano groups, oxo groups, thio groups, and the like.

[1204] R in the general formula (A) 2A and R 3A Can be used in R 2A 、R 3A There are 1 to 3 identical or different groups on the substituted benzene ring.

[1205] As the compound of general formula (A), the following compounds are preferred.

[1206] (A-2)W A tetrazole, 1,2,4-triazole, 1,2,3-triazole, 1,2,4- The compound described in (A-1) of oxadiazole, pyrazole or imidazole.

[1207] (A-3)W A The compound described in (A-1) or (A-2) which may have as a substituent a group selected from tetrazole, 1,2,4-triazole or 1,2,3-triazole, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, and a cyano group.

[1208] (A-4)W A 5-oxo-1,2,4- oxadiazole or 5-thio-1,2,4- The compound according to any one of (A-1) to (A-3) of oxadiazole.

[1209] (A-5)W A The compound described in any one of (A-1) to (A-4) which is a tetrazole.

[1210] (A-6)R 1A The compound described in any one of (A-1) to (A-5), which is a hydrogen atom or an alkyl group having 1 to 8 carbon atoms.

[1211] (A-7)R 1A The compound according to any one of (A-1) to (A-6), wherein the atom is a hydrogen atom.

[1212] (A-8)R 4A is a hydrogen atom and R 5A The compound described in any one of (A-1) to (A-7), which is a hydrogen atom or an alkyl group having 1 to 8 carbon atoms.

[1213] (A-9)R 4A and R 5A The compound according to any one of (A-1) to (A-8), wherein all of the atoms are hydrogen atoms.

[1214] (A-10)R 2AThe compound described in any one of (A-1) to (A-9) which is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, a carboxyl group, an acyl group having 2 to 8 carbon atoms, or an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms).

[1215] (A-11)R 2A The compound according to any one of (A-1) to (A-10), wherein the atom is a hydrogen atom.

[1216] (A-12)R 3A The compound described in any one of (A-1) to (A-11) which is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, a carboxyl group, an acyl group having 2 to 8 carbon atoms, or an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms).

[1217] (A-13)R 3A The compound according to any one of (A-1) to (A-12), wherein the atom is a hydrogen atom.

[1218] As a pharmaceutically acceptable salt of the compound represented by the general formula (A), for example, in the case of R 2A 、R 3A In the case of amino group, hydrochloride and the like can be mentioned. 2A 、R 3A In the case of a carboxyl group, alkali metal salts such as sodium, potassium, and lithium can be mentioned.

[1219] Representative compounds encompassed by the general formula (A) are shown below.

[1220] <Representative Compound A-100>

[1221]

[1222] (Where R 1A 、R 4A 、R 5A and W A and W A The substitution positions are shown in Tables 1 to 3.)

[1223] In Tables 1 to 3, W AThe substitution position of represents the substitution position on the benzene ring. That is, the 2nd, 3rd, and 4th positions in the table correspond to the 2'-, 3'-, and 4'-positions in the formula representing compound A-100, respectively.

[1224] [Table 1]

[1225] <![CDATA[R 1A ]]> <![CDATA[W A Replacement position]]> <![CDATA[W A ]]> <![CDATA[R 4A / R 5A ]]> H 2- 1H-tetrazol-5-yl H / H H 3- 1H-tetrazol-5-yl H / H H 3- (1-Methyl-1H-tetrazolyl)-5-yl H / H H 4- 1H-tetrazol-5-yl H / H <![CDATA[CH3]]> 3- 1H-tetrazol-5-yl H / H <![CDATA[CH3]]> 3- 1H-tetrazol-5-yl <![CDATA[CH3 / H <!-- 66 -->]]> Phenyl 3- 1H-tetrazol-5-yl H / H H 3- 1H-tetrazol-1-yl H / H H 3- 1H-tetrazol-1-yl <![CDATA[CH3 / CH3]]> H 3- (1,2,3-Triazole)-5-yl H / H H 3- (1,2,4-Triazole)-3-yl H / H H 4- (1,2,4-Triazole)-3-yl H / H

[1226] [Table 2]

[1227] <![CDATA[R 1A ]]> <![CDATA[W A Replacement position]]> <![CDATA[W A ]]> <![CDATA[R 4A / R 5A ]]> H 2- (1,2,4-Triazole)-1-yl H / H H 3- (1,2,4-Triazole)-1-yl H / H H 3- (5-Trifluoromethyl-1,2,4-triazole)-3-yl H / H H 3- (5-Trifluoromethyl-1,2,4-triazole)-3-yl ethyl / H H 3- (5-Fluoro-1,2,3-triazole)-4-yl H / H H 3- (5-Fluoro-1,2,3-triazole)-4-yl <![CDATA[CH3 / CH3]]> H 3- (5-cyano-1,2,3-triazole)-4-yl H / H H 4- 1H-imidazol-1-yl H / H H 4- 1H-imidazol-1-yl Pr / H H 3- 1H-imidazol-2-yl H / H H 3- 1H-imidazol-4-yl H / H H 3- imidazolin-2-yl H / H

[1228] [Table 3]

[1229]

[1230] <Representative Compound A-200>

[1231]

[1232] (Where R 1A 、R 2A 、R 4A 、R 5A and W A and W A The substitution positions are shown in Tables 4 and 5)

[1233] In Tables 4 and 5, W A The substitution position of represents the substitution position on the benzene ring. That is, the 2nd, 3rd, and 4th positions in the table correspond to the 2'-, 3'-, and 4'-positions in the formula representing compound A-200, respectively.

[1234] [Table 4]

[1235] <![CDATA[R 1A ]]> <![CDATA[R 2A ]]> <![CDATA[W A Replacement position]]> <![CDATA[W A ]]> <![CDATA[R 4A / R 5A ]]> H 4-OH 3- 1H-tetrazol-5-yl H / H H <![CDATA[4-OCH3]]> 3- 1H-tetrazol-5-yl H / H <![CDATA[CH3]]> 2-Cl 3- 1H-tetrazol-5-yl H / H H 2，6-Cl 3- 1H-tetrazol-5-yl H / H H 4-F 3- 1H-tetrazol-5-yl H / H H 4-Br 3- 1H-tetrazol-5-yl Ethyl / H H <![CDATA[3-OCH3]]> 4- (1-Methyl-1H-tetrazolyl)-5-yl H / H H <![CDATA[4-CH3]]> 3- 1H-tetrazol-5-yl H / H

[1236] [Table 5]

[1237] <![CDATA[R 1A ]]> <![CDATA[R 2A ]]> <![CDATA[W A Replacement position]]> <![CDATA[W A ]]> <![CDATA[R 4A / R 5A ]]> H 4-Cl 3- (1,2,3-Triazole)-5-yl <![CDATA[CH3 / H]]> H <![CDATA[4-CF3]]> 3- (1,2,3-Triazole)-5-yl H / H H <![CDATA[3-SCH3]]> 4- (1,2,4-Triazole)-1-yl H / H H <![CDATA[3-SO2CH3]]> 4- 1H-imidazol-1-yl H / H H <![CDATA[3-NHSO2CH3]]> 4- 1H-imidazol-1-yl H / H H <![CDATA[4-OCH3]]> 3- 1H-imidazol-4-yl H / H H 4-F 2- Pyrazol-3-yl H / H

[1238] <Representative Compound A-300>

[1239]

[1240] (Where R 1A 、R 2A 、R 3A 、R 4A 、R 5A and W A and W A The substitution positions are shown in Tables 6 and 7)

[1241] In Tables 6 and 7, W AThe substitution position of represents the substitution position on the benzene ring. That is, the 3-position and 4-position in the table correspond to the 3'-position and 4'-position in the formula representing compound A-300, respectively.

[1242] [Table 6]

[1243] <![CDATA[R 1A ]]> <![CDATA[R 2A ]]> <![CDATA[W A Replacement position]]> <![CDATA[W A ]]> <![CDATA[R 3A ]]> <![CDATA[R 4A / R 5A ]]> H H 3- 1H-tetrazol-5-yl 9-Br H / H H <![CDATA[4-OCH3]]> 3- 1H-tetrazol-5-yl 9-Cl H / H H 4-OH 3- 1H-tetrazol-5-yl <![CDATA[10-OCH3]]> H / H H 2-Cl 3- 1H-tetrazol-5-yl 9-Br H / H H 2，6-Cl 3- 1H-tetrazol-5-yl <![CDATA[9-CH3]]> H / H H H 3- 1H-tetrazol-5-yl 10-Cl <![CDATA[CH3 / H]]> H <![CDATA[3-OCH3]]> 4- (1-Methyl-1H-tetrazolyl)-5-yl <![CDATA[9-CF3]]> H / H

[1244] [Table 7]

[1245] <![CDATA[R 1A ]]> <![CDATA[R 2A ]]> <![CDATA[W A Replacement position]]> <![CDATA[W A ]]> <![CDATA[R 3A ]]> <![CDATA[R 4A / R 5A ]]> H <![CDATA[4-CH3]]> 3- 1H-tetrazol-1-yl 9-CN Pr / H <![CDATA[CH3]]> H 3- (1,2,3-Triazole)-5-yl 9-OH H / H Ethyl H 3- (1,2,3-Triazole)-5-yl 10-F H / H H 3-Br 4- (1,2,4-Triazole)-1-yl <![CDATA[9-SCH3]]> H / H Allyl H 4- 1H-imidazol-1-yl <![CDATA[8-OCH3]]> H / H H H 3- 1H-imidazol-1-yl <![CDATA[10-OCH3]]> <![CDATA[CH3 / CH3]]>

[1246] (B-1) A compound represented by the following general formula (BI) or a pharmaceutically acceptable salt thereof.

[1247]

[1248] (Where R 1B and R 2B which may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), a phenyl group which may have a substituent, a pyridyl group which may have a substituent, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), or

[1249] R 1B and R 2B Together with the benzene ring to which they are bonded, they can form a condensed ring selected from a naphthalene ring, a quinoline ring, an isoquinoline ring, a tetrahydronaphthalene ring, an indane ring, a tetrahydroquinoline ring or a tetrahydroisoquinoline ring, and R 1B and R 2B Together and R 1B and R 2BThe ring composed of the carbon atoms to which the respective bonds are attached may be substituted by 1 to 4 substituents, which may be the same or different, selected from an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms).

[1250] R 3B and R 4B and may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[1251] R 5B represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxyl group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[1252] R 6B and R 7B may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group or an amino group,

[1253] X B represents C, CH or N,

[1254] Y B represents N, NH or C(=O),

[1255] Among them, X B When N, YB Not N, NH,

[1256] In addition, X B When it is C or CH, Y B Not C(=O),

[1257] A double line consisting of a solid line and a dashed line represents a single bond or a double bond.

[1258] Z B represents an oxygen atom or a sulfur atom,

[1259] A B The group may have 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), a benzene ring, a pyridine ring, a thiophene ring, a pyrimidine ring, a naphthalene ring, a quinoline ring, or an indole ring, or represents a bonding site.

[1260] B B N(R 8B )C(=O)、NHCONH、CON(R 9B )、NHC(=S)NH、N(R 10B )SO2、SO2N(R 11B ) or OSO2,

[1261] Here, R 8B 、R 9B 、R 10B and R 11B represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxy group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[1262] D B represents an alkylene chain having 1 to 6 carbon atoms, which may have 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms or an aralkyl group having 1 to 8 carbon atoms (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), which may be the same or different, as substituents, and further represents an alkylene chain having 1 to 6 carbon atoms, which may have a double bond, or a bonding site,

[1263] E B Indicates O, S, NR 12B , or bonding sites,

[1264] Here, R 12B represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxyl group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[1265] G B represents a group which may have 1 to 4 groups selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acyl group having 2 to 8 carbon atoms, a methylenedioxy group, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), a phenyl group which may have a substituent, a pyridyl group which may have a substituent, an imidazolyl group which may have a substituent, and an oxazolyl, or the same or different substituents in the thiazolyl group which may have a substituent as a substituent, piperazine, piperidine, morpholine, cyclohexane, benzene, naphthalene, quinoline, quinoxaline, benzimidazole, thiophene, imidazole, thiazole, azole, indole, benzofuran, pyrrole, pyridine or pyrimidine,

[1266] Moreover, m B Indicates an integer from 0 to 5.

[1267] Among them, R 1B and R 2B In the case of not forming a ring together, X is not included B C, Y B N, the double line consisting of solid and dotted lines is a double bond, Z B is an oxygen atom, A B is a benzene ring, m B 0, B B C(=O)NH, E B is the bonding site and G B is the case of phenyl.)

[1268] (B-2) A compound represented by the following general formula (BII) or a pharmaceutically acceptable salt thereof.

[1269]

[1270] (Where,

[1271] represents a naphthalene ring, a quinoline ring, an isoquinoline ring, a tetrahydronaphthalene ring, an indane ring, a tetrahydroquinoline ring, or a tetrahydroisoquinoline ring, and these rings may be substituted by 1 to 4 substituents, which may be the same or different, selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[1272] R 3Ba and R 4Ba and may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[1273] R 5Ba represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxyl group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[1274] R 6Ba and R 7Ba may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, or an amino group,

[1275] represents a benzene ring, a pyridine ring, a thiophene ring, a pyrimidine ring, a naphthalene ring, a quinoline ring, or an indole ring which may have, as substituents, 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), a phenyl group, or a pyridyl group, which may have the same or different substituents,

[1276] B Ba N(R 8Ba )C(=O)、NHCONH、CON(R 9Ba )、NHC(=S)NH、N(R 10Ba )SO2、SO2N(R 11Ba ), or OSO2,

[1277] Here, R 8Ba 、R 9Ba 、R 10Ba and R 11Ba represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxy group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[1278] E Ba Indicates O, S, NR 12Ba or bonding sites,

[1279] Here, R 12Ba represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxyl group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms),

[1280] G Barepresents a group which may have 1 to 4 groups selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acyl group having 2 to 8 carbon atoms, a methylenedioxy group, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), a phenyl group which may have a substituent, a pyridyl group which may have a substituent, an imidazolyl group which may have a substituent, and an oxazolyl, or the same or different substituents in the thiazolyl group which may have a substituent as a substituent, piperazine, piperidine, morpholine, cyclohexane, benzene, naphthalene, quinoline, quinoxaline, benzimidazole, thiophene, imidazole, thiazole, azole, indole, benzofuran, pyrrole, pyridine or pyrimidine,

[1281] Moreover, B represents an integer from 0 to 5).

[1282] Hereinafter, substituents in the general formulae (BI) and (BII) of this specification will be described.

[1283] Examples of the alkyl group having 1 to 8 carbon atoms include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl and hexyl groups.

[1284] Examples of the cycloalkyl group having 3 to 8 carbon atoms include cyclopropyl and cyclohexyl.

[1285] Examples of the alkenyl group having 2 to 8 carbon atoms include allyl group and the like.

[1286] Examples of the alkoxy group having 1 to 8 carbon atoms include methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, tert-butoxy, pentyloxy, and hexyloxy.

[1287] Examples of the alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms include methyl, ethyl, propyl, isopropyl, butyl and tert-butyl groups substituted with 1 to 3 halogen atoms such as fluorine, chlorine or bromine atoms, and preferably trifluoromethyl, chloromethyl, 2-chloroethyl, 2-bromoethyl or 2-fluoroethyl.

[1288] Examples of the alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms include methoxy, ethoxy, propoxy, isopropoxy, butoxy and tert-butoxy groups substituted by 1 to 3 halogen atoms such as fluorine atoms, chlorine atoms or bromine atoms, and preferably include trifluoromethoxy, chloromethoxy, 2-chloroethoxy, 2-bromoethoxy and 2-fluoroethoxy groups.

[1289] Examples of the halogen atom include a fluorine atom, a chlorine atom, and a bromine atom.

[1290] Examples of the alkylamino group having 1 to 8 carbon atoms include methylamino and ethylamino groups.

[1291] Examples of the dialkylamino group having 2 to 8 carbon atoms include dimethylamino and diethylamino.

[1292] Examples of the acylamino group having 2 to 8 carbon atoms include acetylamino group.

[1293] Examples of the acyl group having 2 to 8 carbon atoms include acetyl group and the like.

[1294] Examples of the alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms) include a methoxycarbonyl group and the like.

[1295] Examples of the aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms) include benzyl and the like.

[1296] Examples of the alkyl group having 1 to 8 carbon atoms substituted with a hydroxy group include 2-hydroxyethyl and the like.

[1297] Examples of the alkylsulfinyl group having 1 to 6 carbon atoms include methanesulfinyl group and the like.

[1298] Examples of the alkylthio group having 1 to 6 carbon atoms include methylthio group and the like.

[1299] Examples of the alkylsulfonyl group having 1 to 6 carbon atoms include methanesulfonyl group and the like.

[1300] As the phenyl group which may have a substituent, the pyridyl group which may have a substituent, the imidazolyl group which may have a substituent, Examples of the substituents that the oxazolyl group and the thiazolyl group which may have a substituent include a halogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, and an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms.

[1301] As the compound represented by the general formula (BI), the following compounds are preferred.

[1302] (B-1-1)

[1303] R 1B and R 2B The compound described in the above (B-1) which may be the same or different and is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, a phenyl group which may have a substituent, a pyridyl group which may have a substituent, or an aralkyl group (the aryl part has 6 to 10 carbon atoms and the alkylene part has 1 to 8 carbon atoms).

[1304] (B-1-2)

[1305] R 1B and R 2B Together with the benzene ring to which they are bonded, they form a naphthalene ring or a tetralin ring, and R 1B and R 2B Together and R 1B and R 2B The benzene ring or cyclohexene ring formed by the carbon atoms to which they are respectively bonded is the compound described in (B-1) or (B-1-1) above, wherein the benzene ring or cyclohexene ring may be substituted with 1 to 4 substituents which may be the same or different and selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms).

[1306] (B-1-3)

[1307] R 1B and R 2B Together with the benzene ring to which they are bonded, they form a naphthalene ring, and R 1B and R 2B Together and R 1B and R 2B The benzene ring formed by the respectively bonded carbon atoms may be substituted by 1 to 4 substituents which may be the same or different and are selected from the group consisting of an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, and an amino group, which are selected from the compounds described in (B-1) or (B-1-1).

[1308] (B-1-4)

[1309] R 1B and R 2B The compounds described in the above (B-1) or (B-1-1), which together with the benzene ring to which they are bonded form a naphthalene ring or a tetralin ring.

[1310] (B-1-5)

[1311] R 3B and R 4B The compound of any one of the above (B-1) or (B-1-1) to (B-1-4) which may be the same or different and is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms).

[1312] (B-1-6)

[1313] R 5B The compound of any one of (B-1) or (B-1-1) to (B-1-5) which is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms).

[1314] (B-1-7)

[1315] R 5B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-6), wherein the atom is a hydrogen atom.

[1316] (B-1-8)

[1317] R 6B and R 7B The compound or pharmaceutically acceptable salt thereof of any one of (B-1) or (B-1-1) to (B-1-7) above, which may be the same or different and is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, or an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms.

[1318] (B-1-9)

[1319] R 6B and R 7BThe compound according to any one of the above (B-1) or (B-1-1) to (B-1-8), wherein all of the atoms are hydrogen atoms.

[1320] (B-1-10)

[1321] R 3B 、R 4B 、R 5B 、R 6B and R 7B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-9), wherein the atom is a hydrogen atom.

[1322] (B-1-11)

[1323] X B N, Y B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-10), wherein the double line consisting of a solid line and a dotted line is a single bond.

[1324] (B-1-12)

[1325] X B C, Y B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-11), wherein N is represented and the double line consisting of a solid line and a dotted line is a double bond.

[1326] (B-1-13)

[1327] Z B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-12), wherein the compound is an oxygen atom.

[1328] (B-1-14)

[1329] A B The compound of any one of the above (B-1) or (B-1-1) to (B-1-13) which may have 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), a phenyl group or a pyridyl group which may be the same or different substituents.

[1330] (B-1-15)

[1331] AB The compound described in any one of (B-1) or (B-1-1) to (B-1-14) above, which may have 1 to 4 phenyl groups which may be the same or different substituents selected from alkyl groups having 1 to 8 carbon atoms, alkenyl groups having 2 to 8 carbon atoms, alkoxy groups having 1 to 8 carbon atoms, alkyl groups having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, alkoxy groups having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, halogen atoms, hydroxyl groups, nitro groups, cyano groups, or amino groups.

[1332] (B-1-16)

[1333] A B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-15), which is a phenyl group or a pyridyl group.

[1334] (B-1-17)

[1335] A B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-16), which is a bonding site.

[1336] (B-1-18)

[1337] B B NHC(=O), NHCONH, CONH, NHC(=S)NH, NHSO2,

[1338] The compound according to any one of the above (B-1) or (B-1-1) to (B-1-17) which is SO2NH or OSO2.

[1339] (B-1-19)

[1340] B B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-18), which is NHC(═O), NHCONH or NHSO 2 .

[1341] (B-1-20)

[1342] B B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-19), which is NHC(═O) or NHSO 2 .

[1343] (B-1-21)

[1344] B B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-20), which is NHC(═O).

[1345] (B-1-22)

[1346] D B The compound is any one of the above (B-1) or (B-1-1) to (B-1-21), which may have 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms or an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, which may be the same or different, and further has an alkylene chain having 1 to 6 carbon atoms which may have a double bond.

[1347] (B-1-23)

[1348] D B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-22) which is a bonding site.

[1349] (B-1-24)

[1350] D B A compound according to any one of the above (B-1) or (B-1-1) to (B-1-23) having 1 to 4 substituents selected from alkyl groups having 1 to 8 carbon atoms and alkenyl groups having 2 to 8 carbon atoms, which may be the same or different.

[1351] (B-1-25)

[1352] D B A compound according to any one of the above (B-1) or (B-1-1) to (B-1-24) having 1 to 4 substituents selected from alkyl groups having 1 to 3 carbon atoms and alkenyl groups having 2 to 3 carbon atoms, which may be the same or different.

[1353] (B-1-26)

[1354] E B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-25) which is a bonding site.

[1355] (B-1-27)

[1356] G Bpiperazine, piperidine, morpholine, cyclohexane, benzene, naphthalene, quinoline, quinoxaline, benzimidazole, thiophene, imidazole, thiazole, which may have 1 to 4 substituents selected from the group consisting of an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acyl group having 2 to 8 carbon atoms, a methylenedioxy group, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, or an alkylsulfonyl group having 1 to 6 carbon atoms, which may have 1 to 4 substituents selected from the group consisting of The compound according to any one of the above (B-1) or (B-1-1) to (B-1-26) which is oxazole, indole, benzofuran, pyrrole, pyridine or pyrimidine.

[1357] (B-1-28)

[1358] G B The compound of any one of the above (B-1) or (B-1-1) to (B-1-27), which is benzene optionally having 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acyl group having 2 to 8 carbon atoms, a methylenedioxy group, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, or an alkylsulfonyl group having 1 to 6 carbon atoms.

[1359] (B-1-29)

[1360] G B The compound of any one of the above (B-1) or (B-1-1) to (B-1-28) which is benzene or pyridine which may have 1 to 4 substituents, which are the same or different, selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, an amino group, a dialkylamino group having 2 to 8 carbon atoms, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, and an alkylsulfonyl group having 1 to 6 carbon atoms.

[1361] (B-1-30)

[1362] G BThe compound is any one of the above (B-1) or (B-1-1) to (B-1-29), which is benzene optionally substituted with 1 to 4 identical or different substituents selected from alkyl groups having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, halogen atoms, and hydroxyl groups.

[1363] (B-1-31)

[1364] m B The compound according to any one of the above (B-1) or (B-1-1) to (B-1-30) wherein the value is 0.

[1365] (B-1-32)

[1366] A B is a benzene ring, m B 0, B B NHC(=O) or NHSO2, D B is an alkyl group having 1 to 3 carbon atoms or a bonding site, E B is the bonding site, G B The compound is any one of the above (B-1) or (B-1-1) to (B-1-31), which is benzene that may have 1 to 4 substituents selected from the group consisting of an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, and a hydroxyl group.

[1367] (B-1-33)

[1368] A B is a benzene ring, m B 0, B B NHC(=O), D B is the bonding site, E B is the bonding site, G B The compound is any one of the above (B-1) or (B-1-1) to (B-1-32), which is benzene optionally substituted with 1 to 4 identical or different substituents selected from alkyl groups having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, halogen atoms, and hydroxyl groups.

[1369] (B-1-34)

[1370] R 1B and R 2B Together with the benzene ring to which they are bonded, they form a naphthalene ring, R 3B 、R 4B 、R 5B 、R 6B and R 7B represents a hydrogen atom, X B N, Y Bis C(=O), a double line consisting of a solid line and a dotted line represents a single bond, and Z B represents oxygen atom, A B represents a benzene ring, m B Indicates 0, B B Indicates NHC(=O) or NHSO2, D B represents an alkyl group with 1 to 3 carbon atoms or a bonding site, E B Indicates the bonding site, G B The compound is any one of the above (B-1) or (B-1-1) to (B-1-33), which is benzene that may have 1 to 4 substituents selected from the group consisting of an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, and a hydroxyl group, which may be the same or different.

