Solution liquid chromatography experiment anomaly detection method, device and detection equipment

Abstract

The embodiment of the invention relates to a solution liquid chromatography experiment anomaly detection method, device and detection equipment. The method comprises the following steps: determining a detection result according to a liquid chromatogram and a standard liquid chromatogram of a to-be-tested solution in a liquid chromatogram experiment process of the to-be-tested solution; and when the detection result is abnormal, generating prompt information and displaying the prompt information to preset personnel so as to prompt to stop the liquid chromatography experiment of the to-be-tested solution. According to the technical scheme provided by the embodiment of the invention, whether an experiment is abnormal or not can be determined in the liquid chromatogram experiment process of the solution, and related personnel are prompted.

Description

Technical Field

[0001] The present invention relates to the technical field of data processing, and in particular to a method, a device, a detection equipment and a storage medium for detecting abnormalities in a solution liquid chromatography experiment. Background Art

[0002] At present, during the liquid chromatography experiment of the solution, it is impossible to determine whether the experiment has an abnormality, and thus it is impossible to terminate the current experiment when an abnormality occurs. Since it is sometimes necessary to repeat a comparative experiment under a certain condition, if the current experiment cannot be terminated when an abnormality occurs, it will cause a waste of experimental consumables and experimental time.

[0003] Currently, there is no solution to the above problem. Summary of the invention

[0004] The present invention provides a method, device, detection equipment and storage medium for detecting abnormality in a liquid chromatography experiment of a solution, aiming to solve the problem in the prior art that it is impossible to determine whether an abnormality occurs in the experiment during a liquid chromatography experiment of a solution.

[0005] In a first aspect, an embodiment of the present invention provides a method for detecting abnormalities in a liquid chromatography experiment of a solution, comprising: during a liquid chromatography experiment of a solution to be tested, determining a detection result based on a liquid chromatogram of the solution to be tested and a standard liquid chromatogram; when the detection result is abnormal, generating a prompt message and displaying it to a preset person to prompt the person to stop the liquid chromatography experiment of the solution to be tested.

[0006] In a second aspect, an embodiment of the present invention provides a solution liquid chromatography experiment abnormality detection device, comprising: a determination module, used to determine the detection result according to the liquid chromatogram of the solution to be tested and the standard liquid chromatogram during the liquid chromatography experiment of the solution to be tested; a generation module, used to generate a prompt message and display it to a preset person when the detection result is abnormal, so as to prompt to stop the liquid chromatography experiment of the solution to be tested.

[0007] In a third aspect, an embodiment of the present invention provides a detection device, including:

[0008] one or more processors;

[0009] A memory for storing one or more programs;

[0010] When the one or more programs are executed by the one or more processors, the one or more processors implement the solution liquid chromatography experiment anomaly detection method as provided in any embodiment of the present invention.

[0011] In a fourth aspect, an embodiment of the present invention provides a storage medium comprising computer executable instructions, which, when executed by a computer processor, are used to perform a solution liquid chromatography experiment anomaly detection method as provided in any embodiment of the present invention.

[0012] The embodiments of the present invention provide a method, device, detection equipment and storage medium for detecting abnormalities in a liquid chromatography experiment of a solution. During the liquid chromatography experiment of the solution to be tested, the detection result is determined based on the liquid chromatogram of the solution to be tested and the standard liquid chromatogram. If the detection result is abnormal, it is determined that the experiment is abnormal. At this time, a prompt message is generated and displayed to a preset person to prompt the person to stop the liquid chromatography experiment of the solution to be tested. This solves the problem in the prior art that it is impossible to determine whether an abnormality has occurred in the experiment during the liquid chromatography experiment of the solution, and realizes the automatic determination of whether an abnormality has occurred in the experiment during the liquid chromatography experiment of the solution in the prior art. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 A flow chart of a method for detecting abnormalities in a solution liquid chromatography experiment provided in Example 1 of the present invention;

[0014] Figure 2 A schematic diagram of a liquid chromatogram of a solution to be tested and a standard liquid chromatogram provided in Example 1 of the present invention;

[0015] Figure 3 A schematic diagram of a response value threshold range provided in Embodiment 1 of the present invention;

[0016] Figure 4 A schematic diagram of a liquid chromatogram of another solution to be tested and a standard liquid chromatogram provided in Example 1 of the present invention;

[0017] Figure 5 A schematic diagram of the structure of a device for detecting abnormalities in a liquid chromatography experiment of a solution provided in a fourth embodiment of the present invention;

[0018] Figure 6 This is a schematic diagram of the structure of a detection device provided in Example 5 of the present invention. DETAILED DESCRIPTION

[0019] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the present invention, rather than to limit the present invention. It should also be noted that, for ease of description, only parts related to the present invention, rather than all structures, are shown in the accompanying drawings.

