Pharmaceutical composition and application thereof

By designing the optimal extraction path and different extraction methods, the extract of Bawei Agarwood Pills was prepared, which solved the problem of single form of the existing preparation and insufficient basic research, achieved significant efficacy in anti-myocardial ischemia and sleep aid, and laid the foundation for quality The basis for standard improvement and dosage form development.

CN119386099AInactive Publication Date: 2025-02-07TIBET GANLU PHARM TECH CO LTD +1
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Patent Information

Application Number
CN202411564971.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-05
Publication Date
2025-02-07
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The existing Bawei Agarwood Pills have a single preparation form and are relatively weak in basic research, which limits its further development and application, especially in terms of quality standards and dosage form development.

Method used

The optimal extraction path was designed and screened, and different extracts were prepared by water extraction and alcohol extraction methods, and their anti-myocardial ischemia and anti-insomnia efficacy was analyzed, and the mechanism of action of anti-insomnia was initially explored.

Benefits of technology

Through the comparison of different extracts, the significant efficacy of alcohol extract (CT) in anti-myocardial ischemia and the significant effect of water extract (ST) in sleep aid, and the sleep aid is supported by upregulating the GAD67 protein expression mechanism effect.

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Abstract

The invention discloses a pharmaceutical composition, which comprises more than 18 substances, and is prepared by mixing water extracts of radix aucklandiae, agilawood, fructus choerospondiatis, fructus chebulae, myristica fragrans, kapok and frankincense with travertine. The composition prolongs the sleep maintenance time of a subject; and the expression of the brain tissue GAD67 protein of the subject is up-regulated.
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Citation Information

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