[1371] (B-1-35)

[1372] In the above general formula (BI), R 1B and R 2B Together with the benzene ring to which they are bonded, they form a naphthalene ring, R 3B 、R 4B 、R 5B 、R 6B and R 7B represents a hydrogen atom, X B N, Y B is C(=O), a double line consisting of a solid line and a dotted line represents a single bond, and Z B represents oxygen atom, A B represents a benzene ring, m B Indicates 0, B B NHC(=O), D B Indicates the bonding site, E B Indicates the bonding site, G B The compound is any one of (B-1) or (B-1-1) to (B-1-34) of benzene which may have 1 to 4 substituents selected from the group consisting of an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, and a hydroxyl group, which may be the same or different.

[1373] As the compound represented by the general formula (BII), the following compounds are preferred.

[1374] (B-2-1)

[1375] The compound described in the above (B-2) which is a naphthalene ring or tetralin ring which may be substituted with 1 to 4 substituents, which may be the same or different, selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group (the alkoxy moiety has 1 to 8 carbon atoms), or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms).

[1376] (B-2-2)

[1377] The compound described in (B-2) or (B-2-1) above, wherein the naphthalene ring is optionally substituted with 1 to 4 substituents, which may be the same or different, selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, and an amino group.

[1378] (B-2-3)

[1379] R 3Ba and R 4Ba The compound of any one of the above (B-2) or (B-2-1) to (B-2-2) which may be the same or different and is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms).

[1380] (B-2-4)

[1381] R 5Ba The compound described in any one of (B-2) or (B-2-1) to (B-2-3) above, which is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms).

[1382] (B-2-5)

[1383] R 5BaThe compound according to any one of the above (B-2) or (B-2-1) to (B-2-4), wherein the atom is a hydrogen atom.

[1384] (B-2-6)

[1385] R 6Ba and R 7Ba The compound described in any one of (B-2) or (B-2-1) to (B-2-5) above, which may be the same or different and is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, or an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms.

[1386] (B-2-7)

[1387] R 6Ba and R 7Ba The compound according to any one of the above (B-2) or (B-2-1) to (B-2-6), wherein all of the atoms are hydrogen atoms.

[1388] (B-2-8)

[1389] The compound is any one of the above (B-2) or (B-2-1) to (B-2-7) which may have 1 to 4 groups selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an aralkyl group (the aryl moiety has 6 to 10 carbon atoms and the alkylene moiety has 1 to 8 carbon atoms), a phenyl group or a pyridyl group which may be the same or different substituents as substituents, or a pyridyl group.

[1390] (B-2-9)

[1391] The compound described in any one of (B-2) or (B-2-1) to (B-2-8) above, which may have 1 to 4 phenyl groups which may be the same or different substituents selected from alkyl groups having 1 to 8 carbon atoms, alkenyl groups having 2 to 8 carbon atoms, alkoxy groups having 1 to 8 carbon atoms, alkyl groups having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, alkoxy groups having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, halogen atoms, hydroxyl groups, nitro groups, cyano groups, or amino groups.

[1392] (B-2-10)

[1393] The compound according to any one of the above (B-2) or (B-2-1) to (B-2-9) which is a bonding site.

[1394] (B-2-11)

[1395] B Ba NHC(=O), NHCONH, CONH, NHC(=S)NH, NHSO2,

[1396] The compound according to any one of the above (B-2) or (B-2-1) to (B-2-10) which is SO2NH or OSO2.

[1397] (B-2-12)

[1398] B Ba The compound according to any one of the above (B-2) or (B-2-1) to (B-2-11), which is NHC(═O), NHCONH or NHSO 2 .

[1399] (B-2-13)

[1400] E Ba The compound according to any one of the above (B-2) or (B-2-1) to (B-2-12) which is a bonding site.

[1401] (B-2-14)

[1402] G Ba piperazine, piperidine, morpholine, cyclohexane, benzene, naphthalene, quinoline, quinoxaline, benzimidazole, thiophene, imidazole, thiazole, which may have 1 to 4 substituents selected from the group consisting of an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acyl group having 2 to 8 carbon atoms, a methylenedioxy group, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, or an alkylsulfonyl group having 1 to 6 carbon atoms, which may have 1 to 4 substituents selected from the group consisting of The compound according to any one of the above (B-2) or (B-2-1) to (B-2-13) which is oxazole, indole, benzofuran, pyrrole, pyridine or pyrimidine.

[1403] (B-2-15)

[1404] G BaThe compound of any one of the above (B-2) or (B-2-1) to (B-2-14), which is benzene optionally having 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acyl group having 2 to 8 carbon atoms, a methylenedioxy group, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, or an alkylsulfonyl group having 1 to 6 carbon atoms.

[1405] (B-2-16)

[1406] n B The compound according to any one of (B-2) or (B-2-1) to (B-2-15) above, wherein the value is 0.

[1407] In the above general formula (BI), preferably R B1 and R B2 Together with the benzene ring to which they are bonded, they form a condensed ring selected from a naphthalene ring or a tetralin ring, and particularly preferably form a naphthalene ring.

[1408] In the above general formula (BI), preferably R B3 、R B4 、R B5 、R B6 and R B7 Represents a hydrogen atom.

[1409] In the above general formula (BI), X is preferably B N, Y B The double line consisting of a solid line and a dotted line represents a single bond.

[1410] In the above general formula (BI), Z is preferably B For oxygen atoms.

[1411] In the above general formula (BI), A B It preferably represents a benzene ring or a pyridine ring, and particularly preferably represents a benzene ring.

[1412] In the above general formula (BI), m B It preferably represents 0 to 4, and particularly preferably represents 0.

[1413] In the above general formula (BI), B B Preferably represents N(R 8B )C(=O) or N(R 10B )SO2, in this case, more preferably R 8B and R10B In the above general formula (BI), B B Particularly preferably it represents NHC(=O).

[1414] In the above general formula (BI), D B It preferably represents an alkylene chain having 1 to 6 carbon atoms and having 1 to 4 substituents selected from alkyl groups having 1 to 8 carbon atoms or alkenyl groups having 2 to 8 carbon atoms, which may be the same or different, or a bonding site. It more preferably represents an alkylene chain having 1 to 6 carbon atoms and having 1 to 4 substituents selected from alkyl groups having 1 to 3 carbon atoms or alkenyl groups having 2 to 3 carbon atoms, which may be the same or different, or a bonding site. It is particularly preferred to represent a bonding site.

[1415] In the above general formula (BI), E B It preferably represents O or a bonding site, and particularly preferably represents a bonding site.

[1416] In the above general formula (BI), G B Preferably, it represents benzene or pyridine which may have 1 to 4 substituents selected from the group consisting of an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, an amino group, a dialkylamino group having 2 to 8 carbon atoms, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, and an alkylsulfonyl group having 1 to 6 carbon atoms, and G B Particularly preferably, it refers to benzene which may have, as a substituent, 1 to 4 substituents which are the same or different and are selected from an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, and a hydroxyl group.

[1417] In the above general formula (BI), A is particularly preferred B represents a benzene ring, m B Indicates 0, B B Indicates NHC(=O) or NHSO2, D B represents an alkyl group with 1 to 3 carbon atoms or a bonding site, E B Indicates the bonding site, G B It represents benzene which may have 1 to 4 substituents, which may be the same or different, selected from an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, and a hydroxyl group as a substituent.

[1418] In the above general formula (BI), A is particularly preferred B represents a benzene ring, m B Indicates 0, B B NHC(=O), D B Indicates the bonding site, EB Indicates the bonding site, G B It represents benzene which may have 1 to 4 substituents, which may be the same or different, selected from an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, and a hydroxyl group as a substituent.

[1419] In the above general formula (BI), R is more preferably B1 and R B2 Together with the benzene ring to which they are bonded, they form a naphthalene ring, R B3 、R B4 、R B5 、R B6 and R B7 represents a hydrogen atom, X B N, Y B is C(=O), a double line consisting of a solid line and a dotted line represents a single bond, and Z B represents oxygen atom, A B represents a benzene ring, m B Indicates 0, B B Indicates NHC(=O) or NHSO2, D B represents an alkyl group with 1 to 3 carbon atoms or a bonding site, E B Indicates the bonding site, G B It represents benzene which may have 1 to 4 substituents, which may be the same or different, selected from an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, and a hydroxyl group as a substituent.

[1420] In the above general formula (BI), R is particularly preferably B1 and R B2 Together with the benzene ring to which they are bonded, they form a naphthalene ring, R B3 、R B4 、R B5 、R B6 and R B7 represents a hydrogen atom, X B N, Y B is C(=O), a double line consisting of a solid line and a dotted line represents a single bond, and Z B represents oxygen atom, A B represents a benzene ring, m B Indicates 0, B B NHC(=O), D B Indicates the bonding site, E B Indicates the bonding site, G B It represents benzene which may have 1 to 4 substituents, which may be the same or different, selected from an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, and a hydroxyl group as a substituent.

[1421] Representative compounds encompassed by the general formula (BI) and / or (BII) are shown below.

[1422] <Representative Compound Example B-100>

[1423]

[1424] (Where B Ba (replacement position), n B 、E Ba and G Ba As shown in Tables 8 to 17)

[1425] [Table 8]

[1426] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO(4) 0 bonding site Phenyl NHCO(4) 0 bonding site <![CDATA[(2-CF3)phenyl]]> NHCO(4) 0 bonding site (3-Br)phenyl NHCO(4) 0 bonding site <![CDATA[(4-CF3)phenyl]]> NHCO(4) 0 bonding site (2-Me)phenyl NHCO(4) 0 bonding site (2,6-Me)phenyl NHCO(4) 0 bonding site (2,6-Cl)phenyl NHCO(4) 0 bonding site (3-Cl)phenyl NHCO(4) 1 bonding site Phenyl NHC(=S)NH(4) 0 bonding site Phenyl NHCO(4) 0 bonding site (2,3-OMe)phenyl NHCO(4) 0 bonding site (2-OMe)phenyl NHCO(4) 1 bonding site (2-Cl)phenyl NHCO(4) 0 bonding site (2,3-Me)phenyl NHCO(4) 0 bonding site (2,5-Me)phenyl NHCO(4) 0 bonding site (2-Cl, 5-Br)phenyl

[1427] [Table 9]

[1428] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO(4) 0 bonding site (2,4-Cl)phenyl NHCO(4) 0 bonding site (2-OH)phenyl NHCO(4) 0 bonding site (2,3-OH)phenyl NHC(=O)NH(4) 0 bonding site Phenyl NHCO(4) 1 bonding site (2,6-Cl)phenyl NHCO(4) 1 bonding site (2-OMe)phenyl NHCO(4) 1 bonding site (2-OH)phenyl NHC(=S)NH(4) 0 bonding site (2-Cl)phenyl NHCO(4) 0 bonding site <![CDATA[(3-CF3)phenyl]]> NHCO(4) 1 bonding site <![CDATA[(2-CF3)phenyl]]> NHC(=O)NH(4) 0 bonding site (2-Cl)phenyl NHCO(4) 0 bonding site (2-Cl, 3-OMe)phenyl NHCO(4) 2 bonding site Phenyl NHCO(4) 0 bonding site 3-Indolyl NHCO(4) 0 bonding site (2-Cl, 3-OH)phenyl NHCO(4) 1 O Phenyl

[1429] [Table 10]

[1430] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO(4) 1 bonding site (2-Cl,4-OMe)phenyl NHCO(4) 0 bonding site (1-Me)imidazol-2-yl NHCO(4) 1 bonding site (2,4-Cl)phenyl NHCO(4) 1 bonding site (2-Cl, 4-OH)phenyl NHCO(4) 1 bonding site Pyridin-3-yl NHCO(4) 0 bonding site Benzimidazol-2-yl NHCO(4) 0 bonding site (2-Cl)phenyl NHCO(4) 0 bonding site (2-Br)phenyl NHCO(4) 0 bonding site (2-I)phenyl NHCO(4) 1 bonding site (2-Me)phenyl NHCO(4) 0 bonding site Quinoxalin-2-yl NHCO(4) 0 bonding site (5-Me)thiophen-2-yl NHCO(3) 1 bonding site (2-Cl)phenyl NHCO(4) 0 bonding site (2,4,6-Me)phenyl NHCO(4) 0 bonding site (2-Et)phenyl NHC(=S)NH(4) 0 bonding site (2-Me)phenyl

[1431] [Table 11]

[1432] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO(4) 0 bonding site <![CDATA[(4-NMe2)phenyl]]> NHCO(4) 1 O (2,4-Cl)phenyl NHCO(4) 1 O (2-Me)phenyl NHCO(4) 0 bonding site (2-Ac)phenyl NHCO(4) 0 bonding site (2-tBu)phenyl NHCO(3) 0 bonding site (2-I)phenyl NHCO(4) 0 bonding site (1-Me)piperidin-4-yl NHCO(4) 0 bonding site Benzofuran-2-yl NHCO(4) 0 bonding site (1-Me)indol-3-yl NHCO(4) 0 bonding site (2-Allyl)phenyl NHCO(4) 0 bonding site (2-nPr)phenyl NHCO(4) 0 bonding site (2-iPrO)phenyl NHCO(4) 0 bonding site 3-Me-thiophen-2-yl NHCO(4) 1 O (2-Me,3-Cl)phenyl NHCO(4) 0 bonding site <![CDATA[(2-CF3, 4-F)phenyl]]> NHCO(4) 0 bonding site (2-OMe, 4-F)phenyl

[1433] [Table 12]

[1434] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO(4) 0 bonding site (2-OH,4-F)phenyl NHCO(3) 1 bonding site (2-I)phenyl NHCO(4) 0 bonding site <![CDATA[(3-NMe2)phenyl]]> NHCO(4) 0 bonding site (2-OMe,4-I)phenyl NHCO(4) 0 bonding site (2-OMe,6-F)phenyl NHCO(4) 0 bonding site (2-OH,4-I)phenyl NHCO(4) 0 bonding site (2-OH,6-F)phenyl NHCO(4) 0 bonding site (2-F)phenyl NHCO(4) 0 bonding site <![CDATA[(2-NMe2)phenyl]]> NHCO(4) 0 bonding site (2-OMe, 6-Me)phenyl NHCO(4) 0 bonding site (2-OH, 6-Me)phenyl NHCO(4) 2 bonding site (2-Me)phenyl CONH(4) 0 bonding site Phenyl CONH(4) 1 bonding site Phenyl NHCO(4) 2 bonding site (2-Cl)phenyl CONH(4) 1 bonding site (2-Cl)phenyl

[1435] [Table 13]

[1436] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> CONH(4) 0 bonding site (2-Cl)phenyl NHCO(4) 0 bonding site (5-Br,2,3-methylenedioxy)-phenyl NHCO(4) 0 bonding site (2-OMe, 6-Br)phenyl NHCO(4) 0 bonding site (2-OH, 6-Br)phenyl NHCO(4) 0 bonding site (2-OMe, 6-Cl)phenyl NHCO(4) 0 bonding site (2-OH, 6-Cl)phenyl NHCO(4) 0 bonding site (2-OH, 6-OMe)phenyl NHCO(4) 0 bonding site <![CDATA[(2-OMe, 6-CF3)phenyl <!-- 82 -->]]> NHCO(4) 0 bonding site <![CDATA[(2-OH, 6-CF3)phenyl]]> NHCO(4) 0 bonding site (2-Cl, 5-SMe)phenyl NHCO(4) 0 bonding site (2-SMe)phenyl NHCO(4) 0 bonding site (3-SMe)phenyl NHCO(4) 0 bonding site (2-OMe, 6-Et)phenyl NHCO(4) 0 bonding site <![CDATA[(3-SO2Me)phenyl]]> NHCO(4) 0 bonding site (2-OH,6-Et)phenyl NHCO(4) 0 bonding site (3-S(=O)Me)phenyl

[1437] [Table 14]

[1438] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO(4) 0 bonding site (2-Cl,5-S(=O)Me)phenyl NHCO(4) 0 bonding site (2-S(=O)Me)phenyl NHCO(4) 0 bonding site (3-Cl)pyridin-2-yl NHCO(4) 0 bonding site (2-OMe, 3-Cl)phenyl NHCO(4) 0 bonding site (3-Me)pyridin-2-yl NHCO(4) 0 bonding site (2-OH, 3-Cl)phenyl NHCO(4) 0 bonding site (3-OH)pyridin-2-yl NHCO(4) 0 bonding site (3-Vinyl)pyridin-2-yl NHCO(4) 0 bonding site (2-Et)pyridin-2-yl <![CDATA[NHSO2(4)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]> <![CDATA[NHSO2(4)]]> 0 bonding site Phenyl <![CDATA[NHSO2(4)]]> 0 bonding site (3-Br)phenyl <![CDATA[NHSO2(4)]]> 0 bonding site (3-OMe)phenyl <![CDATA[NHSO2(3)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]> <![CDATA[NMeSO2(3)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]> <![CDATA[NHSO2(3)]]> 0 bonding site Naphthalene-2-yl

[1439] [Table 15]

[1440] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> <![CDATA[NHSO2(3)]]> 0 bonding site Naphthalene-1-yl <![CDATA[NHSO2(4)]]> 0 bonding site Cyclohexyl <![CDATA[NHSO2(4)]]> 0 bonding site Pyridin-3-yl <![CDATA[NHSO2(4)]]> 0 bonding site (4-iPr)phenyl <![CDATA[NHSO2(4)]]> 1 bonding site Phenyl <![CDATA[NHSO2(4)]]> 0 bonding site Thiophene-2-yl <![CDATA[NHSO2(4)]]> 0 bonding site Naphthalene-2-yl <![CDATA[NBnSO2(4)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]> <![CDATA[NMeSO2(4)]]> 0 bonding site (3-Br)phenyl <![CDATA[NMeSO2(4)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]> <![CDATA[N(CH2CH2OH)SO2(4)]]> 0 bonding site <![CDATA[(2-NO2)phenyl <!-- 83 -->]]> <![CDATA[NHSO2(4)]]> 1 bonding site (2-Cl)phenyl <![CDATA[NHSO2(4)]]> 1 bonding site (3-Br)phenyl <![CDATA[NHSO2(4)]]> 0 bonding site <![CDATA[(2-CF3)phenyl]]> <![CDATA[NHSO2(4)]]> 1 bonding site (2-Br)phenyl <![CDATA[NHSO2(4)]]> 1 bonding site (2-Me)phenyl

[1441] [Table 16]

[1442] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> <![CDATA[NHSO2(4)]]> 1 bonding site <![CDATA[(2-NO2)phenyl]]> <![CDATA[NHSO2(4)]]> 2 bonding site Phenyl <![CDATA[NHSO2(4)]]> 1 bonding site (4-Cl)phenyl <![CDATA[NMeSO2(4)]]> 1 bonding site <![CDATA[(2-CF3)phenyl]]> <![CDATA[NMeSO2(4)]]> 1 bonding site (2-Et)phenyl <![CDATA[NMeSO2(4)]]> 1 bonding site (2,3-Me)phenyl <![CDATA[NMeSO2(4)]]> 2 bonding site (2-Cl)phenyl <![CDATA[NMeSO2(4)]]> 1 bonding site <![CDATA[(2-NO2)phenyl]]> <![CDATA[NMeSO2(4)]]> 1 bonding site <![CDATA[(2-NH2)phenyl]]> <![CDATA[NMeSO2(4)]]> 1 bonding site <![CDATA[(2-NMe2)phenyl]]>

[1443] [Table 17]

[1444] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO(4) 0 bonding site Pyridin-4-yl NHCO(4) 1 O Pyridin-3-yl NHCO(4) 0 bonding site Pyridin-3-yl NHCO(4) 0 bonding site (2-Me)pyridin-3-yl NHCO(4) 0 bonding site (2-Cl)pyridin-3-yl NHCO4) 1 O Pyridin-2-yl NHCO(4) 0 bonding site <![CDATA[(4-CF3)pyridin-3-yl]]> NHCO(4) 0 bonding site (2-iPr)phenyl

[1445] <Representative Compound Example B-200>

[1446]

[1447] (Where B Ba (replacement position), n B 、E Ba and G Ba As shown in Tables 18 and 19)

[1448] [Table 18]

[1449] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO(4) 0 bonding site Cyclohexyl NHCO(4) 0 bonding site (6-Me)pyridin-2-yl NHCO(4) 0 bonding site (2-Me)pyridin-3-yl NHCO(4) 0 bonding site (2-OMe, 3-Me)phenyl NHCO(4) 0 bonding site (2,3-Cl)phenyl NHCO(4) 0 bonding site (2-OH,3-Me)phenyl NHCO(4) 0 bonding site (2-I)phenyl NHCO(4) 1 bonding site (1-Me)pyrrol-2-yl NHCO(4) 1 bonding site (2-tBu)phenyl NHCO(4) 0 bonding site (2-Isopropyl)phenyl NHCO(4) 0 bonding site (2-iPr)phenyl NHCO(4) 1 bonding site Morpholin-2-yl NHCO(4) 0 bonding site (2-Cl)pyridin-2-yl

[1450] [Table 19]

[1451] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> <![CDATA[NHSO2(4)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]> <![CDATA[NMeSO2(4)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]> <![CDATA[SO2NH(4)]]> 0 bonding site Phenyl <![CDATA[OSO2(4)]]> 0 bonding site (3-Br)phenyl <![CDATA[NHSO2(4)]]> 1 bonding site (2-Cl)phenyl <![CDATA[NHSO2(4)]]> 0 bonding site (3-Br)phenyl <![CDATA[NHSO2(4)]]> 0 bonding site (3-OMe)phenyl <![CDATA[NHSO2(4)]]> 1 bonding site (2,3-Cl)phenyl <![CDATA[NHSO2(4)]]> 1 bonding site (2,6-Cl)phenyl <![CDATA[NHSO2(4)]]> 1 bonding site (2-I)phenyl <![CDATA[NMeSO2(4)]]> 1 bonding site (2-Cl)phenyl

[1452] <Representative Compound Example B-300>

[1453]

[1454] (Where R 1B 、B Ba (replacement position), n B 、E Ba and G Ba As shown in Table 20)

[1455] [Table 20]

[1456] <![CDATA[R 1B ]]> <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> 7-OMe NHCO(4) 0 bonding site (2,3-Me)phenyl 7-OH NHCO(4) 0 bonding site (2,3-Me)phenyl 6-Me NHCO(4) 0 bonding site (2,3-Me)phenyl 6,7-Me NHCO(4) 0 bonding site (2-I)phenyl 6-Et NHCO(4) 0 bonding site (2-I)phenyl 7-Ph NHCO(4) 0 bonding site (2-Isopropyl)phenyl 7-(pyridin-3-yl) NHCO(4) 0 bonding site (2-Isopropyl)phenyl 7-(pyridin-2-yl) NHCO(4) 0 bonding site (2-Isopropyl)phenyl 7-Cl <![CDATA[NHSO2(4)]]> 0 bonding site (2-Isopropyl)phenyl 7-Br <![CDATA[NHSO2(4)]]> 0 bonding site (2-Isopropyl)phenyl <![CDATA[7-CF3]]> <![CDATA[NHSO2(4)]]> 0 bonding site (2-Isopropyl)phenyl H <![CDATA[NHSO2(4)]]> 0 bonding site (2-Isopropyl)phenyl 6-Me, 7-Br <![CDATA[NHSO2(4)]]> 0 bonding site (2-Isopropyl)phenyl 7-OMe <![CDATA[NHSO2(4)]]> 1 bonding site (2-Cl)phenyl 7-OH <![CDATA[NHSO2(4)]]> 1 bonding site (2-Cl)phenyl 6-Me <![CDATA[NHSO2(4)]]> 1 bonding site (2-Cl)phenyl

[1457] <Representative Compound Example B-400>

[1458]

[1459] (Where B Ba (replacement position), n B 、E Ba and G Ba As shown in Table 21)

[1460] [Table 21]

[1461] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO 0 bonding site (2-Cl, 3-OMe)phenyl NHCO 0 bonding site (2-I)phenyl <![CDATA[NHSO2]]> 1 bonding site (2-Cl)phenyl <![CDATA[NHSO2]]> 1 bonding site (2-Cl)phenyl

[1462] <Representative Compound Example B-500>

[1463]

[1464] (Where B Ba (replacement position), n B 、E Ba and G Ba As shown in Table 22)

[1465] [Table 22]

[1466] <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> NHCO(4) 0 bonding site (2-Cl, 3-OMe)phenyl NHCO(4) 0 bonding site (2-Cl, 3-OH)phenyl NHCO(4) 0 bonding site (2-tBu)phenyl NHCO(4) 0 bonding site (2-Cl, 6-OMe)phenyl NHCO(4) 0 bonding site (2-Cl, 6-OH)phenyl NHSO2(3) 0 bonding site Phenyl NHSO2(4) 0 bonding site (2-Cl)phenyl

[1467] <Representative Compound Example B-600>

[1468]