[0020] Embodiment 1

[0021] Figure 1This is a flow chart of a solution liquid chromatography experiment anomaly detection method provided in Embodiment 1 of the present invention. The method can be performed by a solution liquid chromatography experiment anomaly detection device. The device can be implemented by hardware and / or software and can generally be integrated in an electronic device, such as a computer device. The method specifically includes:

[0022] Step 110, during the liquid chromatography experiment of the solution to be tested, determining the test result according to the liquid chromatogram of the solution to be tested and the standard liquid chromatogram;

[0023] Specifically, the above-mentioned standard liquid chromatogram is a standard liquid chromatogram of a solution of the type to which the test solution belongs, and is used as a reference. During the liquid chromatography experiment of the test solution, the obtained liquid chromatogram of the test solution should be completely consistent with the standard liquid chromatogram, or the degree of deviation from the standard liquid chromatogram is very small. At this time, the test result is normal, and the liquid chromatography experiment of the test solution is carried out normally. If the obtained liquid chromatogram of the test solution deviates greatly from the standard liquid chromatogram, at this time, the test result is abnormal, and the liquid chromatography experiment of the test solution is abnormal.

[0024] Step 120: If the test result is abnormal, generate a prompt message and display it to a preset person to prompt the person to stop the liquid chromatography experiment of the solution to be tested.

[0025] The technical solution of this embodiment determines the test result according to the liquid chromatogram of the test solution and the standard liquid chromatogram during the liquid chromatography experiment of the test solution. If the test result is abnormal, it is determined that the experiment is abnormal. At this time, a prompt message is generated and displayed to a preset person to prompt the liquid chromatography experiment of the test solution to be stopped. This solves the problem in the prior art that it is impossible to determine whether the experiment is abnormal during the liquid chromatography experiment of the solution.

[0026] In an optional solution, the above step 110 may be implemented as follows:

[0027] Step 210: Determine whether the current time node is a preset time node;

[0028] Step 220: when the current time node is the preset time node, obtaining a liquid chromatogram of the solution to be tested within a preset time period before the current time node;

[0029] Specifically, if the current time node is the 1st minute and the preset time length is 0.5 minutes, the liquid chromatogram of the solution to be tested between the 0.5th minute and the 1st minute is obtained.

[0030] Step 230, determining whether the response value of each time node in the above-mentioned liquid chromatogram is within the corresponding response value threshold range, the time nodes in the above-mentioned liquid chromatogram correspond one-to-one with the time nodes set in the above-mentioned standard liquid chromatogram, and the response values ​​of the time nodes of the above-mentioned standard liquid chromatogram correspond to the above-mentioned response value threshold range;

[0031] Specifically, Figure 2 As shown, the red curve is the liquid chromatogram of the test solution, and the blue curve is the standard liquid chromatogram. The time nodes of the two curves correspond to each other. Figure 3 As shown, the black curve is the standard liquid chromatogram, the red curve is the upper limit of the response value threshold range corresponding to the response value of the time node of the standard liquid chromatogram, and the blue curve is the lower limit of the response value threshold range corresponding to the response value of the time node of the standard liquid chromatogram.

[0032] Step 240: When the response values ​​of all time nodes in the liquid chromatogram are not within the corresponding response value threshold range, determine that the detection result is abnormal.

[0033] Specifically, Figure 3 As shown in FIG. 1 , if all the liquid chromatograms of the solution to be tested within the preset time length before the current time node are not located between the red curve and the blue curve, it is determined that the liquid chromatogram of the solution to be tested deviates greatly from the standard liquid chromatogram, and the test result is abnormal, such as Figure 4 As shown, the red curve is the liquid chromatogram of the solution to be tested, and the purple curve is the standard liquid chromatogram. If the preset time node is 2.78 min and the preset duration is 0.59 min, it is determined whether the response values ​​of each time node of the red curve between 2.19 min and 2.78 min in the blue rectangular box are within the corresponding response value threshold range.

