一种吡咯喹啉醌二钠盐的分离纯化方法
After removing large particulate impurities, adjusting pH, treating with filter aids and adsorbents, nanofiltration, and salting out, semi-continuous crystallization is carried out using a specific crystal form of pyrroloquinoline quinone disodium salt, crystal form A, as a seed crystal. This solves the problem of obtaining high-purity pyrroloquinoline quinone disodium salt in existing technologies and achieves a highly efficient and environmentally friendly purification process.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INNER MONGOLIA KINGDOMWAY PHARMA LTD
- Filing Date
- 2025-01-08
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies are insufficient to efficiently obtain high-purity pyrroloquinoline quinone disodium salt, and traditional methods involve numerous steps, high energy consumption, and high wastewater treatment costs, which cannot meet the demands of the high-end market.
After removing large particulate impurities, adjusting pH, treating with filter aids and adsorbents, nanofiltration and salting out, semi-continuous crystallization was carried out using a specific crystal form of pyrroloquinoline quinone disodium salt, crystal form A, as a seed crystal. The crystallization process was optimized by combining a gradient cooling crystallization method.
It improves the purity and crystallization efficiency of pyrroloquinoline quinone disodium salt, simplifies the process, reduces energy consumption and wastewater discharge, and reduces environmental pollution and energy waste.