[1469] (Where B B (Replacement), D B 、E B and G B As shown in Table 23)

[1470] [Table 23]

[1471] <![CDATA[B B (Replacement position)]]> <![CDATA[D B ]]> <![CDATA[E B ]]> <![CDATA[G B ]]> NHCO(4) C(Me)H bonding site Phenyl NHCO(4) <![CDATA[C(Me)2]]> bonding site Phenyl NHCO(4) CH=CH bonding site Phenyl NHCO(4) C(Me)H O Phenyl NHCO(4) <![CDATA[C(Me)2]]> O Phenyl NHCO(4) CH=CH bonding site (2-Me)phenyl NHCO(4) CH=CH bonding site (2-Cl)phenyl

[1472] <Representative Compound Example B-700>

[1473]

[1474] (where m B (Replacement), B B 、D B 、E B and G B As shown in Table 24)

[1475] [Table 24]

[1476] <![CDATA[m B (Replacement position)]]> <![CDATA[B B ]]> <![CDATA[D B ]]> <![CDATA[E B ]]> <![CDATA[G B ]]> 1(4) NHCO bonding site bonding site Phenyl 1(4) NHCO bonding site bonding site (2-Cl)phenyl 1(4) <![CDATA[NHSO2]]> <![CDATA[CH2]]> bonding site (2-Cl)phenyl

[1477] <Representative Compound Example B-800>

[1478]

[1479] (Where, X Ba 、Y Ba 、B Ba (replacement position), n B 、E Ba and G Ba As shown in Table 25)

[1480] [Table 25]

[1481] <![CDATA[X Ba ]]> <![CDATA[Y Ba ]]> <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba <!-- 87 -->]]> CH CF NHCO(4) 0 bonding site (2,3-Me)phenyl CH C-OH NHCO(4) 0 bonding site (2,3-Me)phenyl CH CF NHCO(4) 0 bonding site (2-I)phenyl CH N NHCO(4) 0 bonding site (2-I)phenyl CH N NHCO(4) 0 bonding site Phenyl N CH NHCO(4) 0 bonding site (2-I)phenyl CH N NHCO(4) 0 bonding site (2-Cl)phenyl CH N NHCO(4) 0 bonding site (2-OH)phenyl CH N NHC(=O)NH(4) 0 bonding site (2-OH)phenyl CH N NHCO(4) 0 bonding site (2-OH, 6-Me)phenyl CH N NHCO(4) 0 bonding site (2-OH, 6-Cl)phenyl CH N NHCO(3) 0 bonding site (2-OH, 6-Cl)phenyl CH N NHCO(4) 0 bonding site (2-Cl)pyridin-2-yl CH N NHCO(4) 1 bonding site (2-Cl)pyridin-2-yl CH N NHCO(4) 0 bonding site (2-Me)pyridin-2-yl CH C-OMe <![CDATA[NHSO2(4)]]> 1 bonding site (2-Cl)phenyl CH C-OH <![CDATA[NHSO2(4)]]> 1 bonding site (2-Cl)phenyl

[1482] <Representative Compound Example B-900>

[1483]

[1484] (where I = II - III = IV, B Ba (replacement position), n B 、E Ba and G Ba As shown in Table 26)

[1485] [Table 26]

[1486] I=II-III=IV <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> N=CH-CH=CH NHCO(4) 0 bonding site (2-I)phenyl CH=N-CH=CH NHCO(4) 0 bonding site (2-I)phenyl CH=CH-N=CH NHCO(4) 0 bonding site (2-I)phenyl CH=CH-CH=N NHCO(4) 0 bonding site (2-I)phenyl N=CH-CH=CH NHCO(4) 1 O Phenyl N=CH-CH=CH NHCO(3) 0 bonding site (2-I)phenyl N=CH-CH=CH NHCO(4) 0 bonding site (2-Cl)phenyl N=CH-CH=CH NHCO(4) 0 bonding site (2-OH)phenyl N=CH-CH=CH NHC(=O)NH(4) 0 bonding site (2-OH)phenyl N=CH-CH=CH NHCO(4) 1 O (2-OH, 6-Me)phenyl N=CH-CH=CH NHCO(4) 0 bonding site (2-OH, 6-Cl)phenyl N=CH-CH=CH NHCO(3) 0 bonding site (2-OH, 6-Cl)phenyl N=CH-CH=CH NHCO(4) 0 bonding site (2-Cl)pyridin-2-yl N=CH-CH=CH NHCO(4) 1 bonding site (2-Cl)pyridin-2-yl N=CH-CH=CH NHCO(4) 0 bonding site (2-Me)pyridin-2-yl CH=CH-N=CH NHCO(4) 0 bonding site (2-Cl)pyridin-3-yl

[1487] <Representative Compound Example B-1000>

[1488]

[1489] (Wherein, I-II-III-IV, B Ba (replacement position), n B 、E Ba and G Ba As shown in Table 27)

[1490] [Table 27]

[1491] I-II-III-IV <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> <![CDATA[NH-CH2-CH2-CH2]]> NHCO(4) 0 bonding site (2-I)phenyl <![CDATA[CH2-NH-CH2-CH2]]> NHCO(4) 0 bonding site (2-I)phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 0 bonding site (2-I)phenyl <![CDATA[CH2-CH2-CH2-NH]]> NHCO(4) 0 bonding site (2-I)phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 1 O Phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(3) 0 bonding site (2-I)phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 0 bonding site (2-Cl)phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 0 bonding site (2-Cl)pyridin-3-yl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 0 bonding site (2-OH)phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHC(=O)NH(4) 0 bonding site (2-OH)phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 1 O (2-OH, 6-Me)phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 0 bonding site (2-OH, 6-Cl)phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(3) 0 bonding site (2-OH, 6-Cl)phenyl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 0 bonding site (2-Cl)pyridin-2-yl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 1 bonding site (2-Cl)pyridin-2-yl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 0 bonding site (2-Me)pyridin-2-yl <![CDATA[CH2-CH2-NH-CH2]]> NHCO(4) 0 bonding site (2-Cl)pyridin-3-yl

[1492] <Representative Compound Example B-1100>

[1493]

[1494] (Where R 5Ba 、B Ba (replacement position), n B 、E Ba and G Ba As shown in Table 28)

[1495] [Table 28]

[1496] <![CDATA[R 5Ba ]]> <![CDATA[B Ba (Replacement position)]]> <![CDATA[n B ]]> <![CDATA[E Ba ]]> <![CDATA[G Ba ]]> Bn <![CDATA[NBnSO2(4)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]> Me <![CDATA[NBnSO2(4)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]> Et <![CDATA[NBnSO2(4)]]> 0 bonding site <![CDATA[(2-NO2)phenyl]]>

[1497] The compounds represented by the general formula (A) are disclosed in International Publication No. 2010 / 093061, and thus any of these compounds can be easily obtained by referring to these international publications. The contents disclosed in these international publications are all incorporated by reference into the disclosure of this specification.

[1498] The compounds represented by the general formula (BI) and (BII) are disclosed in International Publication No. 2013 / 105608, and thus any of these compounds can be readily obtained by reference to these international publications. The disclosures of these international publications are incorporated herein by reference in their entirety.

[1499] Furthermore, International Publication Nos. 2010 / 093061, 2013 / 105608, and 2015 / 005467 describe that the compounds represented by the general formulae (A) to (BII) have a P2X4 receptor antagonistic activity.

[1500] It should be noted that specific examples of preferred compounds or pharmaceutically acceptable salts thereof included in the compounds represented by the above general formulae (A) to (BII) are shown below, but the compounds or pharmaceutically acceptable salts thereof that can be used as active ingredients in the pharmaceutical compositions of the present invention are not limited thereto.

[1501] (Compound A1) 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1502] (Compound A2) 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[1503] (Compound A3) 5-[3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone potassium salt;

[1504] (Compound A4) 5-[4-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1505] (Compound A5) 5-[4-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[1506] (Compound A6) 1-Methyl-5-[3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1507] (Compound A7) 1,3-dimethyl-5-[3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1508] (Compound A8) 5-[2-chloro-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1509] (Compound A9) 5-[2-chloro-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[1510] (Compound A10) 5-[2-methyl-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1511] (Compound A11) 5-[2-methyl-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[1512] (Compound A12) 5-[2-Bromo-5-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1513] (Compound A13) 5-[3-(2-methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1514] (Compound A14) 5-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1515] (Compound A15) 5-[3-(5-oxo-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1516] (Compound A16) 5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1517] (Compound A17) 5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[1518] (Compound A18)5-[3-( oxazol-2-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1519] (Compound A19) 5-[3-(1H-pyrazol-4-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1520] (Compound A20) 5-[4-Fluoro-3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1521] (Compound A21) 5-[4-Fluoro-3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt;

[1522] (Compound B1) 5-(4-Benzoylaminophenyl)-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1523] (Compound B2) 5-[4-[2-(trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1524] (Compound B3) 5-[4-(3-bromobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1525] (Compound B4) 5-[4-[4-(trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1526] (Compound B5) 5-[4-(2-methylbenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1527] (Compound B6) 5-[4-(2,6-dimethylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1528] (Compound B7) 5-[4-(2,6-dichlorobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1529] (Compound B8) 5-[4-(3-chlorobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1530] (Compound B9) 5-[4-(2-phenylacetylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1531] (Compound B10) 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-phenylthiourea;

[1532] (Compound B11) 5-[4-(2,3-dimethoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1533] (Compound B12) 5-[4-(2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1534] (Compound B13) 5-[4-[(2-chlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1535] (Compound B14) 5-[4-(2,3-dimethylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1536] (Compound B15) 5-[4-(2,5-dimethylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1537] (Compound B16) 5-[4-(5-bromo-2-chlorobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1538] (Compound B17) 5-[4-(2,4-dichlorobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1539] (Compound B18) 5-[4-(2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1540] (Compound B19) 5-[4-(2,3-dihydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1541] (Compound B20) 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-phenylurea;

[1542] (Compound B21) 5-[4-[(2,6-dichlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1543] (Compound B22) 5-[4-[(2-methoxyphenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1544] (Compound B23) 5-[4-[(2-hydroxyphenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1545] (Compound B24) 1-(2-chlorophenyl)-3-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]thiourea;

[1546] (Compound B25) 5-[4-[3-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1547] (Compound B26) 5-[4-[2-[2-(trifluoromethyl)phenyl]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1548] (Compound B27) 1-(2-chlorophenyl)-3-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]urea;

[1549] (Compound B28) 5-[4-[(2-phenylpropionyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1550] (Compound B29) 5-[4-(2-chloro-3-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1551] (Compound B30) 5-[4-(3-phenylpropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1552] (Compound B31) 5-[4-[(1H-indole-3-carbonyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1553] (Compound B32) 5-[4-(2-chloro-3-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1554] (Compound B33) 5-[4-[(2-methyl-2-phenylpropionyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1555] (Compound B34) 5-[4-(2-phenoxyacetylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1556] (Compound B35) 5-[4-[2-(2-chloro-4-methoxyphenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1557] (Compound B36) 5-[4-[(1-methyl-1H-imidazole-2-carbonyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1558] (Compound B37) 5-[4-[2-(2,4-dichlorophenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1559] (Compound B38) 5-[4-[2-(2-chloro-4-hydroxyphenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1560] (Compound B39) 5-[4-(3-phenylpropenylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1561] (Compound B40) 5-[4-[(3-pyridylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[1562] (Compound B41) 5-[4-(1H-benzimidazole-2-carbonylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1563] (Compound B42) 1-[4-(2,3-dimethylbenzoylamino)phenyl]-7-methoxy-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[1564] (Compound B43) 5-[4-[(Benzoylamino)methyl]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1565] (Compound B44) 5-[4-[(2-chlorobenzoylamino)methyl]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1566] (Compound B45) 1-[4-(2,3-dimethylbenzoylamino)phenyl]-7-hydroxy-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[1567] (Compound B46) 5-[4-(2-chlorobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1568] (Compound B47) 5-[4-(2-bromobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1569] (Compound B48) 5-[4-(2-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1570] (Compound B49) 5-[4-(2,3-dimethylbenzoylamino)-3-fluorophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1571] (Compound B50) 5-[4-[2-(2-methylphenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1572] (Compound B51) 5-[4-[(Quinoxalin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1573] (Compound B52) 5-[4-[(5-methylthiophen-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1574] (Compound B53) 5-[3-[(2-chlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1575] (Compound B54) 5-[4-[(2,4,6-trimethylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1576] (Compound B55) 5-[4-(cyclohexylcarbonylamino)phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1577] (Compound B56) 1-[4-(2,3-dimethylbenzoyl)aminophenyl]-6-methyl-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[1578] (Compound B57) 5-[4-[(2-ethylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1579] (Compound B58) 5-[4-[(6-methylpyridin-2-yl)carbonylamino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1580] (Compound B59) 5-[4-[(2-methylpyridin-3-yl)carbonylamino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1581] (Compound B60) 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-(2-methylphenyl)thiourea;

[1582] (Compound B61) 5-[4-(2-methoxy-3-methylbenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1583] (Compound B62) 5-[4-(2,3-dichlorobenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1584] (Compound B63) 5-[4-(2,3-dimethylbenzoylamino)-3-hydroxyphenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1585] (Compound B64) 5-[4-(2-chloro-3-methoxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[1586] (Compound B65) 5-[4-[(4-dimethylaminobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1587] (Compound B66) 5-[4-[2-(2,4-dichlorophenoxy)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1588] (Compound B67) 5-[4-[2-(2-methylphenoxy)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1589] (Compound B68) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)butyl]-2-chloro-3-methoxybenzamide;

[1590] (Compound B69) 5-[4-(2-chloro-3-hydroxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[1591] (Compound B70) 5-[4-(2-acetylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1592] (Compound B71) 5-[4-(2-tert-Butylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1593] (Compound B72) 5-[2-(2-iodobenzoyl)aminoethyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1594] (Compound B73) 5-[3-[(2-iodobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1595] (Compound B74) 6,7-dimethyl-1-[4-(2-iodobenzoyl)aminophenyl]-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[1596] (Compound B75) 5-[4-[(1-methylpiperidin-4-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[1597] (Compound B76) 5-[4-[(Benzofuran-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1598] (Compound B77) 5-[4-[(1-methyl-1H-indol-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1599] (Compound B78) 5-[4-(2-propenylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1600] (Compound B79) 5-[4-(2-propylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1601] (Compound B80) 5-[3-Fluoro-4-(2-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1602] (Compound B81) 5-[4-(2-hydroxy-3-methylbenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1603] (Compound B82) 5-[4-[(2-isopropoxybenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1604] (Compound B83) 5-[4-[(3-methylthiophen-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1605] (Compound B84) 5-[4-(2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1606] (Compound B85) 5-[4-[2-(4-chloro-2-methylphenoxy)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1607] (Compound B86) 5-[4-[(4-fluoro-2-trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1608] (Compound B87) 5-[4-(4-fluoro-2-methoxybenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1609] (Compound B88) 5-[4-(4-Fluoro-2-hydroxybenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1610] (Compound B89) 5-[3-[(2-iodophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1611] (Compound B90) 5-[4-(2-methyl-2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1612] (Compound B91) 5-[4-(2-tert-Butylbenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[1613] (Compound B92) 5-[4-[(3-dimethylaminobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1614] (Compound B93) 5-[4-(4-iodo-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1615] (Compound B94) 5-[4-(6-fluoro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1616] (Compound B95) 5-[4-(2-hydroxy-4-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1617] (Compound B96) 5-[4-(6-fluoro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1618] (Compound B97) 5-[4-(2-fluorobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1619] (Compound B98) 5-[4-[(2-dimethylaminobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1620] (Compound B99) 5-[4-(2-methoxy-6-methylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1621] (Compound B100) 5-[4-(2-hydroxy-6-methylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1622] (Compound B101) 5-[4-[3-(2-methylphenyl)propionylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1623] (Compound B102) 5-(4-phenylcarbamoylphenyl)-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1624] (Compound B103) 5-(4-Benzylcarbamoylphenyl)-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1625] (Compound B104) 5-[4-[3-(2-methylphenyl)acryloylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1626] (Compound B105) 5-[4-[3-(2-chlorophenyl)propionylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1627] (Compound B106) 5-[4-(2-iodobenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1628] (Compound B107) 5-[4-[(1-methyl-1H-pyrrol-2-ylacetyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1629] (Compound B108) 5-[4-(2-chlorobenzyl)carbamoylphenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1630] (Compound B109) 5-[4-[3-(2-chlorophenyl)acryloylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1631] (Compound B110) 5-[4-(2-chlorophenyl)carbamoylphenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1632] (Compound B111) 5-[4-(6-bromo-2,3-methylenedioxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1633] (Compound B112) 5-[4-(6-bromo-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1634] (Compound B113) 5-[4-[(2-tert-Butylbenzoyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1635] (Compound B114) 5-[2-(2-iodobenzoyl)aminopyridin-5-yl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1636] (Compound B115) 5-[4-(6-bromo-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1637] (Compound B116) 5-[4-(6-chloro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1638] (Compound B117) 5-[4-(2-iodobenzoylamino)phenyl]-1H-[1,4]diazepine 2,3-h]quinoline-2,4(3H,5H)-dione;

[1639] (Compound B118) 5-[4-(6-chloro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1640] (Compound B119) 5-[4-(2-Hydroxy-6-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1641] (Compound B120) 5-[4-[2-methoxy-6-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1642] (Compound B121) 5-[4-[2-hydroxy-6-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1643] (Compound B122) 5-[4-[(2-Isopropenylbenzoyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1644] (Compound B123) 5-[4-[(2-isopropylbenzoyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1645] (Compound B124) 5-[4-[2-chloro-5-(methylthio)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1646] (Compound B125) 5-[4-[2-(methylthio)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1647] (Compound B126) 5-[4-[3-(methylthio)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1648] (Compound B127) 5-[4-[2-ethyl-6-methoxybenzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1649] (Compound B128) 5-[4-(3-methanesulfonylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1650] (Compound B129) 6-ethyl-1-[4-(2-iodobenzoyl)aminophenyl]-1H-1,5-benzodiazepine -2,4(3H,5H)-dione;

[1651] (Compound B130) 5-[4-[2-ethyl-6-hydroxybenzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1652] (Compound B131) 5-[4-(3-methanesulfinylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1653] (Compound B132) 5-[4-(2-chloro-5-methanesulfinylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1654] (Compound B133) 5-[4-(2-methanesulfinylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1655] (Compound B134) 5-[4-[[2-(4-morpholinyl)acetyl]amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[1656] (Compound B135) 5-[4-(2-chloro-6-methoxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[1657] (Compound B136) 5-[4-[[(3-chloropyridin-2-yl)carbonyl]amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1658] (Compound B137) 5-[4-(2-chloro-6-hydroxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-ketone;

[1659] (Compound B138) 5-[4-(3-chloro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1660] (Compound B139) 5-[4-[(3-methylpyridin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1661] (Compound B140) 5-[4-[[(3-chloropyridin-2-yl)carbonyl]amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1662] (Compound B141) 5-[4-(3-chloro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1663] (Compound B142) 5-[4-[[(3-hydroxypyridin-2-yl)carbonyl]amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1664] (Compound B143) 5-[4-[(3-vinylpyridin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1665] (Compound B144) 5-[4-[(3-ethylpyridin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1666] (Compound B145) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphthalene[1,2-b][1,4]diazepine -5-amino)phenyl]-2-nitrobenzenesulfonamide;

[1667] (Compound B146) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]benzenesulfonamide;

[1668] (Compound B147) 3-Bromo-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]benzenesulfonamide;

[1669] (Compound B148) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-methoxybenzenesulfonamide;

[1670] (Compound B149) N-[3-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepine] -5-amino)phenyl]benzenesulfonamide;

[1671] (Compound B150) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-2-nitrobenzenesulfonamide;

[1672] (Compound B151) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]-diazepine] -5-amino)phenyl]-2-nitro-benzenesulfonamide;

[1673] (Compound B152) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]-diazepine -5-amino)phenyl]-N-methyl-2-nitrobenzenesulfonamide;

[1674] (Compound B153) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-N-methyl-2-nitrobenzenesulfonamide;

[1675] (Compound B154) 4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)-N-phenylbenzenesulfonamide;

[1676] (Compound B155) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b]-[1,4]diazepine -5-yl)phenyl]-2-naphthalenesulfonamide;

[1677] (Compound B156) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b]-[1,4]diazepine -5-yl)phenyl]-1-naphthalenesulfonamide;

[1678] (Compound B157) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]cyclohexanesulfonamide;

[1679] (Compound B158) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-3-pyridinesulfonamide hydrochloride;

[1680] (Compound B159) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-4-isopropylbenzenesulfonamide;

[1681] (Compound B160) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]phenylmethanesulfonamide;

[1682] (Compound B161) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-thiophene-sulfonamide;

[1683] (Compound B162) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-naphthalenesulfonamide;

[1684] (Compound B163) 4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine-3-bromobenzenesulfonate -5-yl)phenyl ester;

[1685] (Compound B164) N-benzyl-N-[4-(1-benzyl-2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-2-nitrobenzenesulfonamide;

[1686] (Compound B165) N-benzyl-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-2-nitrobenzenesulfonamide;

[1687] (Compound B166) 3-Bromo-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-methylbenzenesulfonamide;

[1688] (Compound B167) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-N-methyl-2-nitrobenzenesulfonamide;

[1689] (Compound B168) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide;

[1690] (Compound B169) N-[4-(7-chloro-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine] -1-yl)phenyl]benzenesulfonamide;

[1691] (Compound B170) N-[4-(7-bromo-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine] -1-yl)phenyl]benzenesulfonamide;

[1692] (Compound B171) N-[4-[(2,4-dioxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine -1-yl)]phenyl]benzenesulfonamide;

[1693] (Compound B172) N-[4-(2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine] -1-yl)phenyl]benzenesulfonamide;

[1694] (Compound B173) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[1695] (Compound B174) 1-(3-bromophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[1696] (Compound B175) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-trifluoromethylbenzenesulfonamide;

[1697] (Compound B176) N-[4-(7-bromo-6-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine] -1-yl)phenyl]benzenesulfonamide;

[1698] (Compound B177) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[1699] (Compound B178) 3-Bromo-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]benzenesulfonamide;

[1700] (Compound B179) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine] -5-amino)phenyl]-3-methoxybenzenesulfonamide;

[1701] (Compound B180) 1-(2-bromophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[1702] (Compound B181) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-1-(2-methylphenyl)methanesulfonamide;

[1703] (Compound B182) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]-1-(2-nitrophenyl)methanesulfonamide;

[1704] (Compound B183) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-phenylethanesulfonamide;

[1705] (Compound B184) 1-(2,3-dichlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[1706] (Compound B185) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-7-methoxy-1H-benzo[1,2-b][1,4]diazepine -1-yl)phenyl]methanesulfonamide;

[1707] (Compound B186) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-7-hydroxy-1H-benzo[1,2-b][1,4]diazepine -1-yl)phenyl]methanesulfonamide;

[1708] (Compound B187) 1-(4-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[1709] (Compound B188) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)benzyl]methanesulfonamide;

[1710] (Compound B189) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)-2-methoxyphenyl]methanesulfonamide;

[1711] (Compound B190) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)-2-hydroxyphenyl]methanesulfonamide;

[1712] (Compound B191) 1-(2,6-dichlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[1713] (Compound B192) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-6-methyl-1H-benzo[1,2-b][1,4]diazepine -1-yl)phenyl]methanesulfonamide;

[1714] (Compound B193) 1-(2-chlorophenyl)-N-[3-(2,4-dioxy-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-amino)propyl]methanesulfonamide;

[1715] (Compound B194) 1-(2-chlorophenyl)-N-[2-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)ethyl]methanesulfonamide;

[1716] (Compound B195) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-1-(2-iodophenyl)methanesulfonamide;

[1717] (Compound B196) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-methylmethanesulfonamide;

[1718] (Compound B197) 1-(2-chlorophenyl)-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepine -5-amino)phenyl]methanesulfonamide;

[1719] (Compound B198) 1-[2-(trifluoromethyl)phenyl]-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[1720] (Compound B199) 1-(2-ethylphenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[1721] (Compound B200) 1-(2,3-dimethylphenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[1722] (Compound B201) 2-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylethanesulfonamide;

[1723] (Compound B202) 1-(2-nitrophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[1724] (Compound B203) 1-(2-aminophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[1725] (Compound B204) 1-(2-dimethylaminophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide;

[1726] (Compound B205) 5-[4-[(pyridin-4-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[1727] (Compound B206) 5-[4-[2-[(pyridin-3-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[1728] (Compound B207) 5-[4-[(pyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[1729] (Compound B208) 5-[4-[(2-methylpyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone hydrochloride;

[1730] (Compound B209) 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1731] (Compound B210) 5-[4-[2-[(pyridin-2-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1732] (Compound B211) 5-[4-[[4-(Trifluoromethyl)pyridin-3-yl]carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione;

[1733] (Compound B212) 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-1H-[1,4]diazepine 2,3-f]isoquinoline-2,4(3H,5H)-dione;

[1734] (Compound B213) 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-8,9,10,11-tetrahydro-1H-[1,4]diazepine 2,4(3H,5H)-dione; and

[1735] (Compound B214) 5-[4-[(2-isopropylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione.