[0034] Specifically, multiple preset time nodes are set, for example, the 1st minute, the 2nd minute, the 3rd minute..., when the experiment reaches the preset time node, that is, the current time node is the preset time node, the liquid chromatogram of the test solution within the preset time length before the current time node is obtained, and the detection result is determined only by determining whether the response value of each time node of the liquid chromatogram of the preset time length is within the corresponding response value threshold range, instead of determining the detection result by determining whether the response value of each time node of the complete liquid chromatogram of the test solution is within the corresponding response value threshold range, thereby reducing the amount of calculation. The longer the preset time length is, the greater the amount of calculation is, and the higher the accuracy of the detection result is; the shorter the preset time length is, the smaller the amount of calculation is, and the lower the accuracy of the detection result is.

[0035] Specifically, the instrument used in the liquid chromatography experiment may have measurement errors, and there is noise interference in the liquid chromatography experiment of the test solution. The response value of the liquid chromatogram of the test solution obtained by the liquid chromatography experiment is generally composed of the superposition of the true response value, the measurement error and the noise interference. During each liquid chromatography experiment, the measurement error or the noise interference may be instantaneously large. Therefore, the test result is determined only by determining whether the response value of each time node of the liquid chromatogram of a preset time is within the corresponding response value threshold range, which can avoid the misjudgment of the test result caused by these two events. In addition, the test result is determined to be abnormal only when the response values ​​of all time nodes in the liquid chromatogram are not within the corresponding response value threshold range, which can further avoid the misjudgment of the test result caused by these two events.

[0036] In an optional solution, after step 230, the method further includes:

[0037] When the response value of at least one time node in the liquid chromatogram is within the corresponding response value threshold range, the detection result is determined to be normal.

[0038] Specifically, the test result is determined to be abnormal only when the response values ​​of all time nodes in the liquid chromatogram are not within the corresponding response value threshold range. Otherwise, the test result is determined to be normal, which can further avoid the two events of measurement error and noise interference causing misjudgment of the test result.

[0039] In an optional solution, the above step 210 may be implemented as follows:

[0040] Step 310, determining whether the response value of the current time node in the liquid chromatogram is within a preset response value range;

[0041] Step 320: Determine whether the current time node is the preset time node, at least when the response value of the current time node in the liquid chromatogram is not within the preset response value range.

[0042] Specifically, when the response value of the standard liquid chromatogram is zero, the true response value of the liquid chromatogram of the test solution is zero. At this time, there is no need to judge the degree to which the liquid chromatogram of the test solution deviates from the standard liquid chromatogram. Due to the presence of noise interference in the liquid chromatography experiment of the test solution, when the response value of the standard liquid chromatogram is zero, the liquid chromatogram of the test solution may have a tiny response value. Therefore, the preset response value range can be (-1, 1). If the response value of the current time node in the liquid chromatogram of the test solution is not within the preset response value range, it is determined that the true response value of the liquid chromatogram of the test solution is not zero. At this time, it is necessary to judge the degree to which the liquid chromatogram of the test solution deviates from the standard liquid chromatogram, that is, it is necessary to determine the test result. If the response value of the current time node in the liquid chromatogram of the test solution is within the preset response value range, it is determined that the true response value of the liquid chromatogram of the test solution is zero. At this time, there is no need to judge the degree to which the liquid chromatogram of the test solution deviates from the standard liquid chromatogram, that is, there is no need to determine the test result.

[0043] In an optional solution, the above step 320 may be implemented as follows:

[0044] In the case where the response value of the current time node in the liquid chromatogram is not within the preset response value range, determining whether the current time node is a zero-crossing time node;

[0045] Specifically, the zero-crossing time node is the time node to which the response value with a value of zero in the standard liquid chromatogram belongs. If the current time node in the liquid chromatogram of the solution to be tested is not the zero-crossing time node, it is determined that the true response value of the liquid chromatogram of the solution to be tested is not zero; otherwise, it is determined that the true response value of the liquid chromatogram of the solution to be tested is zero.

[0046] When the current time node is not the zero-crossing time node, it is determined whether the current time node is the preset time node.

[0047] Specifically, if the response value of the current time node in the liquid chromatogram of the solution to be tested is not within the preset response value range and the current time node is not a zero-crossing time node, it is determined that the true response value of the liquid chromatogram of the solution to be tested is not zero; otherwise, it is determined that the true response value of the liquid chromatogram of the solution to be tested is zero. Through double judgment, it is possible to accurately determine whether the true response value of the liquid chromatogram of the solution to be tested is zero.

