稳定抗菌肽的抗菌涂层及其制备方法与应用
By forming a mineralized calcium phosphate structure with a high specific surface area on the orthopedic external fixator to load antimicrobial peptides, the problem of easy infection of orthopedic external fixators is solved, achieving long-lasting antibacterial effect and good biocompatibility, thereby improving the success rate of surgery and the speed of patient recovery.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- RENMIN HOSPITAL OF WUHAN UNIVERSITY (HUBEI GENERAL HOSPITAL)
- Filing Date
- 2024-09-09
- Publication Date
- 2026-07-17
AI Technical Summary
Existing orthopedic external fixation materials lack effective anti-infection mechanisms, making them prone to infection. Furthermore, antimicrobial peptides are easily inactivated on the implant surface, failing to provide long-lasting antibacterial protection.
By pretreating the matrix of orthopedic external fixators to form a nano-distribution structure, and then treating it in simulated physiological fluid, a mineralized calcium phosphate structure is nested and loaded with antimicrobial peptides to form a high specific surface area double-layer nested hybrid coating, which improves the stability and release of antimicrobial peptides.
It achieves long-lasting antibacterial effects of antimicrobial peptides, significantly reduces the risk of postoperative infection, improves the success rate of surgery, promotes patient recovery, and has good biocompatibility and anti-infection capabilities.
Smart Images
Figure CN119236192B_ABST