[1736] More preferably, the compound or pharmaceutically acceptable salt thereof as the active ingredient of the pharmaceutical composition of the present invention is included in the compounds represented by general formula (A) to (BII) or pharmaceutically acceptable salts thereof. More specifically, 5-[3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine can be exemplified. -2,4(3H,5H)-dione; 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; 5-[3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone potassium salt; 5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione sodium salt; 5-[4-fluoro-3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[4-fluoro-3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; 5-[4-[2-(trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[4-[(2-chlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine 5-[4-(2-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[4-[(2-ethylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[4-(2-tert-butylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[4-(2-iodobenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[4-(6-chloro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine] 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine] 1-(2-bromophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine] -5-yl)phenyl]methanesulfonamide; N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-1-(2-methylphenyl)methanesulfonamide; N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine]-2-phenylethanesulfonamide -5-yl)phenyl]-N-methylmethanesulfonamide; 1-(2-chlorophenyl)-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepine 5-[4-[(2-methylpyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione hydrochloride; 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[4-[2-[(pyridin-2-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione and 5-[4-[(2-isopropylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine Of course, the active ingredient of the pharmaceutical composition of the present invention is not limited to the above-mentioned specific compound or its pharmaceutically acceptable salt.

[1737] More preferably, the compound or pharmaceutically acceptable salt thereof as the active ingredient of the pharmaceutical composition of the present invention is included in the compounds represented by general formula (A) to (BII) or pharmaceutically acceptable salts thereof. More specifically, 5-[3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; 5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; 5-[4-[2-(trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; 5-[4-(2-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione and 5-[4-(6-chloro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine Of course, the active ingredient of the pharmaceutical composition of the present invention is not limited to the above-mentioned specific compound or its pharmaceutically acceptable salt.

[1738] As the active ingredient of the pharmaceutical composition of the present invention, a compound represented by the following general formula (C) or a pharmaceutically acceptable salt thereof can be used. These compounds can be produced by known methods (Patent Document 4).

[1739]

[1740] Where,

[1741] A stands for CR 5 or N;

[1742] R 1 represents a group selected from the following groups;

[1743]

[1744] (where * represents the binding site of the above group to the rest of the molecule)

[1745] R 2 represents a cycloalkyl group having 3 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms-an alkyl group having 1 to 4 carbon atoms, a four- to six-membered heterocycloalkyl group, a four- to six-membered heterocycloalkyl group-an alkyl group having 1 to 4 carbon atoms, a phenyl group, a phenyl group-an alkyl group having 1 to 4 carbon atoms, a heteroaryl group, or a heteroaryl group-an alkyl group having 1 to 4 carbon atoms,

[1746] The above groups are independently composed of the same or different R 11 Replace 1 to 4 times depending on the situation, or

[1747] By R 11a Replaced once, independently by the same or different R 11 Replace 1-2 times according to the situation, or

[1748] Two adjacent substituents R together representing a methylenedioxy group 11 Substitute to form a five-membered ring, or

[1749] substituted by 1 to 5 deuterium atoms, independently of each other by the same or different R 11 Replace 1-2 times depending on the situation, or

[1750] R 2 represents a branched (alkyl group having 1 to 4 carbon atoms)-alkyl group having 1 to 4 carbon atoms;

[1751] R 3 represents hydrogen, deuterium, fluorine or methyl;

[1752] R 4 represents hydrogen, deuterium or fluorine;

[1753] R 5 、R 5a and R 5b are the same or different and independently represent hydrogen, halogen, an alkyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, or a haloalkoxy group having 1 to 4 carbon atoms;

[1754] R 6 、R 6a 、R 6b and R 6c The same or different, independently of each other are as follows:

[1755] R 6 represents hydrogen, halogen, cyano, alkyl having 1 to 4 carbon atoms, haloalkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, haloalkoxy having 1 to 4 carbon atoms, HO-(alkoxy having 2 to 4 carbon atoms)-, (alkoxy having 1 to 4 carbon atoms)-(alkoxy having 2 to 4 carbon atoms)-, or F3C-S-;

[1756] R 6a represents hydrogen, halogen, hydroxy, nitro, cyano, alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, haloalkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, haloalkoxy having 1 to 4 carbon atoms, HO-(alkoxy having 2 to 4 carbon atoms)-, (alkoxy having 1 to 4 carbon atoms)-(alkoxy having 2 to 4 carbon atoms)-, R 9 R 10 N-、R 8 -C(O)-NH-, R 8 -C(O)-, R 8 -O-C(O)-, R 9 R 10N-C(O)-, or (alkyl with 1 to 4 carbon atoms)-SO2-;

[1757] R 6b represents hydrogen, halogen, hydroxy, nitro, cyano, alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, haloalkyl having 1 to 4 carbon atoms, haloalkoxy having 1 to 4 carbon atoms, HO-(alkoxy having 2 to 4 carbon atoms)-, (alkoxy having 1 to 4 carbon atoms)-(alkoxy having 2 to 4 carbon atoms)-, R 9 R 10 N-、R 8 -C(O)-NH-, R 8 -C(O)-, R 8 -O-C(O)-, R 9 R 10 N-C(O)-, or (alkyl with 1 to 4 carbon atoms)-SO2-; or

[1758] Adjacent R 6a and R 6b Together they represent a group selected from -O-CH2-CH2-, -O-CH2-O-, or -O-CH2-CH2-O-;

[1759] R 6c represents hydrogen or halogen;

[1760] R 7a and R 7b The same or different, independently of each other, represent hydrogen, hydroxy, halogen, alkyl having 1 to 4 carbon atoms, or haloalkyl having 1 to 4 carbon atoms;

[1761] R 8 When each occurs, it independently represents an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 4 carbon atoms-an alkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, or a haloalkyl group having 1 to 4 carbon atoms;

[1762] R 9 and R 10 are the same or different and independently represent hydrogen, an alkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms, (alkoxy group having 1 to 4 carbon atoms)-(alkyl group having 2 to 4 carbon atoms), a phenyl group, or a heteroaryl group, wherein the above phenyl and heteroaryl groups are independently substituted 1 to 3 times by hydrogen, a halogen, an alkyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, or a haloalkoxy group having 1 to 4 carbon atoms, as the case may be,

[1763] R 9a and R 10aTogether with the nitrogen atom to which they are bonded, they form a four- to six-membered nitrogen-containing heterocyclic ring, wherein the ring contains a member selected from O, NH, NR a (Where R a represents an alkyl group having 1 to 6 carbon atoms or a haloalkyl group having 1 to 6 carbon atoms) or one of S, and is substituted 1 to 3 times, independently of each other, by halogen or alkyl group having 1 to 4 carbon atoms;

[1764] R 11 and R are independently halogen, hydroxy, nitro, cyano, alkyl having 1 to 4 carbon atoms, alkenyl having 2 to 4 carbon atoms, haloalkyl having 1 to 4 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, haloalkoxy having 1 to 4 carbon atoms, HO-(alkoxy having 2 to 4 carbon atoms)-, (alkoxy having 1 to 4 carbon atoms)-(alkoxy having 2 to 4 carbon atoms)-, (haloalkyl having 1 to 4 carbon atoms)-S-, R 9 R 10 N-、R 8 -C(O)-NH-, R 8 -C(O)-, R 8 -O-C(O)-, R 9 R 10 N-C(O)-, or (alkyl with 1 to 4 carbon atoms)-SO2-;

[1765] R 11a represents a cycloalkyl group having 3 to 6 carbon atoms, morpholino, R 9a R 10a N-、R 9a R 10a N—C(O)—, and optionally a group in a five- to six-membered heteroaryl group substituted with a methyl group, or represents the following group,

[1766]

[1767] (where * represents the binding site of the above group to the rest of the molecule).

[1768] Examples of the compound of the general formula (C) include the following compounds. Specifically, preferred compounds as active ingredients of the pharmaceutical composition of the present invention include the following compounds (C1) to (C297) or their pharmaceutically acceptable salts. These compounds can be produced by known methods (Patent Document 4).

[1769] (C1) N-[4-(3-chloro-5-cyanophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1770] (C2) 2-(2-chlorophenyl)-N-4-[3-(dimethylamino)phenoxy]-3-sulfamoylphenylacetamide

[1771] (C3) 2-(2-chlorophenyl)-N-4-[(2-chloropyridin-4-yl)oxy]-3-sulfamoylphenylacetamide

[1772] (C4) 2-(2-chlorophenyl)-N-[4-(3-isopropylphenoxy)-3-sulfamoylphenyl]acetamide

[1773] (C5) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(trifluoromethyl)phenoxy]phenylacetamide

[1774] (C6) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(trifluoromethoxy)phenoxy]phenylacetamide

[1775] (C7) N-[4-(3-acetylphenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1776] (C8)N-[4-(1,3-benzodibenzoylmethane) [5-cyclopentyloxy]-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1777] (C9) N-[4-(3-acetamidophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1778] (C10) 2-(2-chlorophenyl)-N-[4-(2-fluorophenoxy)-3-sulfamoylphenyl]acetamide

[1779] (C11) 2-(2-chlorophenyl)-N-[4-(3-fluorophenoxy)-3-sulfamoylphenyl]acetamide

[1780] (C12) 2-(2-chlorophenyl)-N-[4-(4-fluorophenoxy)-3-sulfamoylphenyl]acetamide

[1781] (C13) 2-(2-chlorophenyl)-N-[4-(pyridin-2-yloxy)-3-sulfamoylphenyl]acetamide

[1782] (C14) 2-(2-chlorophenyl)-N-(4-phenoxy-3-sulfamoylphenyl)acetamide

[1783] (C15) 2-(2-chlorophenyl)-N-[4-(3-cyanophenoxy)-3-sulfamoylphenyl]acetamide

[1784] (C16) 2-(2-chlorophenyl)-N-4-[3-(methylsulfonyl)phenoxy]-3-sulfamoylphenylacetamide

[1785] (C17) 3-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)benzamide

[1786] (C18) 2-(2-chlorophenyl)-N-[4-(3-methylphenoxy)-3-sulfamoylphenyl]acetamide

[1787] (C19) 2-(2-chlorophenyl)-N-[4-(pyrimidin-5-yloxy)-3-sulfamoylphenyl]acetamide

[1788] (C20) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(4H-1,2,4-triazol-4-yl)phenoxy]phenylacetamide

[1789] (C21) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(1H-tetrazol-5-yl)phenoxy]phenylacetamide

[1790] (C22) 2-(2-chlorophenyl)-N-[4-(3-methoxyphenoxy)-3-sulfamoylphenyl]acetamide

[1791] (C23) 2-(2-chlorophenyl)-N-[4-(4-methoxyphenoxy)-3-sulfamoylphenyl]acetamide

[1792] (C24) 2-(2-chlorophenyl)-N-4-[3-(difluoromethoxy)phenoxy]-3-sulfamoylphenylacetamide

[1793] (C25) 2-(2-chlorophenyl)-N-[4-(3,4-dicyanophenoxy)-3-sulfamoylphenyl]acetamide

[1794] (C26) 2-(2-chlorophenyl)-N-4-[3-(morpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide

[1795] (C27) 2-(2-chlorophenyl)-N-[4-(3-4-[(2-chlorophenyl)acetyl]piperazin-1-ylphenoxy)-3-sulfamoylphenyl]acetamide

[1796] (C28) 2-(2-Chlorophenyl)-N-[4-(pyridin-3-yloxy)-3-sulfamoylphenyl]acetamide

[1797] (C29) 2-(2-Chlorophenyl)-N-4-[(5-chloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide

[1798] (C30) 2-(2-chlorophenyl)-N-[4-(4-cyanophenoxy)-3-sulfamoylphenyl]acetamide

[1799] (C31) 2-(2-chlorophenyl)-N-4-[3-(difluoromethyl)phenoxy]-3-sulfamoylphenylacetamide

[1800] (C32) 2-(2-chlorophenyl)-N-[4-(2-methoxyphenoxy)-3-sulfamoylphenyl]acetamide

[1801] (C33) 2-(2-chlorophenyl)-N-[4-(3,5-dicyanophenoxy)-3-sulfamoylphenyl]acetamide

[1802] (C34) 2-(2-chlorophenyl)-N-[4-(5-cyano-2-methoxyphenoxy)-3-sulfamoylphenyl]acetamide

[1803] (C35) 2-(2-Chlorophenyl)-N-4-[(2,5-dichloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide

[1804] (C36) 2-(2-Chlorophenyl)-N-4-[(5,6-dichloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide

[1805] (C37) 3-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)-N-cyclopropylbenzamide

[1806] (C38) 2-(2-Chlorophenyl)-N-4-[(3-chloropyridin-2-yl)oxy]-3-sulfamoylphenylacetamide

[1807] (C39) 2-(2-Chlorophenyl)-N-4-[(4-chloropyridin-2-yl)oxy]-3-sulfamoylphenylacetamide

[1808] (C40) 2-(2-Chlorophenyl)-N-4-[(6-chloropyridin-2-yl)oxy]-3-sulfamoylphenylacetamide

[1809] (C41) 2-(2-chlorophenyl)-N-4-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]-3-sulfamoylphenylacetamide

[1810] (C42) 2-(2-chlorophenyl)-N-4-[4-(1H-imidazol-1-yl)phenoxy]-3-sulfamoylphenylacetamide

[1811] (C43) 2-(2-chlorophenyl)-N-4-[4-(2-oxopyrrolidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide

[1812] (C44) 2-(2-chlorophenyl)-N-4-[4-(morpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide

[1813] (C45) 2-(2-chlorophenyl)-N-[4-(5-cyano-2-methylphenoxy)-3-sulfamoylphenyl]acetamide

[1814] (C46) 2-(2-chlorophenyl)-N-[4-(3-cyano-2-methylphenoxy)-3-sulfamoylphenyl]acetamide

[1815] (C47) 2-(2-Chlorophenyl)-N-[4-(3-cyano-4-fluorophenoxy)-3-sulfamoylphenyl]acetamide

[1816] (C48) N-4-[(5-chloro-2-cyanopyridin-3-yl)oxy]-3-sulfamoylphenyl-2-(2-chlorophenyl)acetamide

[1817] (C49) 2-(2-chlorophenyl)-N-4-[3-(piperidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide

[1818] (C50) 2-(2-chlorophenyl)-N-4-[3-(2-oxopyrrolidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide

[1819] (C51) 2-(2-chlorophenyl)-N-4-[3-(2-oxo-1,3- [3-oxazolidin-3-yl)phenoxy]-3-sulfamoylphenylacetamide

[1820] (C52) 2-(2-chlorophenyl)-N-4-[3-(morpholin-4-ylcarbonyl)phenoxy]-3-sulfamoylphenylacetamide

[1821] (C53) 2-(2-Chlorophenyl)-N-4-[(4-methyltetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide

[1822] (C54) 2-(2-Chlorophenyl)-N-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide

[1823] (C55) 2-(2-Chlorophenyl)-N-4-[(4-cyanotetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide

[1824] (C56) 2-(2-chlorophenyl)-N-(3-sulfamoyl-4-[2-(trifluoromethyl)pyrimidin-5-yl]oxyphenyl)acetamide

[1825] (C57) 2-(2-chlorophenyl)-N-4-[(2-isopropylpyrimidin-5-yl)oxy]-3-sulfamoylphenylacetamide

[1826] (C58) 2-(2-chlorophenyl)-N-4-[(2-cyclopropyl-4-methylpyrimidin-5-yl)oxy]-3-sulfamoylphenylacetamide

[1827] (C59) N-[4-(3-bromophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1828] (C60) N-[4-(4-bromophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1829] (C61) 2-(2-chlorophenyl)-N-4-[3-(2-methyl-1,3-thiazol-4-yl)phenoxy]-3-sulfamoylphenylacetamide

[1830] (C62) 2-(2-chlorophenyl)-N-4-[4-(5-oxopyrrolidin-2-yl)phenoxy]-3-sulfamoylphenylacetamide

[1831] (C63) 2-(2-chlorophenyl)-N-4-[4-(2-oxo-1,3- [3-oxazolidin-3-yl)phenoxy]-3-sulfamoylphenylacetamide

[1832] (C64) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[4-(1,3-thiazol-2-yl)phenoxy]phenylacetamide

[1833] (C65) N-[4-(2-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1834] (C66) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1835] (C67) 2-(2-Chlorophenyl)-N-4-[3-(piperidin-1-ylcarbonyl)phenoxy]-3-sulfamoylphenylacetamide

[1836] (C68) 2-(2-Chlorophenyl)-N-3-sulfamoyl-4-[4-(tetrahydrofuran-3-yl)phenoxy]phenylacetamide

[1837] (C69) 2-(2-chlorophenyl)-N-[4-(3-cyano-5-fluorophenoxy)-3-sulfamoylphenyl]acetamide

[1838] (C70) N-[4-(2-methoxyphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide

[1839] (C71) N-[4-(2-methoxyphenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide

[1840] (C72) N-3-Sulfamoyl-4-[2-(trifluoromethoxy)phenoxy]phenyl-2-[4-(trifluoromethyl)phenyl]acetamide

[1841] (C73) N-[4-(2-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide

[1842] (C74) 2-phenyl-N-3-sulfamoyl-4-[2-(trifluoromethoxy)phenoxy]phenylacetamide

[1843] (C75) 2-(2-chlorophenyl)-N-4-[(2-oxo-1,2-dihydropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide

[1844] (C76) N-[4-(2-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide

[1845] (C77) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide

[1846] (C78) N-4-[(5-chloropyridin-3-yl)oxy]-3-sulfamoylphenyl-2-phenylacetamide

[1847] (C79) 2-(2-chlorophenyl)-N-4-[(2-chloropyrimidin-5-yl)oxy]-3-sulfamoylphenylacetamide

[1848] (C80) 2-(2-Chlorophenyl)-N-4-[(5-fluoropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide

[1849] (C81) 2-(2-Chlorophenyl)-N-4-[(6-chloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide

[1850] (C82) N-[2-chloro-4-(3-chlorophenoxy)-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1851] (C83) N-[2-chloro-4-(3-chlorophenoxy)-5-sulfamoylphenyl]-2-(2-chloro-3-fluorophenyl)acetamide

[1852] (C84) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-fluorophenyl)acetamide

[1853] (C85) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide

[1854] (C86) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide

[1855] (C87) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-isopropylphenyl)acetamide

[1856] (C88) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-ethoxyphenyl)acetamide

[1857] (C89) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(difluoromethyl)phenyl]acetamide

[1858] (C90) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[(trifluoromethyl)thio]phenylacetamide

[1859] (C91) 2-(2-Bromophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1860] (C92) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methylpyridin-3-yl)acetamide

[1861] (C93) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chloropyridin-3-yl)acetamide

[1862] (C94) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)-2,2-difluoroacetamide

[1863] (C95) 2-(2-chloro-4-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1864] (C96) 2-(2-chloro-6-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1865] (C97) 2-(2-chloro-5-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1866] (C98) 2-(2-chloro-3-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1867] (C99) 2-(2-chloro-5-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1868] (C100) 2-(2-chloro-6-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1869] (C101) 2-(2-chloro-6-methoxyphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1870] (C102) 2-(2-chloro-5-methoxyphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1871] (C103) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3-dichlorophenyl)acetamide

[1872] (C104) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichlorophenyl)acetamide

[1873] (C105) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide

[1874] (C106) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2,2-difluoro-2-phenylacetamide

[1875] (C107) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-3-(trifluoromethyl)phenyl]acetamide

[1876] (C108) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-6-(trifluoromethyl)phenyl]acetamide

[1877] (C109) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-5-(trifluoromethyl)phenyl]acetamide

[1878] (C110) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,4-dichlorophenyl)acetamide

[1879] (C111) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4,6-dichloropyridin-3-yl)acetamide

[1880] (C112) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-chloropyridin-2-yl)acetamide

[1881] (C113) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(difluoromethoxy)phenyl]acetamide

[1882] (C114) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,5-dichlorophenyl)acetamide

[1883] (C115) 2-[6-chloro-2,3-difluoro-4-(trifluoromethyl)phenyl]-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1884] (C116) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide

[1885] (C117) 2-(5-bromo-2-chlorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1886] (C118) 2-(4-bromo-2-chloro-5-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1887] (C119) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-chloropyridin-4-yl)acetamide

[1888] (C120) 2-(2-chloro-6-fluoro-3-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1889] (C121) 2-(6-chloro-2-fluoro-3-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1890] (C122) 2-(2-chloro-3,6-difluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1891] (C123) 2-(2-chloro-4,5-difluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1892] (C124) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3-dichloro-6-fluorophenyl)acetamide

[1893] (C125) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3,6-trichlorophenyl)acetamide

[1894] (C126) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichloro-4-methylphenyl)acetamide

[1895] (C127) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2,3-dichloro-6-(trifluoromethyl)phenyl]acetamide

[1896] (C128) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichloro-3-methylphenyl)acetamide

[1897] (C129) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichloro-3-cyclopropylphenyl)acetamide

[1898] (C130) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2,6-dichloro-3-(trifluoromethyl)phenyl]acetamide

[1899] (C131) 2-(3-Bromo-2,6-dichlorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1900] (C132) 2-(3-Bromo-2-chloro-6-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1901] (C133) 2-(3-Bromo-6-chloro-2-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[1902] (C134) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide

[1903] (C135) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-4-(trifluoromethyl)phenyl]acetamide

[1904] (C136) 2-(2-chlorophenyl)-N-(4-[3-(methylsulfonyl)benzyl]oxy-3-sulfamoylphenyl)acetamide

[1905] (C137) 2-(2-chlorophenyl)-N-4-[(2-fluorobenzyl)oxy]-3-sulfamoylphenylacetamide

[1906] (C138) 2-(2-Chlorophenyl)-N-4-[(4-cyanobenzyl)oxy]-3-sulfamoylphenylacetamide

[1907] (C139) N-4-[(3-chlorobenzyl)oxy]-3-sulfamoylphenyl-2-(2-chlorophenyl)acetamide

[1908] (C140) 2-(2-chlorophenyl)-N-4-[(3-methoxybenzyl)oxy]-3-sulfamoylphenylacetamide

[1909] (C141) N-[4-(Benzyloxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1910] (C142) 2-(2-chlorophenyl)-N-4-[(3-cyanobenzyl)oxy]-3-sulfamoylphenylacetamide

[1911] (C143) 2-(2-Chlorophenyl)-N-4-[(4-fluorobenzyl)oxy]-3-sulfamoylphenylacetamide

[1912] (C144) N-4-[(2-chlorobenzyl)oxy]-3-sulfamoylphenyl-2-(2-chlorophenyl)acetamide

[1913] (C145) 2-(2-chlorophenyl)-N-4-[(2-cyanobenzyl)oxy]-3-sulfamoylphenylacetamide

[1914] (C146) N-[4-(Benzyloxy)-3-sulfamoylphenyl]-2-phenylacetamide

[1915] (C147) 2-(2-chlorophenyl)-N-(4-[4-(methylsulfonyl)benzyl]oxy-3-sulfamoylphenyl)acetamide

[1916] (C148) 2-(2-Chlorophenyl)-N-[4-(1-phenylethoxy)-3-sulfamoylphenyl]acetamide

[1917] (C149) 2-(2-chlorophenyl)-N-[4-(1-phenylethoxy)-3-sulfamoylphenyl]acetamide

[1918] (C150) 2-(2-chlorophenyl)-N-[4-(pyridin-3-ylmethoxy)-3-sulfamoylphenyl]acetamide

[1919] (C151) 2-(2-chlorophenyl)-N-[4-(pyridin-2-ylmethoxy)-3-sulfamoylphenyl]acetamide

[1920] (C152) 2-(2-chlorophenyl)-N-[4-(pyridin-4-ylmethoxy)-3-sulfamoylphenyl]acetamide

[1921] (C153) N-[4-(pyridin-2-ylmethoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide

[1922] (C154) 2-(2-chlorophenyl)-N-[4-(pyrimidin-4-ylmethoxy)-3-sulfamoylphenyl]acetamide

[1923] (C155) 2-(2-chlorophenyl)-N-[4-(pyrimidin-2-ylmethoxy)-3-sulfamoylphenyl]acetamide

[1924] (C156) 2-(2-chlorophenyl)-N-[4-(2-phenylethoxy)-3-sulfamoylphenyl]acetamide

[1925] (C157) 2-(2-chlorophenyl)-N-4-[2-(3-chlorophenyl)ethoxy]-3-sulfamoylphenylacetamide

[1926] (C158) 2-(2-Chlorophenyl)-N-[4-(cyclobutylmethoxy)-3-sulfamoylphenyl]acetamide