[0048] In an optional solution, before the above step 230, the above method further includes:

[0049] Step 410, determining the response value deviation value corresponding to the response value of all time nodes of the standard liquid chromatogram according to the standard liquid chromatogram and the preset rule, wherein the preset rule is that the response value of a time node in the standard liquid chromatogram is negatively correlated with the tolerance value of the response value of the time node, and the tolerance value is the ratio of the response value deviation value corresponding to the response value to the response value;

[0050] Step 420, determining the response value threshold range corresponding to the response value of each time node in the standard liquid chromatogram according to the response values ​​of all time nodes of the standard liquid chromatogram and the response value deviation values ​​corresponding to the response values ​​of all time nodes of the standard liquid chromatogram.

[0051] Specifically, the response value threshold range is [x+d, xd], wherein x is the response value of the standard liquid chromatogram, and d is the response value deviation value.

[0052] Specifically, the instrument used in the liquid chromatography experiment will have measurement errors. This measurement error is positively correlated with the true response value of the liquid chromatogram of the test solution, but the growth slope of the measurement error is much smaller than the growth slope of the true response value of the liquid chromatogram of the test solution. In addition, the noise interference is generally stable in amplitude and will not change with the change of the true response value. The response value of the liquid chromatogram of the test solution obtained by the liquid chromatography experiment is generally composed of the superposition of the true response value, the measurement error and the noise interference. The true response value in the liquid chromatogram of the test solution is small, and the measurement error and the noise interference have a relatively large impact. The superposition of the measurement error and the noise interference causes the liquid chromatogram of the test solution to deviate from the standard liquid chromatogram to a large extent (a is large, a is the degree to which the liquid chromatogram of the test solution deviates from the standard liquid chromatogram). The degree of the spectrum, a = |bc| / c×100%, wherein b is the response value of the liquid chromatogram of the test solution, and c is the response value of the standard phase chromatogram). The actual response value in the liquid chromatogram of the test solution is larger, and the influence of measurement error and noise interference is smaller. The superposition of measurement error and noise interference causes the degree of deviation of the liquid chromatogram of the test solution from the standard liquid chromatogram to be smaller (a is smaller). Therefore, in order to further avoid the misjudgment of the detection result caused by these two events of measurement error and noise interference, when determining the response value deviation value, follow the preset rules. When the response value of the standard liquid chromatogram is smaller, the degree of deviation of the liquid chromatogram of the test solution from the standard liquid chromatogram is larger, and the tolerance value is larger. When the response value of the standard liquid chromatogram is larger, the degree of deviation from the standard liquid chromatogram is required to be smaller, and the tolerance value is smaller.

[0053] In an optional solution, the above step 410 may be implemented as follows:

[0054] According to the above standard liquid chromatogram and Determine the above-mentioned response value deviation value corresponding to the response value of all time nodes of the above-mentioned standard liquid chromatogram, wherein k is a preset value, x is the response value of the above-mentioned standard liquid chromatogram, and d is the above-mentioned response value deviation value.

[0055] Specifically, the formula Follow the preset rules above.

[0056] Specifically, liquid chromatogram: Liquid chromatography is an efficient physical separation technology that achieves separation by utilizing the differences in the distribution coefficients and adsorption capacities of different substances in two phases. The liquid chromatogram shows the distribution of the detection signals of the separated components over time, helping analysts to identify and quantitatively analyze the components in the sample, such as Figure 2 , Figure 3 and Figure 4 As shown, the horizontal axis of the liquid chromatogram is time, the unit is minute (min), and the vertical axis is the response value, the unit is milli-absorbance unit (mAU).

[0057] Embodiment 2

[0058] Figure 5 A schematic diagram of a solution liquid chromatography experiment abnormality detection device provided in Embodiment 4 of the present invention is shown in FIG. Figure 5 As shown, the solution liquid chromatography experiment abnormality detection device includes: a determination module 510 and a generation module 520, wherein:

[0059] The determination module 510 is used to determine the detection result according to the liquid chromatogram of the test solution and the standard liquid chromatogram during the liquid chromatography experiment of the test solution;

[0060] The generating module 520 is used to generate a prompt message and display it to a preset person in case that the above detection result is abnormal, so as to prompt to stop the liquid chromatography experiment of the above test solution.

