一种癫痫动物模型的构建方法以及由该模型筛选获得的用于治疗癫痫的药物
By constructing a zebrafish model of permethrin exposure, the problem of the lack of animal models of epilepsy related to environmental factors in the existing technology has been solved, and effective simulation of epilepsy caused by permethrin exposure and drug screening have been achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACAD OF SCI
- Filing Date
- 2024-11-15
- Publication Date
- 2026-07-17
AI Technical Summary
The lack of animal models of epilepsy related to environmental factors in existing technologies has affected the screening and research of related drugs.
A zebrafish model induced by permethrin exposure was constructed. By immersing zebrafish embryos in an environment containing permethrin, the epilepsy caused by environmental factors was simulated. Combined with gene knockout and drug screening, a model suitable for screening antiepileptic drugs was established.
The established model can effectively simulate epilepsy symptoms caused by environmental factors. By observing behaviors such as nystagmus and convulsions and changes in neurons, it can screen for specific drugs for epilepsy caused by permethrin exposure, providing a targeted drug screening method.
Smart Images
Figure CN119453115B_ABST