[1927] (C159) 2-(2-chlorophenyl)-N-[4-(oxetan-2-ylmethoxy)-3-sulfamoylphenyl]acetamide

[1928] (C160) 2-(2-chlorophenyl)-N-[4-(oxetan-3-ylmethoxy)-3-sulfamoylphenyl]acetamide

[1929] (C161) 2-(2-chlorophenyl)-N-[4-(cyclopentylmethoxy)-3-sulfamoylphenyl]acetamide

[1930] (C162) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydrofuran-2-ylmethoxy)phenyl]acetamide

[1931] (C163) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydrofuran-3-ylmethoxy)phenyl]acetamide

[1932] (C164) 2-(2-Chloro-5-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide

[1933] (C165) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide

[1934] (C166) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-3-ylmethoxy)phenyl]acetamide

[1935] (C167) 2-(2-Chloro-6-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide

[1936] (C168) 2-(2-Chloro-3-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide

[1937] (C169) 2-(2-Chlorophenyl)-N-5-sulfamoyl-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl acetamide

[1938] (C170) 2-phenyl-N-5-sulfamoyl-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl acetamide

[1939] (C171) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-phenylacetamide

[1940] (C172) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(2-methylphenyl)acetamide

[1941] (C173) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(3-methylphenyl)acetamide

[1942] (C174) 2-(2-chlorophenyl)-N-4-[3-(3-oxomorpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide

[1943] (C175) 2-(2-Chlorophenyl)-N-4-[4-(3-oxomorpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide

[1944] (C176) 2-(2-chlorophenyl)-N-4-[4-(2-oxopiperidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide

[1945] (C177) 2-(2-chlorophenyl)-N-4-[3-(2-oxopiperidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide

[1946] (C178) 2-(2-Chlorophenyl)-N-4-[3-(prop-1-en-2-yl)phenoxy]-3-sulfamoylphenylacetamide

[1947] (C179) 2-(2-chlorophenyl)-N-4-[2-(prop-1-en-2-yl)phenoxy]-3-sulfamoylphenylacetamide

[1948] (C180) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide

[1949] (C181) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-chlorophenyl)acetamide

[1950] (C182) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(pyridin-3-yl)acetamide

[1951] (C183) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide

[1952] (C184) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-methylphenyl)acetamide

[1953] (C185) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylpropionamide

[1954] (C186) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(pyridin-2-yl)acetamide

[1955] (C187) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-chlorophenyl)acetamide

[1956] (C188) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide

[1957] (C189) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(pyridin-4-yl)acetamide

[1958] (C190) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(6-methylpyridin-2-yl)acetamide

[1959] (C191) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide

[1960] (C192) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-methoxyphenyl)acetamide

[1961] (C193) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-methoxyphenyl)acetamide

[1962] (C194) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(5-methylpyridin-2-yl)acetamide

[1963] (C195)(2S)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylpropionamide

[1964] (C196)(2R)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylpropionamide

[1965] (C197) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)propionamide

[1966] (C198) 2-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-(2-methoxyethyl)-N-methylbenzamide

[1967] (C199) 2-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N,N-dimethylbenzamide

[1968] (C200) N-[4-(cyclohexyloxy)-3-sulfamoylphenyl]-2-phenylacetamide

[1969] (C201) 2-(2-chlorophenyl)-N-[4-(cyclohexyloxy)-3-sulfamoylphenyl]acetamide

[1970] (C202) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-(2-methoxyethyl)benzamide

[1971] (C203) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N,N-dimethylbenzamide

[1972] (C204) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-methylbenzamide

[1973] (C205) N-[4-(cyclobutyloxy)-3-sulfamoylphenyl]-2-phenylacetamide

[1974] (C206) 2-(2-chlorophenyl)-N-[4-(cyclobutyloxy)-3-sulfamoylphenyl]acetamide

[1975] (C207) 2-Phenyl-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]acetamide

[1976] (C208) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]acetamide

[1977] (C209) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-(2-methoxyethyl)-N-methylbenzamide

[1978] (C210) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(5-chloropyridin-2-yl)acetamide

[1979] (C211) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[3-(2-methoxyethoxy)phenyl]acetamide

[1980] (C212) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(2-methoxyethoxy)phenyl]acetamide

[1981] (C213) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[3-(2-hydroxyethoxy)phenyl]acetamide

[1982] (C214) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(2-hydroxyethoxy)phenyl]acetamide

[1983] (C215) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide

[1984] (C216) N-[4-(oxetan-3-yloxy)-3-sulfamoylphenyl]-2-phenylacetamide

[1985] (C217) 2-(2-chlorophenyl)-N-[4-(oxetan-3-yloxy)-3-sulfamoylphenyl]acetamide

[1986] (C218) N-[4-(cyclopentyloxy)-3-sulfamoylphenyl]-2-phenylacetamide

[1987] (C219) 2-(2-chlorophenyl)-N-[4-(cyclopentyloxy)-3-sulfamoylphenyl]acetamide

[1988] (C220) N-4-[(1-methylpiperidin-3-yl)oxy]-3-sulfamoylphenyl-2-phenylacetamide

[1989] (C221) 2-(2-Chlorophenyl)-N-4-[(1-methylpiperidin-3-yl)oxy]-3-sulfamoylphenylacetamide

[1990] (C222) N-4-[(1-methylpyrrolidin-3-yl)oxy]-3-sulfamoylphenyl-2-phenylacetamide

[1991] (C223) 2-(2-Chlorophenyl)-N-4-[(1-methylpyrrolidin-3-yl)oxy]-3-sulfamoylphenylacetamide

[1992] (C224) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide

[1993] (C225) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-cyanophenyl)acetamide

[1994] (C226) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-cyanophenyl)acetamide

[1995] (C227) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-cyanophenyl)acetamide

[1996] (C228) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide

[1997] (C229) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-chlorophenyl)acetamide

[1998] (C230) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide

[1999] (C231) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide

[2000] (C232) 2-(2-chloro-4-fluorophenyl)-N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[2001] (C233) 2-(2-Chlorophenyl)-N-4-[(1,1-dioxidotetrahydrothiophen-3-yl)oxy]-3-sulfamoylphenylacetamide

[2002] (C234) 2-(2-Chlorophenyl)-N-4-[(1-methyl-1H-pyrazol-4-yl)oxy]-3-sulfamoylphenylacetamide

[2003] (C235) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide

[2004] (C236) 2-(2-chloro-4-methoxyphenyl)-N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]acetamide

[2005] (C237) 2-(2-Chlorophenyl)-N-4-[(1-methyl-1H-pyrazol-3-yl)oxy]-3-sulfamoylphenylacetamide

[2006] (C238) 2-(2-Chlorophenyl)-N-4-[(1-methyl-1H-pyrazol-5-yl)oxy]-3-sulfamoylphenylacetamide

[2007] (C239) 2-(2-Chlorophenyl)-N-4-[(1-methylpiperidin-4-yl)oxy]-3-sulfamoylphenylacetamide

[2008] (C240) 2-(2-chlorophenyl)-N-(4-[5-methyl-2-(pyridin-3-yl)-1,3-thiazol-4-yl]oxy-3-sulfamoylphenyl)acetamide

[2009] (C241) N-[4-(3-chlorophenoxy)-2-methyl-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide [...

Claims

1. A pharmaceutical composition for preventing, inhibiting or treating symptoms associated with pseudoallergic reactions, comprising a compound having a P2X4 receptor antagonistic effect or a pharmaceutically acceptable salt thereof as an active ingredient.

2. The pharmaceutical composition according to claim 1, wherein The symptoms associated with pseudoallergic reactions are selected from skin and mucous membrane symptoms including rash, punctate erythema, urticaria, angioedema, eyelid edema, conjunctival edema, and itching; digestive tract symptoms including throat and laryngeal edema, vomiting, abdominal pain, and diarrhea; respiratory tract symptoms including wheezing and dyspnea; cardiovascular system symptoms including arrhythmia, pallor, hypothermia, and hypotension; and central nervous system symptoms including headache and loss of consciousness.

3. The pharmaceutical composition according to claim 1 or 2, wherein The pseudoallergic reaction is caused by an allergen having a cationic group.

4. The pharmaceutical composition according to claim 3, wherein The allergens are amorolfine hydrochloride, atracurium, beta-defensin, bleomycin, cetrorelix, C48 / 80 as a monomer or a cyclized monomer, ciprofloxacin, cisatracurium, codeine, polymyxin E mesylate, planolycopoeia A, cortistatin-14, degarelix, enfuvirtide, exenatide, fluoroquinolone, ganirelix, gentamicin sulfate, glatiramer acetate, glucagon, goserelin, histrelin, icatiban , ketoconazole, lanreotide, leuprolide, levofloxacin, liraglutide, LL-37, mafenide acetate, bee venom peptide, metronidazole sulfate, mivacurium, morphine, moxifloxacin, octreotide, ofloxacin, PAMP-12, PAMP-20, pasireotide, PMX-53, pramlint, rocuronium, sermorelin, sisomicin sulfate, substance P, succinylcholine, sulfadoxine, sulfamethoxazole azole, terbinafine hydrochloride, teriparatide, temorelin, triptorelin, tubocurarine, or vancomycin.

5. The pharmaceutical composition according to any one of claims 1 to 4, wherein The compound is a compound represented by the following general formula (A): In the formula, R 1A represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, or an alkyl group having 1 to 3 carbon atoms substituted with a phenyl group, R 2A and R 3A may be the same or different, and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkylsulfonylamino group having 1 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group having 1 to 8 carbon atoms in the alkoxy moiety, a carbamoyl group, an alkylthio group having 1 to 8 carbon atoms, an alkylsulfinyl group having 1 to 8 carbon atoms, an alkylsulfonyl group having 1 to 8 carbon atoms, or a sulfamoyl group, R 4A and R 5A may be the same or different, and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, or an alkyl group having 1 to 3 carbon atoms substituted with a phenyl group, Moreover, W A It represents a 5- or 6-membered heterocyclic ring which may have a substituent and contains 1 to 4 nitrogen atoms as ring constituent elements.

6. The pharmaceutical composition according to any one of claims 1 to 4, wherein The compound is a compound represented by the following general formula (BI), In the formula, R 1B and R 2B may be the same or different, and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group having 1 to 8 carbon atoms in the alkoxy moiety, a phenyl group which may have a substituent, a pyridyl group which may have a substituent, or an aralkyl group having 6 to 10 carbon atoms in the aryl moiety and 1 to 8 carbon atoms in the alkylene moiety, or R 1B and R 2B Together with the benzene ring to which they are bonded, they may form a condensed ring selected from a naphthalene ring, a quinoline ring, an isoquinoline ring, a tetrahydronaphthalene ring, an indane ring, a tetrahydroquinoline ring or a tetrahydroisoquinoline ring, and R 1B and R 2B Together with R 1B and R 2B The ring consisting of the carbon atoms to which they are respectively bonded may be substituted by 1 to 4 substituents which may be the same or different and are selected from an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group having 1 to 8 carbon atoms in the alkoxy moiety, or an aralkyl group having 6 to 10 carbon atoms in the aryl moiety and 1 to 8 carbon atoms in the alkylene moiety, R 3B and R 4B may be the same or different, and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, a carboxyl group, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group having 1 to 8 carbon atoms in the alkoxy moiety, or an aralkyl group having 6 to 10 carbon atoms in the aryl moiety and 1 to 8 carbon atoms in the alkylene moiety, R 5B represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxyl group, or an aralkyl group having 6 to 10 carbon atoms in the aryl part and 1 to 8 carbon atoms in the alkylene part, R 6B and R 7B may be the same or different, and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group or an amino group, X B represents C, CH or N, Y B represents N, NH or C(=O), Among them, X B When N, Y B Not N, NH, In addition, X B When it is C or CH, Y B Not C(=O), A double line consisting of a solid line and a dashed line represents a single bond or a double bond. Z B represents an oxygen atom or a sulfur atom, A B represents a benzene ring, pyridine ring, thiophene ring, pyrimidine ring, naphthalene ring, quinoline ring, or indole ring which may have 1 to 4 substituents selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an aralkyl group having 6 to 10 carbon atoms in the aryl moiety and 1 to 8 carbon atoms in the alkylene moiety, a phenyl group, or a pyridyl group which may have the same or different substituents as substituents, or represents a bonding site, B B N(R 8B )C(=O), NHCONH, CON(R 9B )、NHC(=S) NH、N(R 10B )SO2、SO2N(R 11B ) or OSO2, Here, R 8B , R 9B , R 10B and R 11B represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted by 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted by a hydroxyl group, or an aralkyl group having 6 to 10 carbon atoms in the aryl part and 1 to 8 carbon atoms in the alkylene part, D B represents an alkylene chain having 1 to 6 carbon atoms which may have 1 to 4 substituents selected from alkyl having 1 to 8 carbon atoms, alkenyl having 2 to 8 carbon atoms, alkyl having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, alkyl having 1 to 8 carbon atoms substituted with hydroxyl groups, or aralkyl having 6 to 10 carbon atoms in the aryl part and 1 to 8 carbon atoms in the alkylene part, which may be the same or different, and further has a double bond, or a bonding site, E B Indicates O, S, NR 12B , or bonding sites, Here, R 12B represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkyl group having 1 to 8 carbon atoms substituted with a hydroxyl group, or an aralkyl group having 6 to 10 carbon atoms in the aryl part and 1 to 8 carbon atoms in the alkylene part, G B The present invention represents an alkyl group which may have 1 to 4 groups selected from an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acyl group having 2 to 8 carbon atoms, a methylenedioxy group, a carboxyl group, an alkylsulfinyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, an alkylsulfonyl group having 1 to 6 carbon atoms, an aralkyl group having 6 to 10 carbon atoms in the aryl part and 1 to 8 carbon atoms in the alkylene part, a phenyl group which may have a substituent, a pyridyl group which may have a substituent, an imidazolyl group which may have a substituent, oxazolyl, or the same or different substituents in the thiazolyl group which may have a substituent as a substituent, piperazine, piperidine, morpholine, cyclohexane, benzene, naphthalene, quinoline, quinoxaline, benzimidazole, thiophene, imidazole, thiazole, oxazole, indole, benzofuran, pyrrole, pyridine or pyrimidine, Moreover, m B represents an integer from 0 to 5, Among them, R 1B and R 2B In the case where they do not form a ring together, X is not included B C, Y B N, the double line consisting of solid and dotted lines is a double bond, Z B is an oxygen atom, A B is a benzene ring, m B 0, B B C(=O)NH, E B is the bonding site and G B For the case of phenyl.

7. The pharmaceutical composition according to any one of claims 1 to 4, wherein The compound or a pharmaceutically acceptable salt thereof is a compound or a pharmaceutically acceptable salt thereof selected from the following (A1) to (A21) and (B1) to (B214), (A1) 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A2) 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; (A3) 5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone potassium salt; (A4) 5-[4-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A5) 5-[4-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; (A6) 1-methyl-5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A7) 1,3-dimethyl-5-[3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A8) 5-[2-chloro-5-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A9) 5-[2-chloro-5-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; (A10) 5-[2-methyl-5-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A11) 5-[2-methyl-5-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; (A12) 5-[2-bromo-5-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A13) 5-[3-(2-methyl-2H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A14) 5-[3-(1-methyl-1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A15)5-[3-(5-oxo-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A16)5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A17)5-[3-(5-thio-4H-[1,2,4] oxadiazole-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; (A18)5-[3-( oxazol-2-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A19) 5-[3-(1H-pyrazol-4-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (A20) 5-[4-fluoro-3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; and (A21) 5-[4-fluoro-3-(1H-tetrazolyl-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-diketone sodium salt; as well as (B1) 5-(4-Benzoylaminophenyl)-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B2) 5-[4-[2-(trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B3) 5-[4-(3-bromobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B4) 5-[4-[4-(trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B5) 5-[4-(2-methylbenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B6) 5-[4-(2,6-dimethylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B7) 5-[4-(2,6-dichlorobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B8) 5-[4-(3-chlorobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B9) 5[4-(2-phenylacetylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B10) 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-3-phenylthiourea; (B11) 5-[4-(2,3-dimethoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B12) 5-[4-(2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B13) 5-[4-[(2-chlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B14) 5-[4-(2,3-dimethylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B15) 5-[4-(2,5-dimethylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B16) 5-[4-(5-bromo-2-chlorobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B17) 5-[4-(2,4-dichlorobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B18) 5-[4-(2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B19) 5-[4-(2,3-dihydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B20) 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-3-phenylurea; (B21) 5-[4-[(2,6-dichlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B22) 5-[4-[(2-methoxyphenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B23) 5-[4-[(2-hydroxyphenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B24) 1-(2-chlorophenyl)-3-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]thiourea; (B25) 5-[4-[3-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B26) 5-[4-[2-[2-(trifluoromethyl)phenyl]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B27) 1-(2-chlorophenyl)-3-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]urea; (B28) 5-[4-[(2-phenylpropionyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B29) 5-[4-(2-chloro-3-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B30) 5-[4-(3-phenylpropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B31) 5-[4-[(1H-indole-3-carbonyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B32) 5-[4-(2-chloro-3-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B33) 5-[4-[(2-methyl-2-phenylpropionyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B34) 5-[4-(2-phenoxyacetylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B35) 5-[4-[2-(2-chloro-4-methoxyphenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B36) 5-[4-[(1-methyl-1H-imidazole-2-carbonyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B37) 5-[4-[2-(2,4-dichlorophenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B38) 5-[4-[2-(2-chloro-4-hydroxyphenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B39) 5-[4-(3-phenylpropenylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B40) 5-[4-[(3-pyridylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione hydrochloride; (B41) 5-[4-(1H-benzimidazole-2-carbonylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B42) 1-[4-(2,3-dimethylbenzoylamino)phenyl]-7-methoxy-1H-1,5-benzodiazepine -2,4(3H,5H)-dione; (B43) 5-[4-[(Benzoylamino)methyl]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B44) 5-[4-[(2-chlorobenzoylamino)methyl]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B45) 1-[4-(2,3-dimethylbenzoylamino)phenyl]-7-hydroxy-1H-1,5-benzodiazepine -2,4(3H,5H)-dione; (B46) 5-[4-(2-chlorobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B47) 5-[4-(2-bromobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B48) 5-[4-(2-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B49) 5-[4-(2,3-dimethylbenzoylamino)-3-fluorophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B50) 5-[4-[2-(2-methylphenyl)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B51) 5-[4-[(quinoxalin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B52) 5-[4-[(5-methylthiophen-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B53) 5-[3-[(2-chlorophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B54) 5-[4-[(2,4,6-trimethylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B55) 5-[4-(cyclohexylcarbonylamino)phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B56) 1-[4-(2,3-dimethylbenzoyl)aminophenyl]-6-methyl-1H-1,5-benzodiazepine -2,4(3H,5H)-dione; (B57) 5-[4-[(2-ethylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B58) 5-[4-[(6-methylpyridin-2-yl)carbonylamino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B59) 5-[4-[(2-methylpyridin-3-yl)carbonylamino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B60) 1-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-3-(2-methylphenyl)thiourea; (B61) 5-[4-(2-methoxy-3-methylbenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B62) 5-[4-(2,3-dichlorobenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B63) 5-[4-(2,3-dimethylbenzoylamino)-3-hydroxyphenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B64) 5-[4-(2-chloro-3-methoxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-Keto; (B65) 5-[4-[(4-dimethylaminobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B66) 5-[4-[2-(2,4-dichlorophenoxy)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B67) 5-[4-[2-(2-methylphenoxy)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B68) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)butyl]-2-chloro-3-methoxybenzamide; (B69) 5-[4-(2-chloro-3-hydroxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-Keto; (B70) 5-[4-(2-acetylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B71) 5-[4-(2-tert-butylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B72) 5-[2-(2-iodobenzoyl)aminoethyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B73) 5-[3-[(2-iodobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B74) 6,7-dimethyl-1-[4-(2-iodobenzoyl)aminophenyl]-1H-1,5-benzodiazepine -2,4(3H,5H)-dione; (B75) 5-[4-[(1-methylpiperidin-4-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione hydrochloride; (B76) 5[4-[(Benzofuran-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B77) 5-[4-[(1-methyl-1H-indol-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B78) 5-[4-(2-propenylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B79) 5-[4-(2-propylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B80) 5-[3-fluoro-4-(2-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B81) 5-[4-(2-hydroxy-3-methylbenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B82) 5-[4-[(2-isopropoxybenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B83) 5-[4-[(3-methylthiophen-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B84) 5-[4-(2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B85) 5-[4-[2-(4-chloro-2-methylphenoxy)acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B86) 5-[4-[(4-fluoro-2-trifluoromethyl)benzoyl]aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B87) 5-[4-(4-fluoro-2-methoxybenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B88) 5-[4-(4-fluoro-2-hydroxybenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B89) 5-[3-[(2-iodophenylacetyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B90) 5-[4-(2-methyl-2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B91) 5-[4-(2-tert-butylbenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-Keto; (B92) 5-[4-[(3-dimethylaminobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B93) 5-[4-(4-iodo-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B94) 5-[4-(6-fluoro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B95) 5-[4-(2-hydroxy-4-iodobenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B96) 5-[4-(6-fluoro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B97) 5-[4-(2-fluorobenzoyl)aminophenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B98) 5-[4-[(2-dimethylaminobenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B99) 5-[4-(2-methoxy-6-methylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B100) 5-[4-(2-hydroxy-6-methylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B101) 5-[4-[3-(2-methylphenyl)propionylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B102) 5-(4-phenylcarbamoylphenyl)-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B103) 5-(4-Benzylcarbamoylphenyl)-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B104) 5-[4-[3-(2-methylphenyl)acryloylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B105) 5-[4-[3-(2-chlorophenyl)propionylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B106) 5-[4-(2-iodobenzoyl)aminophenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B107) 5-[4-[(1-methyl-1H-pyrrol-2-ylacetyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B108) 5-[4-(2-chlorobenzyl)carbamoylphenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B109) 5-[4-[3-(2-chlorophenyl)acryloylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B110) 5-[4-(2-chlorophenyl)carbamoylphenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B111) 5-[4-(6-bromo-2,3-methylenedioxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B112) 5-[4-(6-bromo-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B113) 5-[4-[(2-tert-butylbenzoyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B114) 5-[2-(2-iodobenzoyl)aminopyridin-5-yl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B115) 5-[4-(6-bromo-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B116) 5-[4-(6-chloro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B117) 5-[4-(2-iodobenzoylamino)phenyl]-1H-[1,4]diazepine 2,3-h-quinoline-2,4(3H,5H)-dione; (B118) 5-[4-(6-chloro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B119) 5-[4-(2-hydroxy-6-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B120) 5-[4-[2-methoxy-6-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B121) 5-[4-[2-hydroxy-6-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B122) 5-[4-[(2-isopropenylbenzoyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B123) 5-[4-[(2-isopropylbenzoyl)amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B124) 5-[4-[2-chloro-5-(methylthio)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B125) 5-[4-[2-(methylthio)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B126) 5-[4-[3-(methylthio)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B127) 5-[4-[2-ethyl-6-methoxybenzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B128) 5-[4-(3-methanesulfonylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B129) 6-ethyl-1-[4-(2-iodobenzoyl)aminophenyl]-1H-1,5-benzodiazepine -2,4(3H,5H)-dione; (B130) 5-[4-[2-ethyl-6-hydroxybenzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B131) 5-[4-(3-methanesulfinylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B132) 5-[4-(2-chloro-5-methanesulfinylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B133) 5-[4-(2-methanesulfinylbenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B134) 5-[4-[[2-(4-morpholinyl)acetyl]amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione hydrochloride; (B135) 5-[4-(2-chloro-6-methoxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-Keto; (B136) 5-[4-[[(3-chloropyridin-2-yl)carbonyl]amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B137) 5-[4-(2-chloro-6-hydroxybenzoylamino)phenyl]-1,3-dihydronaphtho[1,2-e]-1,4-diazepine -2-Keto; (B138) 5-[4-(3-chloro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B139) 5-[4-[(3-methylpyridin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B140) 5-[4-[[(3-chloropyridin-2-yl)carbonyl]amino]phenyl]-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B141) 5-[4-(3-chloro-2-hydroxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B142) 5-[4-[[(3-hydroxypyridin-2-yl)carbonyl]amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B143) 5-[4-[(3-vinylpyridin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B144) 5-[4-[(3-ethylpyridin-2-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B145) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-nitrobenzenesulfonamide; (B146) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]benzenesulfonamide; (B147) 3-bromo-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]benzenesulfonamide; (B148) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-3-methoxybenzenesulfonamide; (B149) N-[3-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepine -5-yl)phenyl]benzenesulfonamide; (B150) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-nitrobenzenesulfonamide; (B151) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]-diazepine -5-yl)phenyl]-2-nitro-benzenesulfonamide; (B152) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]-diazepine -5-yl)phenyl]-N-methyl-2-nitrobenzenesulfonamide; (B153) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-methyl-2-nitrobenzenesulfonamide; (B154) 4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)-N-phenylbenzenesulfonamide; (B155) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b]-[1,4]diazepine -5-yl)phenyl]-2-naphthalenesulfonamide; (B156) N-[3-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b]-[1,4]diazepine -5-yl)phenyl]-1-naphthalenesulfonamide; (B157) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]cyclohexanesulfonamide; (B158) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-3-pyridinesulfonamide hydrochloride; (B159) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-4-isopropylbenzenesulfonamide; (B160) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenylmethanesulfonamide; (B161) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-thiophene-sulfonamide; (B162) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-naphthalenesulfonamide; (B163) 4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine 3-bromobenzenesulfonate -5-yl)phenyl ester; (B164) N-benzyl-N-[4-(1-benzyl-2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-nitrobenzenesulfonamide; (B165) N-benzyl-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-nitrobenzenesulfonamide; (B166) 3-bromo-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-methylbenzenesulfonamide; (B167) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-methyl-2-nitrobenzenesulfonamide; (B168) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide; (B169) N-[4-(7-chloro-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine -1-yl)phenyl]benzenesulfonamide; (B170) N-[4-(7-bromo-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine -1-yl)phenyl]benzenesulfonamide; (B171) N-[4-[(2,4-dioxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine -1-yl)]phenyl]benzenesulfonamide; (B172) N-[4-(2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine -1-yl)phenyl]benzenesulfonamide; (B173) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]methanesulfonamide; (B174) 1-(3-bromophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]methanesulfonamide; (B175) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-trifluoromethylbenzenesulfonamide; (B176) N-[4-(7-bromo-6-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine -1-yl)phenyl]benzenesulfonamide; (B177) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]methanesulfonamide; (B178) 3-bromo-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]benzenesulfonamide; (B179) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-3-methoxybenzenesulfonamide; (B180) 1-(2-bromophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]methanesulfonamide; (B181) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-1-(2-methylphenyl)methanesulfonamide; (B182) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-aminophenyl]-1-(2-nitrophenyl)methanesulfonamide; (B183) N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-2-phenylethanesulfonamide; (B184) 1-(2,3-dichlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]methanesulfonamide; (B185) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-7-methoxy-1H-benzo[1,2-b][1,4]diazepine -1-yl)phenyl]methanesulfonamide; (B186) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-7-hydroxy-1H-benzo[1,2-b][1,4]diazepine -1-yl)phenyl]methanesulfonamide; (B187) 1-(4-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]methanesulfonamide; (B188) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)benzyl]methanesulfonamide; (B189) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)-2-methoxyphenyl]methanesulfonamide; (B190) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)-2-hydroxyphenyl]methanesulfonamide; (B191) 1-(2,6-dichlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]methanesulfonamide; (B192) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-6-methyl-1H-benzo[1,2-b][1,4]diazepine -1-yl)phenyl]methanesulfonamide; (B193) 1-(2-chlorophenyl)-N-[3-(2,4-dioxy-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)propyl]methanesulfonamide; (B194) 1-(2-chlorophenyl)-N-[2-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)ethyl]methanesulfonamide; (B195) N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-1-(2-iodophenyl)methanesulfonamide; (B196) 1-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]-N-methylmethanesulfonamide; (B197) 1-(2-chlorophenyl)-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepine -5-yl)phenyl]methanesulfonamide; (B198) 1-[2-(trifluoromethyl)phenyl]-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide; (B199) 1-(2-ethylphenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide; (B200) 1-(2,3-dimethylphenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide; (B201) 2-(2-chlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylethanesulfonamide; (B202) 1-(2-nitrophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide; (B203) 1-(2-aminophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide; (B204) 1-(2-dimethylaminophenyl)-N-[4-(2,4-dioxo-1,2,3,4-tetrahydronaphtho[1,2-b][1,4]diazepine -5-yl)phenyl]phenyl-N-methylmethanesulfonamide; (B205) 5-[4-[(pyridin-4-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione hydrochloride; (B206) 5-[4-[2-[(pyridin-3-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione hydrochloride; (B207) 5-[4-[(pyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione hydrochloride; (B208) 5-[4-[(2-methylpyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione hydrochloride; (B209) 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B210) 5-[4-[2-[(pyridin-2-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B211) 5-[4-[[4-(trifluoromethyl)pyridin-3-yl]carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione; (B212) 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-1H-[1,4]diazepine 2,3-f]isoquinoline-2,4(3H,5H)-dione; (B213) 5-[4-[(2-chloropyridin-3-yl)carbonylamino]phenyl]-8,9,10,11-tetrahydro-1H-[1,4]diazepine 2,4(3H,5H)-dione; and (B214) 5-[4-[(2-isopropylbenzoyl)amino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine -2,4(3H,5H)-dione.