[0061] The technical solution of this embodiment determines the test result according to the liquid chromatogram of the test solution and the standard liquid chromatogram during the liquid chromatography experiment of the test solution. If the test result is abnormal, it is determined that the experiment is abnormal. At this time, a prompt message is generated and displayed to a preset person to prompt the liquid chromatography experiment of the test solution to be stopped. This solves the problem in the prior art that it is impossible to determine whether the experiment is abnormal during the liquid chromatography experiment of the solution.

[0062] The device for detecting anomalies in a solution liquid chromatography experiment provided in an embodiment of the present invention can execute the method for detecting anomalies in a solution liquid chromatography experiment provided in any embodiment of the present invention, and has the corresponding functional modules and beneficial effects of the execution method.

[0063] Embodiment 3

[0064] Figure 6 A structural diagram of a detection device provided in Embodiment 5 of the present invention is shown as follows: Figure 6 As shown, the detection device includes a processor 610, a memory 620, an input device 630 and an output device 640; the number of the processor 610 in the detection device can be one or more. Figure 6 A processor 610 is taken as an example; the processor 610, the memory 620, the input device 630 and the output device 640 in the detection device can be connected via a bus or other means. Figure 5 The example of connecting through bus is taken in the following.

[0065] The memory 620, as a computer-readable storage medium, can be used to store software programs, computer executable programs and modules, such as program instructions / modules corresponding to the solution liquid chromatography experiment abnormality detection method in the embodiment of the present invention (for example, the determination module 510 and the generation module 520 in the solution liquid chromatography experiment abnormality detection device). The processor 610 executes various functional applications and data processing of the detection device by running the software programs, instructions and modules stored in the memory 620, that is, realizing the above-mentioned solution liquid chromatography experiment abnormality detection method.

[0066] The memory 620 may mainly include a program storage area and a data storage area, wherein the program storage area may store an operating system, an application required for at least one function; the data storage area may store data created according to the use of the terminal, etc. In addition, the memory 620 may include a high-speed random access memory, and may also include a non-volatile memory, such as at least one disk storage device, a flash memory device, or other non-volatile solid-state storage device. In some instances, the memory 620 may further include a memory remotely arranged relative to the processor 610, and these remote memories may be connected to the detection device via a network. Examples of the above-mentioned network include, but are not limited to, the Internet, an intranet, a local area network, a mobile communication network, and combinations thereof.

[0067] The input device 630 can be used to receive input digital or character information and generate key signal input related to user settings and function control of the detection device. The output device 640 can include a display device such as a display screen.

[0068] Embodiment 4

[0069] Embodiment 6 of the present invention further provides a storage medium comprising computer executable instructions, wherein the computer executable instructions are used to execute a method for detecting abnormalities in a solution liquid chromatography experiment when executed by a computer processor, including:

[0070] During the liquid chromatography experiment of the solution to be tested, the test result is determined according to the liquid chromatogram of the solution to be tested and the standard liquid chromatogram;

[0071] In the case that the above detection result is abnormal, a prompt message is generated and displayed to a preset person to prompt the person to stop the liquid chromatography experiment of the above test solution.

[0072] Of course, the storage medium containing computer executable instructions provided in an embodiment of the present invention is not limited to the above-mentioned method operations, and the computer executable instructions can also execute related operations in the solution liquid chromatography experiment anomaly detection method provided in any embodiment of the present invention.

[0073] Through the above description of the implementation methods, the technicians in the relevant field can clearly understand that the present invention can be implemented by means of software and necessary general hardware, and of course it can also be implemented by hardware, but in many cases the former is a better implementation method. Based on such an understanding, the technical solution of the present invention is essentially or the part that contributes to the prior art can be embodied in the form of a software product, and the computer software product can be stored in a computer-readable storage medium, such as a computer floppy disk, read-only memory (ROM), random access memory (RAM), flash memory (FLASH), hard disk or optical disk, etc., including a number of instructions for a computer device (which can be a personal computer, server, or network device, etc.) to perform the above methods of each embodiment of the present invention.

[0074] It is worth noting that in the embodiment of the above-mentioned solution liquid chromatography experiment abnormality detection device, the various units and modules included are only divided according to functional logic, but are not limited to the above-mentioned division, as long as the corresponding functions can be achieved; in addition, the specific names of the functional units are only for the convenience of distinguishing each other, and are not used to limit the scope of protection of the present invention.

