Preparation method of ferroptosis inducer Erastatin

Abstract

The invention discloses a preparation method of a ferroptosis inducer Erastatin, which is characterized in that o-nitrobenzoic acid and o-aminophenyl ether which are cheap and easy to obtain are used as initial raw materials, and the target product Erastatin is obtained through condensation, reduction, amidation, cyclization, bromination, nucleophilic substitution, deprotection and amidation reaction. The synthesis process has the advantages of cheap and easily available raw materials, environmental friendliness, mild conditions, high yield, simple and safe operation, and practical application value; # imgabs0 #

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