8. The pharmaceutical composition according to any one of claims 1 to 4, wherein The compound is selected from the following compounds (C1) to (C297), (C1) N-[4-(3-chloro-5-cyanophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C2) 2-(2-chlorophenyl)-N-4-[3-(dimethylamino)phenoxy]-3-sulfamoylphenylacetamide; (C3) 2-(2-chlorophenyl)-N-4-[(2-chloropyridin-4-yl)oxy]-3-sulfamoylphenylacetamide; (C4) 2-(2-chlorophenyl)-N-[4-(3-isopropylphenoxy)-3-sulfamoylphenyl]acetamide; (C5) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(trifluoromethyl)phenoxy]phenylacetamide; (C6) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(trifluoromethoxy)phenoxy]phenylacetamide; (C7) N-[4-(3-acetylphenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C8)N-[4-(1,3-Benzodiphenylamine) [(5-nitroquinoline-5-yloxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C9) N-[4-(3-acetamidophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C10) 2-(2-chlorophenyl)-N-[4-(2-fluorophenoxy)-3-sulfamoylphenyl]acetamide; (C11) 2-(2-chlorophenyl)-N-[4-(3-fluorophenoxy)-3-sulfamoylphenyl]acetamide; (C12) 2-(2-chlorophenyl)-N-[4-(4-fluorophenoxy)-3-sulfamoylphenyl]acetamide; (C13) 2-(2-chlorophenyl)-N-[4-(pyridin-2-yloxy)-3-sulfamoylphenyl]acetamide; (C14) 2-(2-chlorophenyl)-N-(4-phenoxy-3-sulfamoylphenyl)acetamide; (C15) 2-(2-chlorophenyl)-N-[4-(3-cyanophenoxy)-3-sulfamoylphenyl]acetamide; (C16) 2-(2-chlorophenyl)-N-4-[3-(methylsulfonyl)phenoxy]-3-sulfamoylphenylacetamide; (C17) 3-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)benzamide; (C18) 2-(2-chlorophenyl)-N-[4-(3-methylphenoxy)-3-sulfamoylphenyl]acetamide; (C19) 2-(2-chlorophenyl)-N-[4-(pyrimidin-5-yloxy)-3-sulfamoylphenyl]acetamide; (C20) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(4H-1,2,4-triazol-4-yl)phenoxy]phenylacetamide; (C21) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[3-(1H-tetrazolyl-5-yl)phenoxy]phenylacetamide; (C22) 2-(2-chlorophenyl)-N-[4-(3-methoxyphenoxy)-3-sulfamoylphenyl]acetamide; (C23) 2-(2-chlorophenyl)-N-[4-(4-methoxyphenoxy)-3-sulfamoylphenyl]acetamide; (C24) 2-(2-chlorophenyl)-N-4-[3-(difluoromethoxy)phenoxy]-3-sulfamoylphenylacetamide; (C25) 2-(2-chlorophenyl)-N-[4-(3,4-dicyanophenoxy)-3-sulfamoylphenyl]acetamide; (C26) 2-(2-chlorophenyl)-N-4-[3-(morpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide; (C27) 2-(2-chlorophenyl)-N-[4-(3-4-[(2-chlorophenyl)acetyl]piperazin-1-ylphenoxy)-3-sulfamoylphenyl]acetamide; (C28) 2-(2-chlorophenyl)-N-[4-(pyridin-3-yloxy)-3-sulfamoylphenyl]acetamide; (C29) 2-(2-chlorophenyl)-N-4-[(5-chloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide; (C30) 2-(2-chlorophenyl)-N-[4-(4-cyanophenoxy)-3-sulfamoylphenyl]acetamide; (C31) 2-(2-chlorophenyl)-N-4-[3-(difluoromethyl)phenoxy]-3-sulfamoylphenylacetamide; (C32) 2-(2-chlorophenyl)-N-[4-(2-methoxyphenoxy)-3-sulfamoylphenyl]acetamide; (C33) 2-(2-chlorophenyl)-N-[4-(3,5-dicyanophenoxy)-3-sulfamoylphenyl]acetamide; (C34) 2-(2-chlorophenyl)-N-[4-(5-cyano-2-methoxyphenoxy)-3-sulfamoylphenyl]acetamide; (C35) 2-(2-chlorophenyl)-N-4-[(2,5-dichloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide; (C36) 2-(2-chlorophenyl)-N-4-[(5,6-dichloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide; (C37) 3-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)-N-cyclopropylbenzamide; (C38) 2-(2-chlorophenyl)-N-4-[(3-chloropyridin-2-yl)oxy]-3-sulfamoylphenylacetamide; (C39) 2-(2-chlorophenyl)-N-4-[(4-chloropyridin-2-yl)oxy]-3-sulfamoylphenylacetamide; (C40) 2-(2-chlorophenyl)-N-4-[(6-chloropyridin-2-yl)oxy]-3-sulfamoylphenylacetamide; (C41) 2-(2-chlorophenyl)-N-4-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]-3-sulfamoylphenylacetamide; (C42) 2-(2-chlorophenyl)-N-4-[4-(1H-imidazol-1-yl)phenoxy]-3-sulfamoylphenylacetamide; (C43) 2-(2-chlorophenyl)-N-4-[4-(2-oxopyrrolidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide; (C44) 2-(2-chlorophenyl)-N-4-[4-(morpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide; (C45) 2-(2-chlorophenyl)-N-[4-(5-cyano-2-methylphenoxy)-3-sulfamoylphenyl]acetamide; (C46) 2-(2-chlorophenyl)-N-[4-(3-cyano-2-methylphenoxy)-3-sulfamoylphenyl]acetamide; (C47) 2-(2-chlorophenyl)-N-[4-(3-cyano-4-fluorophenoxy)-3-sulfamoylphenyl]acetamide; (C48) N-4-[(5-chloro-2-cyanopyridin-3-yl)oxy]-3-sulfamoylphenyl-2-(2-chlorophenyl)acetamide; (C49) 2-(2-chlorophenyl)-N-4-[3-(piperidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide; (C50) 2-(2-chlorophenyl)-N-4-[3-(2-oxopyrrolidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide; (C51) 2-(2-chlorophenyl)-N-4-[3-(2-oxo-1,3- [3-(2-nitrophenyl)oxazolidin-3-yl)phenoxy]-3-sulfamoylphenylacetamide; (C52) 2-(2-chlorophenyl)-N-4-[3-(morpholin-4-ylcarbonyl)phenoxy]-3-sulfamoylphenylacetamide; (C53) 2-(2-chlorophenyl)-N-4-[(4-methyltetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide; (C54) 2-(2-Chlorophenyl)-N-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide; (C55) 2-(2-chlorophenyl)-N-4-[(4-cyanotetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide; (C56) 2-(2-chlorophenyl)-N-(3-sulfamoyl-4-[2-(trifluoromethyl)pyrimidin-5-yl]oxyphenyl)acetamide; (C57) 2-(2-chlorophenyl)-N-4-[(2-isopropylpyrimidin-5-yl)oxy]-3-sulfamoylphenylacetamide; (C58) 2-(2-chlorophenyl)-N-4-[(2-cyclopropyl-4-methylpyrimidin-5-yl)oxy]-3-sulfamoylphenylacetamide; (C59) N-[4-(3-bromophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C60) N-[4-(4-bromophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C61) 2-(2-chlorophenyl)-N-4-[3-(2-methyl-1,3-thiazol-4-yl)phenoxy]-3-sulfamoylphenylacetamide; (C62) 2-(2-chlorophenyl)-N-4-[4-(5-oxopyrrolidin-2-yl)phenoxy]-3-sulfamoylphenylacetamide; (C63) 2-(2-chlorophenyl)-N-4-[4-(2-oxo-1,3- [3-(2-nitrophenyl)oxazolidin-3-yl)phenoxy]-3-sulfamoylphenylacetamide; (C64) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[4-(1,3-thiazol-2-yl)phenoxy]phenylacetamide; (C65) N-[4-(2-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C66) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C67) 2-(2-chlorophenyl)-N-4-[3-(piperidin-1-ylcarbonyl)phenoxy]-3-sulfamoylphenylacetamide; (C68) 2-(2-chlorophenyl)-N-3-sulfamoyl-4-[4-(tetrahydrofuran-3-yl)phenoxy]phenylacetamide; (C69) 2-(2-chlorophenyl)-N-[4-(3-cyano-5-fluorophenoxy)-3-sulfamoylphenyl]acetamide; (C70) N-[4-(2-methoxyphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C71) N-[4-(2-methoxyphenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide; (C72) N-3-sulfamoyl-4-[2-(trifluoromethoxy)phenoxy]phenyl-2-[4-(trifluoromethyl)phenyl]acetamide; (C73) N-[4-(2-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide; (C74) 2-phenyl-N-3-sulfamoyl-4-[2-(trifluoromethoxy)phenoxy]phenylacetamide; (C75) 2-(2-chlorophenyl)-N-4-[(2-oxo-1,2-dihydropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide; (C76) N-[4-(2-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C77) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C78) N-4-[(5-chloropyridin-3-yl)oxy]-3-sulfamoylphenyl-2-phenylacetamide; (C79) 2-(2-chlorophenyl)-N-4-[(2-chloropyrimidin-5-yl)oxy]-3-sulfamoylphenylacetamide; (C80) 2-(2-chlorophenyl)-N-4-[(5-fluoropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide; (C81) 2-(2-chlorophenyl)-N-4-[(6-chloropyridin-3-yl)oxy]-3-sulfamoylphenylacetamide; (C82) N-[2-chloro-4-(3-chlorophenoxy)-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C83) N-[2-chloro-4-(3-chlorophenoxy)-5-sulfamoylphenyl]-2-(2-chloro-3-fluorophenyl)acetamide; (C84) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-fluorophenyl)acetamide; (C85) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide; (C86) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide; (C87) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-isopropylphenyl)acetamide; (C88) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-ethoxyphenyl)acetamide; (C89) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(difluoromethyl)phenyl]acetamide; (C90) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-2-[(trifluoromethyl)thio]phenylacetamide; (C91) 2-(2-bromophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C92) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methylpyridin-3-yl)acetamide; (C93) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chloropyridin-3-yl)acetamide; (C94) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)-2,2-difluoroacetamide; (C95) 2-(2-chloro-4-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C96) 2-(2-chloro-6-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C97) 2-(2-chloro-5-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C98) 2-(2-chloro-3-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C99) 2-(2-chloro-5-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C100) 2-(2-chloro-6-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C101) 2-(2-chloro-6-methoxyphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C102) 2-(2-chloro-5-methoxyphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C103) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3-dichlorophenyl)acetamide; (C104) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichlorophenyl)acetamide; (C105) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide; (C106) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2,2-difluoro-2-phenylacetamide; (C107) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-3-(trifluoromethyl)phenyl]acetamide; (C108) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-6-(trifluoromethyl)phenyl]acetamide; (C109) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-5-(trifluoromethyl)phenyl]acetamide; (C110) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,4-dichlorophenyl)acetamide; (C111) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4,6-dichloropyridin-3-yl)acetamide; (C112) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-chloropyridin-2-yl)acetamide; (C113) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(difluoromethoxy)phenyl]acetamide; (C114) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,5-dichlorophenyl)acetamide; (C115) 2-[6-chloro-2,3-difluoro-4-(trifluoromethyl)phenyl]-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C116) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide; (C117) 2-(5-bromo-2-chlorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C118) 2-(4-bromo-2-chloro-5-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C119) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-chloropyridin-4-yl)acetamide; (C120) 2-(2-chloro-6-fluoro-3-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C121) 2-(6-chloro-2-fluoro-3-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C122) 2-(2-chloro-3,6-difluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C123) 2-(2-chloro-4,5-difluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C124) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3-dichloro-6-fluorophenyl)acetamide; (C125) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3,6-trichlorophenyl)acetamide; (C126) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichloro-4-methylphenyl)acetamide; (C127) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2,3-dichloro-6-(trifluoromethyl)phenyl]acetamide; (C128) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichloro-3-methylphenyl)acetamide; (C129) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichloro-3-cyclopropylphenyl)acetamide; (C130) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2,6-dichloro-3-(trifluoromethyl)phenyl]acetamide; (C131) 2-(3-bromo-2,6-dichlorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C132) 2-(3-bromo-2-chloro-6-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C133) 2-(3-bromo-6-chloro-2-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C134) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide; (C135) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-chloro-4-(trifluoromethyl)phenyl]acetamide; (C136) 2-(2-chlorophenyl)-N-(4-[3-(methylsulfonyl)benzyl]oxy-3-sulfamoylphenyl)acetamide; (C137) 2-(2-chlorophenyl)-N-4-[(2-fluorobenzyl)oxy]-3-sulfamoylphenylacetamide; (C138) 2-(2-chlorophenyl)-N-4-[(4-cyanobenzyl)oxy]-3-sulfamoylphenylacetamide; (C139) N-4-[(3-chlorobenzyl)oxy]-3-sulfamoylphenyl-2-(2-chlorophenyl)acetamide; (C140) 2-(2-chlorophenyl)-N-4-[(3-methoxybenzyl)oxy]-3-sulfamoylphenylacetamide; (C141) N-[4-(Benzyloxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C142) 2-(2-chlorophenyl)-N-4-[(3-cyanobenzyl)oxy]-3-sulfamoylphenylacetamide; (C143) 2-(2-chlorophenyl)-N-4-[(4-fluorobenzyl)oxy]-3-sulfamoylphenylacetamide; (C144) N-4-[(2-chlorobenzyl)oxy]-3-sulfamoylphenyl-2-(2-chlorophenyl)acetamide; (C145) 2-(2-chlorophenyl)-N-4-[(2-cyanobenzyl)oxy]-3-sulfamoylphenylacetamide; (C146) N-[4-(Benzyloxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C147) 2-(2-chlorophenyl)-N-(4-[4-(methylsulfonyl)benzyl]oxy-3-sulfamoylphenyl)acetamide; (C148) 2-(2-chlorophenyl)-N-[4-(1-phenylethoxy)-3-sulfamoylphenyl]acetamide; (C149) 2-(2-chlorophenyl)-N-[4-(1-phenylethoxy)-3-sulfamoylphenyl]acetamide; (C150) 2-(2-chlorophenyl)-N-[4-(pyridin-3-ylmethoxy)-3-sulfamoylphenyl]acetamide; (C151) 2-(2-chlorophenyl)-N-[4-(pyridin-2-ylmethoxy)-3-sulfamoylphenyl]acetamide; (C152) 2-(2-chlorophenyl)-N-[4-(pyridin-4-ylmethoxy)-3-sulfamoylphenyl]acetamide; (C153) N-[4-(pyridin-2-ylmethoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide; (C154) 2-(2-chlorophenyl)-N-[4-(pyrimidin-4-ylmethoxy)-3-sulfamoylphenyl]acetamide; (C155) 2-(2-chlorophenyl)-N-[4-(pyrimidin-2-ylmethoxy)-3-sulfamoylphenyl]acetamide; (C156) 2-(2-chlorophenyl)-N-[4-(2-phenylethoxy)-3-sulfamoylphenyl]acetamide; (C157) 2-(2-chlorophenyl)-N-4-[2-(3-chlorophenyl)ethoxy]-3-sulfamoylphenylacetamide; (C158) 2-(2-chlorophenyl)-N-[4-(cyclobutylmethoxy)-3-sulfamoylphenyl]acetamide; (C159) 2-(2-chlorophenyl)-N-[4-(oxetane-2-ylmethoxy)-3-sulfamoylphenyl]acetamide; (C160) 2-(2-chlorophenyl)-N-[4-(oxetane-3-ylmethoxy)-3-sulfamoylphenyl]acetamide; (C161) 2-(2-chlorophenyl)-N-[4-(cyclopentylmethoxy)-3-sulfamoylphenyl]acetamide; (C162) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydrofuran-2-ylmethoxy)phenyl]acetamide; (C163) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydrofuran-3-ylmethoxy)phenyl]acetamide; (C164) 2-(2-Chloro-5-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide; (C165) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide; (C166) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-3-ylmethoxy)phenyl]acetamide; (C167) 2-(2-Chloro-6-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide; (C168) 2-(2-Chloro-3-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide; (C169) 2-(2-chlorophenyl)-N-5-sulfamoyl-6-[3-(trifluoromethyl)phenoxy]pyridin-3-ylacetamide; (C170) 2-phenyl-N-5-sulfamoyl-6-[3-(trifluoromethyl)phenoxy]pyridin-3-ylacetamide; (C171) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-phenylacetamide; (C172) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(2-methylphenyl)acetamide; (C173) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(3-methylphenyl)acetamide; (C174) 2-(2-chlorophenyl)-N-4-[3-(3-oxomorpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide; (C175) 2-(2-chlorophenyl)-N-4-[4-(3-oxomorpholin-4-yl)phenoxy]-3-sulfamoylphenylacetamide; (C176) 2-(2-chlorophenyl)-N-4-[4-(2-oxopiperidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide; (C177) 2-(2-chlorophenyl)-N-4-[3-(2-oxopiperidin-1-yl)phenoxy]-3-sulfamoylphenylacetamide; (C178) 2-(2-chlorophenyl)-N-4-[3-(prop-1-en-2-yl)phenoxy]-3-sulfamoylphenylacetamide; (C179) 2-(2-chlorophenyl)-N-4-[2-(prop-1-en-2-yl)phenoxy]-3-sulfamoylphenylacetamide; (C180) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide; (C181) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-chlorophenyl)acetamide; (C182) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(pyridin-3-yl)acetamide; (C183) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide; (C184) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-methylphenyl)acetamide; (C185) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylpropionamide; (C186) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(pyridin-2-yl)acetamide; (C187) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-chlorophenyl)acetamide; (C188) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C189) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(pyridin-4-yl)acetamide; (C190) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(6-methylpyridin-2-yl)acetamide; (C191) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide; (C192) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-methoxyphenyl)acetamide; (C193) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-methoxyphenyl)acetamide; (C194) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(5-methylpyridin-2-yl)acetamide; (C195)(2S)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylpropionamide; (C196)(2R)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylpropionamide; (C197) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-chlorophenyl)propionamide; (C198) 2-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-(2-methoxyethyl)-N-methylbenzamide; (C199) 2-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N,N-dimethylbenzamide; (C200) N-[4-(cyclohexyloxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C201) 2-(2-chlorophenyl)-N-[4-(cyclohexyloxy)-3-sulfamoylphenyl]acetamide; (C202) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-(2-methoxyethyl)benzamide; (C203) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N,N-dimethylbenzamide; (C204) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-methylbenzamide; (C205) N-[4-(cyclobutyloxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C206) 2-(2-chlorophenyl)-N-[4-(cyclobutyloxy)-3-sulfamoylphenyl]acetamide; (C207) 2-phenyl-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]acetamide; (C208) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]acetamide; (C209) 3-(2-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]amino-2-oxoethyl)-N-(2-methoxyethyl)-N-methylbenzamide; (C210) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(5-chloropyridin-2-yl)acetamide; (C211) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[3-(2-methoxyethoxy)phenyl]acetamide; (C212) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(2-methoxyethoxy)phenyl]acetamide; (C213) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[3-(2-hydroxyethoxy)phenyl]acetamide; (C214) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-[2-(2-hydroxyethoxy)phenyl]acetamide; (C215) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (C216) N-[4-(oxetane-3-yloxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C217) 2-(2-chlorophenyl)-N-[4-(oxetan-3-yloxy)-3-sulfamoylphenyl]acetamide; (C218) N-[4-(cyclopentyloxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C219) 2-(2-chlorophenyl)-N-[4-(cyclopentyloxy)-3-sulfamoylphenyl]acetamide; (C220) N-4-[(1-methylpiperidin-3-yl)oxy]-3-sulfamoylphenyl-2-phenylacetamide; (C221) 2-(2-chlorophenyl)-N-4-[(1-methylpiperidin-3-yl)oxy]-3-sulfamoylphenylacetamide; (C222) N-4-[(1-methylpyrrolidin-3-yl)oxy]-3-sulfamoylphenyl-2-phenylacetamide; (C223) 2-(2-chlorophenyl)-N-4-[(1-methylpyrrolidin-3-yl)oxy]-3-sulfamoylphenylacetamide; (C224) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide; (C225) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-cyanophenyl)acetamide; (C226) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-cyanophenyl)acetamide; (C227) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(3-cyanophenyl)acetamide; (C228) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide; (C229) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-chlorophenyl)acetamide; (C230) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide; (C231) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (C232) 2-(2-chloro-4-fluorophenyl)-N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C233) 2-(2-Chlorophenyl)-N-4-[(1,1-dioxytetrahydrothiophen-3-yl)oxy]-3-sulfamoylphenylacetamide; (C234) 2-(2-Chlorophenyl)-N-4-[(1-methyl-1H-pyrazol-4-yl)oxy]-3-sulfamoylphenylacetamide; (C235) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide; (C236) 2-(2-chloro-4-methoxyphenyl)-N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C237) 2-(2-chlorophenyl)-N-4-[(1-methyl-1H-pyrazol-3-yl)oxy]-3-sulfamoylphenylacetamide; (C238) 2-(2-chlorophenyl)-N-4-[(1-methyl-1H-pyrazol-5-yl)oxy]-3-sulfamoylphenylacetamide; (C239) 2-(2-chlorophenyl)-N-4-[(1-methylpiperidin-4-yl)oxy]-3-sulfamoylphenylacetamide; (C240) 2-(2-chlorophenyl)-N-(4-[5-methyl-2-(pyridin-3-yl)-1,3-thiazol-4-yl]oxy-3-sulfamoylphenyl)acetamide; (C241) N-[4-(3-chlorophenoxy)-2-methyl-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C242) 2-(2-Chlorophenyl)-N-{4-[(1-oxytetrahydrothiophen-3-yl)oxy]-3-sulfamoylphenyl}acetamide; (C243) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-[2,6-dichloro-4-(trifluoromethyl)phenyl]acetamide; (C244) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,5-dichloro-4-cyanophenyl)acetamide; (C245) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C246) N-[4-(Cyclopropylmethoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C247) N-[4-(3,5-dimethylphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C248) N-[4-(2,4-difluorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C249) N-[4-(4-fluorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C250) N-[4-(3-fluorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C251) N-[4-(3-methoxyphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C252) N-[4-(2-fluoro-5-methylphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C253) 2-phenyl-N-3-sulfamoyl-4-[4-(trifluoromethoxy)phenoxy]phenylacetamide; (C254) 2-phenyl-N-3-sulfamoyl-4-[3-(trifluoromethyl)phenoxy]phenylacetamide; (C255) N-[4-(3,5-dimethoxyphenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C256) N-[4-(3-cyanophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide; (C257) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(4-hydroxyphenyl)acetamide; (C258) 2-(2-chloro-6-methoxy-4-methylphenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C259) 2-(2-chloro-6-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]propanamide; (C260) 2-(2-chloro-4,6-difluorophenyl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C261) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,6-dichlorophenyl)propionamide; (C262) 2-(2-chlorophenyl)-N-4-[(2H5)phenyloxy]-3-sulfamoylphenylacetamide; (C263) 2-(2-chlorophenyl)-N-(4-{[4-chloro(2H4)phenyl]oxy}-3-sulfamoylphenyl)acetamide; (C264) 2-(2-chlorophenyl)-N-(4-{[2-chloro(2H4)phenyl]oxy}-3-sulfamoylphenyl)acetamide; (C265) 2-(2-chlorophenyl)-N-4-[4-(2-hydroxypropane-2-yl)phenoxy]-3-sulfamoylphenylacetamide; (C266) 2-(2-chlorophenyl)-N-4-[(2,2-dimethyltetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide; (C267) 2-(2-Chlorophenyl)-N-{4-[(1R,5S,6r)-3-oxabicyclo[3.1.0]hexane-6-ylmethoxy]-3-sulfamoylphenyl}acetamide; (C268) 2-(2-Chlorophenyl)-N-4-[(4-chlorotetrahydro-2H-pyran-4-yl)methoxy]-3-sulfamoylphenylacetamide; (C269) 2-(2-chlorophenyl)-N-[4-(1,4-diphenyl)- [(2-alkylmethoxy)-3-sulfamoylphenyl]acetamide; (C270) 2-(2-Chlorophenyl)-N-3-sulfamoyl-4-[(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)oxy]phenylacetamide; (C271) N-[4-(3-chlorophenoxy)-3-methyl-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C272) N-[4-(3-chlorophenoxy)-3-methyl-5-sulfamoylphenyl]-2-phenylacetamide; (C273) methyl 2-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)benzoate; (C274) 4-(4-[(2-chlorophenyl)acetyl]amino-2-sulfamoylphenoxy)benzoic acid methyl ester; (C275) 2-(2-chlorophenyl)-N-4-[3-(2-hydroxypropane-2-yl)phenoxy]-3-sulfamoylphenylacetamide; (C276) 2-(2-chlorophenyl)-N-4-[2-(2-hydroxypropane-2-yl)phenoxy]-3-sulfamoylphenylacetamide; (C277) N-[4-(4-chlorophenoxy)-3-sulfamoylphenyl]-2-(2,3-dihydro-1,4-benzodihydrophenoxy)-3-sulfamoylphenyl Ethyl-6-oxoacetamide; (C278) 2-(7-chloro-2,3-dihydro-1,4-benzodihydrogen (6-in-1-yl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C279) 2-(5-chloro-2,3-dihydro-1-benzofuran-4-yl)-N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]acetamide; (C280) 2-(2-Fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide; (C281) N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]-2-[2-(trifluoromethyl)phenyl]acetamide; (C282) 2-[2-(Difluoromethyl)phenyl]-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide; (C283) 2-(2-Chloro-4-fluorophenyl)-N-[3-sulfamoyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]acetamide; (C284) 2-(2-Chlorophenyl)-N-(3-sulfamoyl-4-{[6-(trifluoromethyl)pyridin-3-yl]oxy}phenyl)-acetamide; (C285) 2-(2-chlorophenyl)-N-(4-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]oxy}-3-sulfamoyl-phenyl)acetamide; (C286) N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenyl(2H2)acetamide; (C287) N-{4-[(6-chloro-5-fluoropyridin-3-yl)oxy]-3-sulfamoylphenyl}-2-(2-chlorophenyl)-acetamide; (C288) 2-(2-Chlorophenyl)-N-{4-[(4,4-difluoro-1-hydroxycyclohexyl)methoxy]-3-sulfamoyl-phenyl}acetamide; (C289) 2-(2-chlorophenyl)-N-{4-[(1-hydroxycyclohexyl)methoxy]-3-sulfamoylphenyl}-acetamide; (C290) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (C291) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-[2-(difluoromethyl)-phenyl]acetamide; (C292) N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (C293) 2-(2-chloro-5-fluorophenyl)-N-[4-(3-chlorophenoxy)-3-fluoro-5-sulfamoyl-phenyl]acetamide; (C294) N-[6-(3-chlorophenoxy)-5-sulfamoylpyridin-3-yl]-2-(2-fluorophenyl)acetamide; (C295) N-[6-(3-chlorophenoxy)-5-sulfamoylpyridin-3-yl]-2-[2-(trifluoromethyl)phenyl]-acetamide; (C296) N-[6-(3-chlorophenoxy)-5-sulfamoylpyridin-3-yl]-2-[2-(difluoromethyl)phenyl]-acetamide; as well as (C297) 2-(2-Chloro-5-fluorophenyl)-N-[6-(3-chlorophenoxy)-5-sulfamoylpyridin-3-yl]-acetamide.