[0075] Although the present invention has been described in detail above by means of general description, specific implementation methods and tests, it is obvious to those skilled in the art that some modifications or improvements may be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.

Claims

1. A method for detecting abnormality in a solution liquid chromatography experiment, characterized in that: include: During the liquid chromatography experiment of the solution to be tested, the test result is determined according to the liquid chromatogram of the solution to be tested and the standard liquid chromatogram; In the case where the detection result is abnormal, a prompt message is generated and displayed to a preset person to prompt the person to stop the liquid chromatography experiment of the solution to be tested.

2. The method according to claim 1, characterized in that During the liquid chromatography experiment of the solution to be tested, the test result is determined according to the liquid chromatogram of the solution to be tested and the standard liquid chromatogram, including: Determine whether the current time node is a preset time node; When the current time node is the preset time node, obtaining a liquid chromatogram of the solution to be tested within a preset time period before the current time node; Determine whether the response value of each time node in the liquid chromatogram is within a corresponding response value threshold range, the time nodes in the liquid chromatogram correspond one-to-one with the time nodes set in the standard liquid chromatogram, and the response values ​​of the time nodes of the standard liquid chromatogram correspond to the response value threshold range; When the response values ​​of all time nodes in the liquid chromatogram are not within the corresponding response value threshold range, it is determined that the detection result is abnormal.

3. The method according to claim 2, characterized in that After determining whether the response value of each time node in the liquid chromatogram is within the corresponding response value threshold range, the method further includes: When the response value of at least one time node in the liquid chromatogram is within the corresponding response value threshold range, the detection result is determined to be normal.

4. The method according to claim 2, characterized in that: The determining whether the current time node is a preset time node includes: Determining whether the response value of the current time node in the liquid chromatogram is within a preset response value range; At least when the response value of the current time node in the liquid chromatogram is not within the preset response value range, it is determined whether the current time node is the preset time node.

5. The method according to claim 4, characterized in that The step of determining whether the current time node is the preset time node when at least the response value of the current time node in the liquid chromatogram is not within the preset response value range comprises: When the response value of the current time node in the liquid chromatogram is not within the preset response value range, determining whether the current time node is a zero-crossing time node; When the current time node is not the zero-crossing time node, it is determined whether the current time node is the preset time node.

6. The method according to claim 2, characterized in that Before determining whether the response value of each time node in the liquid chromatogram is within the corresponding response value threshold range, the method further includes: Determine, according to the standard liquid chromatogram and a preset rule, a response value deviation value corresponding to the response values ​​of all time nodes of the standard liquid chromatogram, wherein the preset rule is that the response value of a time node in the standard liquid chromatogram is negatively correlated with the tolerance value of the response value of the time node, and the tolerance value is the ratio of the response value deviation value corresponding to the response value to the response value; The response value threshold range corresponding to the response value of each time node in the standard liquid chromatogram is determined according to the response values ​​of all time nodes of the standard liquid chromatogram and the response value deviation values ​​corresponding to the response values ​​of all time nodes of the standard liquid chromatogram.

7. The method according to claim 6, characterized in that The step of determining the response value deviation values ​​corresponding to the response values ​​of all time nodes of the standard liquid chromatogram according to the standard liquid chromatogram and a preset rule includes: According to the standard liquid chromatogram and Determine the response value deviation value corresponding to the response values ​​of all time nodes of the standard liquid chromatogram, wherein k is a preset value, x is the response value of the standard liquid chromatogram, and d is the response value deviation value.

8. A solution liquid chromatography experiment abnormality detection device, characterized in that: include: A determination module, used to determine the detection result according to the liquid chromatogram of the solution to be tested and the standard liquid chromatogram during the liquid chromatography experiment of the solution to be tested; The generating module is used to generate a prompt message and display it to a preset person in case that the detection result is abnormal, so as to prompt the person to stop the liquid chromatography experiment of the solution to be tested.

9. A detection device, characterized in that: include: one or more processors; A memory for storing one or more programs; When the one or more programs are executed by the one or more processors, the one or more processors implement the solution liquid chromatography experiment anomaly detection method as described in any one of claims 1-7.

10. A storage medium containing computer executable instructions, characterized in that: The computer executable instructions are used to execute the solution liquid chromatography experiment abnormality detection method as described in any one of claims 1-7 when executed by a computer processor.

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