Chiral resolution method of Corey lactone diol precursor

CN119350281APending Publication Date: 2025-01-24CHONGQING ANGE LONGXIANG PHARM TECH CO LTD
2 Cites 0 Cited by

Patent Information

Application Number
CN202411456237.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-18
Publication Date
2025-01-24

AI Technical Summary

Technical Problem

The existing method for resolving colilactone diol precursors has problems such as complex operation, low yield, difficulty in extracting compounds after hydrolysis, and pollution of three wastes, which is not conducive to industrial production.

Method used

The racemate is hydrolyzed by a base (R)-(+)-1-phenylethylamine method, followed by direct concentration to obtain the chiral ammonium salt of the carboxylic acid, and a single configuration is obtained through multiple recrystallizations. ammonium salt, and finally use dilute hydrochloric acid to adjust the ring and obtain a single-configuration corylide diol precursor.

Benefits of technology

Simplified process operations, shortened production hours, improved product revenue, and avoided hydrolyzed compounds that distributed difficulties in organic solvents, and were more suitable for industrial production.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN119350281A_ABST
    Figure CN119350281A_ABST
Patent Text Reader

Abstract

The invention relates to the technical field of chemical engineering, in particular to a chiral resolution method of a Corey lactone diol precursor, which comprises the following steps: firstly, hydrolyzing racemate by using alkali; directly concentrating the hydrolyzed reaction liquid to obtain chiral ammonium salt of carboxylic acid, and recrystallizing for multiple times to obtain ammonium salt with single configuration; finally, dilute hydrochloric acid is adopted for acid regulation and ring closing, and the Corey lactone diol precursor of a single configuration is obtained. In this way, the technical problem that in the prior art, an existing resolution method of the Corey lactone diol precursor is not beneficial to industrial production is solved.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Preparation method of Corey lactone diol

    CN107573309A

  • Preparation method of Corey lactone diol

    CN107573310A