9. The pharmaceutical composition according to any one of claims 1 to 4, wherein The compound is selected from the following compounds (D1) to (D558), (D1) 2-(2-chlorophenyl)-N-[4-(2-oxopyridin-1(2H)-yl)-3-sulfamoylphenyl]acetamide; (D2) N-[4-(4-chloro-2-oxopyridin-1(2H)-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D3) 2-(2-chlorophenyl)-N-[4-(3,5-dichloro-2-oxopyridin-1(2H)-yl)-3-sulfamoylphenyl]acetamide; (D4) N-[4-(3-chloro-2-oxopyridin-1(2H)-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D5) 2-(2-chlorophenyl)-N-[4-(3-methyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D6) 2-(2-chlorophenyl)-N-[4-(5-methyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D7) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D8) 2-(2-chlorophenyl)-N-{4-[5-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide; (D9) 2-(2-chlorophenyl)-N-[4-(1H-imidazol-1-yl)-3-sulfamoylphenyl]acetamide; (D10) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-imidazol-1-yl]phenyl}acetamide; (D11) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D12) 2-(2-chlorophenyl)-N-{4-[3-(difluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D13) 2-(2-chlorophenyl)-N-{4-[5-cyclopropyl-3-(difluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D14) 2-(2-chlorophenyl)-N-{4-[4-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D15) 2-(2-chlorophenyl)-N-{4-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D16) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(1H-1,2,4-triazol-1-yl)phenyl]acetamide; (D17) 2-(2-chlorophenyl)-N-{4-[3-(difluoromethyl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide; (D18) N-{4-[3-(difluoromethyl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}-2-(2-fluorophenyl)acetamide; (D19) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D20) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D21) 2-[2-(difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D22) N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[2-(trifluoromethyl)phenyl]acetamide; (D23) N-[4-(3-tert-butyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D24) 2-(2-chlorophenyl)-N-[4-(3-chloro-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D25) 2-(2-chlorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D26) 2-(2-chlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D27) 2-(2-chlorophenyl)-N-[4-(4-isopropoxy-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D28) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D29) 2-(2-chlorophenyl)-N-[4-(3-isobutyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D30) 2-(2-chlorophenyl)-N-{4-[4-(methylthio)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D31) 2-(2-chlorophenyl)-N-[4-(4-methoxy-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D32) N-[4-(1H-benzimidazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D33) N-[4-(4-chloro-1H-imidazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D34) 2-(2-chlorophenyl)-N-{4-[3-(dimethylamino)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide; (D35) 2-(2-chlorophenyl)-N-[4-(3-ethyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D36)(2-Chlorophenyl)-N-[4-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D37) 2-(2-chlorophenyl)-N-[4-(5-cyclopropyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D38) 2-(2-chlorophenyl)-N-{4-[3-(methoxymethyl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide; (D39) 2-(2-chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D40) N-[4-(4-tert-butyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D41) 2-(2-chlorophenyl)-N-[4-(3-cyano-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D42) N-[4-(4-bromo-1H-imidazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D43) 2-(2-chlorophenyl)-N-[4-(3H-imidazo[4,5-b]pyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D44) 2-(2-chlorophenyl)-N-[4-(1H-imidazo[4,5-b]pyridin-1-yl)-3-sulfamoylphenyl]acetamide; (D45) 2-(2-chlorophenyl)-N-[4-(1H-imidazo[4,5-c]pyridin-1-yl)-3-sulfamoylphenyl]acetamide; (D46) 2-(2-chlorophenyl)-N-[4-(3H-imidazo[4,5-c]pyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D47) 2-(2-chlorophenyl)-N-[4-(2,4-dimethyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]acetamide; (D48) 2-(2-Fluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D49) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(difluoromethyl)phenyl]acetamide; (D50) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D51) 2-[2-(Difluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D52) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D53) 2-(2-methoxyphenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D54) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D55) 2-(3-Fluorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D56) 2-(2-Chloro-4-fluorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D57) 2-[2-(difluoromethoxy)phenyl]-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D58) 2-(2-Chloro-5-fluorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D59) 2-(3-chloropyridin-4-yl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D60) 2-[4-(difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D61) 2-(2-Chlorophenyl)-2,2-difluoro-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D62) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)-2,2-difluoroacetamide; (D63) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D64) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide; (D65) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-fluorophenyl)acetamide; (D66) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide; (D67) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chloropyridin-3-yl)acetamide; (D68) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chloro-4-fluorophenyl)acetamide; (D69) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(difluoromethoxy)phenyl]acetamide; (D70) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide; (D71) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chloro-4,5-difluorophenyl)acetamide; (D72) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-chloropyridin-4-yl)acetamide; (D73) N-[4-(4-bromo-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide; (D74) 2-(2-Bromophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D75) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methoxyphenyl)acetamide; (D76) 2-(4-chlorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D77) 2-(2-Chloro-6-fluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D78) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-nitrophenyl)acetamide; (D79) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,4-dichlorophenyl)acetamide; (D80) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,6-dichlorophenyl)acetamide; (D81) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3,4-difluorophenyl)acetamide; (D82) 2-(3-Chlorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D83) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3,5-difluorophenyl)acetamide; (D84) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide; (D85) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-hydroxyphenyl)acetamide; (D86) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-hydroxyphenyl)acetamide; (D87) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,3-difluorophenyl)acetamide; (D88) 2-(2-Chloro-4-fluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D89) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chloropyridin-3-yl)acetamide; (D90) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-chloro-3-(trifluoromethyl)phenyl]acetamide; (D91) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(difluoromethoxy)phenyl]acetamide; (D92) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide; (D93) 2-(2-Chloro-4,5-difluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D94) 2-(2-chloro-4-methoxyphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D95) 2-(2-chloro-6-fluoro-3-methylphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D96) 2-(2-chloro-3,6-difluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D97) 2-(2-chloro-5-methylphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D98) 2-(2-Chloro-5-fluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D99) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,5-dichlorophenyl)acetamide; (D100) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-isopropylphenyl)acetamide; (D101) 2-(2-chloro-5-methoxyphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D102) 2-(2-chloro-4,6-difluorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D103) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-chloro-6-(trifluoromethyl)phenyl]acetamide; (D104) 2-(5-bromo-4-fluoro-2-methylphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D105) 2-(2-chloro-6-methoxyphenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D106) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,6-difluorophenyl)propionamide; (D107) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide; (D108) 2-(4-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D109) 2-(2-chlorophenyl)-N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2,2-difluoroacetamide; (D110) 2-(2-nitrophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D111) 2-(2,4-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D112) 2-(2-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D113) 2-(2-Chloro-6-fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D114) 2-(3-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D115) 2-(3,5-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D116) 2-(2,6-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D117) 2-(2-bromophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D118) 2-(3,4-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D119) 2-(4-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D120) 2-(3-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D121) 2-(4-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D122) 2-(2,3-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D123) 2-(2-Methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D124) 2-(3-Methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D125) 2-[2-(Difluoromethoxy)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D126) 2-(2-chloropyridin-3-yl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D127) 2-(2-Chloro-4-fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D128) 2-(2-Chloro-5-methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D129) N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[2-(trifluoromethoxy)phenyl]acetamide; (D130) 2-(2-Chloro-4,5-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D131) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D132) 2-(2-chloro-6-fluoro-3-methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D133) 2-(2-Chloro-3,6-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D134) 2-[2-Chloro-6-(trifluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D135) 2-(2-Chloro-4-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D136) 2-(2,5-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D137) 2-(2-isopropylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D138) 2-(2-Chloro-5-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D139) 2-(2-Chloro-5-fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D140) N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide; (D141) 2-(5-bromo-4-fluoro-2-methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D142) 2-(2-Chloro-6-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D143) 2-(2-Chloro-4,6-difluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D144) 2-(3-Fluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D145) 2-(3,4-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D146) 2-(3,5-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D147) N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-hydroxyphenyl)acetamide; (D148) 2-(3-Chlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D149) 2-(4-Fluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D150) N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-hydroxyphenyl)acetamide; (D151) N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-methylphenyl)acetamide; (D152) N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide; (D153) N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide; (D154) N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide; (D155) 2-(2,3-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D156) 2-(2-ethoxyphenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D157) 2-[2-(Difluoromethoxy)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D158) 2-(2-chloropyridin-3-yl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D159) 2-(2-chloro-6-fluoro-3-methylphenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D160) N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide; (D161) 2-(2-Chloro-4,5-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D162) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D163) 2-(2,5-dichlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D164) 2-(2-chloro-3,6-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D165) 2-(2-chloro-5-methylphenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D166) 2-(5-bromo-4-fluoro-2-methylphenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D167) N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-isopropylphenyl)acetamide; (D168) 2-(2-Chloro-5-fluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D169) 2-[2-Chloro-6-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D170) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide; (D171) 2-(2,6-difluorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]propanamide; (D172) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide; (D173) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide; (D174) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-methylphenyl)acetamide; (D175) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-ethoxyphenyl)acetamide; (D176) 2-(2-ethoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D177) 2-(2-Bromophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D178) 2-(2,4-dichlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D179) 2-(2,6-dichlorophenyl)-N-[4-(4-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D180) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-nitrophenyl)acetamide; (D181) 2-(4-chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D182) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methoxyphenyl)acetamide; (D183) 2-(2-Chloro-6-fluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D184) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide; (D185) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-fluorophenyl)acetamide; (D186) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,4-dichlorophenyl)acetamide; (D187) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,6-dichlorophenyl)acetamide; (D188) 2-(2-Bromophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D189) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3,4-difluorophenyl)acetamide; (D190) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3,5-difluorophenyl)acetamide; (D191) 2-(3-chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D192) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-fluorophenyl)acetamide; (D193) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-hydroxyphenyl)acetamide; (D194) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-hydroxyphenyl)acetamide; (D195) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide; (D196) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide; (D197) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-methylphenyl)acetamide; (D198) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(3-methylphenyl)acetamide; (D199) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-ethoxyphenyl)acetamide; (D200) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,3-difluorophenyl)acetamide; (D201) 2-(2-chloropyridin-3-yl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D202) 2-(2-Chloro-4-fluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D203) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(difluoromethoxy)phenyl]acetamide; (D204) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethoxy)phenyl]acetamide; (D205) 2-(2-Chloro-4,5-difluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D206) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D207) 2-(2-chloro-6-fluoro-3-methylphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D208) 2-(2-Chloro-3,6-difluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D209) 2-(2-chloro-5-methylphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D210) 2-(2-chloro-4-methoxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D211) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2,5-dichlorophenyl)acetamide; (D212) 2-(5-chloro-2-methoxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D213) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(propan-2-yl)phenyl]acetamide; (D214) 2-(2-Chloro-5-fluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D215) 2-[2-Chloro-6-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D216) 2-(2-Chloro-6-methoxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D217) 2-(2-Chloro-4,6-difluorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D218) 2-(3-chloropyridin-4-yl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D219) N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide; (D220) 2-(2-chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2,2-difluoroacetamide; (D221) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D222) N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}-2-[2-(trifluoromethoxy)phenyl]acetamide; (D223) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(2-methylphenyl)acetamide; (D224) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-[2-(trifluoromethyl)phenyl]acetamide; (D225) 2-[2-(Difluoromethyl)phenyl]-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D226) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(2-methoxyphenyl)acetamide; (D227) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(4-fluorophenyl)acetamide; (D228) 2-(2-Chloro-5-fluorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D229) 2-(2,3-dichlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D230) 2-(3-chloropyridin-4-yl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D231) 2-(2-chlorophenyl)-N-[4-(3-cyclobutyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D232) N-[4-(4-acetyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D233) 2-(2-chlorophenyl)-N-[4-(3-isopropyl-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D234) N-[4-(4-chloro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide; (D235) 1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazole-4-carboxylic acid ethyl ester; (D236) 1-(4-{[(2-fluorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazole-4-carboxylic acid ethyl ester; (D237) 2-(2-Fluorophenyl)-N-{4-[4-(2-hydroxypropane-2-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D238) 2-(2-Chlorophenyl)-N-{4-[4-(2-hydroxypropane-2-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D239) 2-(2-chloropyridin-3-yl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]phenyl}acetamide; (D240) 2-(2-Chlorophenyl)-N-methyl-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D241) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide; (D242) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide; (D243) 2-(2-Chloro-5-cyanophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D244) 2-(2-Chlorophenyl)-N-{3-cyano-5-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D245) 2-(5-bromo-2-chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D246) N-[4-(3-chloro-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D247) 2-(2-Chlorophenyl)-N-[3-cyano-4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoylphenyl]acetamide; (D248) 2-(2-Chlorophenyl)-N-[4-(4-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D249) 2-(2-chlorophenyl)-N-[4-(3-methoxy-1H-1,2,4-triazol-1-yl)-3-sulfamoylphenyl]acetamide; (D250) 2-(2-chlorophenyl)-N-[4-(4-cyclopropyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]acetamide; (D251) 2-(2-chlorophenyl)-N-[4-(4-methyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]acetamide; (D252) 2-(2-Chlorophenyl)-N-[4-(3-cyclopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D253) 2-(2-Chlorophenyl)-N-[4-(2H-pyrazolo[3,4-b]pyridin-2-yl)-3-sulfamoylphenyl]acetamide; (D254) 2-(2-Chlorophenyl)-N-[4-(2H-pyrazolo[3,4-c]pyridin-2-yl)-3-sulfamoylphenyl]acetamide; (D255) 2-(2-Chlorophenyl)-N-[4-(2H-pyrazolo[4,3-b]pyridin-2-yl)-3-sulfamoylphenyl]acetamide; (D256) 2-(2-chlorophenyl)-N-{4-[4-(2-methoxyethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D257) 2-(2-Chlorophenyl)-N-[4-(3-fluoro-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D258) 2-(2-chlorophenyl)-N-(4-{4-[(2,2-difluoroethyl)amino]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide; (D259) 2-(2-Chlorophenyl)-N-{4-[4-(2,2-difluoroethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D260) 2-(2-chlorophenyl)-N-[4-(4-{[(2,2-difluoroethyl)amino]methyl}-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D261) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)-1,2,4- oxadiazol-3-yl]phenyl}acetamide; (D262) 2-(2-Fluorophenyl)-N-[4-(4-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D263) N-[4-(4-cyclopropyl-1H-imidazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D264) N-[4-(3-cyclopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D265) 2-(2-Fluorophenyl)-N-{4-[4-(2-methoxyethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D266) 2-(2-chlorophenyl)-N-(2-sulfamoylbiphenyl-4-yl)acetamide; (D267) 2-(2-Chlorophenyl)-N-{4-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D268) 2-(2-chlorophenyl)-N-{4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D269) 2-(2-Chlorophenyl)-N-{4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D270) 2-(2-Fluorophenyl)-N-{4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D271) N-{4-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(2-chlorophenyl)acetamide; (D272) 2-(3-chlorophenyl)-N-(2-sulfamoylbiphenyl-4-yl)acetamide; (D273) 2-(2-Chlorophenyl)-N-[4-(3-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D274) 2-(2-chlorophenyl)-N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D275) 2-(2-chlorophenyl)-N-[4-(3,5-dimethyl-1,2- [(4-oxazol-4-yl)-3-sulfamoylphenyl]acetamide; (D276) 2-(2-chlorophenyl)-N-(4-{1-[(3-methyloxetane-3-yl)methyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide; (D277) 2-(2-Chloro-4-fluorophenyl)-N-{4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D278) 2-(2-Chloro-4-fluorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D279) 2-(2-chlorophenyl)-N-(3-sulfamoyl-4-{1-[2-(trifluoromethoxy)ethyl]-1H-pyrazol-4-yl}phenyl)acetamide; (D280) 2-(2-chlorophenyl)-N-[4-(1-cyclobutyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D281) 2-(2-chlorophenyl)-N-(4-{1-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide; (D282) 2-(2-chlorophenyl)-N-[4-(5-cyanopyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D283) 2-(2-chlorophenyl)-N-(4-{1-[oxetan-2-ylmethyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide; (D284) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl]phenyl}acetamide; (D285) 2-(2-chlorophenyl)-N-[4-(2-methoxypyrimidin-5-yl)-3-sulfamoylphenyl]acetamide; (D286) 2-(2-chlorophenyl)-N-(4-{1-[2-(propan-2-yloxy)ethyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide; (D287) 2-(2-Chlorophenyl)-N-{4-[1-(3-hydroxy-3-methylbutyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D288) 2-(2-chlorophenyl)-N-{4-[5-(2-hydroxypropane-2-yl)-1-methyl-1H-pyrazol-3-yl]-3-sulfamoylphenyl}acetamide; (D289) 2-(2-Chlorophenyl)-N-{4-[5-(difluoromethoxy)pyridin-3-yl]-3-sulfamoylphenyl}acetamide; (D290) N-[4-(2-chloro-5-methoxypyridin-3-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D291) 2-(2-Chlorophenyl)-N-{4-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D292) N-[4-(5-tert-butyl-1H-pyrazol-3-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D293) N-[4-(1-benzyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D294) 2-(2-chlorophenyl)-N-[4-(6-methylpyridazin-4-yl)-3-sulfamoylphenyl]acetamide; (D295) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[6-(trifluoromethyl)pyridin-2-yl]phenyl}acetamide; (D296) N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-(2-fluorophenyl)acetamide; (D297) 2-(2-Chlorophenyl)-N-{6-[1-(difluoromethyl)-1H-pyrazol-4-yl]-5-sulfamoylpyridin-3-yl}acetamide; (D298) N-[4-(6-chloro-5-methylpyridin-3-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D299) 2-(2-chlorophenyl)-N-{4-[2-(cyclopropylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide; (D300) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl]phenyl}acetamide; (D301) 2-(2-chlorophenyl)-N-{4-[2-(methylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide; (D302) 2-(2-Chlorophenyl)-N-[6-(1-methyl-1H-pyrazol-4-yl)-5-sulfamoylpyridin-3-yl]acetamide; (D303) 2-(2-chlorophenyl)-N-{4-[1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D304) N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}-2-[2-(trifluoromethyl)phenyl]acetamide; (D305) 2-(2-chlorophenyl)-N-[3-sulfamoyl-5'-(trifluoromethyl)-2,3'-bipyridin-5-yl]acetamide; (D306) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[2-(trifluoromethyl)pyrimidin-5-yl]phenyl}acetamide; (D307) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethoxy)pyridin-3-yl]phenyl}acetamide; (D308) 2-(2-chlorophenyl)-N-[4-(2-cyclopropylpyrimidin-5-yl)-3-sulfamoylphenyl]acetamide; (D309) 2-(2-chlorophenyl)-N-[4-(2-ethoxypyrimidin-5-yl)-3-sulfamoylphenyl]acetamide; (D310) 2-(2-chlorophenyl)-N-{4-[2-(propan-2-ylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide; (D311) 2-(2-chlorophenyl)-N-{4-[2-(propan-2-yloxy)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide; (D312) 2-(2-chlorophenyl)-N-{4-[2-(ethylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide; (D313) 2-(2-chlorophenyl)-N-[4-(2-methylpyrimidin-5-yl)-3-sulfamoylphenyl]acetamide; (D314) 2-(2-chlorophenyl)-N-{4-[2-(propylamino)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide; (D315) 2-(2-chlorophenyl)-N-(3-sulfamoyl-4-{2-[(2,2,2-trifluoroethyl)amino]pyrimidin-5-yl}phenyl)acetamide; (D316) 2-(2-chlorophenyl)-N-{4-[2-(cyclobutyloxy)pyrimidin-5-yl]-3-sulfamoylphenyl}acetamide; (D317) N-[4-(2-chloro-4-methylpyrimidin-5-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D318) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)pyridin-2-yl]phenyl}acetamide; (D319) 2-(2-chlorophenyl)-N-[4-(5-chloropyridin-2-yl)-3-sulfamoylphenyl]acetamide; (D320) 2-(2-chlorophenyl)-N-[4-(1,2-dimethyl-1H-imidazol-4-yl)-3-sulfamoylphenyl]acetamide; (D321) N-{6-[1-(difluoromethyl)-1H-pyrazol-4-yl]-5-sulfamoylpyridin-3-yl}-2-(2-fluorophenyl)acetamide; (D322) 2-(2-Chlorophenyl)-N-{4-[5-(pyrrolidin-1-yl)pyridin-3-yl]-3-sulfamoylphenyl}acetamide; (D323) 2-(2-chlorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-hydroxyethaneamide; (D324) 2-(2-chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}-2-hydroxyethaneamide; (D325) 2-(2-chlorophenyl)-N-[4-(5-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D326) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D327) 2-(2-chlorophenyl)-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D328) 2-(2-Chlorophenyl)-N-{4-[1-(2-methylpropyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D329) 2-(2-chlorophenyl)-N-[4-(1-cyclopentyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D330) 2-(2-chlorophenyl)-N-[2'-fluoro-3'-(propan-2-yloxy)-2-sulfamoylbiphenyl-4-yl]acetamide; (D331) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D332) N-[4-(6-chloro-5-methoxypyridin-3-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D333) 2-(2-Chloro-6-fluorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D334) 2-(2-Chloro-3-fluorophenyl)-N-[4-(1-methyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D335) N-[4-(1-tert-butyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D336) 2-(2-chlorophenyl)-N-{4-[2-(propan-2-yloxy)pyridin-3-yl]-3-sulfamoylphenyl}acetamide; (D337) 2-(2-chloro-3-fluorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D338) 2-(2-Fluorophenyl)-N-[4-(pyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D339) 2-(2-Chloro-6-fluorophenyl)-N-[4-(1-methyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D340) 2-(2-chlorophenyl)-N-[3'-fluoro-5'-(2-hydroxypropane-2-yl)-2-sulfamoylbiphenyl-4-yl]acetamide; (D341) 2-(2-chlorophenyl)-N-[4-(5-methoxypyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D342) 2-(2-chlorophenyl)-N-[3'-(2-hydroxypropane-2-yl)-2-sulfamoylbiphenyl-4-yl]acetamide; (D343) 2-(2-Fluorophenyl)-N-{4-[1-(propan-2-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D344) N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D345) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenyl}acetamide; (D346) N-[4-(1-tert-butyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D347) N-[3'-Fluoro-5'-(2-hydroxypropane-2-yl)-2-sulfamoylbiphenyl-4-yl]-2-(2-fluorophenyl)acetamide; (D348) N-[4-(1-cyclopentyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D349) 2-(2-chlorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D350) 2-(2-chloro-6-fluorophenyl)-N-{4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D351) 2-(2-chlorophenyl)-N-[4-(1,3-dimethyl-1H-pyrazol-5-yl)-3-sulfamoylphenyl]acetamide; (D352) 2-(2-chlorophenyl)-N-(4'-chloro-2-sulfamoylbiphenyl-4-yl)acetamide; (D353) 2-(2-Chlorophenyl)-N-{4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-sulfamoylphenyl}acetamide; (D354) 2-(2-chlorophenyl)-N-[4-(pyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D355) 2-(2-Chlorophenyl)-N-{4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D356) 2-(2-chlorophenyl)-N-(3'-chloro-2-sulfamoylbiphenyl-4-yl)acetamide; (D357) 2-(2-chlorophenyl)-N-(4-{1-[(2,2-dichlorocyclopropyl)methyl]-1H-pyrazol-4-yl}-3-sulfamoylphenyl)acetamide; (D358) 2-(2-chlorophenyl)-N-[4-(1,3-dimethyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D359) 2-(2-chlorophenyl)-N-{4-[1-(propan-2-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D360) 2-(2-chlorophenyl)-N-[4-(1-methyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D361) 2-(2-chlorophenyl)-N-{4-[1-(2-hydroxy-3,3-dimethylbutyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D362) 2-(2-Fluorophenyl)-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D363) 2-(2-chlorophenyl)-N-[4-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D364) 4'-{[(2-chlorophenyl)acetyl]amino}-N-[2-(dimethylamino)ethyl]-2'-sulfamoylbiphenyl-3-carboxamide; (D365) 2-(2-chlorophenyl)-N-[4-(pyrazolo[1,5-a]pyrimidin-3-yl)-3-sulfamoylphenyl]acetamide; (D366) 2-(2-Chlorophenyl)-N-{4-[5-(pyrrolidin-1-ylcarbonyl)pyridin-3-yl]-3-sulfamoylphenyl}acetamide; (D367) 2-(2-Chlorophenyl)-N-[4-(1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D368) 2-(2-Fluorophenyl)-N-{4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-sulfamoylphenyl}acetamide; (D369) 2-(2-Fluorophenyl)-N-{4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D370) 2-(2-chlorophenyl)-N-{4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D371) 2-(5-chloro-2-fluorophenyl)-N-[4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D372) 2-(2-chlorophenyl)-N-[4-(6-methylpyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D373) 2-(2-chlorophenyl)-N-{4-[1-(oxetane-3-yl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D374) 2-(2-Fluorophenyl)-N-[4-(1-methyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]acetamide; (D375) N-[4-(1,3-dimethyl-1H-pyrazol-4-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D376) N-[4-(5-cyclopropyl-1,3,4- Oxazolyl-2-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D377) 2-(2-chlorophenyl)-N-[4-(5-cyclopropyl-1,3,4- oxadiazole-2-yl)-3-sulfamoylphenyl]acetamide; (D378) N-{4-[4-(difluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}-2-(2-fluorophenyl)acetamide; (D379) 2-(2-Chlorophenyl)-N-{4-[4-(difluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D380) 2-(2-Chlorophenyl)-N-{5-sulfamoyl-6-[4-(trifluoromethyl)-1H-pyrazol-1-yl]pyridin-3-yl}acetamide; (D381) 2-(2-Fluorophenyl)-N-{5-sulfamoyl-6-[4-(trifluoromethyl)-1H-pyrazol-1-yl]pyridin-3-yl}acetamide; (D382) N-[6-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]-2-(2-fluorophenyl)acetamide; (D383) 2-(2-Chlorophenyl)-N-[6-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]acetamide; (D384) 2-(2-Fluorophenyl)-N-[6-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]acetamide; (D385) 2-(2-Chlorophenyl)-N-[6-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]acetamide; (D386) N-[6-(4-bromo-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]-2-(2-fluorophenyl)acetamide; (D387) 2-(2-Chlorophenyl)-N-[6-(4-chloro-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]acetamide; (D388) N-[6-(4-chloro-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]-2-(2-fluorophenyl)acetamide; (D389) N-[6-(4-bromo-1H-pyrazol-1-yl)-5-sulfamoylpyridin-3-yl]-2-(2-chlorophenyl)acetamide; (D390) 2-(2-fluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)-1,3,4- oxadiazol-2-yl]phenyl}acetamide; (D391) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)-1,3,4- oxadiazol-2-yl]phenyl}acetamide; (D392) 2-(2-Chlorophenyl)-N-{4-[3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl]-3-sulfamoylphenyl}acetamide; (D393) 2-(2-Fluorophenyl)-N-[4-(1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D394) N-[4-(4-tert-butyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D395) 2-(2-Chlorophenyl)-N-[4-(1H-indazol-1-yl)-3-sulfamoylphenyl]acetamide; (D396) 2-(2-chlorophenyl)-N-[4-(2H-indazol-2-yl)-3-sulfamoylphenyl]acetamide; (D397) 2-(2-Fluorophenyl)-N-[4-(2H-indazol-2-yl)-3-sulfamoylphenyl]acetamide; (D398) 2-(2-Fluorophenyl)-N-[4-(1H-indazol-1-yl)-3-sulfamoylphenyl]acetamide; (D399) 1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-N,N-dimethyl-1H-pyrazole-4-carboxamide; (D400) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]cyclopropanecarboxamide; (D401) 2-(2-Chlorophenyl)-N-{4-[4-(pyrazin-2-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D402) 2-(2-Chlorophenyl)-N-{4-[4-(pyridin-2-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D403) 2-(2-Chlorophenyl)-N-{4-[4-(pyridin-3-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D404) 2-(2-Chlorophenyl)-N-{4-[4-(pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D405) 2-(2-Fluorophenyl)-N-{4-[4-(pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D406) 2-(4-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide; (D407) 2-(4-methoxyphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide; (D408) 2-(4-methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-(D)2-yl]phenyl}acetamide; (D409) 2-(4-Methylphenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide; (D410) 2-[4-(difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide; (D411) 2-[4-(difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide; (D412) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide; (D413) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide; (D414) 2-[2-Chloro-4-(trifluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide; (D415) 2-[2-Chloro-4-(trifluoromethyl)phenyl]-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide; (D416) 2-(2,4-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-2H-1,2,3-triazol-2-yl]phenyl}acetamide; (D417) 2-(2,4-dichlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}acetamide; (D418) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(1,3-thiazol-5-yl)phenyl]acetamide; (D419) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(1,2-thiazol-3-yl)phenyl]acetamide; (D420) 2-(2-chlorophenyl)-N-[4-(2-methyl-1,3-thiazol-4-yl)-3-sulfamoylphenyl]acetamide; (D421) 2-(2-chlorophenyl)-N-[4-(2-methoxy-1,3-thiazol-4-yl)-3-sulfamoylphenyl]acetamide; (D422) 2-(2-chlorophenyl)-N-[4-(2-methoxy-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide; (D423) 2-(2-chlorophenyl)-N-[4-(2-methyl-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide; (D424) 2-(2-chlorophenyl)-N-[4-(3-methyl-1,2-thiazol-5-yl)-3-sulfamoylphenyl]acetamide; (D425) 2-(2-chlorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-3-sulfamoylphenyl]acetamide; (D426) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(1,2-thiazol-4-yl)phenyl]acetamide; (D427) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(1,3-thiazol-2-yl)phenyl]acetamide; (D428) 2-(2-Chlorophenyl)-N-[4-(4-cyano-1,3-thiazol-2-yl)-3-sulfamoylphenyl]acetamide; (D429) 2-(2-chlorophenyl)-N-{4-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3-sulfamoylphenyl}acetamide; (D430) 2-(2-chlorophenyl)-N-[4-(2-cyclopropyl-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide; (D431) 2-(2-chlorophenyl)-N-[4-(2-cyclopropyl-1,3-thiazol-4-yl)-3-sulfamoylphenyl]acetamide; (D432) 2-(2-chlorophenyl)-N-[4-(4-methyl-1,3- [(2-oxazol-2-yl)-3-sulfamoylphenyl]acetamide; (D433) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[2-(trifluoromethyl)-1,3-thiazol-4-yl]phenyl}acetamide; (D434) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl}acetamide; (D435) 2-(2-chlorophenyl)-N-{4-[2-(2-hydroxypropane-2-yl)-1,3-thiazol-5-yl]-3-sulfamoylphenyl}acetamide; (D436) 2-(2-chlorophenyl)-N-{4-[2-(2-hydroxypropane-2-yl)-1,3-thiazol-4-yl]-3-sulfamoylphenyl}acetamide; (D437) 2-(2-Chlorophenyl)-N-[3-sulfamoyl-4-(1,3-thiazol-4-yl)phenyl]acetamide; (D438) 2-(2-chlorophenyl)-N-[4-(5-cyclopropyl-1,2- [(3-oxazol-3-yl)-3-sulfamoylphenyl]acetamide; (D439) ​​2-(2-chlorophenyl)-N-[4-(2-cyclopropyl-1,3- [(4-((2-nitro-1-oxazol-5-yl)-3-sulfamoylphenyl)acetamide; (D440) 2-(2-chlorophenyl)-N-(4-{4-[(3,3-difluoroazetidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide; (D441) N-{4-[4-(azetidin-1-ylcarbonyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}-2-(2-chlorophenyl)acetamide; (D442) 2-(2-Chlorophenyl)-N-{4-[4-(pyrrolidin-1-ylcarbonyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D443) 2-(2-chlorophenyl)-N-(4-{4-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide; (D444) 2-(4-chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D445) 2-(2-Chloro-6-fluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D446) N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}-2-[4-(trifluoromethyl)phenyl]acetamide; (D447) 2-(3-Fluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D448) 2-(2,4-dichlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D449) 2-(2-Bromophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D450) 2-(2,4-difluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D451) 2-(3,4-difluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D452) 2-(3,5-difluorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D453) 2-(3-Chlorophenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D454) 2-(4-Methylphenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D455) 2-(4-methoxyphenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D456) 2-(2-Fluoro-4-methylphenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D457) 2-(2-Fluoro-4-methoxyphenyl)-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D458) 2-[4-(Difluoromethyl)phenyl]-N-{3-sulfamoyl-4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetamide; (D459) 2-(4-chlorophenyl)-N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D460) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D461) 2-(2-Chloro-6-fluorophenyl)-N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D462) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-[4-(trifluoromethyl)phenyl]acetamide; (D463) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-[2-(trifluoromethyl)phenyl]acetamide; (D464) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(3-fluorophenyl)acetamide; (D465) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2,4-dichlorophenyl)acetamide; (D466) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2,4-difluorophenyl)acetamide; (D467) 2-(2-bromophenyl)-N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D468) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(3,4-difluorophenyl)acetamide; (D469) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide; (D470) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(4-methoxyphenyl)acetamide; (D471) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2-fluoro-4-methylphenyl)acetamide; (D472) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-(2-fluoro-4-methoxyphenyl)acetamide; (D473) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-[4-(difluoromethyl)phenyl]acetamide; (D474) N-[4-(6-chloropyridin-3-yl)-3-sulfamoylphenyl]-2-[2-chloro-4-(trifluoromethyl)phenyl]acetamide; (D475) 2-(2,4-dichlorophenyl)-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D476) 2-(2-Fluoro-4-methylphenyl)-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D477) 2-[4-(Difluoromethyl)phenyl]-N-[4-(5-fluoropyridin-3-yl)-3-sulfamoylphenyl]acetamide; (D478) 2-(2-Chlorophenyl)-N-[4-(4-cyclopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D479) N-[4-(4,6-difluoro-2H-benzotriazol-2-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D480) N-[4-(4,6-difluoro-1H-benzotriazol-1-yl)-3-sulfamoylphenyl]-2-(2-fluorophenyl)acetamide; (D481) 2-(2-Chlorophenyl)-N-[4-(4,6-difluoro-1H-benzotriazol-1-yl)-3-sulfamoylphenyl]acetamide; (D482) 2-(2-Chlorophenyl)-N-[4-(4,6-difluoro-2H-benzotriazol-2-yl)-3-sulfamoylphenyl]acetamide; (D483) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[2-(trifluoromethyl)-1,3-thiazol-5-yl]phenyl}acetamide; (D484) 2-(2-Chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide; (D485) 2-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D486) 2-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide; (D487) 2-(2-Chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide; (D488) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-[4-(4-cyano-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide; (D489) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoyl-2-(trifluoromethyl)phenyl}acetamide; (D490) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D491) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-5-sulfamoyl-2-(trifluoromethyl)phenyl}acetamide; (D492) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl]-3-sulfamoylphenyl}acetamide; (D493) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-2-fluoro-3-sulfamoylphenyl}acetamide; (D494) 2-(2-Chlorophenyl)-N-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-2-fluoro-5-sulfamoylphenyl}acetamide; (D495) 2-(2-chlorophenyl)-N-{4-[2-(dimethylamino)-1,3-thiazol-4-yl]-3-sulfamoylphenyl}acetamide; (D496) 2-(2-chlorophenyl)-N-[3-sulfamoyl-4-(1,2-thiazol-5-yl)phenyl]acetamide; (D497) 1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-N-cyclopropyl-N-methyl-1H-pyrazole-4-carboxamide; (D498) 2-(2-Chlorophenyl)-2-hydroxy-N-{3-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D499) 2-(2-Chlorophenyl)-N-{3-chloro-5-sulfamoyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D500) 2-(2-chlorophenyl)-N-[4-(4-cyano-3-hydroxy-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D501) 2-(2-Chlorophenyl)-N-[4-(1H-pyrazolo[4,3-c]pyridin-1-yl)-3-sulfamoylphenyl]acetamide; (D502) 2-(2-chlorophenyl)-N-[4-(4,5-dimethyl-1,3-thiazol-2-yl)-3-sulfamoylphenyl]acetamide; (D503) 2-(2-chlorophenyl)-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide; (D504) 2-(2-chlorophenyl)-N-[4-(4-methyl-1,3-thiazol-5-yl)-3-sulfamoylphenyl]acetamide; (D505) N-{4-(4-amino-1H-pyrazol-1-yl)-3-[(2,4-dimethoxybenzyl)sulfamoyl]phenyl}-2-(2-chlorophenyl)acetamide; (D506) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-2,2-difluoroacetamide; (D507) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-3,3,3-trifluoropropionamide; (D508) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-3,3,3-trifluoro-2-methylpropanamide (racemic); (D509) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-3,3,3-trifluoro-2-methylpropanamide (Enantiomer A); (D510) N-[1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazol-4-yl]-3,3,3-trifluoro-2-methylpropanamide (enantiomer B); (D511) 2-(2-chlorophenyl)-N-(4-{4-[(cis)-2,5-dimethylpyrrolidin-1-yl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide; (D512) 2-(2-chlorophenyl)-N-(4-{4-[(trans)-2,5-dimethylpyrrolidin-1-yl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide (Enantiomer A); (D513) 2-(2-chlorophenyl)-N-(4-{4-[(trans)-2,5-dimethylpyrrolidin-1-yl]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)acetamide (enantiomer B); (D514) N-(4-{4-[(2,2-difluoroethyl)amino]-1H-pyrazol-1-yl}-3-sulfamoylphenyl)-2-(2-fluorophenyl)acetamide; (D515) 2-(2-chlorophenyl)-N-(3-sulfamoyl-4-{4-[(2,2,2-trifluoroethyl)amino]-1H-pyrazol-1-yl}phenyl)acetamide; (D516) 2-(2-Chlorophenyl)-N-[4-(4-isopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D517) 2-(2-Fluorophenyl)-N-[4-(4-isopropyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D518) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-4-[4-(2,2,2-trifluoroethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D519) 2-(2-Fluorophenyl)-N-{3-sulfamoyl-4-[4-(2,2,2-trifluoroethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D520) 2-(2-chlorophenyl)-N-[4-(5-cyclopropyl-1,2,4- Oxazolyl-3-yl)-3-sulfamoylphenyl]acetamide; (D521) 2-(2-chlorophenyl)-N-{3-sulfamoyl-4-[3-(trifluoromethyl)-1,2,4- oxadiazol-5-yl]phenyl}acetamide; (D522) 2-(2-chlorophenyl)-N-{4-[5-(difluoromethyl)-1,3,4- oxadiazol-2-yl]-3-sulfamoylphenyl}acetamide; (D523)N-{4-[5-(difluoromethyl)-1,3,4- Oxazolyl-2-yl]-3-sulfamoylphenyl}-2-(2-fluorophenyl)acetamide; (D524) 2-(2-chlorophenyl)-N-[4-(5-methyl-1,3,4- oxadiazole-2-yl)-3-sulfamoylphenyl]acetamide; (D525) 2-(2-fluorophenyl)-N-[4-(5-methyl-1,3,4- oxadiazole-2-yl)-3-sulfamoylphenyl]acetamide; (D526) N-[4-(5-methyl-1,3,4- Oxazolyl-2-yl)-3-sulfamoylphenyl]-2-(4-methylphenyl)acetamide; (D527) 2-(2-Chlorophenyl)-N-[4-(1H-pyrrol-3-yl)-3-sulfamoylphenyl]acetamide; (D528) 2-(2-Chlorophenyl)-N-{4-[5-(difluoroacetyl)-1H-pyrrol-3-yl]-3-sulfamoylphenyl}acetamide; (D529) 2-(2-chlorophenyl)-N-[4-(1-methyl-1H-pyrrol-3-yl)-3-sulfamoylphenyl]acetamide; (D530) 2-(2-chlorophenyl)-N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)-3-sulfamoylphenyl]acetamide; (D531) 2-(2-Chlorophenyl)-N-{3-sulfamoyl-2-(trifluoromethyl)-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D532) 2-(2-chlorophenyl)-N-{5-sulfamoyl-2-(trifluoromethyl)-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D533) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-{5-sulfamoyl-2-(trifluoromethyl)-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D534) 2-[2-Chloro-5-(trifluoromethyl)phenyl]-N-{5-sulfamoyl-2-(trifluoromethyl)-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide; (D535) 2-[2-Chloro-6-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide; (D536) 2-[2-Chloro-3-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide; (D537) 2-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide; (D538) 2-[2-Chloro-4-(trifluoromethyl)phenyl]-N-[4-(4-fluoro-1H-pyrazol-1-yl)-5-sulfamoyl-2-(trifluoromethyl)phenyl]acetamide; (D539) N-[4-(3-tert-butyl-4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D540) N-[4-(3-bromo-4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D541) 2-(2-Chlorophenyl)-N-{4-[4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-sulfamoylphenyl}acetamide; (D542) 2-(2-Chlorophenyl)-N-[4-(3,4-dimethyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D543) N-[4-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-(2-chlorophenyl)acetamide; (D544) 2-(2-Chlorophenyl)-N-[4-(1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D545) 2-(2-Chlorophenyl)-N-[4-(3-cyano-5-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D546) 2-(2-Chlorophenyl)-N-[4-(3-hydroxy-5-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D547) 2-(2-Chlorophenyl)-N-[4-(4-cyano-5-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D548) 2-(2-Chlorophenyl)-N-[4-(4-cyano-3-methyl-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D549) 2-(2-Chlorophenyl)-N-{4-[4-(morpholin-4-yl)-1,3-thiazol-2-yl]-3-sulfamoylphenyl}acetamide; (D550) 2-(2-chlorophenyl)-N-{4-[5-(morpholin-4-yl)-1,3-thiazol-2-yl]-3-sulfamoylphenyl}acetamide; (D551) 2-(2-chlorophenyl)-N-[4-(5-methyl-1,3-thiazol-2-yl)-3-sulfamoylphenyl]acetamide; (D552) 2-(2-chlorophenyl)-N-[4-(pyridin-4-yl)-3-sulfamoylphenyl]acetamide; (D553) 1-(4-{[(2-chlorophenyl)acetyl]amino}-2-sulfamoylphenyl)-1H-pyrazole-4-carboxamide; (D554) 2-(2-Chloro-3-hydroxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D555) 2-(2-Chloro-4-hydroxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D556) 2-(2-Chloro-5-hydroxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; (D557) 2-(2-Chloro-6-hydroxyphenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]acetamide; as well as (D558) 2-(2-Chlorophenyl)-N-[4-(4-cyano-1H-pyrazol-1-yl)-3-sulfamoylphenyl]-2-hydroxyacetamide.

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